Species

KNApSAcK Entry

Organism name Parthenium incanum
Genus Parthenium
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Parthenium
Linked NCBI taxonomy ID 35934
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004597 External link 512 5,6,4'-Trihydroxy-3,7-dimethoxyflavone
/ 6-Hydroxykaempferol 3,7-dimethyl ether
/ 5,6-Dihydroxy-2-(4-hydroxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
No. 3 No. 15
C00004712 External link 512 Artemetin
/ 3,6,7,3',4'-Pentamethylquercetagetin
/ Quercetagetin 3,6,7,3',4'-pentamethyl ether
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL225700
C054132
0 / 5 No. 8 No. 15
C00003898 External link 512 5-Hydroxy-6,7,3',4'-tetramethoxyflavone
/ 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL226508
C045324
No. 8 No. 15
C00004709 External link 512 Quercetagetin 6,7,3',4'-tetramethyl ether
/ 2-(3,4-Dimethoxyphenyl)-3,5-dihydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
No. 8 No. 15
C00004705 External link 512 Casticin
/ Vitexicarpin
/ Quercetagetin 3,6,7,4'-tetramethyl ether
/ 3,6,7,4'-Tetra-O-methyl-5,3'-dihydroxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL452767
C054133
No. 8 No. 15
C00004704 External link 512 Polycladin
/ Chrysosplenetin
/ Quercetagetin 3,6,7,3'-tetramethyl ether
/ 5,4'-Dihydroxy-3,6,7,3'-tetramethoxyflavone
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL33256
C072749
No. 8 No. 15
C00004607 External link 512 Penduletin 4'-methyl ether
/ 5-Hydroxy-3,6,7,4'-tetramethoxyflavone
/ 6-Hydroxykaempferol-3,6,7,4'-tetramethyl ether
/ 5-Hydroxy-3,6,7-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL521934
No. 8 No. 15
C00003239 External link 512 Coronopilin
CHEMBL248564
11 / 12 / 41 No. 340 No. 38
C00003316 External link 512 Ligulatin B
No. 2862 No. 38

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00003239 7 / 37
Q99700 Ataxin-2 Unclassified protein C00003239 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003239 2 / 0
O75496 Geminin Unclassified protein C00003239 0 / 0
P10145 Interleukin-8 Secreted protein C00003239 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003239 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003239 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003239 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003239 1 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00003239 0 / 3
Q06710 Paired box protein Pax-8 Unclassified protein C00003239 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
#133239 Esophageal cancer P04637
#137800 Glioma susceptibility 1; glm1 O75874
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#260500 Papilloma of choroid plexus; cpp P04637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (41)

KEGG name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
Q06710 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
Q06710 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00004712
D004487 Edema C00004712
D006099 Granuloma C00004712
D007022 Hypotension C00004712
D007249 Inflammation C00004712