Actinomycete ATCC 39366
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00018590
|
PD 114721
/ Kazusamycin / Kazusamycin A / Antibiotic 81-484 / Antibiotic CL 1957B |
CHEMBL207141
CHEMBL2002570 |
No. 1021 |
|
||||
|
C00018636
|
CI 940
/ Elactocin / Mantuamycin / Leptomycin B / Antibiotic CI 940 / Antibiotic CL 1957A |
CHEMBL486133
CHEMBL2001508 |
C038753
|
11 / 5 / 10 | 49 / 0 | No. 1021 |
|
Human Protein / Gene in interactions
11 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P54132 | Bloom syndrome protein | Enzyme | C00018636 | 1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00018636 | 2 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00018636 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00018636 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00018636 | 0 / 0 |
| O14980 | Exportin-1 | Unclassified protein | C00018636 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00018636 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00018636 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00018636 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00018636 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00018636 | 1 / 4 |
49 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00018636
|
| 317 | APAF1, APAF-1, CED4 | apoptotic peptidase activating factor 1 |
C00018636
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00018636
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00018636
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00018636
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00018636
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00018636
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00018636
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00018636
|
| 672 | BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 | breast cancer 1, early onset |
C00018636
|
| 7832 | BTG2, PC3, TIS21 | BTG family, member 2 |
C00018636
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00018636
|
| 9133 | CCNB2, HsT17299 | cyclin B2 |
C00018636
|
| 9134 | CCNE2, CYCE2 | cyclin E2 |
C00018636
|
| 993 | CDC25A, CDC25A2 | cell division cycle 25A (EC:3.1.3.48) |
C00018636
|
| 995 | CDC25C, CDC25, PPP1R60 | cell division cycle 25C (EC:3.1.3.48) |
C00018636
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00018636
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00018636
|
| 1111 | CHEK1, CHK1 | checkpoint kinase 1 (EC:2.7.11.1) |
C00018636
|
| 11200 | CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 | checkpoint kinase 2 (EC:2.7.11.1) |
C00018636
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00018636
|
| 1786 | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT | DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) |
C00018636
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00018636
|
| 1871 | E2F3, E2F-3 | E2F transcription factor 3 |
C00018636
|
| 9538 | EI24, EPG4, PIG8, TP53I8 | etoposide induced 2.4 |
C00018636
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00018636
|
| 1647 | GADD45A, DDIT1, GADD45 | growth arrest and DNA-damage-inducible, alpha |
C00018636
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00018636
|
| 3099 | HK2, HKII, HXK2 | hexokinase 2 (EC:2.7.1.1) |
C00018636
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00018636
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00018636
|
| 57913 |
C00018636
|
||
| 4193 | MDM2, ACTFS, HDMX, hdm2 | MDM2 oncogene, E3 ubiquitin protein ligase |
C00018636
|
| 4194 | MDM4, HDMX, MDMX, MRP1 | Mdm4 p53 binding protein homolog (mouse) |
C00018636
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00018636
|
| 3164 | NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3 | nuclear receptor subfamily 4, group A, member 1 |
C00018636
|
| 9055 | PRC1, ASE1 | protein regulator of cytokinesis 1 |
C00018636
|
| 5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) |
C00018636
|
| 9232 | PTTG1, EAP1, HPTTG, PTTG, TUTR1 | pituitary tumor-transforming 1 |
C00018636
|
| 6199 | RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb | ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1) |
C00018636
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00018636
|
| 27244 | SESN1, PA26, SEST1 | sestrin 1 |
C00018636
|
| 6775 | STAT4, SLEB11 | signal transducer and activator of transcription 4 |
C00018636
|
| 6789 | STK4, KRS2, MST1, TIIAC, YSK3 | serine/threonine kinase 4 (EC:2.7.11.1) |
C00018636
|
| 8795 | TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 | tumor necrosis factor receptor superfamily, member 10b |
C00018636
|
| 8793 | TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain |
C00018636
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00018636
|
| 8626 | TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L | tumor protein p63 |
C00018636
|
| 126374 | WTIP | Wilms tumor 1 interacting protein |
C00018636
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #210900 | Bloom syndrome; blm |
P54132
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (10)
| KEGG | name | UniProt |
|---|---|---|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|