Entry
Symbol
HMGCR
Name
hydroxymethylglutaryl-CoA reductase (NADPH) [EC:
1.1.1.34 ]
Pathway
map00900 Terpenoid backbone biosynthesis
map01110 Biosynthesis of secondary metabolites
Module
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
M00849 C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Reaction
R02082 (R)-mevalonate:NADP+ oxidoreductase (CoA acylating)
Disease
H00593 Limb-girdle muscular dystrophy
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
K00021 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
09130 Environmental Information Processing
09132 Signal transduction
04152 AMPK signaling pathway
K00021 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
09150 Organismal Systems
09154 Digestive system
04976 Bile secretion
K00021 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
K00021 HMGCR; hydroxymethylglutaryl-CoA reductase (NADPH)
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Luskey KL, Stevens B
Title
Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.
Journal
J Biol Chem 260:10271-7 (1985)
Sequence
Reference
Authors
Lam WL, Doolittle WF
Title
Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii.
Journal
J Biol Chem 267:5829-34 (1992)
Sequence