KEGG   DRUG: Imidafenacin
Entry
D06273                      Drug                                   
Name
Imidafenacin (JAN/INN);
Uritos (TN);
Staybla (TN)
Formula
C20H21N3O
Exact mass
319.1685
Mol weight
319.4002
Structure
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03182  UGT1A4 substrate
Remark
Therapeutic category: 2590
ATC code: G04BD14
Product: D06273<JP>
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Target
CHRM1 [HSA:1128] [KO:K04129]
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], UGT1A4 [HSA:54657]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Drugs for urinary frequency and incontinence
     G04BD14 Imidafenacin
      D06273  Imidafenacin (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D06273  Imidafenacin (JAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   D06273  Imidafenacin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D06273  Imidafenacin
  DG02924  UGT substrate
   DG03182  UGT1A4 substrate
    D06273  Imidafenacin
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM1
     D06273  Imidafenacin (JAN/INN) <JP>
    CHRM3
     D06273  Imidafenacin (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06273
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06273
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06273
Other DBs
CAS: 170105-16-5
PubChem: 47207931
LigandBox: D06273
KCF data

ATOM        24
            1   N5x N    26.6000  -18.6900
            2   C8x C    26.9623  -20.1123
            3   C8x C    28.3604  -20.1156
            4   N4y N    28.8622  -18.8085
            5   C8y C    27.7742  -17.9275
            6   C1b C    30.0524  -18.1300
            7   C1b C    31.2649  -18.8300
            8   C1d C    32.4773  -18.1300
            9   C8y C    33.6897  -18.8300
            10  C8y C    32.4773  -16.7300
            11  C8x C    33.6897  -20.2300
            12  C8x C    33.6918  -16.0288
            13  C8x C    33.6918  -14.6288
            14  C8x C    32.4793  -13.9288
            15  C8x C    31.2649  -14.6300
            16  C8x C    31.2649  -16.0300
            17  C8x C    34.9022  -20.9300
            18  C8x C    36.1146  -20.2300
            19  C8x C    36.1146  -18.8300
            20  C8x C    34.9022  -18.1300
            21  C5a C    35.5097  -16.4500
            22  C1a C    27.7742  -16.5275
            23  O5a O    36.6950  -17.1627
            24  N1a N    35.4645  -15.0507
BOND        26
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     4   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   11  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22    9  20 1
            23    8  21 1
            24    5  22 1
            25   21  23 2
            26   21  24 1

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   KEGG BRITE (7)   
Drug (4)   
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   LigandBox (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
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