Species

KNApSAcK Entry

Organism name Mildbraediodendron excelsum
Genus Mildbraediodendron
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Mildbraediodendron excelsum
Linked NCBI taxonomy ID 149663
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009392 External link 512 Glycitein
/ 7,4'-Dihydroxy-6-methoxyisoflavone
CHEMBL513024
C086566
2 / 2 / 2 40 / 4 No. 3 No. 15
C00009428 External link 512 6,7,2',4',5'-Pentamethoxyisoflavone
CHEMBL234933
No. 8 No. 15
C00009422 External link 512 6,7,3'-Trimethoxy-4',5'-methylenedioxyisoflavone
No. 27 No. 15
C00009421 External link 512 Milldurone
/ 6,7,2'-Trimethoxy-4',5'-methylenedioxyisoflavone
CHEMBL234717
No. 27 No. 15
C00009418 External link 512 6-Hydroxy-7,2'-dimethoxy-4',5'-methylenedioxyisoflavone
No. 27 No. 15
C00020211 External link 512 6,7-Dihydroxy-3',4'-methylenedioxyisoflavone
CHEMBL239030
3 / 2 / 0 No. 27 No. 15
C00009544 External link 512 6,7-Dimethoxy-3',4'-methylenedioxyisoflavanone
No. 77 No. 14

Human Protein / Gene in interactions

5 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00009392 1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme C00020211 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00020211 2 / 0
P03372 Estrogen receptor NR3A1 C00009392 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00020211 0 / 0

40 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00009392
119 ADD2, ADDB adducin 2 (beta) C00009392
396 ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 Rho GDP dissociation inhibitor (GDI) alpha C00009392
23545 ATP6V0A2, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS ATPase, H+ transporting, lysosomal V0 subunit a2 (EC:3.6.3.6) C00009392
11177 BAZ1A, ACF1, WALp1, WCRF180, hACF1 bromodomain adjacent to zinc finger domain, 1A C00009392
890 CCNA2, CCN1, CCNA cyclin A2 C00009392
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00009392
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00009392
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00009392
1795 DOCK3, MOCA, PBP dedicator of cytokinesis 3 C00009392
2041 EPHA1, EPH, EPHT, EPHT1 EPH receptor A1 (EC:2.7.10.1) C00009392
83715 ESPN, DFNB36 espin C00009392
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00009392
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00009392
56776 FMN2 formin 2 C00009392
7866 IFRD2, IFNRP, SKMc15, SM15 interferon-related developmental regulator 2 C00009392
26145 IRF2BP1 interferon regulatory factor 2 binding protein 1 C00009392
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00009392
26251 KCNG2, KCNF2, KV6.2 potassium voltage-gated channel, subfamily G, member 2 C00009392
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00009392
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00009392
4314 MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) C00009392
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00009392
8204 NRIP1, RIP140 nuclear receptor interacting protein 1 C00009392
56944 OLFML3, HNOEL-iso, OLF44 olfactomedin-like 3 C00009392
5111 PCNA proliferating cell nuclear antigen C00009392
64236 PDLIM2, MYSTIQUE, SLIM PDZ and LIM domain 2 (mystique) C00009392
5411 PNN, DRS, DRSP, SDK3, memA pinin, desmosome associated protein C00009392
5458 POU4F2, BRN3.2, BRN3B, Brn-3b POU class 4 homeobox 2 C00009392
6197 RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) C00009392
81537 SGPP1, SPPase1 sphingosine-1-phosphate phosphatase 1 C00009392
6558 SLC12A2, BSC, BSC2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 C00009392
6667 SP1 Sp1 transcription factor C00009392
6781 STC1, STC stanniocalcin 1 C00009392
6870 TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL tachykinin receptor 3 C00009392
7130 TNFAIP6, TSG-6, TSG6 tumor necrosis factor, alpha-induced protein 6 C00009392
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00009392
9537 TP53I11, PIG11 tumor protein p53 inducible protein 11 C00009392
7345 UCHL1, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, Uch-L1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) C00009392
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00009392

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P18054
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#278300 Xanthinuria, type i P47989

KEGG DISEASE (2)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00192 Xanthinuria P47989 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001254 Astrocytoma C00009392
D009361 Neoplasm Invasiveness C00009392
D019636 Neurodegenerative Diseases C00009392
D010243 Paralysis C00009392