PCIDB

Annona muricata

Species

KNApSAcK Entry

Organism name Annona muricata
Genus Annona
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Annona muricata
Linked NCBI taxonomy ID 13337
Linked level species

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Natural Activity

List (45)

Species Activity
Annona muricata L. Analgesic
Annona muricata L. Anthelmintic
Annona muricata L. Antibilious
Annona muricata L. Antidepressant
Annona muricata L. AntiHIV
Annona muricata L. Antiinflammatory
Annona muricata L. Antimalarial
Annona muricata L. Antimitotic
Annona muricata L. Antiparasitic
Annona muricata L. Antiplasmodial
Annona muricata L. Antiscorbutic
Annona muricata L. Antiseptic
Annona muricata L. Antispasmodic
Annona muricata L. Artemicide
Annona muricata L. Astringent
Annona muricata L. Cardiodepressant
Annona muricata L. Cardiotonic
Annona muricata L. Cicatrizant
Annona muricata L. CNS-Depressant
Annona muricata L. Cyanogenic
Annona muricata L. Cytotoxic
Annona muricata L. Depurative
Annona muricata L. Emetic
Annona muricata L. Febrifuge
Annona muricata L. Filaricide
Annona muricata L. Fungicide
Annona muricata L. Hemostat
Annona muricata L. Hypotensive
Annona muricata L. Insecticide
Annona muricata L. Lactagogue
Annona muricata L. Molluscicide
Annona muricata L. Parasiticide
Annona muricata L. Pectoral
Annona muricata L. Pediculicide
Annona muricata L. Piscicide
Annona muricata L. Plasmodicide
Annona muricata L. Sedative
Annona muricata L. Soporific
Annona muricata L. Spasmogenic
Annona muricata L. Stomachic
Annona muricata L. Suppurative
Annona muricata L. Tranquilizer
Annona muricata L. Trichomonacide
Annona muricata L. Uterotonic
Annona muricata L. Vermifuge

