Species

KNApSAcK Entry

Organism name Griffonia simplicifolia
Genus Griffonia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Griffonia simplicifolia
Linked NCBI taxonomy ID 3850
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001371 External link 512 5-Hydroxy-L-tryptophan
CHEMBL350221
CHEMBL162789
27 / 34 / 26 No. 1910 No. 4

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P42345 Serine/threonine-protein kinase mTOR Enzyme C00001371 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001371 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001371 2 / 0
P02545 Prelamin-A/C Unclassified protein C00001371 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00001371 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00001371 3 / 1
P54132 Bloom syndrome protein Enzyme C00001371 1 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00001371 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001371 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001371 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001371 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001371 3 / 3
Q01453 Peripheral myelin protein 22 Unclassified protein C00001371 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00001371 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001371 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001371 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001371 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001371 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00001371 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001371 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001371 4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein C00001371 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001371 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00001371 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001371 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001371 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001371 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (34)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (26)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)