Species

KNApSAcK Entry

Organism name Picramnia pentandra
Genus Picramnia
Family Picramniaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Picramnia pentandra
Linked NCBI taxonomy ID 85239
Linked level species

Family

Family in NCBI taxonomy Picramniaceae
ID 85159

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (10)

Species Activity
Picramnia pentandra Sw. Antifertility
Picramnia pentandra Sw. Antispasmodic
Picramnia pentandra Sw. Aphrodisiac
Picramnia pentandra Sw. Carminative
Picramnia pentandra Sw. Diuretic
Picramnia pentandra Sw. Febrifuge
Picramnia pentandra Sw. Orexigenic
Picramnia pentandra Sw. Sedative
Picramnia pentandra Sw. Tonic
Picramnia pentandra Sw. Vermifuge

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00034390 External link 512 3-epi-Betulinic acid
CHEMBL269277
CHEMBL71690
CHEMBL519059
CHEMBL1318530
CHEMBL2005635
34 / 17 / 14 No. 23 No. 51

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00034390 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00034390 2 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00034390 0 / 0
P06746 DNA polymerase beta Enzyme C00034390 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00034390 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00034390 0 / 0
P02545 Prelamin-A/C Unclassified protein C00034390 11 / 10
Q02156 Protein kinase C epsilon type Eta C00034390 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00034390 0 / 1
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00034390 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00034390 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00034390 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00034390 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00034390 0 / 0
O75496 Geminin Unclassified protein C00034390 0 / 0
P15121 Aldose reductase Enzyme C00034390 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00034390 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00034390 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00034390 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00034390 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00034390 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00034390 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00034390 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00034390 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00034390 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00034390 0 / 0
P05771 Protein kinase C beta type Alpha C00034390 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00034390 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00034390 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00034390 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00034390 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00034390 0 / 0
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00034390 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00034390 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)