Hyoscyamus albus
Species
KNApSAcK Entry
| Organism name | Hyoscyamus albus |
|---|---|
| Genus | Hyoscyamus |
| Family | Solanaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Hyoscyamus albus |
|---|---|
| Linked NCBI taxonomy ID | 310458 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Solanaceae |
|---|---|
| ID | 4070 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (10)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003163
|
Lubimin
|
C044124
|
No. 398 | No. 38 |
|
|||
|
C00049948
|
3-Hydroxysolavetivone
/ (+)-3-Hydroxysolavetivone |
No. 543 | No. 38 |
|
||||
|
C00003191
|
Solavetivone
|
CHEMBL465907
|
No. 543 | No. 38 |
|
|||
|
C00036870
|
Calystegine N1
|
No. 643 | No. 1 |
|
||||
|
C00002283
|
Calystegin B2
/ Calystegine B2 |
CHEMBL526330
CHEMBL513797 CHEMBL1213469 CHEMBL1984376 |
C095613
|
1 / 6 / 4 | No. 643 | No. 1 |
|
|
|
C00035552
|
Calystegine B3
/ (+)-Calystegine B3 |
CHEMBL526330
CHEMBL513797 CHEMBL1213469 CHEMBL1984376 |
1 / 6 / 4 | No. 643 | No. 1 |
|
||
|
C00028001
|
Calystegine B1
|
CHEMBL1965915
|
C110567
|
No. 643 | No. 1 |
|
||
|
C00002282
|
Calystegin A3
/ Calystegine A3 |
No. 643 | No. 1 |
|
||||
|
C00002292
|
Hyoscine
/ Scopolamine / Scopine tropate / Scopine (-)-tropate |
CHEMBL13030
CHEMBL253569 CHEMBL508322 CHEMBL569713 CHEMBL608810 CHEMBL1187846 CHEMBL1201069 CHEMBL1324521 CHEMBL1418417 CHEMBL1434831 CHEMBL1531863 CHEMBL1620047 CHEMBL1906925 |
D012601
|
23 / 26 / 19 | 8 / 72 | No. 666 | No. 1 |
|
|
C00025560
|
7beta-Hydroxyhyoscyamine
/ (+)-7b-Hydroxyhyoscyamine |
CHEMBL2165224
|
No. 666 | No. 1 |
|
Human Protein / Gene in interactions
24 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04062 | Glucosylceramidase | Enzyme | C00002283 C00035552 | 6 / 4 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00002292 | 2 / 0 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | C00002292 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002292 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002292 | 3 / 2 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00002292 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00002292 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00002292 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002292 | 0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002292 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00002292 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002292 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002292 | 1 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00002292 | 0 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00002292 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002292 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00002292 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00002292 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002292 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002292 | 0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002292 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00002292 | 0 / 0 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00002292 | 2 / 2 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00002292 | 3 / 2 |
8 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00002292
|
| 183 | AGT, ANHU, SERPINA8 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
C00002292
|
| 1103 | CHAT, CHOACTASE, CMS1A, CMS1A2 | choline O-acetyltransferase (EC:2.3.1.6) |
C00002292
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00002292
