PCIDB

Actinomadura sp. SF-2370

Species

KNApSAcK Entry

Organism name Actinomadura sp. SF-2370
Genus Actinomadura
Family Thermomonosporaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Actinomadura
Linked NCBI taxonomy ID 1988
Linked level genus

Family

Family in NCBI taxonomy Thermomonosporaceae
ID 2012

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00017726 External link 512 SF 2370
/ (+)-Antibiotic K 252a
/ (+)-Antibiotic SF 2370
/ Protein kinase inhibitor K252a
CHEMBL281948
CHEMBL416056
CHEMBL94678
CHEMBL1490533
CHEMBL1591330
C047321
258 / 119 / 82 No. 251

Human Protein / Gene in interactions

258 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P42345 Serine/threonine-protein kinase mTOR Enzyme C00017726 0 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00017726 1 / 1
P36897 TGF-beta receptor type-1 TKL dual-specificity kinase STKR type 1 subfamily C00017726 3 / 2
Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2 C00017726 0 / 0
P29322 Ephrin type-A receptor 8 Eph C00017726 0 / 0
P42685 Tyrosine-protein kinase FRK Src C00017726 0 / 0
Q13043 Serine/threonine-protein kinase 4 STE serine/threonine protein kinase MST subfamily C00017726 1 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00017726 0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek C00017726 0 / 0
Q5VT25 Serine/threonine-protein kinase MRCK alpha AGC serine/threonine protein kinase GEK subfamily C00017726 0 / 0
Q14289 Protein-tyrosine kinase 2-beta Fak C00017726 0 / 0
P08922 Proto-oncogene tyrosine-protein kinase ROS TK tyrosine-protein kinase SEV C00017726 0 / 1
Q15831 Serine/threonine-protein kinase STK11 Lkb C00017726 2 / 2
Q9BYP7 Serine/threonine-protein kinase WNK3 WNK serine/threonine protein kinase subfamily C00017726 0 / 0
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily C00017726 1 / 3
Q15759 Mitogen-activated protein kinase 11 p38 C00017726 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00017726 0 / 0
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00017726 9 / 3
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00017726 0 / 0
Q9UIK4 Death-associated protein kinase 2 Dapk C00017726 0 / 0
P41240 Tyrosine-protein kinase CSK Csk C00017726 0 / 0
P45984 Mitogen-activated protein kinase 9 Jnk C00017726 0 / 0
P17252 Protein kinase C alpha type Alpha C00017726 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00017726 0 / 0
Q15349 Ribosomal protein S6 kinase alpha-2 Rskb C00017726 0 / 0
P04629 High affinity nerve growth factor receptor Trk C00017726 2 / 3
Q05655 Protein kinase C delta type Delta C00017726 0 / 0
Q04759 Protein kinase C theta type Delta C00017726 0 / 1
Q15303 Receptor tyrosine-protein kinase erbB-4 TK tyrosine-protein kinase EGFR subfamily C00017726 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00017726 0 / 0
O14965 Aurora kinase A Aur C00017726 0 / 0
Q7KZI7 Serine/threonine-protein kinase MARK2 CAMK serine/threonine protein kinase MARK subfamily C00017726 0 / 0
Q13882 Protein-tyrosine kinase 6 Src C00017726 0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily C00017726 0 / 0
Q9UHD2 Serine/threonine-protein kinase TBK1 Ikk C00017726 1 / 0
P21709 Ephrin type-A receptor 1 Eph C00017726 0 / 0
Q9P0L2 Serine/threonine-protein kinase MARK1 CAMK serine/threonine protein kinase MARK subfamily C00017726 0 / 0
Q96PF2 Testis-specific serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase TSSK subfamily C00017726 0 / 0
P51956 Serine/threonine-protein kinase Nek3 Nek1 C00017726 0 / 0
P00519 Tyrosine-protein kinase ABL1 Abl C00017726 1 / 2
Q05513 Protein kinase C zeta type Iota C00017726 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00017726 0 / 0
Q02156 Protein kinase C epsilon type Eta C00017726 0 / 0
P41743 Protein kinase C iota type Iota C00017726 0 / 0
Q9UK32 Ribosomal protein S6 kinase alpha-6 Rskb C00017726 0 / 0
Q04912 Macrophage-stimulating protein receptor TK tyrosine-protein kinase MET subfamily C00017726 0 / 0
Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta Camk2 C00017726 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00017726 0 / 0
