PCIDB

Pellia epiphylla

Species

KNApSAcK Entry

Organism name Pellia epiphylla
Genus Pellia
Family Pelliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pellia epiphylla
Linked NCBI taxonomy ID 40340
Linked level species

Family

Family in NCBI taxonomy Pelliaceae
ID 40338

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Embryophyta
ID 3193

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003740 External link 512 Betulin
CHEMBL23236
CHEMBL140040
CHEMBL1610940
CHEMBL2000891
CHEMBL2069124
C002503
18 / 16 / 17 0 / 2 No. 23 No. 51
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00029821 External link 512 Sitostenone
/ beta-Sitostenone
/ Stigmast-4-en-3-one
/ Stigmast-4-ene-3-one
CHEMBL66926
No. 53 No. 11
C00021304 External link 512 9(15)-Africanene
No. 149 No. 38
C00021213 External link 512 Globulol
/ (-)-Globulol
CHEMBL2171207
1 / 2 / 3 No. 197 No. 38
C00003428 External link 512 Geranylgeraniol
CHEMBL478589
3 / 4 / 3 No. 369 No. 38
C00003467 External link 512 Phytol
/ trans-Phytol
CHEMBL390773
CHEMBL1644111
D010836
0 / 5 No. 641 No. 38
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6
C00007363 External link 512 delta-Tocopherol
CHEMBL1451395
CHEMBL1734310
C479072
3 / 11 / 10 1 / 0 No. 1290
C00049072 External link 512 1-Himachalen-4beta-ol
/ (+)-1-Himachalen-4beta-ol
No. 1401
C00000149 External link 512 Spathulenol
CHEMBL518542
CHEMBL1774433
C013258
No. 1603
C00049293 External link 512 Sacculaporellin
No. 2455
C00049150 External link 512 epi-Swartzianin A
/ (-)-epi-Swartzianin A
No. 2464
C00049259 External link 512 Pellialactone
/ (-)-Pellialactone
No. 6224
C00049067 External link 512 12,14-Dihydroxyphytol
/ (-)-12,14-Dihydroxyphytol
No. 7721

Human Protein / Gene in interactions

84 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000615 C00003672 C00003740 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 C00003672 C00003740 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000615 C00003672 C00003740 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000615 C00003672 C00003740 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000615 C00003672 C00003740 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000615 C00003672 C00003740 1 / 1
P02545 Prelamin-A/C Unclassified protein C00000615 C00003740 C00007363 11 / 10
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000615 C00003740 0 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00000615 C00007363 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000615 C00003428 4 / 3
P06746 DNA polymerase beta Enzyme C00000615 C00003672 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 C00003428 0 / 0
P14679 Tyrosinase Oxidoreductase C00000615 C00003672 4 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 C00003740 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00003428 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 C00003672 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00000615 C00003740 3 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00003672 3 / 2
P03372 Estrogen receptor NR3A1 C00000615 C00003672 1 / 1
P05771 Protein kinase C beta type Alpha C00003740 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003740 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 1 / 1
P14780 Matrix metalloproteinase-9 M10A C00000615 2 / 2
P00918 Carbonic anhydrase 2 Lyase C00000615 1 / 2
Q02156 Protein kinase C epsilon type Eta C00003740 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 4 / 2
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000615 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00003740 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00003740 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000615 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000615 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000615 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000615 1 / 2
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000615 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000615 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000615 0 / 0
O75496 Geminin Unclassified protein C00007363 0 / 0
P15121 Aldose reductase Enzyme C00000615 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000615 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P03956 Interstitial collagenase M10A C00000615 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003740 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000615 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000615 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00003740 0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00021213 2 / 3
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000615 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 1 / 1
Q16790 Carbonic anhydrase 9 Lyase C00000615 0 / 1
P08253 72 kDa type IV collagenase M10A C00000615 1 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 3 / 3
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000615 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 5 / 2
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000615 3 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003740 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 2 / 2
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000615 1 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000615 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P07451 Carbonic anhydrase 3 Lyase C00000615 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000615 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
Q9UBT6 DNA polymerase kappa Enzyme C00000615 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000615 1 / 0
O00255 Menin Unclassified protein C00000615 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 1 / 2
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1382 CRABP2, CRABP-II, RBP6 cellular retinoic acid binding protein 2 C00007363

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (74)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#600807 Asthma, susceptibility to Q13093
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#163950 Noonan syndrome 1; ns1 Q06124
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278300 Xanthinuria, type i P47989

KEGG DISEASE (66)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003110 Colonic Neoplasms C00003740
D064420 Drug-Related Side Effects and Adverse Reactions C00003740
D056486 Drug-Induced Liver Injury C00003467
D006965 Hyperplasia C00003467
D006984 Hypertrophy C00003467
D009336 Necrosis C00003467
D015431 Weight Loss C00003467