Species

KNApSAcK Entry

Organism name Amomum melegueta
Genus Amomum
Family Zingiberaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Amomum
Linked NCBI taxonomy ID 188482
Linked level genus

Family

Family in NCBI taxonomy Zingiberaceae
ID 4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002774 External link 512 [6]-Shogaol
CHEMBL25948
C040115
8 / 3 / 4 10 / 1 No. 293 No. 32

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002774 1 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002774 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002774 0 / 3
P08183 Multidrug resistance protein 1 drug C00002774 1 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002774 0 / 0
Q8NER1 Transient receptor potential cation channel subfamily V member 1 TRPV (Vanilloid) C00002774 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002774 0 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00002774 1 / 0

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00002774
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00002774
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00002774
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002774
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00002774
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00002774
1676 DFFA, DFF-45, DFF1, ICAD DNA fragmentation factor, 45kDa, alpha polypeptide C00002774
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00002774
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00002774
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00002774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (3)

OMIM preferred title UniProt
#608902 Drug metabolism, poor, cyp2d6-related P10635
#612244 Inflammatory bowel disease 13; ibd13 P08183
#614674 Periodic fever, menstrual cycle-dependent P08908

KEGG DISEASE (4)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D019636 Neurodegenerative Diseases C00002774