P80192 Mitogen-activated protein kinase kinase kinase 9 TKL dual-specificity kinase MLK C00017726 0 / 0
P43403 Tyrosine-protein kinase ZAP-70 Syk C00017726 1 / 2
P16234 Platelet-derived growth factor receptor alpha Pdgfr C00017726 2 / 1
P19784 Casein kinase II subunit alpha' Ck2 C00017726 0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 C00017726 0 / 0
Q9UQB9 Aurora kinase C Aur C00017726 1 / 1
P49761 Dual specificity protein kinase CLK3 Clk C00017726 0 / 0
P51813 Cytoplasmic tyrosine-protein kinase BMX Tec C00017726 0 / 0
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily C00017726 0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily C00017726 0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK C00017726 0 / 0
Q06187 Tyrosine-protein kinase BTK Tec C00017726 2 / 2
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK C00017726 0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk C00017726 0 / 0
Q9UBE8 Serine/threonine-protein kinase NLK CMGC serine/threonine protein kinase NMO subfamily C00017726 0 / 0
Q12866 Tyrosine-protein kinase Mer TK tyrosine-protein kinase AXL C00017726 1 / 1
Q00535 Cyclin-dependent kinase 5 Cdk5 C00017726 0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00017726 0 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00017726 1 / 3
P24385 G1/S-specific cyclin-D1 Other cytosolic protein C00017726 1 / 8
Q9Y5S2 Serine/threonine-protein kinase MRCK beta AGC serine/threonine protein kinase GEK subfamily C00017726 0 / 0
Q8N4C8 Misshapen-like kinase 1 STE serine/threonine protein kinase MSN subfamily C00017726 0 / 0
Q9NYY3 Serine/threonine-protein kinase PLK2 Plk2 C00017726 0 / 0
P43250 G protein-coupled receptor kinase 6 AGC serine/threonine protein kinase GRK subfamily C00017726 0 / 0
Q96BR1 Serine/threonine-protein kinase Sgk3 AGC serine/threonine protein kinase SGK subfamily C00017726 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00017726 1 / 8
O43293 Death-associated protein kinase 3 Dapk C00017726 0 / 0
Q15746 Myosin light chain kinase, smooth muscle Mlck C00017726 1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily C00017726 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00017726 2 / 2
Q9Y243 RAC-gamma serine/threonine-protein kinase Akt C00017726 1 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00017726 0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00017726 0 / 0
Q13464 Rho-associated protein kinase 1 Rock C00017726 0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn C00017726 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00017726 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00017726 0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 C00017726 0 / 0
Q16584 Mitogen-activated protein kinase kinase kinase 11 TKL dual-specificity kinase MLK C00017726 0 / 0
Q02779 Mitogen-activated protein kinase kinase kinase 10 TKL dual-specificity kinase MLK C00017726 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00017726 1 / 1
P07947 Tyrosine-protein kinase Yes Src C00017726 0 / 0
P51617 Interleukin-1 receptor-associated kinase 1 Irak C00017726 0 / 0
Q9NWZ3 Interleukin-1 receptor-associated kinase 4 Irak C00017726 2 / 1
O43353 Receptor-interacting serine/threonine-protein kinase 2 Ripk C00017726 0 / 0
P29320 Ephrin type-A receptor 3 Eph C00017726 1 / 0
P54764 Ephrin type-A receptor 4 Eph C00017726 0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily C00017726 0 / 0
Q16620 BDNF/NT-3 growth factors receptor Trk C00017726 1 / 1
P42680 Tyrosine-protein kinase Tec Tec C00017726 0 / 0
P42681 Tyrosine-protein kinase TXK Tec C00017726 0 / 0
Q96SB4 SRSF protein kinase 1 Srpk C00017726 0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 C00017726 0 / 0
P07332 Tyrosine-protein kinase Fes/Fps Fer C00017726 0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily C00017726 0 / 0
P09769 Tyrosine-protein kinase Fgr Src C00017726 0 / 0
P54760 Ephrin type-B receptor 4 Eph C00017726 0 / 0
Q09013 Myotonin-protein kinase AGC serine/threonine protein kinase GEK subfamily C00017726 1 / 1
Q16832 Discoidin domain-containing receptor 2 Ddr C00017726 1 / 1
