KCF-S cluster No. 987 (9 metabolites)
Corresponding Phytochemical cluster No. 4
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 12 |
| Liliopsida | 8 |
Cumulative family count
| class name | count |
|---|---|
| Clavicipitaceae | 17 |
| Convolvulaceae | 12 |
| Poaceae | 8 |
| Aspergillaceae | 2 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Indole alkaloids | 2 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Indole alkaloids | C09023 | C00001677 |
| Indole alkaloids | C06068 | C00001717 |
Metabolite list (9)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001677
|
Agroclavine
|
CHEMBL449081
CHEMBL481772 CHEMBL1999620 |
C004465
|
19 / 13 / 16 |
|
|
|
C00001707
|
Chanoclavine-I
|
C006959
|
|
|||
|
C00001717
|
Elymoclavine
|
CHEMBL1356713
|
C007586
|
9 / 12 / 17 | 0 / 2 |
|
|
C00011207
|
6,7-seco-Agroclavine
|
|
||||
|
C00011212
|
Isochanoclavine-I
|
|
||||
|
C00011213
|
Chanoclavine-II
|
|
||||
|
C00011214
|
Norchanoclavine II
/ N-Demethylchanoclavine-II |
C007244
|
|
|||
|
C00011219
|
Molliclavine
|
|
||||
|
C00038732
|
Chanoclavine
|
C006959
|
|
Human Protein / Gene in interactions
24 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | C00001677 C00001717 | 2 / 3 |
| O00255 | Menin | Unclassified protein | C00001677 C00001717 | 2 / 5 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001677 C00001717 | 4 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001677 C00001717 | 1 / 2 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001677 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001677 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001677 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001677 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001717 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00001677 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001717 | 3 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001717 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001677 | 1 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001677 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001677 | 0 / 1 |
| P43405 | Tyrosine-protein kinase SYK | Syk | C00001677 | 0 / 0 |
| P51451 | Tyrosine-protein kinase Blk | Src | C00001677 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001717 | 0 / 0 |
| Q14145 | Kelch-like ECH-associated protein 1 | Unclassified protein | C00001677 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001717 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001677 | 0 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00001677 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001677 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001677 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (16)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #613375 | Maturity-onset diabetes of the young, type 11; mody11 |
P51451
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (20)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00410 | Maturity onset diabetes of the young (MODY) |
P51451
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|