PCIDB

Streptomyces toyoycaensis

Species

KNApSAcK Entry

Organism name Streptomyces toyoycaensis
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces
Linked NCBI taxonomy ID 1883
Linked level genus

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000740 External link 512 Gabaculine
CHEMBL1394922
CHEMBL1474486
17 / 12 / 13 No. 8239

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000740 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000740 2 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000740 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000740 0 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00000740 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000740 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000740 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000740 3 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000740 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000740 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000740 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000740 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000740 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000740 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000740 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00000740 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000740 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (13)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)