Q8IYT8 Serine/threonine-protein kinase ULK2 ULK serine/threonine protein kinase C00017726 0 / 0
Q9BYT3 Serine/threonine-protein kinase 33 Unique CAMK serine/threonine protein kinase C00017726 0 / 0
P57059 Serine/threonine-protein kinase SIK1 CAMK serine/threonine protein kinase QIK subfamily C00017726 0 / 0
P78362 SRSF protein kinase 2 Srpk C00017726 0 / 0
Q9HBY8 Serine/threonine-protein kinase Sgk2 AGC serine/threonine protein kinase SGK subfamily C00017726 0 / 0
Q86Y07 Serine/threonine-protein kinase VRK2 Enzyme C00017726 0 / 0
Q9Y3S1 Serine/threonine-protein kinase WNK2 WNK serine/threonine protein kinase subfamily C00017726 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00017726 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00017726 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00017726 0 / 0
P42684 Abelson tyrosine-protein kinase 2 Abl C00017726 0 / 0
Q05397 Focal adhesion kinase 1 Fak C00017726 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00017726 0 / 1
P29323 Ephrin type-B receptor 2 Eph C00017726 2 / 0
O75914 Serine/threonine-protein kinase PAK 3 STE serine/threonine protein kinase PAKA subfamily C00017726 1 / 1
P15735 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Phk C00017726 1 / 1
Q02763 Angiopoietin-1 receptor Tie C00017726 1 / 1
P29317 Ephrin type-A receptor 2 Eph C00017726 1 / 1
P51955 Serine/threonine-protein kinase Nek2 Nek C00017726 0 / 0
Q15375 Ephrin type-A receptor 7 Eph C00017726 0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily C00017726 0 / 0
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 C00017726 0 / 0
Q9H4B4 Serine/threonine-protein kinase PLK3 PLK serine/threonine protein kinase subfamily C00017726 0 / 0
P54753 Ephrin type-B receptor 3 Eph C00017726 0 / 0
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00017726 1 / 1
O15146 Muscle, skeletal receptor tyrosine-protein kinase Musk C00017726 1 / 1
O60285 NUAK family SNF1-like kinase 1 CAMK serine/threonine protein kinase NUAK subfamily C00017726 0 / 0
Q96RG2 PAS domain-containing serine/threonine-protein kinase Pask C00017726 0 / 0
P34947 G protein-coupled receptor kinase 5 AGC serine/threonine protein kinase GRK subfamily C00017726 0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00017726 5 / 4
P09619 Platelet-derived growth factor receptor beta Pdgfr C00017726 5 / 1
P52564 Dual specificity mitogen-activated protein kinase kinase 6 Ste7 C00017726 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00017726 1 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00017726 0 / 0
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha Other serine/threonine protein kinase C00017726 1 / 1
Q96GD4 Aurora kinase B Aur C00017726 0 / 0
O75676 Ribosomal protein S6 kinase alpha-4 CAMK serine/threonine protein kinase MSKB subfamily C00017726 0 / 0
P05129 Protein kinase C gamma type Alpha C00017726 1 / 1
O60674 Tyrosine-protein kinase JAK2 Jakb C00017726 5 / 1
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00017726 1 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00017726 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00017726 2 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00017726 0 / 0
P35916 Vascular endothelial growth factor receptor 3 Vegfr C00017726 2 / 1
P22455 Fibroblast growth factor receptor 4 Fgfr C00017726 0 / 0
P22607 Fibroblast growth factor receptor 3 Fgfr C00017726 14 / 6
P45983 Mitogen-activated protein kinase 8 Jnk C00017726 0 / 0
O94804 Serine/threonine-protein kinase 10 STE serine/threonine protein kinase SLK subfamily C00017726 1 / 0
P53667 LIM domain kinase 1 Limk C00017726 0 / 0
Q13177 Serine/threonine-protein kinase PAK 2 STE serine/threonine protein kinase PAKA subfamily C00017726 0 / 0
Q06418 Tyrosine-protein kinase receptor TYRO3 TK tyrosine-protein kinase AXL C00017726 0 / 0
Q6PHR2 Serine/threonine-protein kinase ULK3 ULK serine/threonine protein kinase C00017726 0 / 0
Q7L7X3 Serine/threonine-protein kinase TAO1 STE serine/threonine protein kinase TAO subfamily C00017726 0 / 0
