| Organism name | Bergenia cordifolia | 
|---|---|
| Genus | Bergenia | 
| Family | Saxifragaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Bergenia crassifolia var. cordifolia | 
|---|---|
| Linked NCBI taxonomy ID | 885526 | 
| Linked level | varietas | 
| Family in NCBI taxonomy | Saxifragaceae | 
|---|---|
| ID | 3792 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | eudicotyledons | 
|---|---|
| ID | 71240 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | 
                        # of proteins in
                         ChEMBL interaction / related OMIM / related KEGG DISEASE  | 
                      
                        # of genes in
                         CTD interaction / related diseases  | 
                      
                        KCF-S
                         cluster  | 
                      
                        phytochemical
                         cluster  | 
                      figure | 
|---|---|---|---|---|---|---|---|---|
| 
                        C00008865
                        
                           | 
                      
                        Catechin 3-O-gallate
                         | 
                      
                        CHEMBL36327
                         CHEMBL78573 CHEMBL328085 CHEMBL126142 CHEMBL129451 CHEMBL483083 CHEMBL1514905  | 
                      41 / 20 / 30 | No. 219 | No. 14 | 
                         
                       | 
                    
| accession | description | class description | KNApSAcK metabolite in interactions | 
                          # of diseases
                           (OMIM / KEGG)  | 
                      
|---|---|---|---|---|
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00008865 | 0 / 0 | 
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00008865 | 0 / 0 | 
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00008865 | 0 / 0 | 
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00008865 | 0 / 0 | 
| P02768 | Serum albumin | Secreted protein | C00008865 | 0 / 0 | 
| P11473 | Vitamin D3 receptor | NR1I1 | C00008865 | 2 / 3 | 
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00008865 | 0 / 0 | 
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00008865 | 0 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00008865 | 0 / 0 | 
| P41143 | Delta-type opioid receptor | Opioid receptor | C00008865 | 0 / 0 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00008865 | 0 / 0 | 
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00008865 | 2 / 3 | 
| P56817 | Beta-secretase 1 | A1A | C00008865 | 0 / 0 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00008865 | 3 / 3 | 
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00008865 | 1 / 1 | 
| P27540 | Aryl hydrocarbon receptor nuclear translocator | Unclassified protein | C00008865 | 0 / 0 | 
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00008865 | 1 / 1 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00008865 | 1 / 0 | 
| P35372 | Mu-type opioid receptor | Opioid receptor | C00008865 | 0 / 0 | 
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00008865 | 0 / 0 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00008865 | 0 / 1 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00008865 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00008865 | 4 / 3 | 
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00008865 | 0 / 7 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00008865 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00008865 | 0 / 0 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00008865 | 0 / 0 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00008865 | 1 / 1 | 
| O00255 | Menin | Unclassified protein | C00008865 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00008865 | 1 / 2 | 
| Q05513 | Protein kinase C zeta type | Iota | C00008865 | 0 / 0 | 
| Q04759 | Protein kinase C theta type | Delta | C00008865 | 0 / 1 | 
| Q02156 | Protein kinase C epsilon type | Eta | C00008865 | 0 / 0 | 
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00008865 | 0 / 0 | 
| P17252 | Protein kinase C alpha type | Alpha | C00008865 | 0 / 0 | 
| Q05655 | Protein kinase C delta type | Delta | C00008865 | 0 / 0 | 
| P05129 | Protein kinase C gamma type | Alpha | C00008865 | 1 / 1 | 
| P05771 | Protein kinase C beta type | Alpha | C00008865 | 0 / 0 | 
| P24723 | Protein kinase C eta type | Eta | C00008865 | 1 / 0 | 
| P41743 | Protein kinase C iota type | Iota | C00008865 | 0 / 0 | 
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00008865 | 0 / 0 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | 
                            Q99714
                             | 
                        
| #237500 | Dubin-johnson syndrome; djs | 
                            Q92887
                             | 
                        
| #600274 | Frontotemporal dementia; ftd | 
                            P10636
                             | 
                        
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | 
                            Q03164
                             | 
                        
| #114550 | Hepatocellular carcinoma | 
                            P08581
                             | 
                        
| #145000 | Hyperparathyroidism 1; hrpt1 | 
                            O00255
                             | 
                        
