Helenium autumnale
Species
KNApSAcK Entry
| Organism name | Helenium autumnale |
|---|---|
| Genus | Helenium |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Helenium autumnale |
|---|---|
| Linked NCBI taxonomy ID | 138408 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (24)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006662
|
Cyanidin 3-(2''-glucuronosylglucoside)
|
No. 1 | No. 15 |
|
||||
|
C00020960
|
11,13-Dehydrocarolenalin
|
No. 69 | No. 38 |
|
||||
|
C00003286
|
Florilenalin
|
No. 69 | No. 38 |
|
||||
|
C00020927
|
(-)-Helenium lactone
|
CHEMBL1163771
CHEMBL1644107 |
No. 69 | No. 38 |
|
|||
|
C00003223
|
Autumnolide
|
CHEMBL1986322
|
No. 144 | No. 38 |
|
|||
|
C00020886
|
Dihydroflorilenalin
|
No. 275 |
|
|||||
|
C00021175
|
Picrohelenin
|
CHEMBL520363
|
1 / 0 / 0 | No. 303 |
|
|||
|
C00020961
|
Carolenalin 4-O-beta-D-glucoside
|
No. 324 |
|
|||||
|
C00020964
|
11,13-Dihydroarnifolin
|
CHEMBL509147
|
No. 484 | No. 38 |
|
|||
|
C00020963
|
Brevelin A
/ 6-O-Angeloylprenolin |
CHEMBL454838
|
3 / 0 / 0 | No. 484 | No. 38 |
|
||
|
C00003326
|
Mexicanin I
|
CHEMBL338474
CHEMBL354946 CHEMBL486996 CHEMBL1728820 CHEMBL1911137 |
37 / 36 / 29 | No. 495 | No. 38 |
|
||
|
C00003298
|
Helenalin
|
CHEMBL338474
CHEMBL354946 CHEMBL486996 CHEMBL1728820 CHEMBL1911137 |
C001329
|
37 / 36 / 29 | 18 / 3 | No. 495 | No. 38 |
|
|
C00003352
|
Plenolin
/ Dihydrohelenalin / 11,13-Dihydrohelenalin |
CHEMBL309952
CHEMBL354842 CHEMBL188283 CHEMBL1911129 |
C026745
|
3 / 0 / 0 | No. 755 | No. 38 |
|
|
|
C00020962
|
4-O-Tigloyl-11,13-dihydroautumnolide
|
No. 1190 |
|
|||||
|
C00020957
|
3-O-Angeloylcarolenalone
|
No. 2391 |
|
|||||
|
C00020893
|
Carolenin
|
C004186
|
No. 2391 |
|
||||
|
C00020958
|
3-O-Tigloylcarolenalone
|
No. 2391 |
|
|||||
|
C00020959
|
3-O-TigloylCarolenalin
|
No. 2391 |
|
|||||
|
C00020954
|
Akihalin
|
No. 2433 |
|
|||||
|
C00020956
|
Carolenalone
|
No. 2835 |
|
|||||
|
C00020955
|
Carolenalol
|
No. 2835 |
|
|||||
|
C00020892
|
Carolenalin
|
CHEMBL1441064
|
C004187
|
3 / 0 / 0 | No. 2835 |
|
||
|
C00003774
|
Helenien
/ adaptinol / lutein dipalmitate |
C042447
|
No. 5142 |
|
||||
|
C00003372
|
Tenulin
|
CHEMBL490324
CHEMBL1544783 |
C011124
|
6 / 1 / 7 | No. 5688 | No. 38 |
|
Human Protein / Gene in interactions
42 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q04206 | Transcription factor p65 | Transcription Factor | C00003298 C00003326 C00003352 C00020963 C00021175 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003298 C00003326 C00003352 C00020963 | 0 / 0 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | C00003298 C00003326 C00003352 C00020963 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003298 C00003326 C00003372 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00003298 C00003326 C00003372 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003298 C00003326 C00003372 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003298 C00003326 C00003372 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003298 C00003326 | 4 / 1 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00003298 C00003326 | 0 / 3 |
| Q9Y5X4 | Photoreceptor-specific nuclear receptor | NR2E3 | C00003298 C00003326 | 2 / 2 |
| P30556 | Type-1 angiotensin II receptor | Angiotensin receptor | C00003298 C00003326 | 1 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003298 C00003326 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003298 C00003326 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00003298 C00003326 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00003298 C00003326 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003298 C00003326 | 2 / 0 |
| P17861 | X-box-binding protein 1 | Unclassified protein | C00003298 C00003326 | 1 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003298 C00003326 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00003298 C00003326 | 4 / 2 |
| Q9Y2T6 | G-protein coupled receptor 55 | Lysophosphatidylinositol receptor | C00003298 C00003326 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003298 C00003326 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00003298 C00003326 | 6 / 4 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00003298 C00003326 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003298 C00003326 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003298 C00003326 | 0 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00003298 C00003326 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00003298 C00003326 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003298 C00003326 | 0 / 0 |
| Q00987 | E3 ubiquitin-protein ligase Mdm2 | Other nuclear protein | C00003298 C00003326 | 1 / 5 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003298 C00003326 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003298 C00003326 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003298 C00003326 | 2 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003298 C00003326 | 4 / 3 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003298 C00003326 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003298 C00003326 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00003298 C00003326 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003298 C00003326 | 1 / 1 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00020892 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00020892 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00020892 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003372 | 0 / 3 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00003372 | 1 / 4 |
18 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 468 | ATF4, CREB-2, CREB2, TAXREB67, TXREB | activating transcription factor 4 |
C00003298
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003298
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003298
|
| 958 | CD40, Bp50, CDW40, TNFRSF5, p50 | CD40 molecule, TNF receptor superfamily member 5 |
C00003298
|
| 941 | CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7 | CD80 molecule |
C00003298
|
| 9308 | CD83, BL11, HB15 | CD83 molecule |
C00003298
|
| 942 | CD86, B7-2, B7.2, B70, CD28LG2, LAB72 | CD86 molecule |
C00003298
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00003298
|
| 54541 | DDIT4, Dig2, REDD-1, REDD1 | DNA-damage-inducible transcript 4 |
C00003298
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003298
|
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00003298
|
| 3592 | IL12A, CLMF, IL-12A, NFSK, NKSF1, P35 | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) |
C00003298
|
| 3593 | IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) |
C00003298
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00003298
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003298
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003298
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00003298
|
| 8797 | TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1 | tumor necrosis factor receptor superfamily, member 10a |
C00003298
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (37)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614401 | Accelerated tumor formation, susceptibility to; actfs |
Q00987
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #268100 | Enhanced s-cone syndrome; escs |
Q9Y5X4
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #143100 | Huntington disease; hd |
P42858
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #612371 | Major affective disorder 7; mafd7 |
P17861
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #267430 | Renal tubular dysgenesis; rtd |
P30556
|
| #611131 | Retinitis pigmentosa 37; rp37 |
Q9Y5X4
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (35)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00575 | Renal tubular dysgenesis |
P30556
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
Q00987 (related) |
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00028 | Choriocarcinoma |
Q00987
(related)
|
| H00036 | Osteosarcoma |
Q00987
(related)
|
| H00037 | Alveolar rhabdomyosarcoma |
Q00987
(related)
|
| H00042 | Glioma |
Q00987
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00094 | DNA repair defects |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
Q9Y5X4
(related)
|
| H00805 | Vitreoretinal degeneration |
Q9Y5X4
(related)
|