Species

KNApSAcK Entry

Organism name Pseudopiptadenia leptostachya
Genus Pseudopiptadenia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pseudopiptadenia
Linked NCBI taxonomy ID 397645
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001509 External link 512 Theobromine
CHEMBL1114
D013805
13 / 9 / 7 2 / 1 No. 2266 No. 12

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001509 1 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001509 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001509 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001509 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001509 0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00001509 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001509 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001509 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001509 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00001509 5 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001509 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001509 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001509 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001509
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001509

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#139393 Guillain-barre syndrome, familial; gbs Q01453
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#613688 Long qt syndrome 2; lqt2 Q12809
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#609620 Short qt syndrome 1; sqt1 Q12809

KEGG DISEASE (7)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D011230 Precancerous Conditions C00001509