PCIDB

Harpagophytum procumbens

Species

KNApSAcK Entry

Organism name Harpagophytum procumbens
Genus Harpagophytum
Family Pedaliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Harpagophytum procumbens
Linked NCBI taxonomy ID 222879
Linked level species

Family

Family in NCBI taxonomy Pedaliaceae
ID 4180

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (24)

Species Activity
Harpagophytum procumbens (Burch.) DC ex. Meisn. Allergenic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Analgesic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antiarrhythmic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antiarthritic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antiedemic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antiexudative
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antiinflammatory
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antipyretic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Antirheumatic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Aperitif
Harpagophytum procumbens (Burch.) DC ex. Meisn. Bitter
Harpagophytum procumbens (Burch.) DC ex. Meisn. Choleretic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Depurative
Harpagophytum procumbens (Burch.) DC ex. Meisn. Digestive
Harpagophytum procumbens (Burch.) DC ex. Meisn. Diuretic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Hypocholesterolemic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Hypotensive
Harpagophytum procumbens (Burch.) DC ex. Meisn. Hypouricemic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Laxative
Harpagophytum procumbens (Burch.) DC ex. Meisn. Secretagogue
Harpagophytum procumbens (Burch.) DC ex. Meisn. Sedative
Harpagophytum procumbens (Burch.) DC ex. Meisn. Tonic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Uricolytic
Harpagophytum procumbens (Burch.) DC ex. Meisn. Uterocontractant

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003083 External link 512 Harpagoside
CHEMBL516702
CHEMBL464888
CHEMBL1525311
C033249
11 / 5 / 8 No. 120 No. 36
C00010666 External link 512 Procumboside
No. 3854

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003083 1 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003083 0 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00003083 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003083 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00003083 0 / 0
O75496 Geminin Unclassified protein C00003083 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003083 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003083 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003083 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003083 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003083 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473

KEGG DISEASE (8)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)