Rauvolfia caffra
Species
KNApSAcK Entry
| Organism name | Rauvolfia caffra |
|---|---|
| Genus | Rauvolfia |
| Family | Apocynaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Rauvolfia caffra |
|---|---|
| Linked NCBI taxonomy ID | 947877 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apocynaceae |
|---|---|
| ID | 4056 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (7)
| Species | Activity |
|---|---|
| Rauvolfia caffra Sond. | Antipyretic |
| Rauvolfia caffra Sond. | Depurative |
| Rauvolfia caffra Sond. | Diuretic |
| Rauvolfia caffra Sond. | Emetic |
| Rauvolfia caffra Sond. | Larvicide |
| Rauvolfia caffra Sond. | Laxative |
| Rauvolfia caffra Sond. | Tranquilizer |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00024309
|
Diacetylajmaline
/ 17,21-Diacetylajmaline / 17,21-O,O-Diacetylajmaline |
No. 407 | No. 4 |
|
||||
|
C00024294
|
Ritmos
/ Ignazin / Takycor / Ajmalin / Siddiqui / Rytmalin / Merabitol / Rhytmaton / Tachmalin / Rauwolfin / Rauwolfine / Raugalline / Gilurytmal / (+)-Ajmaline / Cardiorythmine |
CHEMBL1434779
CHEMBL1452040 CHEMBL1460192 CHEMBL1515845 CHEMBL1525248 CHEMBL2105617 CHEMBL2356868 CHEMBL2357792 |
D000404
|
96 / 49 / 43 | 2 / 32 | No. 407 | No. 4 |
|
|
C00024289
|
17-O-Acetylajmaline
|
No. 407 | No. 4 |
|
||||
|
C00024279
|
Raucaffrine
/ (+)-Perakine |
CHEMBL521036
|
No. 523 | No. 4 |
|
|||
|
C00024282
|
(+)-Raucaffrinoline
|
No. 523 | No. 4 |
|
||||
|
C00024338
|
(-)-Vomilenine
|
No. 523 | No. 4 |
|
||||
|
C00024291
|
21-Deoxyvomilenine
|
No. 523 | No. 4 |
|
||||
|
C00024313
|
Vinorine
/ (-)-Vinorine / 21-Deoxyvomilenine |
No. 523 | No. 4 |
|
||||
|
C00024322
|
Vomilenine
/ Z-Vomilenine |
No. 523 | No. 4 |
|
||||
|
C00024318
|
Raucaffriline
|
No. 523 | No. 4 |
|
||||
|
C00024300
|
(+)-Raucaffricine
/ Vomilenine beta-D-glucoside |
No. 5273 | No. 4 |
|
||||
|
C00024346
|
Raucaffricin
/ Raucaffricine / Vomilenine beta-D-glucoside / Vomilenine beta-D-glucopyranoside |
No. 5273 | No. 4 |
|
Human Protein / Gene in interactions
96 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00024294 | 1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00024294 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00024294 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00024294 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00024294 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00024294 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00024294 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00024294 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00024294 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00024294 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00024294 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00024294 | 2 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00024294 | 3 / 2 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00024294 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00024294 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00024294 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00024294 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00024294 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00024294 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00024294 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00024294 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00024294 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00024294 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00024294 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00024294 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00024294 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00024294 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00024294 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00024294 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00024294 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00024294 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00024294 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00024294 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00024294 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00024294 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00024294 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00024294 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00024294 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00024294 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00024294 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00024294 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00024294 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00024294 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00024294 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00024294 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00024294 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00024294 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00024294 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00024294 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00024294 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00024294 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00024294 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00024294 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00024294 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00024294 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00024294 | 7 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00024294 | 1 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00024294 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00024294 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00024294 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00024294 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00024294 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00024294 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00024294 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00024294 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00024294 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00024294 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00024294 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00024294 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00024294 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00024294 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00024294 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00024294 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00024294 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00024294 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00024294 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00024294 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00024294 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00024294 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00024294 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00024294 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00024294 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00024294 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00024294 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00024294 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00024294 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00024294 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00024294 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00024294 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00024294 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00024294 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00024294 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00024294 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00024294 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00024294 | 2 / 5 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00024294 | 0 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3757 | KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
C00024294
|
| 6331 | SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1 | sodium channel, voltage-gated, type V, alpha subunit |
C00024294
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (49)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (43)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
32 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D015746 | Abdominal Pain |
C00024294
|
| D058186 | Acute Kidney Injury |
C00024294
|
| D000743 | Anemia, Hemolytic |
C00024294
|
| D001002 | Anuria |
C00024294
|
| D001145 | Arrhythmias, Cardiac |
C00024294
|
| D001281 | Atrial Fibrillation |
C00024294
|
| D054537 | Atrioventricular Block |
C00024294
|
| C535438 | Bidirectional tachycardia |
C00024294
|
| D053840 | Brugada Syndrome |
C00024294
|
| D002037 | Bundle-Branch Block |
C00024294
|
| D023341 | Chills |
C00024294
|
| D002779 | Cholestasis |
C00024294
|
| D002780 | Cholestasis, Intrahepatic |
C00024294
|
| D004342 | Drug Hypersensitivity |
C00024294
|
| D056486 | Drug-Induced Liver Injury |
C00024294
|
| D056487 | Drug-Induced Liver Injury, Chronic |
C00024294
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00024294
|
| D004802 | Eosinophilia |
C00024294
|
| D005334 | Fever |
C00024294
|
| D006461 | Hemolysis |
C00024294
|
| D006505 | Hepatitis |
C00024294
|
| D007565 | Jaundice |
C00024294
|
| D009461 | Neurologic Manifestations |
C00024294
|
| D011537 | Pruritus |
C00024294
|
| D013611 | Tachycardia, Atrioventricular Nodal Reentry |
C00024294
|
| D013617 | Tachycardia, Supraventricular |
C00024294
|
| D017180 | Tachycardia, Ventricular |
C00024294
|
| D013921 | Thrombocytopenia |
C00024294
|
| D016171 | Torsades de Pointes |
C00024294
|
| D014693 | Ventricular Fibrillation |
C00024294
|
| D018879 | Ventricular Premature Complexes |
C00024294
|
| D014973 | Xanthomatosis |
C00024294
|