Maytenus chiapensis
Species
KNApSAcK Entry
| Organism name | Maytenus chiapensis |
|---|---|
| Genus | Maytenus |
| Family | Celastraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Maytenus |
|---|---|
| Linked NCBI taxonomy ID | 123430 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Celastraceae |
|---|---|
| ID | 4305 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00023788
|
Glochidone
|
CHEMBL469628
|
No. 23 | No. 51 |
|
|||
|
C00003740
|
Betulin
|
CHEMBL23236
CHEMBL140040 CHEMBL1610940 CHEMBL2000891 CHEMBL2069124 |
C002503
|
18 / 16 / 17 | 0 / 2 | No. 23 | No. 51 |
|
|
C00003751
|
Messagenin
|
CHEMBL513542
|
No. 23 | No. 51 |
|
|||
|
C00042283
|
Betulone
/ (+)-Betulone |
CHEMBL469284
|
No. 23 | No. 51 |
|
|||
|
C00034197
|
Resinone
|
C469684
|
No. 23 | No. 51 |
|
|||
|
C00023789
|
Glochidonol
|
CHEMBL469838
|
No. 23 | No. 51 |
|
|||
|
C00019220
|
Lupenone
|
CHEMBL486393
CHEMBL575188 |
3 / 4 / 2 | No. 23 | No. 51 |
|
||
|
C00001987
|
Wilfordin
|
CHEMBL449308
CHEMBL525628 |
No. 43 |
|
||||
|
C00013191
|
Wilforidine
/ (8R,9R,10R,11S,12S,13R,14R,15S,21S,22S,23R)-[partial]-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-14,18,21-trihydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17-dione |
CHEMBL504312
CHEMBL1950977 |
No. 43 |
|
||||
|
C00013126
|
Euonymin
/ Euonymine |
CHEMBL346753
CHEMBL503447 |
No. 43 |
|
||||
|
C00013158
|
Mayteine
/ [8R-(8R*,9R*,10R*,11S*,12S*,13R*,14R*,15S*,18S*,19S*,20S*,21S*,22R*)]-10,14,21,22-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-13-(benzoyloxy)-7,8,9,10,12,13,14,15,18,19-decahydro-20-hydroxy-8,18,19,20-tetramethyl-8,11-epoxy-9,12-ethano-11,15-methano-11H-[1,8]dioxacycloheptadecino[4,3-b]pyridine-5,17-dione |
CHEMBL526919
CHEMBL1813072 |
C096143
|
No. 43 |
|
|||
|
C00013119
|
Alatamine
/ O2-Benzoyl-O2-deacetyl-26-hydroxyevonimine |
CHEMBL503871
|
No. 43 |
|
||||
|
C00013118
|
Euonine
/ Wilformine / (8alpha)-8-(Acetyloxy)-8-deoxoevonimine |
CHEMBL498972
CHEMBL443712 |
C062678
|
No. 43 |
|
|||
|
C00013107
|
Alatusinine
/ (8a)-8-(Acetyloxy)-8-deoxo-26-hydroxyevonimine |
CHEMBL508998
CHEMBL501360 |
No. 43 |
|
||||
|
C00043386
|
Chiapenine ES-I
|
CHEMBL505015
|
No. 43 |
|
||||
|
C00043387
|
Chiapenine ES-II
|
CHEMBL510337
|
No. 43 |
|
||||
|
C00043388
|
Chiapenine ES-III
|
No. 43 |
|
|||||
|
C00043389
|
Chiapenine ES-IV
|
No. 43 |
|
|||||
|
C00043473
|
Ebenifoline E-I
|
CHEMBL510159
|
No. 43 |
|
||||
|
C00043510
|
Forrestine
|
CHEMBL508997
|
No. 43 |
|
Human Protein / Gene in interactions
19 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003740 C00019220 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003740 C00019220 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003740 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003740 | 1 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003740 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003740 | 11 / 10 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003740 | 3 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00003740 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003740 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003740 | 0 / 3 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003740 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003740 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003740 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00019220 | 4 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003740 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003740 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00003740 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003740 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003740 | 0 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (19)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|