Metabolite list (57)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00049881 External link 512 Muricapentocin
/ (+)-Muricapentocin
CHEMBL505936
No. 6 No. 70
C00049861 External link 512 cis-Uvariamicin I
/ (+)-cis-Uvariamicin I
CHEMBL447985
No. 6 No. 70
C00049860 External link 512 cis-Solamin
CHEMBL311127
CHEMBL396297
CHEMBL452922
CHEMBL2323448
No. 6 No. 70
C00040875 External link 512 Annonacin A
CHEMBL67945
CHEMBL439797
CHEMBL476498
CHEMBL457276
CHEMBL1992986
No. 6 No. 70
C00040949 External link 512 Donhexocin
/ (+)-Donhexocin
No. 6 No. 70
C00041066 External link 512 Murihexol
/ (+)-Murihexol
No. 6 No. 70
C00043267 External link 512 Annomontacin
CHEMBL110442
CHEMBL110441
C073066
No. 6 No. 70
C00043268 External link 512 Annonacin
/ (+)-Annonacin
CHEMBL67945
CHEMBL439797
CHEMBL476498
CHEMBL457276
CHEMBL1992986
C053442
0 / 1 No. 6 No. 70
C00043395 External link 512 cis-Annomontacin
/ (+)-cis-Annomontacin
CHEMBL110442
CHEMBL110441
No. 6 No. 70
C00049859 External link 512 cis-Reticulatacin-10-one
/ (+)-cis-Reticulatacin-10-one
No. 6 No. 70
C00044085 External link 512 Annonacinone
CHEMBL110183
CHEMBL134189
CHEMBL450539
No. 6 No. 70
C00044087 External link 512 Annopentocin A
/ (+)-Annopentocin A
CHEMBL509118
CHEMBL504712
CHEMBL450241
No. 6 No. 70
C00044088 External link 512 Annopentocin B
/ (+)-Annopentocin B
CHEMBL509118
CHEMBL504712
CHEMBL450241
No. 6 No. 70
C00044089 External link 512 Annopentocin C
/ (+)-Annopentocin C
CHEMBL509118
CHEMBL504712
CHEMBL450241
No. 6 No. 70
C00044121 External link 512 cis-Annonacin
CHEMBL67945
CHEMBL439797
CHEMBL476498
CHEMBL457276
CHEMBL1992986
No. 6 No. 70
C00044123 External link 512 cis-Goniothalamicin
CHEMBL504825
CHEMBL499805
CHEMBL448532
CHEMBL2002469
No. 6 No. 70
C00044129 External link 512 Cohibin A
C417924
No. 6 No. 70
C00044130 External link 512 Cohibin B
C417925
No. 6 No. 70
C00049858 External link 512 cis-Reticulatacin
CHEMBL504013
CHEMBL444743
No. 6 No. 70
C00049857 External link 512 cis-Panatellin
/ (+)-cis-Panatellin
No. 6 No. 70
C00044175 External link 512 Gigantetrocin B
CHEMBL67341
CHEMBL606761
No. 6 No. 70
C00044228 External link 512 Longifolicin
/ (+)-Longifolicin
CHEMBL323471
CHEMBL504169
No. 6 No. 70
C00044239 External link 512 Montecristin
No. 6 No. 70
C00044245 External link 512 Muricatalin
No. 6 No. 70
C00044246 External link 512 Muricatetrocin A
CHEMBL323001
CHEMBL450107
No. 6 No. 70
C00044247 External link 512 Muricatetrocin B
CHEMBL323001
CHEMBL450107
No. 6 No. 70
C00044249 External link 512 Muricatin A
/ Muricatin A(Annona)
No. 6 No. 70
C00047030 External link 512 Cohibin C
No. 6 No. 70
C00049862 External link 512 cis-Uvariamicin IV
No. 6 No. 70
C00047031 External link 512 Cohibin D
No. 6 No. 70
C00044257 External link 512 Murihexocin A
CHEMBL63330
CHEMBL262458
CHEMBL444496
No. 6 No. 70
C00044258 External link 512 Murihexocin B
CHEMBL63330
CHEMBL262458
CHEMBL444496
No. 6 No. 70
C00044387 External link 512 Xylomaticin
CHEMBL322993
CHEMBL507669
No. 6 No. 70
C00045223 External link 512 Annocatalin
/ (+)-Annocatalin
CHEMBL458263
No. 6 No. 70
C00045260 External link 512 cis-Corossolone
/ (+)-cis-Corossolone
CHEMBL315283
CHEMBL418831
CHEMBL108962
No. 6 No. 70
C00045353 External link 512 Muricin H
/ (+)-Muricin H
No. 6 No. 70
C00045354 External link 512 Muricin I
CHEMBL108188
CHEMBL506324
No. 6 No. 70
C00046173 External link 512 Muricin A
/ (+)-Muricin A
CHEMBL454673
CHEMBL448181
No. 6 No. 70
C00046174 External link 512 Muricin B
/ (+)-Muricin B
CHEMBL454673
CHEMBL448181
No. 6 No. 70
C00046175 External link 512 Muricin C
CHEMBL508622
No. 6 No. 70
C00046176 External link 512 Muricin D
/ (+)-Muricin D
CHEMBL323170
CHEMBL458590
No. 6 No. 70
C00046177 External link 512 Muricin E
/ (+)-Muricin E
CHEMBL447464
No. 6 No. 70
C00046178 External link 512 Muricin F
/ (+)-Muricin F
CHEMBL444850
CHEMBL460494
No. 6 No. 70
C00046179 External link 512 Muricin G
/ (+)-Muricin G
CHEMBL321463
CHEMBL501930
No. 6 No. 70
C00044250 External link 512 Muricatin B
/ (-)-Muricatin B(Annona)
No. 6 No. 70
C00044080 External link 512 Annomuricatin B
/ (-)-Annomuricatin B
No. 290
C00044158 External link 512 Epoxymurin B
No. 421
C00048960 External link 512 Chatenaytrienin 2
No. 421
C00048961 External link 512 Chatenaytrienin 3
No. 421
C00048962 External link 512 Chatenaytrienin 4
No. 421
C00048959 External link 512 Chatenaytrienin 1
No. 421
C00044144 External link 512 Diepomuricanin A
/ (+)-Diepomuricanin A
No. 421
C00044256 External link 512 Muridienin 2
No. 421
C00040180 External link 512 Sabadelin
/ (+)-Sabadelin
No. 421
C00001307 External link 512 Epoxymurin-A
No. 421
C00044255 External link 512 Muridienin 1
/ (+)-Muridienin 1
No. 421
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 1 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 3 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000152 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000152 1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 1 / 8
P23280 Carbonic anhydrase 6 Lyase C00000152 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000152 1 / 2
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 0 / 0
P15121 Aldose reductase Enzyme C00000152 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000152 0 / 0
P14679 Tyrosinase Oxidoreductase C00000152 4 / 2
Q16790 Carbonic anhydrase 9 Lyase C00000152 0 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 0 / 0
P03372 Estrogen receptor NR3A1 C00000152 1 / 1
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 1 / 0
P07451 Carbonic anhydrase 3 Lyase C00000152 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000152 1 / 1

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#615363 Estrogen resistance; estrr P03372
#143860 Hyperchlorhidrosis, isolated O43570
#147050 Ige responsiveness, atopic; iger Q13093
#211980 Lung cancer P00533
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#600852 Retinitis pigmentosa 17; rp17 P22748
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (18)

KEGG name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008545 Melanoma C00000152
D018827 Carcinoma, Lewis Lung C00043268