Species

KNApSAcK Entry

Organism name Datura quercifolia
Genus Datura
Family Solanaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Datura quercifolia
Linked NCBI taxonomy ID 45451
Linked level species

Family

Family in NCBI taxonomy Solanaceae
ID 4070

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002292 External link 512 Hyoscine
/ Scopolamine
/ Scopine tropate
/ Scopine (-)-tropate
CHEMBL13030
CHEMBL253569
CHEMBL508322
CHEMBL569713
CHEMBL608810
CHEMBL1187846
CHEMBL1201069
CHEMBL1324521
CHEMBL1418417
CHEMBL1434831
CHEMBL1531863
CHEMBL1620047
CHEMBL1906925
D012601
23 / 26 / 19 8 / 72 No. 666 No. 1
C00002293 External link 512 Hyoscyamine
/ (-)-Hyoscyamine
CHEMBL9751
CHEMBL517712
CHEMBL1257084
CHEMBL1331216
CHEMBL1379091
CHEMBL2112074
D064692
110 / 58 / 58 No. 666 No. 1

Human Protein / Gene in interactions

113 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002292 C00002293 1 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x C00002292 C00002293 2 / 2
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x C00002292 C00002293 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002292 C00002293 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002292 C00002293 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002292 C00002293 1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002292 C00002293 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002292 C00002293 0 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002292 C00002293 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002292 C00002293 0 / 0
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002292 C00002293 1 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002292 C00002293 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002292 C00002293 2 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00002292 C00002293 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002292 C00002293 11 / 10
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002292 C00002293 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002292 C00002293 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002292 C00002293 0 / 1
P02768 Serum albumin Secreted protein C00002292 C00002293 0 / 0
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x C00002292 C00002293 3 / 2
P35367 Histamine H1 receptor Histamine receptor C00002293 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002293 1 / 0
P25021 Histamine H2 receptor Histamine receptor C00002293 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002293 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002293 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002293 1 / 1
P08183 Multidrug resistance protein 1 drug C00002292 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002293 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002293 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002293 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002293 0 / 1
P54132 Bloom syndrome protein Enzyme C00002293 1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002293 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00002293 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002293 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002293 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002293 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002293 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002293 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002293 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002293 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002293 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002293 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002293 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002292 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002293 0 / 0
O75496 Geminin Unclassified protein C00002293 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002293 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002293 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00002293 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002293 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002293 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002293 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002293 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002293 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002293 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002293 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00002293 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002293 0 / 0
P08311 Cathepsin G S1A C00002293 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00002293 1 / 2
P03956 Interstitial collagenase M10A C00002293 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002293 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002292 3 / 2
P04150 Glucocorticoid receptor NR3C1 C00002293 0 / 1
P14780 Matrix metalloproteinase-9 M10A C00002293 2 / 2
P27361 Mitogen-activated protein kinase 3 Erk C00002293 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002293 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002293 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002293 5 / 9
P17252 Protein kinase C alpha type Alpha C00002293 0 / 0
P21452 Substance-K receptor Neurokinin receptor C00002293 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002293 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002293 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002293 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002293 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002293 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002293 2 / 1
P29466 Caspase-1 C14 C00002293 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00002293 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002293 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002293 0 / 0
P03372 Estrogen receptor NR3A1 C00002293 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002293 1 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002293 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002293 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002293 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002293 0 / 0
P06746 DNA polymerase beta Enzyme C00002293 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002293 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002293 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002293 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002293 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00002293 0 / 0
P08246 Neutrophil elastase S1A C00002293 2 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002293 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002293 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002293 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002293 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002293 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002293 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002293 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00002293 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002293 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002293 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002293 2 / 2
O00255 Menin Unclassified protein C00002293 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002293 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00002293 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002293 1 / 4
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002293 0 / 3
P21728 D(1A) dopamine receptor Dopamine receptor C00002293 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002293 1 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
43 ACHE, ACEE, ARACHE, N-ACHE, YT acetylcholinesterase (EC:3.1.1.7) C00002292
183 AGT, ANHU, SERPINA8 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) C00002292
1103 CHAT, CHOACTASE, CMS1A, CMS1A2 choline O-acetyltransferase (EC:2.3.1.6) C00002292
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00002292
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00002292
2914 GRM4, GPRC1D, MGLUR4, mGlu4 glutamate receptor, metabotropic 4 C00002292
3760 KCNJ3, GIRK1, KGA, KIR3.1 potassium inwardly-rectifying channel, subfamily J, member 3 C00002292
4012 LNPEP, CAP, IRAP, P-LAP, PLAP leucyl/cystinyl aminopeptidase (EC:3.4.11.3) C00002292

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (60)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)

Diseases related to CTD interactions

72 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00002292
D020324 Amnesia, Anterograde C00002292
D000648 Amnesia, Retrograde C00002292
D015875 Anisocoria C00002292
D001037 Aphasia C00002292
D001072 Apraxias C00002292
D001259 Ataxia C00002292
D001919 Bradycardia C00002292
D001927 Brain Diseases C00002292
D001930 Brain Injuries C00002292
D002375 Catalepsy C00002292
D002389 Catatonia C00002292
D019970 Cocaine-Related Disorders C00002292
D003072 Cognition Disorders C00002292
D003128 COMA C00002292
D003221 Confusion C00002292
D003693 Delirium C00002292
D003704 Dementia C00002292
D004195 Disease Models, Animal C00002292
D006970 Disorders of Excessive Somnolence C00002292
D004244 Dizziness C00002292
D056486 Drug-Induced Liver Injury C00002292
D062787 Drug Overdose C00002292
D015352 Dry Eye Syndromes C00002292
D004401 Dysarthria C00002292
D004409 Dyskinesia, Drug-Induced C00002292
D004948 Esotropia C00002292
D005402 Fistula C00002292
D006212 Hallucinations C00002292
D006327 Heart Block C00002292
D006948 Hyperkinesis C00002292
D006973 Hypertension C00002292
D018476 Hypokinesia C00002292
D007035 Hypothermia C00002292
D007634 Keratitis C00002292
D007638 Keratoconjunctivitis Sicca C00002292
D007859 Learning Disorders C00002292
D008103 Liver Cirrhosis C00002292
D055370 Lung Injury C00002292
D008569 Memory Disorders C00002292
D020326 Migraine without Aura C00002292
D009041 Motion Sickness C00002292
D009069 Movement Disorders C00002292
D009127 Muscle Rigidity C00002292
D015878 Mydriasis C00002292
D009203 Myocardial Infarction C00002292
D009325 Nausea C00002292
D009410 Nerve Degeneration C00002292
D009293 Opioid-Related Disorders C00002292
D010259 Paranoid Disorders C00002292
D020795 Photophobia C00002292
D011183 Postoperative Complications C00002292
D020250 Postoperative Nausea and Vomiting C00002292
D011595 Psychomotor Agitation C00002292
D011596 Psychomotor Disorders C00002292
D011605 Psychoses, Substance-Induced C00002292
D011681 Pupil Disorders C00002292
D012021 Reflex, Abnormal C00002292
D012640 Seizures C00002292
D012798 Sialorrhea C00002292
D013226 Status Epilepticus C00002292
D053608 Stupor C00002292
D013375 Substance Withdrawal Syndrome C00002292
D013610 Tachycardia C00002292
D005879 Tourette Syndrome C00002292
D014202 Tremor C00002292
D014549 Urinary Incontinence C00002292
D014786 Vision Disorders C00002292
D014839 Vomiting C00002292
D015431 Weight Loss C00002292
D014985 Xerophthalmia C00002292
D014987 Xerostomia C00002292