KEGG   ENZYME: 1.1.1.78
Entry
EC 1.1.1.78                 Enzyme                                 
Name
methylglyoxal reductase (NADH);
methylglyoxal reductase;
D-lactaldehyde dehydrogenase;
methylglyoxal reductase (NADH-dependent)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-lactaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+ [RN:R02527]
Reaction(KEGG)
R02527
Substrate
(R)-lactaldehyde [CPD:C00937];
NAD+ [CPD:C00003]
Product
2-oxopropanal [CPD:C00546];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH), by its cosubstrate requirement, reaction direction, and enantiomeric preference.
History
EC 1.1.1.78 created 1972, modified 2005, modified 2013
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:14323585]
  Authors
TING SM, MILLER ON, SELLINGER OZ.
  Title
THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER.
  Journal
Biochim Biophys Acta 97:407-15 (1965)
DOI:10.1016/0304-4165(65)90151-0
Reference
2  [PMID:6386056]
  Authors
Ray M, Ray S
  Title
Purification and partial characterization of a methylglyoxal reductase from goat  liver.
  Journal
Biochim Biophys Acta 802:119-27 (1984)
DOI:10.1016/0304-4165(84)90041-2
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.78
IUBMB Enzyme Nomenclature: 1.1.1.78
ExPASy - ENZYME nomenclature database: 1.1.1.78
BRENDA, the Enzyme Database: 1.1.1.78
CAS: 37250-16-1

  All links  
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (2)   
   EMBL (1)   
Protein domain (6)   
   InterPro (6)   
All databases (12)   

Download RDF
KEGG   REACTION: R02527
Entry
R02527                      Reaction                               
Name
(R)-lactaldehyde:NAD+ oxidoreductase
Definition
(R)-Lactaldehyde + NAD+ <=> Methylglyoxal + NADH + H+
Equation
C00937 + C00003 <=> C00546 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00670  C00546_C00937
Enzyme
1.1.1.78        1.1.1.79
Pathway
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.78
     R02527  (R)-Lactaldehyde + NAD+ <=> Methylglyoxal + NADH + H+
    1.1.1.79
     R02527  (R)-Lactaldehyde + NAD+ <=> Methylglyoxal + NADH + H+
Orthology
K00049  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
K12972  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
Other DBs
RHEA: 24531

  All links  
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