Species

KNApSAcK Entry

Organism name Taxus cuspidata Sieb et Zucc
Genus Taxus
Family Taxaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Taxus
Linked NCBI taxonomy ID 25628
Linked level genus

Family

Family in NCBI taxonomy Taxaceae
ID 25623

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00040457 External link 512 Taxuspine J
CHEMBL403321
No. 137
C00038289 External link 512 5-Cinnamoyltaxicin I triacetate
CHEMBL128197
No. 137
C00036220 External link 512 Taxinine B
CHEMBL308259
No. 137
C00002323 External link 512 Taxol B
/ Cephalomannine
CHEMBL305522
CHEMBL137681
CHEMBL400128
CHEMBL1314572
CHEMBL1397662
CHEMBL1473676
C056348
28 / 15 / 11 No. 238 No. 49
C00038159 External link 512 Taxayuntin
/ 13-Decinnamoyl-taxchinin B
CHEMBL340846
No. 307
C00040455 External link 512 Taxinine A 11,12-epoxide
/ (+)-Taxinine A 11,12-epoxide
No. 481
C00037888 External link 512 Taxinine M
CHEMBL309359
CHEMBL448698
CHEMBL1889966
C071771
7 / 1 / 1 No. 1263
C00033406 External link 512 Taxinine A
/ (-)-Taxinine A
CHEMBL113940
No. 1557

Human Protein / Gene in interactions

31 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00002323 C00037888 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002323 C00037888 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002323 C00037888 0 / 0
O75496 Geminin Unclassified protein C00002323 C00037888 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002323 1 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00037888 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002323 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002323 2 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00037888 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00002323 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002323 0 / 0
P39748 Flap endonuclease 1 Enzyme C00037888 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002323 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002323 1 / 0
O00255 Menin Unclassified protein C00002323 2 / 5
P51151 Ras-related protein Rab-9A Unclassified protein C00002323 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00002323 0 / 0
P68366 Tubulin alpha-4A chain Structural C00002323 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00002323 1 / 0
P04350 Tubulin beta-4A chain Structural C00002323 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00002323 0 / 0
P07437 Tubulin beta chain Structural C00002323 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00002323 1 / 1
P68371 Tubulin beta-4B chain Structural C00002323 0 / 0
Q13509 Tubulin beta-3 chain Structural C00002323 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00002323 0 / 0
Q13885 Tubulin beta-2A chain Structural C00002323 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00002323 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00002323 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00002323 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00002323 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257220 Niemann-pick disease, type c1; npc1 O15118
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (11)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)