KCF-S cluster No. 7722 (1 metabolites)

Corresponding Phytochemical cluster No. 1


Plant Species


Cumulative plant class count

class name count

Cumulative family count

class name count
Nectriaceae 1

KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Piperidine alkaloids 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Piperidine alkaloids C10146 C00002040

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00002040 External link 512 Fusaric acid
CHEMBL24510
D005669
38 / 39 / 39 0 / 2

Human Protein / Gene in interactions

38 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002040 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002040 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00002040 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002040 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002040 2 / 2
P22894 Neutrophil collagenase M10A C00002040 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002040 2 / 2
P02545 Prelamin-A/C Unclassified protein C00002040 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00002040 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002040 0 / 1
P54132 Bloom syndrome protein Enzyme C00002040 1 / 2
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002040 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002040 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002040 0 / 0
O75496 Geminin Unclassified protein C00002040 0 / 0
Q9NXG6 Transmembrane prolyl 4-hydroxylase Enzyme C00002040 0 / 0
P03956 Interstitial collagenase M10A C00002040 0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002040 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002040 0 / 0
P08253 72 kDa type IV collagenase M10A C00002040 1 / 3
Q01453 Peripheral myelin protein 22 Unclassified protein C00002040 5 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002040 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002040 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002040 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002040 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002040 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002040 0 / 0
P08254 Stromelysin-1 M10A C00002040 1 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein C00002040 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002040 0 / 0
P40225 Thrombopoietin Unclassified protein C00002040 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002040 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002040 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002040 1 / 0
O00255 Menin Unclassified protein C00002040 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002040 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00002040 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002040 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225

KEGG DISEASE (39)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001523 Mental Disorders C00002040
D010554 Personality Disorders C00002040