Species

KNApSAcK Entry

Organism name Streptomyces No. NH435-hF3
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces
Linked NCBI taxonomy ID 1883
Linked level genus

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00017751 External link 512 MH 435A
/ Erbstatin
/ Antibiotic MH 435A
CHEMBL47986
CHEMBL2001273
C048212
26 / 12 / 14 No. 3417 No. 6

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00017751 0 / 0
Q99700 Ataxin-2 Unclassified protein C00017751 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00017751 2 / 0
P14618 Pyruvate kinase PKM Enzyme C00017751 0 / 0
P06746 DNA polymerase beta Enzyme C00017751 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00017751 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00017751 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00017751 1 / 8
P00352 Retinal dehydrogenase 1 Enzyme C00017751 0 / 0
P39748 Flap endonuclease 1 Enzyme C00017751 0 / 0
O75496 Geminin Unclassified protein C00017751 0 / 0
P07711 Cathepsin L1 C1A C00017751 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00017751 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00017751 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00017751 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00017751 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00017751 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00017751 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00017751 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00017751 4 / 3
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter C00017751 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00017751 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00017751 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00017751 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00017751 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00017751 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#211980 Lung cancer P00533
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)