Species

KNApSAcK Entry

Organism name Salvia drobovii
Genus Salvia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvia
Linked NCBI taxonomy ID 21880
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00037506 External link 512 Miltirone
CHEMBL45830
C068880
6 / 1 / 0 No. 3136
C00031697 External link 512 Cryptotanshinone
CHEMBL187460
CHEMBL1518673
C037886
45 / 36 / 34 7 / 0 No. 5489

Human Protein / Gene in interactions

48 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O00748 Cocaine esterase Enzyme C00031697 C00037506 0 / 0
P23141 Liver carboxylesterase 1 Enzyme C00031697 C00037506 0 / 0
P22303 Acetylcholinesterase Hydrolase C00031697 C00037506 1 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00031697 2 / 2
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00037506 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00031697 3 / 1
P54132 Bloom syndrome protein Enzyme C00031697 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00031697 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00031697 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00031697 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00031697 0 / 0
P39748 Flap endonuclease 1 Enzyme C00031697 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00031697 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00031697 2 / 0
O75496 Geminin Unclassified protein C00031697 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00031697 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00031697 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00031697 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00031697 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00031697 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00031697 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00031697 0 / 0
P30304 M-phase inducer phosphatase 1 Ser_Thr_Tyr C00037506 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00031697 3 / 3
P06746 DNA polymerase beta Enzyme C00031697 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00031697 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00031697 2 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00037506 0 / 0
P55210 Caspase-7 C14 C00031697 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00031697 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00031697 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00031697 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00031697 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00031697 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00031697 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00031697 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00031697 0 / 0
O14746 Telomerase reverse transcriptase Enzyme C00031697 5 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00031697 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00031697 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00031697 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00031697 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00031697 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00031697 1 / 0
O00255 Menin Unclassified protein C00031697 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00031697 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00031697 1 / 4
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00031697 2 / 1

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00031697
196 AHR, bHLHe76 aryl hydrocarbon receptor C00031697
590 BCHE, CHE1, CHE2, E1 butyrylcholinesterase (EC:3.1.1.8) C00031697
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00031697
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00031697
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00031697
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00031697

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609135 Aplastic anemia O14746
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#210900 Bloom syndrome; blm P54132
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#613989 Dyskeratosis congenita, autosomal dominant, 2; dkca2 O14746
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#615134 Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 O14746
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614742 Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 O14746
#178500 Pulmonary fibrosis, idiopathic; ipf O14746
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (34)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00764 Cri du chat syndrome O14746 (related)
H01132 Aplastic anemia (AA) O14746 (related)
H01299 Idiopathic pulmonary fibrosis O14746 (related)
H00022 Bladder cancer O14746 (marker)
H00024 Prostate cancer O14746 (marker)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)