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00002292
|
| 2914 | GRM4, GPRC1D, MGLUR4, mGlu4 | glutamate receptor, metabotropic 4 |
C00002292
|
| 3760 | KCNJ3, GIRK1, KGA, KIR3.1 | potassium inwardly-rectifying channel, subfamily J, member 3 |
C00002292
|
| 4012 | LNPEP, CAP, IRAP, P-LAP, PLAP | leucyl/cystinyl aminopeptidase (EC:3.4.11.3) |
C00002292
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
KEGG DISEASE (23)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
Diseases related to CTD interactions
72 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00002292
|
| D020324 | Amnesia, Anterograde |
C00002292
|
| D000648 | Amnesia, Retrograde |
C00002292
|
| D015875 | Anisocoria |
C00002292
|
| D001037 | Aphasia |
C00002292
|
| D001072 | Apraxias |
C00002292
|
| D001259 | Ataxia |
C00002292
|
| D001919 | Bradycardia |
C00002292
|
| D001927 | Brain Diseases |
C00002292
|
| D001930 | Brain Injuries |
C00002292
|
| D002375 | Catalepsy |
C00002292
|
| D002389 | Catatonia |
C00002292
|
| D019970 | Cocaine-Related Disorders |
C00002292
|
| D003072 | Cognition Disorders |
C00002292
|
| D003128 | COMA |
C00002292
|
| D003221 | Confusion |
C00002292
|
| D003693 | Delirium |
C00002292
|
| D003704 | Dementia |
C00002292
|
| D004195 | Disease Models, Animal |
C00002292
|
| D006970 | Disorders of Excessive Somnolence |
C00002292
|
| D004244 | Dizziness |
C00002292
|
| D056486 | Drug-Induced Liver Injury |
C00002292
|
| D062787 | Drug Overdose |
C00002292
|
| D015352 | Dry Eye Syndromes |
C00002292
|
| D004401 | Dysarthria |
C00002292
|
| D004409 | Dyskinesia, Drug-Induced |
C00002292
|
| D004948 | Esotropia |
C00002292
|
| D005402 | Fistula |
C00002292
|
| D006212 | Hallucinations |
C00002292
|
| D006327 | Heart Block |
C00002292
|
| D006948 | Hyperkinesis |
C00002292
|
| D006973 | Hypertension |
C00002292
|
| D018476 | Hypokinesia |
C00002292
|
| D007035 | Hypothermia |
C00002292
|
| D007634 | Keratitis |
C00002292
|
| D007638 | Keratoconjunctivitis Sicca |
C00002292
|
| D007859 | Learning Disorders |
C00002292
|
| D008103 | Liver Cirrhosis |
C00002292
|
| D055370 | Lung Injury |
C00002292
|
| D008569 | Memory Disorders |
C00002292
|
| D020326 | Migraine without Aura |
C00002292
|
| D009041 | Motion Sickness |
C00002292
|
| D009069 | Movement Disorders |
C00002292
|
| D009127 | Muscle Rigidity |
C00002292
|
| D015878 | Mydriasis |
C00002292
|
| D009203 | Myocardial Infarction |
C00002292
|
| D009325 | Nausea |
C00002292
|
| D009410 | Nerve Degeneration |
C00002292
|
| D009293 | Opioid-Related Disorders |
C00002292
|
| D010259 | Paranoid Disorders |
C00002292
|
| D020795 | Photophobia |
C00002292
|
| D011183 | Postoperative Complications |
C00002292
|
| D020250 | Postoperative Nausea and Vomiting |
C00002292
|
| D011595 | Psychomotor Agitation |
C00002292
|
| D011596 | Psychomotor Disorders |
C00002292
|
| D011605 | Psychoses, Substance-Induced |
C00002292
|
| D011681 | Pupil Disorders |
C00002292
|
| D012021 | Reflex, Abnormal |
C00002292
|
| D012640 | Seizures |
C00002292
|
| D012798 | Sialorrhea |
C00002292
|
| D013226 | Status Epilepticus |
C00002292
|
| D053608 | Stupor |
C00002292
|
| D013375 | Substance Withdrawal Syndrome |
C00002292
|
| D013610 | Tachycardia |
C00002292
|
| D005879 | Tourette Syndrome |
C00002292
|
| D014202 | Tremor |
C00002292
|
| D014549 | Urinary Incontinence |
C00002292
|
| D014786 | Vision Disorders |
C00002292
|
| D014839 | Vomiting |
C00002292
|
| D015431 | Weight Loss |
C00002292
|
| D014985 | Xerophthalmia |
C00002292
|
| D014987 | Xerostomia |
C00002292
|