KEGG   DRUG: フロセミド
エントリ  
D00331                      Drug                                   
一般名   
フロセミド (JP18);
Furosemide (JP18/USP/INN);
Frusemide
商品名   
フロセミド (エルメッド), ラシックス (サノフィ), ラシックス (サノフィ), ラシックス (サノフィ)
  後発品
フロセミド (シオノケミカル), フロセミド (ニプロ), フロセミド (日医工), フロセミド (日医工岐阜工場), フロセミド (日医工岐阜工場), フロセミド (日本ジェネリック), フロセミド (東和薬品), フロセミド (東和薬品)
米国の商品 
FUROSCIX (scPharmaceuticals), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (Golden State Medical Supply), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (Hikma Pharmaceuticals USA), FUROSEMIDE (Hospira), FUROSEMIDE (Hospira), FUROSEMIDE (Mylan Institutional), FUROSEMIDE (Mylan Pharmaceuticals), FUROSEMIDE (Northwind Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Phlow Corporation), LASIX (Validus Pharmaceuticals LLC)
  後発品
FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Accord Healthcare), FUROSEMIDE (Amneal Pharmaceuticals LLC), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Athenex Pharmaceutical Division), FUROSEMIDE (AuroMedics Pharma LLC), FUROSEMIDE (AvKARE), FUROSEMIDE (Avenacy), FUROSEMIDE (Baxter Healthcare Corporation), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Calvin Scott &), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Civica), FUROSEMIDE (DIRECT RX), FUROSEMIDE (Direct_Rx), FUROSEMIDE (Gland Pharma Limited), FUROSEMIDE (Graviti Pharmaceuticals Private Limited), FUROSEMIDE (Henry Schein), FUROSEMIDE (Henry Schein), FUROSEMIDE (Henry Schein), FUROSEMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Leading Pharma), FUROSEMIDE (Lifestar Pharma LLC), FUROSEMIDE (Major Pharmaceuticals), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Meitheal Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NorthStar Rx LLC), FUROSEMIDE (Northwind Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Precision Dose), FUROSEMIDE (Precision Dose), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (QPharma), FUROSEMIDE (QPharma), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (RPK Pharmaceuticals), FUROSEMIDE (RPK Pharmaceuticals), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (Redpharm Drug), FUROSEMIDE (Rising Pharma Holdings), FUROSEMIDE (ST. MARY'S MEDICAL PARK PHARMACY), FUROSEMIDE (Sagent Pharmaceuticals), FUROSEMIDE (Solco Healthcare LLC), FUROSEMIDE (St Mary's Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (Wockhardt USA LLC.), UDSX MEDICATED SYSTEM (Wellbeing Medical Supply), UDSXMP MEDICATED SYSTEM (Wellbeing Medical Supply)
組成式   
C12H11ClN2O5S
質量    
330.0077
分子量   
330.7441
構造式   
Simcomp   
クラス   
心血管系用薬
 DG01690  スルホンアミド系利尿薬
  DG01747  フロセミド系利尿薬
 DG01748  ループ利尿薬
  DG01747  フロセミド系利尿薬
トランスポーター基質薬
 DG02920  ABCC4基質薬
 DG02859  SLC22A6基質薬
 DG02860  SLC22A8基質薬
コード   
同一コード: C07017
薬効分類: 2139
ATCコード: C03CA01
化学構造グループ: DG00272
商品 (DG00272): D00331<JP/US>
効能    
利尿薬, Na-K-Cl共輸送体阻害薬
  疾患
本態性高血圧症 [DS:H01633]
高血圧症 [DS:H01633]
コメント  
ループ利尿薬
スルホンアミド誘導体
ターゲット 
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
代謝    
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
相互作用  

構造マップ 
map07017  スルホンアミド誘導体 - 利尿剤
map07055  スルホンアミド誘導体 - 構造展開
map07233  イオントランスポーター阻害薬
他のマップ 
map04976  胆汁の分泌
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   213  利尿剤
    2139  その他の利尿剤
     D00331  フロセミド (JP18)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C03 利尿薬
   C03C 高許容値の利尿薬
    C03CA スルホンアミド、単剤
     C03CA01 フロセミド
      D00331  フロセミド (JP18) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  ループ利尿薬
   フロセミド
    D00331  フロセミド (JP18)
医薬品グループ [BR:jp08330]
 心血管系用薬
  DG01690  スルホンアミド系利尿薬
   DG01747  フロセミド系利尿薬
    DG00272  フロセミド
     D00331  フロセミド
  DG01748  ループ利尿薬
   DG01747  フロセミド系利尿薬
    DG00272  フロセミド
     D00331  フロセミド
 トランスポーター基質薬
  DG02920  ABCC4基質薬
   DG00272  フロセミド
    D00331  フロセミド
  DG02859  SLC22A6基質薬
   DG00272  フロセミド
    D00331  フロセミド
  DG02860  SLC22A8基質薬
   DG00272  フロセミド
    D00331  フロセミド
ターゲットに基づく医薬品分類 [BR:jp08310]
 トランスポーター
  SLC ファミリー
   SLC12
    SLC12A1 (NKCC2)
     D00331  フロセミド (JP18) <JP/US>
    SLC12A2 (NKCC1)
     D00331  フロセミド (JP18) <JP/US>
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00331  フロセミド
  D00331  フロセミド錠
  D00331  フロセミド注射液
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物トランスポーター
  D00331
医薬品グループ [BR:jp08330]
 心血管系用薬
  DG01690  スルホンアミド系利尿薬
   DG01747  フロセミド系利尿薬
    DG00272  フロセミド
  DG01748  ループ利尿薬
   DG01747  フロセミド系利尿薬
    DG00272  フロセミド
 トランスポーター基質薬
  DG02920  ABCC4基質薬
   DG00272  フロセミド
  DG02859  SLC22A6基質薬
   DG00272  フロセミド
  DG02860  SLC22A8基質薬
   DG00272  フロセミド
リンク   
CAS: 54-31-9
PubChem: 7847397
PDB-CCD: FUN[PDBj]
LigandBox: D00331
日化辞: J1.913E

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Ontology (7)   
   KEGG BRITE (7)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
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