Epimedium spp.

• Index
• Plant Species
• Natural Activity
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Epimedium spp.
Genus	Epimedium
Family	Berberidaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Epimedium
Linked NCBI taxonomy ID	63350
Linked level	genus

Family

Family in NCBI taxonomy	Berberidaceae
ID	41773

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	eudicotyledons
ID	71240

Natural Activity

List (28)

Species	Activity
Epimedium spp.	Antiaggregant
Epimedium spp.	Antiarthritic
Epimedium spp.	Antibacterial
Epimedium spp.	Anticancer
Epimedium spp.	Antiglucocorticoid
Epimedium spp.	Antiinflammatory
Epimedium spp.	Antiosteoporotic
Epimedium spp.	Antirheumatic
Epimedium spp.	Antiseptic
Epimedium spp.	Antitussive
Epimedium spp.	Antiviral
Epimedium spp.	Aphrodisiac
Epimedium spp.	Cardioprotective
Epimedium spp.	Catacholamine Inhibitor
Epimedium spp.	Expectorant
Epimedium spp.	Fibrinolytic
Epimedium spp.	Hepatoprotective
Epimedium spp.	Hypotensive
Epimedium spp.	Immunomodulator
Epimedium spp.	Immunostimulant
Epimedium spp.	Leukocytogenic
Epimedium spp.	Memorigenic
Epimedium spp.	Osteogenic
Epimedium spp.	Phagocytotic
Epimedium spp.	Proaggregant
Epimedium spp.	Spermatogenic
Epimedium spp.	Tonic
Epimedium spp.	Vasodilator

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005811	Epimedoside A		C092397			No. 1	No. 15
C00005824	Icariin	CHEMBL553204 CHEMBL1515685 CHEMBL2308655	C056599	6 / 1 / 1	6 / 9	No. 1	No. 15

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P06746	DNA polymerase beta	Enzyme	C00005824	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00005824	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00005824	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00005824	0 / 0
P51160	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	PDE_6C	C00005824	1 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00005824	0 / 0

6 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
650	BMP2, BDA2, BMP2A	bone morphogenetic protein 2	C00005824
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00005824
8654	PDE5A, CGB-PDE, CN5A, PDE5	phosphodiesterase 5A, cGMP-specific (EC:3.1.4.35)	C00005824
5241	PGR, NR3C3, PR	progesterone receptor	C00005824
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00005824
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00005824

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions