Species

KNApSAcK Entry

Organism name Helenium linifolium
Genus Helenium
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Helenium
Linked NCBI taxonomy ID 53720
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003318 External link 512 Linifolin A
CHEMBL312003
CHEMBL270297
CHEMBL486196
CHEMBL486997
22 / 17 / 18 No. 470 No. 38
C00021135 External link 512 Linifolin B
CHEMBL309895
No. 3701

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17861 X-box-binding protein 1 Unclassified protein C00003318 1 / 0
Q99700 Ataxin-2 Unclassified protein C00003318 1 / 1
P30556 Type-1 angiotensin II receptor Angiotensin receptor C00003318 1 / 1
P11473 Vitamin D3 receptor NR1I1 C00003318 2 / 3
P42858 Huntingtin Unclassified protein C00003318 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003318 2 / 0
O75496 Geminin Unclassified protein C00003318 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00003318 0 / 0
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor C00003318 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003318 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003318 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003318 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00003318 0 / 0
Q00987 E3 ubiquitin-protein ligase Mdm2 Other nuclear protein C00003318 1 / 5
O15118 Niemann-Pick C1 protein Unclassified protein C00003318 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003318 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003318 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003318 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003318 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003318 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003318 1 / 0
Q06710 Paired box protein Pax-8 Unclassified protein C00003318 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#614401 Accelerated tumor formation, susceptibility to; actfs Q00987
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#143100 Huntington disease; hd P42858
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#267430 Renal tubular dysgenesis; rtd P30556
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (18)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00575 Renal tubular dysgenesis P30556 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00025 Penile cancer Q00987 (related)
H00028 Choriocarcinoma Q00987 (related)
H00036 Osteosarcoma Q00987 (related)
H00037 Alveolar rhabdomyosarcoma Q00987 (related)
H00042 Glioma Q00987 (related)
H00032 Thyroid cancer Q06710 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) Q06710 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)