Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

4-aminobutanal:NAD+ 1-oxidoreductase

4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ [RN:R02549]

R02549;
(other) R00904 R12215
Reaction

4-aminobutanal [CPD:C00555];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].

EC 1.2.1.19 created 1965, modified 1989 (EC 1.5.1.35 created 2006, incorporated 2007)

1  [PMID:4817964]

2

3  [PMID:13673029]

4  [PMID:16663901]

5

6  [PMID:3510672]

7  [PMID:3129020]

8  [PMID:16023116]

9  [PMID:15381418]

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

succinate-semialdehyde:NAD+ oxidoreductase

succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ [RN:R00713]

R00713
Reaction

succinate semialdehyde [CPD:C00232];
NAD+ [CPD:C00003];
H2O [CPD:C00001]

This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.

EC 1.2.1.24 created 1972, modified 2010