Species

KNApSAcK Entry

Organism name Rauvolfia tetraphylla
Genus Rauvolfia
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rauvolfia tetraphylla
Linked NCBI taxonomy ID 545371
Linked level species

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (10)

Species Activity
Rauvolfia tetraphylla L. Allergenic
Rauvolfia tetraphylla L. Antiedemic
Rauvolfia tetraphylla L. Avicide
Rauvolfia tetraphylla L. Diuretic
Rauvolfia tetraphylla L. Expectorant
Rauvolfia tetraphylla L. Hypotensive
Rauvolfia tetraphylla L. Narcotic
Rauvolfia tetraphylla L. Parasiticide
Rauvolfia tetraphylla L. Poison
Rauvolfia tetraphylla L. Tranquilizer

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00024294 External link 512 Ritmos
/ Ignazin
/ Takycor
/ Ajmalin
/ Siddiqui
/ Rytmalin
/ Merabitol
/ Rhytmaton
/ Tachmalin
/ Rauwolfin
/ Rauwolfine
/ Raugalline
/ Gilurytmal
/ (+)-Ajmaline
/ Cardiorythmine
CHEMBL1434779
CHEMBL1452040
CHEMBL1460192
CHEMBL1515845
CHEMBL1525248
CHEMBL2105617
CHEMBL2356868
CHEMBL2357792
D000404
96 / 49 / 43 2 / 32 No. 407 No. 4

Human Protein / Gene in interactions

96 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00024294 1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00024294 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00024294 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00024294 2 / 2
P08246 Neutrophil elastase S1A C00024294 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00024294 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00024294 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00024294 0 / 0
P29466 Caspase-1 C14 C00024294 0 / 0
P17252 Protein kinase C alpha type Alpha C00024294 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00024294 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00024294 2 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00024294 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00024294 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00024294 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00024294 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00024294 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00024294 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00024294 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00024294 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00024294 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00024294 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00024294 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00024294 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00024294 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00024294 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00024294 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00024294 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00024294 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00024294 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00024294 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00024294 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00024294 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00024294 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00024294 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00024294 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00024294 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00024294 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00024294 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00024294 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00024294 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00024294 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00024294 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00024294 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00024294 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00024294 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00024294 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00024294 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00024294 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00024294 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00024294 0 / 0
P08311 Cathepsin G S1A C00024294 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00024294 1 / 0
P03956 Interstitial collagenase M10A C00024294 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00024294 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00024294 7 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00024294 1 / 2
P04150 Glucocorticoid receptor NR3C1 C00024294 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00024294 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00024294 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00024294 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00024294 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00024294 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00024294 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00024294 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00024294 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00024294 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00024294 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00024294 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00024294 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00024294 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00024294 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00024294 0 / 0
P03372 Estrogen receptor NR3A1 C00024294 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00024294 1 / 0
P22303 Acetylcholinesterase Hydrolase C00024294 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00024294 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00024294 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00024294 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00024294 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00024294 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00024294 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00024294 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00024294 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00024294 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00024294 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00024294 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00024294 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00024294 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00024294 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00024294 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00024294 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00024294 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00024294 0 / 0
O00255 Menin Unclassified protein C00024294 2 / 5
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00024294 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00024294
6331 SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1 sodium channel, voltage-gated, type V, alpha subunit C00024294

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (49)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

32 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D015746 Abdominal Pain C00024294
D058186 Acute Kidney Injury C00024294
D000743 Anemia, Hemolytic C00024294
D001002 Anuria C00024294
D001145 Arrhythmias, Cardiac C00024294
D001281 Atrial Fibrillation C00024294
D054537 Atrioventricular Block C00024294
C535438 Bidirectional tachycardia C00024294
D053840 Brugada Syndrome C00024294
D002037 Bundle-Branch Block C00024294
D023341 Chills C00024294
D002779 Cholestasis C00024294
D002780 Cholestasis, Intrahepatic C00024294
D004342 Drug Hypersensitivity C00024294
D056486 Drug-Induced Liver Injury C00024294
D056487 Drug-Induced Liver Injury, Chronic C00024294
D064420 Drug-Related Side Effects and Adverse Reactions C00024294
D004802 Eosinophilia C00024294
D005334 Fever C00024294
D006461 Hemolysis C00024294
D006505 Hepatitis C00024294
D007565 Jaundice C00024294
D009461 Neurologic Manifestations C00024294
D011537 Pruritus C00024294
D013611 Tachycardia, Atrioventricular Nodal Reentry C00024294
D013617 Tachycardia, Supraventricular C00024294
D017180 Tachycardia, Ventricular C00024294
D013921 Thrombocytopenia C00024294
D016171 Torsades de Pointes C00024294
D014693 Ventricular Fibrillation C00024294
D018879 Ventricular Premature Complexes C00024294
D014973 Xanthomatosis C00024294