Plant Species


Cumulative plant class count

class name count
asterids 1

Cumulative family count

class name count
Hymenochaetaceae 2
Solanaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00043575 External link 512 Hispidin
CHEMBL1224512
CHEMBL1336985
C007946
43 / 46 / 37 0 / 1

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00043575 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00043575 4 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00043575 2 / 0
P06746 DNA polymerase beta Enzyme C00043575 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00043575 0 / 0
P02545 Prelamin-A/C Unclassified protein C00043575 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00043575 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00043575 0 / 1
P54132 Bloom syndrome protein Enzyme C00043575 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00043575 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00043575 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00043575 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00043575 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00043575 0 / 0
P39748 Flap endonuclease 1 Enzyme C00043575 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00043575 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00043575 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00043575 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00043575 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00043575 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00043575 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00043575 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00043575 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00043575 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00043575 5 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00043575 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00043575 0 / 0
P55210 Caspase-7 C14 C00043575 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00043575 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00043575 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00043575 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00043575 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00043575 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00043575 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00043575 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00043575 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00043575 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00043575 0 / 0
P40225 Thrombopoietin Unclassified protein C00043575 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00043575 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00043575 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00043575 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00043575 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#600274 Frontotemporal dementia; ftd P10636
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (37)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D011041 Poisoning C00043575