P14616 Insulin receptor-related protein TK tyrosine-protein kinase INSR C00017726 0 / 0
O43318 Mitogen-activated protein kinase kinase kinase 7 Tak1 C00017726 0 / 0
Q9BXA7 Testis-specific serine/threonine-protein kinase 1 Tssk C00017726 0 / 0
Q9H2K8 Serine/threonine-protein kinase TAO3 STE serine/threonine protein kinase TAO subfamily C00017726 0 / 0
Q8NG66 Serine/threonine-protein kinase Nek11 Nek11 C00017726 0 / 0
Q8WTQ7 G protein-coupled receptor kinase 7 AGC serine/threonine protein kinase GRK subfamily C00017726 0 / 0
Q8TF76 Serine/threonine-protein kinase haspin Haspin C00017726 0 / 0
P11362 Fibroblast growth factor receptor 1 Fgfr C00017726 4 / 5
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily C00017726 0 / 0
Q08881 Tyrosine-protein kinase ITK/TSK Tec C00017726 1 / 1
P49840 Glycogen synthase kinase-3 alpha Gsk C00017726 0 / 0
Q13976 cGMP-dependent protein kinase 1 Pkg C00017726 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00017726 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00017726 0 / 0
P05771 Protein kinase C beta type Alpha C00017726 0 / 0
P08631 Tyrosine-protein kinase HCK Src C00017726 0 / 0
P07948 Tyrosine-protein kinase Lyn Src C00017726 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00017726 4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00017726 0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb C00017726 2 / 2
P07333 Macrophage colony-stimulating factor 1 receptor Pdgfr C00017726 1 / 1
P16591 Tyrosine-protein kinase Fer Fer C00017726 0 / 0
Q8IU85 Calcium/calmodulin-dependent protein kinase type 1D Camk1 C00017726 0 / 0
Q9HC98 Serine/threonine-protein kinase Nek6 Nek C00017726 0 / 0
Q9UEE5 Serine/threonine-protein kinase 17A Dapk C00017726 0 / 0
P07949 Proto-oncogene tyrosine-protein kinase receptor Ret Ret C00017726 9 / 4
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK C00017726 0 / 0
P36896 Activin receptor type-1B TKL serine/threonine protein kinase STKR type 1 subfamily C00017726 0 / 0
Q86UE8 Serine/threonine-protein kinase tousled-like 2 TLK serine/threonine protein kinase C00017726 0 / 0
Q86Z02 Homeodomain-interacting protein kinase 1 CMGC serine/threonine protein kinase HIPK subfamily C00017726 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00017726 4 / 3
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00017726 4 / 3
P06239 Tyrosine-protein kinase Lck Src C00017726 0 / 1
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00017726 0 / 0
Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2 C00017726 0 / 0
O96017 Serine/threonine-protein kinase Chk2 Rad53 C00017726 4 / 1
P52333 Tyrosine-protein kinase JAK3 Jakb C00017726 1 / 1
P04049 RAF proto-oncogene serine/threonine-protein kinase Raf C00017726 2 / 0
P43405 Tyrosine-protein kinase SYK Syk C00017726 0 / 0
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 C00017726 0 / 0
Q16566 Calcium/calmodulin-dependent protein kinase type IV Camk1 C00017726 0 / 0
P53355 Death-associated protein kinase 1 Dapk C00017726 0 / 1
P24723 Protein kinase C eta type Eta C00017726 1 / 0
P51451 Tyrosine-protein kinase Blk Src C00017726 1 / 1
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00017726 0 / 0
O14733 Dual specificity mitogen-activated protein kinase kinase 7 Ste7 C00017726 0 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00017726 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00017726 0 / 0
P35557 Glucokinase Enzyme C00017726 3 / 3
P49760 Dual specificity protein kinase CLK2 Clk C00017726 0 / 0
P54756 Ephrin type-A receptor 5 Eph C00017726 0 / 0
P54762 Ephrin type-B receptor 1 Eph C00017726 0 / 0
Q07912 Activated CDC42 kinase 1 TK tyrosine-protein kinase ACK subfamily C00017726 0 / 0
P30530 Tyrosine-protein kinase receptor UFO TK tyrosine-protein kinase AXL subfamily C00017726 0 / 0
Q9BZL6 Serine/threonine-protein kinase D2 Pkd C00017726 0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim C00017726 0 / 0
Q9UPE1 SRSF protein kinase 3 Srpk C00017726 0 / 0
Q9Y6E0 Serine/threonine-protein kinase 24 STE serine/threonine protein kinase YSK subfamily C00017726 0 / 0
Q9Y6M4 Casein kinase I isoform gamma-3 Ck1-g C00017726 0 / 0
