Species

KNApSAcK Entry

Organism name Bergenia cordifolia
Genus Bergenia
Family Saxifragaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Bergenia crassifolia var. cordifolia
Linked NCBI taxonomy ID 885526
Linked level varietas

Family

Family in NCBI taxonomy Saxifragaceae
ID 3792

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008865 External link 512 Catechin 3-O-gallate
CHEMBL36327
CHEMBL78573
CHEMBL328085
CHEMBL126142
CHEMBL129451
CHEMBL483083
CHEMBL1514905
41 / 20 / 30 No. 219 No. 14

Human Protein / Gene in interactions

41 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs C00008865 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00008865 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00008865 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00008865 0 / 0
P02768 Serum albumin Secreted protein C00008865 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00008865 2 / 3
P41145 Kappa-type opioid receptor Opioid receptor C00008865 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00008865 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00008865 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00008865 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00008865 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00008865 2 / 3
P56817 Beta-secretase 1 A1A C00008865 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00008865 3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00008865 1 / 1
P27540 Aryl hydrocarbon receptor nuclear translocator Unclassified protein C00008865 0 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00008865 1 / 1
P22303 Acetylcholinesterase Hydrolase C00008865 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00008865 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00008865 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00008865 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00008865 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00008865 4 / 3
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00008865 0 / 7
Q9UBT6 DNA polymerase kappa Enzyme C00008865 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00008865 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00008865 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00008865 1 / 1
O00255 Menin Unclassified protein C00008865 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00008865 1 / 2
Q05513 Protein kinase C zeta type Iota C00008865 0 / 0
Q04759 Protein kinase C theta type Delta C00008865 0 / 1
Q02156 Protein kinase C epsilon type Eta C00008865 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00008865 0 / 0
P17252 Protein kinase C alpha type Alpha C00008865 0 / 0
Q05655 Protein kinase C delta type Delta C00008865 0 / 0
P05129 Protein kinase C gamma type Alpha C00008865 1 / 1
P05771 Protein kinase C beta type Alpha C00008865 0 / 0
P24723 Protein kinase C eta type Eta C00008865 1 / 0
P41743 Protein kinase C iota type Iota C00008865 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00008865 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#237500 Dubin-johnson syndrome; djs Q92887
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#112100 Yt blood group antigen P22303

KEGG DISEASE (30)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00036 Osteosarcoma P08684 (marker)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)