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency | 
                            P00374
                             | 
                        
| #300705 | Mental retardation, x-linked 17; mrx17 | 
                            Q99714
                             | 
                        
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | 
                            Q99714
                             | 
                        
| #131100 | Multiple endocrine neoplasia, type i; men1 | 
                            O00255
                             | 
                        
| #607948 | Mycobacterium tuberculosis, susceptibility to | 
                            P11473
                             | 
                        
| #260540 | Parkinson-dementia syndrome | 
                            P10636
                             | 
                        
| #172700 | Pick disease of brain | 
                            P10636
                             | 
                        
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 | 
                            P08581
                             | 
                        
| #605361 | Spinocerebellar ataxia 14; sca14 | 
                            P05129
                             | 
                        
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | 
                            Q9NUW8
                             | 
                        
| #601367 | Stroke, ischemic | 
                            P24723
                             | 
                        
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | 
                            P10636
                             | 
                        
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a | 
                            P11473
                             | 
                        
| #112100 | Yt blood group antigen | 
                            P22303
                             | 
                        
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | 
                            O00255
                            (related)
                             | 
                        
| H00034 | Carcinoid | 
                            O00255
                            (related)
                             | 
                        
| H00045 | Malignant islet cell carcinoma | 
                            O00255
                            (related)
                             | 
                        
| H00246 | Primary hyperparathyroidism | 
                            O00255
                            (related)
                             | 
                        
| H01102 | Pituitary adenomas | 
                            O00255
                            (related)
                             | 
                        
| H01197 | Dihydrofolate reductase (DHFR) deficiency | 
                            P00374
                            (related)
                             | 
                        
| H00063 | Spinocerebellar ataxia (SCA) | 
                            P05129
                            (related)
                             Q9NUW8 (related)  | 
                        
| H00018 | Gastric cancer | 
                            P08581
                            (related)
                             P10415 (related)  | 
                        
| H00021 | Renal cell carcinoma | 
                            P08581
                            (related)
                             | 
                        
| H00046 | Cholangiocarcinoma | 
                            P08581
                            (related)
                             | 
                        
| H00036 | Osteosarcoma | 
                            P08684
                            (marker)
                             | 
                        
| H00005 | Chronic lymphocytic leukemia (CLL) | 
                            P10415
                            (related)
                             | 
                        
| H00013 | Small cell lung cancer | 
                            P10415
                            (related)
                             | 
                        
| H00028 | Choriocarcinoma | 
                            P10415
                            (related)
                             | 
                        
| H00030 | Cervical cancer | 
                            P10415
                            (related)
                             | 
                        
| H00041 | Kaposi's sarcoma | 
                            P10415
                            (related)
                             | 
                        
| H00054 | Nasopharyngeal cancer | 
                            P10415
                            (related)
                             | 
                        
| H00058 | Amyotrophic lateral sclerosis (ALS) | 
                            P10636
                            (related)
                             | 
                        
| H00077 | Progressive supranuclear palsy (PSP) | 
                            P10636
                            (related)
                             | 
                        
| H00078 | Frontotemporal lobar degeneration (FTLD) | 
                            P10636
                            (related)
                             | 
                        
| H00342 | Tuberculosis | 
                            P11473
                            (related)
                             | 
                        
| H00784 | Localized autosomal recessive hypotrichosis | 
                            P11473
                            (related)
                             | 
                        
| H01143 | Vitamin D-dependent rickets | 
                            P11473
                            (related)
                             | 
                        
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | 
                            Q03164
                            (related)
                             Q03164 (marker)  | 
                        
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | 
                            Q03164
                            (related)
                             | 
                        
| H00408 | Type I diabetes mellitus | 
                            Q04759
                            (related)
                             | 
                        
| H00208 | Hyperbilirubinemia | 
                            Q92887
                            (related)
                             | 
                        
| H00480 | Non-syndromic X-linked mental retardation | 
                            Q99714
                            (related)
                             | 
                        
| H00658 | Syndromic X-linked mental retardation | 
                            Q99714
                            (related)
                             | 
                        
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | 
                            Q99714
                            (related)
                             |