Q8N568 Serine/threonine-protein kinase DCLK2 CAMK serine/threonine protein kinase DCAMK1 C00017726 0 / 0
Q8TDC3 Serine/threonine-protein kinase BRSK1 CAMK serine/threonine protein kinase BRSK subfamily C00017726 0 / 0
P19525 Interferon-induced, double-stranded RNA-activated protein kinase Pkr C00017726 0 / 0
P51817 cAMP-dependent protein kinase catalytic subunit PRKX Pka C00017726 0 / 0
Q9UL54 Serine/threonine-protein kinase TAO2 STE serine/threonine protein kinase TAO subfamily C00017726 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00017726 0 / 0
P51946 Cyclin-H Other cytosolic protein C00017726 0 / 0
P50613 Cyclin-dependent kinase 7 Cdk7 C00017726 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00017726 0 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00017726 0 / 0
O96020 G1/S-specific cyclin-E2 Other cytosolic protein C00017726 0 / 2
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00017726 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00017726 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00017726 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00017726 0 / 0
P20248 Cyclin-A2 Other cytosolic protein C00017726 0 / 0
P78396 Cyclin-A1 Other cytosolic protein C00017726 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00017726 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00017726 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00017726 0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00017726 0 / 0
P54619 5'-AMP-activated protein kinase subunit gamma-1 REG serine/threonine protein kinase family C00017726 0 / 0
Q9Y478 5'-AMP-activated protein kinase subunit beta-1 REG serine/threonine protein kinase family C00017726 0 / 0
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk C00017726 0 / 0
Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 Ampk C00017726 0 / 0
O43741 5'-AMP-activated protein kinase subunit beta-2 REG serine/threonine protein kinase family C00017726 0 / 0
Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 REG serine/threonine protein kinase family C00017726 3 / 3
Q16816 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Phk C00017726 0 / 0
Q93100 Phosphorylase b kinase regulatory subunit beta REG serine/threonine protein kinase family C00017726 1 / 1
P46020 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform REG serine/threonine protein kinase family C00017726 1 / 1
P46019 Phosphorylase b kinase regulatory subunit alpha, liver isoform REG serine/threonine protein kinase family C00017726 1 / 1
O60563 Cyclin-T1 Other cytosolic protein C00017726 0 / 0
P50750 Cyclin-dependent kinase 9 Cdk9 C00017726 0 / 0
Q00526 Cyclin-dependent kinase 3 Cdc2 C00017726 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00017726 1 / 0
P30281 G1/S-specific cyclin-D3 Other cytosolic protein C00017726 0 / 1
P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A Isomerase C00017726 0 / 0
Q01538 Myelin transcription factor 1 Unclassified protein C00017726 0 / 0
Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 Kinase C00017726 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (119)

OMIM preferred title UniProt
#100800 Achondroplasia; ach P22607
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#300755 Agammaglobulinemia, x-linked; xla Q06187
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#101200 Apert syndrome P21802
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#109800 Bladder cancer P22607
#114480 Breast cancer O96017
P31749
#600880 Budd-chiari syndrome; bdchs O60674
#610474 Camptodactyly, tall stature, and hearing loss syndrome P22607
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#600858 Cardiomyopathy, familial hypertrophic, 6; cmh6 Q9UGJ0
#116600 Cataract 6, multiple types; ctrct6 P29317
#209880 Central hypoventilation syndrome, congenital; cchs P07949
#603956 Cervical cancer P22607
#613630 Cocoon syndrome O15111
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P07949
P29320
P31749
#615109 Cowden syndrome 6; cws6 P31749
#123500 Crouzon syndrome P21802
