PCIDB

Vernonia spp.

Species

KNApSAcK Entry

Organism name Vernonia spp.
Genus Vernonia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Vernonia
Linked NCBI taxonomy ID 13753
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00000970 External link 512 Hesperidin
CHEMBL265606
CHEMBL449317
CHEMBL1314714
CHEMBL1328143
CHEMBL1535112
CHEMBL1574000
CHEMBL2140112
D006569
24 / 9 / 14 10 / 5 No. 48 No. 14
C00020728 External link 512 Trifloculoside
No. 69 No. 38
C00020800 External link 512 Vernudifloride
No. 206 No. 38
C00003397 External link 512 Zaluzanin C
CHEMBL461700
CHEMBL462318
CHEMBL1988754
C009697
No. 306 No. 38
C00003256 External link 512 Eremanthine
/ (-)-Eremanthin
CHEMBL451364
C002601
0 / 2 No. 306 No. 38
C00011876 External link 512 Marginatin
No. 4005

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000970 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000970 0 / 0
P06746 DNA polymerase beta Enzyme C00000970 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000970 0 / 0
P62158 Calmodulin Unclassified protein C00000970 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000970 0 / 1
Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Enzyme C00000970 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000970 1 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00000970 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00000970 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000970 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000970 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000970 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000970 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000970 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000970 0 / 0
Q9Y251 Heparanase Enzyme C00000970 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000970 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000970 1 / 1
O00255 Menin Unclassified protein C00000970 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000970 1 / 2
Q02410 Amyloid beta A4 precursor protein-binding family A member 1 Unclassified protein C00000970 0 / 0
Q00975 Voltage-dependent N-type calcium channel subunit alpha-1B N-TYPE C00000970 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000970 0 / 0

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000970
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000970
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00000970
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000970
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000970
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00000970
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000970
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000970
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000970
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00000970

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#612219 Ewing sarcoma; es P11308
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (14)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003921 Diabetes Mellitus, Experimental C00003256
D050171 Dyslipidemias C00003256
D058186 Acute Kidney Injury C00000970
D055371 Acute Lung Injury C00000970
D056486 Drug-Induced Liver Injury C00000970
D008171 Lung Diseases C00000970
D012128 Respiratory Distress Syndrome, Adult C00000970