Species

KNApSAcK Entry

Organism name Karenia brevis
Genus
Family
Kingdom

NCBI taxonomy

Entry

Linked NCBI taxonomy name Karenia brevis
Linked NCBI taxonomy ID 156230
Linked level species

Family

Family in NCBI taxonomy Kareniaceae
ID 1003176

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Eukaryota
ID 2759

Plant class

Plant class
ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00042300 External link 512 Brevetoxin A
CHEMBL1448627
CHEMBL2152260
C076262
18 / 15 / 16 No. 2725
C00042301 External link 512 Brevetoxin B
CHEMBL216458
CHEMBL413858
C043466
3 / 5 / 4 1 / 0 No. 2725
C00048634 External link 512 Brevisamide
No. 5856

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00042300 1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00042300 1 / 4
P11473 Vitamin D3 receptor NR1I1 C00042300 2 / 3
P42858 Huntingtin Unclassified protein C00042300 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00042300 2 / 0
O75496 Geminin Unclassified protein C00042300 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00042300 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00042300 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00042300 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00042300 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00042300 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00042300 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00042300 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00042300 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00042300 4 / 3
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00042300 1 / 0
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00042301 0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00042301 2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00042301 3 / 2
P01215 Glycoprotein hormones alpha chain Unclassified protein C00042300 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00042300 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00042301

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#607208 Dravet syndrome P35498
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#600274 Frontotemporal dementia; ftd P10636
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#137800 Glioma susceptibility 1; glm1 O75874
#143100 Huntington disease; hd P42858
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (20)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)