#612247 Crouzon syndrome with acanthosis nigricans; can P22607
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
P31751
#246200 Donohue syndrome P06213
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
P16234
#177700 Glaucoma 1, open angle, p; glc1p Q9UHD2
#306000 Glycogen storage disease ixa1; gsd9a1 P46019
#261750 Glycogen storage disease ixb; gsd9b Q93100
#613027 Glycogen storage disease ixc; gsd9c P15735
#261740 Glycogen storage disease of heart, lethal congenital Q9UGJ0
#300559 Glycogen storage disease, type ixd; gsd9d P46020
#602089 Hemangioma, capillary infantile P35916
P35968
#114550 Hepatocellular carcinoma P08581
#142623 Hirschsprung disease, susceptibility to, 1; hscr1 P07949
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#602485 Hyperinsulinemic hypoglycemia, familial, 3; hhf3 P35557
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#146000 Hypochondroplasia; hch P22607
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#256800 Insensitivity to pain, congenital, with anhidrosis; cipa P04629
#270450 Insulin-like growth factor i, resistance to P08069
#610799 Invasive pneumococcal disease, recurrent isolated, 1; ipd1 Q9NWZ3
#607676 Irak4 deficiency Q9NWZ3
#307200 Isolated growth hormone deficiency, type iii; ighd3 Q06187
#123150 Jackson-weiss syndrome; jws P21802
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P22607
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
P22607
#611554 Leopard syndrome 2 P04049
#601626 Leukemia, acute myeloid; aml O60674
P09619
P10721
P36888
#608232 Leukemia, chronic myeloid; cml P00519
#221820 Leukoencephalopathy, diffuse hereditary, with spheroids; hdls P07333
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#609192 Loeys-dietz syndrome, type 1a; lds1a P36897
#608967 Loeys-dietz syndrome, type 2a; lds2a P36897
#211980 Lung cancer P00533
#153100 Lymphedema, hereditary, ia P35916
#613011 Lymphoproliferative syndrome 1; lpfs1 Q08881
#613375 Maturity-onset diabetes of the young, type 11; mody11 P51451
#125851 Maturity-onset diabetes of the young, type 2; mody2 P35557
#606391 Maturity-onset diabetes of the young; mody P35557
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph Q9Y243
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300558 Mental retardation, x-linked 30; mrx30 O75914
#602849 Muenke syndrome; mnkes P22607
#171400 Multiple endocrine neoplasia, type iia; men2a P07949
#162300 Multiple endocrine neoplasia, type iib; men2b P07949
#132800 Multiple self-healing squamous epithelioma, susceptibility to; msse P36897
#608931 Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency O15146
#254450 Myelofibrosis O60674
#254500 Myeloma, multiple P22607
P24385
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q09013
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#162900 Nevus, epidermal P22607
#611553 Noonan syndrome 5; ns5 P04049
#613886 Obesity, hyperphagia, and developmental delay Q16620
#259500 Osteogenic sarcoma O96017
#166250 Osteoglophonic dysplasia; ogd P11362
#260540 Parkinson-dementia syndrome P10636
#175200 Peutz-jeghers syndrome; pjs Q15831
#101600 Pfeiffer syndrome P11362
P21802
#171300 Pheochromocytoma P07949
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#263300 Polycythemia vera; pv O60674
#176807 Prostate cancer O96017
P29323
#603688 Prostate cancer/brain cancer susceptibility P29323
#176920 Proteus syndrome P31749
#191830 Renal adysplasia P07949
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#613862 Retinitis pigmentosa 38; rp38 Q12866
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#269840 Selective t-cell defect; stcd P43403
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#605361 Spinocerebellar ataxia 14; sca14 P05129
#271665 Spondylometaepiphyseal dysplasia, short limb-hand type Q16832
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#614868 T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations; tiiac Q13043
#273300 Testicular germ cell tumor; tgct O94804
P10721
P22607
Q15831
#187600 Thanatophoric dysplasia, type i; td1 P22607
#187601 Thanatophoric dysplasia, type ii; td2 P22607
#614521 Thrombocythemia 3; thcyt3 O60674
