| Organism name | Heuchera spp. |
|---|---|
| Genus | Heuchera |
| Family | Saxifragaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Heuchera |
|---|---|
| Linked NCBI taxonomy ID | 3794 |
| Linked level | genus |
| Family in NCBI taxonomy | Saxifragaceae |
|---|---|
| ID | 3792 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00005140
|
Afzelin
/ Kaempferol 3-O-alpha-rhamnoside / Kaempferol 3-O-alpha-L-rhamnopyranoside |
CHEMBL240528
CHEMBL515798 |
C477954
|
4 / 2 / 2 | No. 2 | No. 15 |
|
|
|
C00005370
|
Reynoutrin
|
CHEMBL183031
CHEMBL185461 CHEMBL488198 CHEMBL464507 CHEMBL520637 |
No. 2 | No. 15 |
|
|||
|
C00005729
|
Myricetin 3-glucoside
/ Myricetin 3-O-beta-D-glucoside / Myricetin 3-O-beta-D-glucopyranoside |
CHEMBL462244
CHEMBL1221722 |
No. 2 | No. 15 |
|
|||
|
C00005730
|
Myricitrin
/ Myricetin 3-O-rhamnoside / Myricetin 3-O-alpha-L-rhamnoside / Myricetin 3-O-alpha-L-rhamnopyranoside |
CHEMBL454576
CHEMBL522983 CHEMBL1599224 |
C008577
|
25 / 11 / 11 | No. 2 | No. 15 |
|
|
|
C00005847
|
Kaempferol 3-(6''-galloylglucoside)
|
CHEMBL503183
|
No. 98 |
|
||||
|
C00005958
|
Quercetin 3-(6''-galloylglucoside)
|
CHEMBL499432
|
No. 98 |
|
||||
|
C00006040
|
Myricetin 3-(6''-galloylglucoside)
|
No. 98 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00005140 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005730 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00005730 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00005730 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005730 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005730 | 0 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005730 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005730 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00005730 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005730 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005730 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005730 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00005730 | 0 / 0 |
| P16083 | Ribosyldihydronicotinamide dehydrogenase [quinone] | Enzyme | C00005140 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00005140 | 0 / 1 |
| P98170 | E3 ubiquitin-protein ligase XIAP | Other cytosolic protein | C00005140 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005730 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005730 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005730 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00005730 | 4 / 3 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005730 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005730 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005730 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00005730 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00005730 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00005730 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005730 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005730 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005730 | 0 / 0 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #300635 | Lymphoproliferative syndrome, x-linked, 2; xlp2 |
P98170
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P98170
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|