#155240 Thyroid carcinoma, familial medullary; mtc P07949
#188550 Thyroid carcinoma, papillary P04629
P07949
#190440 Trigonocephaly 1; trigno1 P11362
#600195 Venous malformations, multiple cutaneous and mucosal; vmcm Q02763
#194200 Wolff-parkinson-white syndrome Q9UGJ0

KEGG DISEASE (82)

KEGG name UniProt
H00882 Cocoon syndrome O15111 (related)
H00770 Congenital myasthenic syndrome O15146 (related)
H00012 Polycythemia vera O60674 (related)
O60674 (marker)
H00480 Non-syndromic X-linked mental retardation O75914 (related)
P51812 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
H00018 Gastric cancer O96020 (related)
P00533 (related)
P08581 (related)
P21802 (related)
P24864 (related)
H00055 Laryngeal cancer O96020 (related)
P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
P24864 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P00519 (related)
P00519 (marker)
H00004 Chronic myeloid leukemia (CML) P00519 (related)
P00519 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
H00017 Esophageal cancer P00533 (related)
P24385 (related)
H00022 Bladder cancer P00533 (related)
P22607 (related)
P53355 (related)
H00028 Choriocarcinoma P00533 (related)
P07333 (related)
H00030 Cervical cancer P00533 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P11802 (related)
P16234 (related)
H00032 Thyroid cancer P04629 (related)
P07949 (related)
P07949 (marker)
H00043 Neuroblastoma P04629 (related)
P04629 (marker)
Q16620 (related)
H00265 Hereditary sensory and autonomic neuropathy (HSAN) P04629 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
P35557 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
P43403 (related)
H00822 Renal agenesis and Renal adysplasia P07949 (related)
H00910 Hirschsprung disease (HD) P07949 (related)
H00916 Congenital central hypoventilation syndrome (CCHS) P07949 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
H00014 Non-small cell lung cancer P08922 (related)
Q9UM73 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
P36888 (related)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
P22607 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00038 Malignant melanoma P11802 (related)
H00069 Glycogen storage diseases (GSD) P15735 (related)
P46019 (related)
P46020 (related)
Q93100 (related)
Q9UGJ0 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
P22607 (related)
H00010 Multiple myeloma P22607 (related)
P24385 (related)
P30281 (related)
H00505 FGFR3-related short limb skeletal dysplasias P22607 (related)
H00997 CATSHL syndrome P22607 (related)
H00006 Hairy-cell leukemia P24385 (related)
H00031 Breast cancer P24385 (related)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00047 Gallbladder cancer P24385 (marker)
H01202 Cataract P29317 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H00420 Familial partial lipodystrophy (FPL) P31751 (related)
H00410 Maturity onset diabetes of the young (MODY) P35557 (related)
P51451 (related)
H00512 Permanent neonatal diabetes mellitus (PNDM) P35557 (related)
H00535 Lymphedemas P35916 (related)
H00800 Loeys-Dietz syndrome (LDS) P36897 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) P36897 (related)
Q15746 (related)
H00005 Chronic lymphocytic leukemia (CLL) P43403 (marker)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P52333 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00531 Venous malformations Q02763 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00085 Agammaglobulinemias Q06187 (related)
H00254 Pituitary Dwarfism (PD) Q06187 (related)
H00107 Other well-defined immunodeficiency syndromes Q08881 (related)
H00568 Myotonic dystrophy (DM) Q09013 (related)
H00527 Retinitis pigmentosa (RP) Q12866 (related)
H00019 Pancreatic cancer Q15831 (related)
H00666 Peutz-Jeghers syndrome Q15831 (related)
H00777 Spondylometaepiphyseal dysplasia, short limb-hand type Q16832 (related)
H00096 Defects of toll-like receptor signaling Q9NWZ3 (related)
H00292 Hypertrophic cardiomyopathy (HCM) Q9UGJ0 (related)
H01154 Wolff-Parkinson-White (WPW) syndrome Q9UGJ0 (related)
H01282 Spermatogenic failure Q9UQB9 (related)