KEGG   ORTHOLOGY: K00552
Entry
K00552                      KO                                     

Name
GNMT
Definition
glycine N-methyltransferase [EC:2.1.1.20]
Pathway
ko00260  Glycine, serine and threonine metabolism
ko01100  Metabolic pathways
Disease
H00184  Hypermethioninemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K00552  GNMT; glycine N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.20  glycine N-methyltransferase
     K00552  GNMT; glycine N-methyltransferase
Other DBs
RN: R00367
GO: 0017174
Genes
HSA: 27232(GNMT)
PTR: 462703(GNMT)
PPS: 100993237(GNMT)
GGO: 101143848(GNMT)
PON: 100432507(GNMT)
NLE: 100603199(GNMT)
MCC: 697722(GNMT)
MCF: 102133929(GNMT)
CSAB: 103221484(GNMT)
RRO: 104667328(GNMT)
RBB: 108533480(GNMT)
CJC: 100413047(GNMT)
SBQ: 101053276(GNMT)
MMU: 14711(Gnmt)
MCAL: 110284012(Gnmt)
MPAH: 110335591
RNO: 100911564 25134(Gnmt)
MUN: 110550343(Gnmt)
CGE: 100769585
NGI: 103730804(Gnmt)
HGL: 101697457(Gnmt)
CCAN: 109682081(Gnmt)
OCU: 100009512(GNMT)
TUP: 102501380(GNMT)
CFA: 474905(GNMT)
VVP: 112913997(GNMT)
AML: 100477196(GNMT)
UMR: 103664079(GNMT)
UAH: 113261284(GNMT)
ORO: 101377523(GNMT)
FCA: 101083006(GNMT)
PTG: 102965502(GNMT)
PPAD: 109271639(GNMT)
AJU: 106973967(GNMT)
BTA: 112443696 538212(GNMT)
BOM: 102287446(GNMT)
BIU: 109577223(GNMT)
BBUB: 102395585(GNMT)
CHX: 102170645(GNMT)
OAS: 101111134(GNMT)
SSC: 397444(GNMT)
CFR: 102506340(GNMT)
CDK: 105088648(GNMT)
BACU: 103001201(GNMT)
LVE: 103077097(GNMT)
OOR: 101270773(GNMT)
DLE: 111178834(GNMT)
PCAD: 102994709(GNMT)
ECB: 100067145(GNMT)
EPZ: 103548169(GNMT)
EAI: 106828715(GNMT)
MYB: 102250180(GNMT)
MYD: 102760706(GNMT)
MNA: 107536922(GNMT)
HAI: 109382878
DRO: 112302127(GNMT)
PALE: 102898977(GNMT)
RAY: 107501992(GNMT)
MJV: 108395057(GNMT)
LAV: 100660725(GNMT)
TMU: 101355018
MDO: 100010632(GNMT)
SHR: 100925098
PCW: 110201291(GNMT)
OAA: 100092827(GNMT)
GGA: 769542(GNMT)
MGP: 100540940(GNMT)
CJO: 107310908(GNMT)
NMEL: 110395296(GNMT)
APLA: 113842961
TGU: 100231507(GNMT)
LSR: 110472810(GNMT)
SCAN: 103821310
FAB: 101818171(GNMT)
PHI: 102109993(GNMT)
PMAJ: 107202337(GNMT)
CCAE: 111922583
ETL: 114066770(GNMT)
FCH: 102046712
CLV: 102096572
EGZ: 104128772(GNMT)
NNI: 104015806(GNMT)
AAM: 106494152(GNMT)
ASN: 102386281
AMJ: 102566047(GNMT)
PSS: 102460961
CMY: 102938095(GNMT)
CPIC: 101948133(GNMT)
ACS: 100552842(gnmt)
PVT: 110087012(GNMT)
PBI: 103067312(GNMT)
PMUR: 107297201(GNMT)
TSR: 106538009(GNMT)
PMUA: 114594784(GNMT)
GJA: 107123075(GNMT)
XTR: 116410885(gnmt)
NPR: 108803755
DRE: 403338(gnmt)
SANH: 107697528(gnmt) 107703804
CCAR: 109106978
IPU: 108270118(gnmt)
PHYP: 113545046(gnmt)
AMEX: 103028138
EEE: 113572147(gnmt)
LCO: 104932648(gnmt)
NCC: 104954782(gnmt)
MZE: 101484870(gnmt)
ONL: 100706279(gnmt)
OLA: 101154832(gnmt)
XMA: 102219353(gnmt)
XCO: 114134382(gnmt)
CVG: 107084845(gnmt)
NFU: 107389170 107392578(gnmt)
KMR: 108246999(gnmt)
ALIM: 106521247(gnmt)
AOCE: 111562587(gnmt)
CSEM: 103380842(gnmt)
POV: 109628164(gnmt)
LCF: 108898000(gnmt)
SDU: 111226206(gnmt)
SLAL: 111668120(gnmt)
HCQ: 109530231(gnmt)
BPEC: 110155508(gnmt)
MALB: 109973687(gnmt)
SASA: 106561891(gnmt)
OTW: 112263437(gnmt)
SALP: 111969168(gnmt)
ELS: 105006939(gnmt)
SFM: 108923148(gnmt)
PKI: 111834432(gnmt)
LCM: 102360222(GNMT)
CMK: 103187634(gnmt)
RTP: 109919411
SKO: 100378448
DME: Dmel_CG6188(Gnmt)
DER: 6553637
DSE: 6606629
DSI: Dsimw501_GD18854(Dsim_GD18854)
DAN: 6499903
DSR: 110186710
DPE: 113566232
DMN: 108156785
DWI: 6651484
DAZ: 108608851
DNV: 115561966
DHE: 111598317
DVI: 6630429
MDE: 101892983
LCQ: 111682604
AAG: 5576784
AME: 552832
BIM: 100742588
BTER: 100647936
CCAL: 108624035
OBB: 114880987
SOC: 105193482
MPHA: 105837902
AEC: 105154304
ACEP: 105618894
PBAR: 105430839
VEM: 105561988
HST: 105191076
DQU: 106745158
CFO: 105256576
LHU: 105675201
PGC: 109860071
OBO: 105277551
PCF: 106788778
CSOL: 105367921
DPA: 109541622
ATD: 109598594
NVL: 108569224
PMAC: 106708644
PRAP: 110995024
HAW: 110374194
PXY: 105387574
ZNE: 110837685
FCD: 110843745
PVM: 113822744
CSCU: 111617666
PTEP: 107452716
LAK: 106167602
NVE: 5504443
EPA: 110240485
AMIL: 114967239
PDAM: 113684111
SPIS: 111338256
DGT: 114520307
HMG: 100206590
 » show all
Reference
  Authors
Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME
  Title
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.
  Journal
Proteins 57:331-7 (2004)
DOI:10.1002/prot.20209
  Sequence
[hsa:27232] [mmu:14711]

KEGG   ENZYME: 2.1.1.20
Entry
EC 2.1.1.20                 Enzyme                                 

Name
glycine N-methyltransferase;
glycine methyltransferase;
S-adenosyl-L-methionine:glycine methyltransferase;
GNMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:glycine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine [RN:R00367]
Reaction(KEGG)
R00367
Substrate
S-adenosyl-L-methionine [CPD:C00019];
glycine [CPD:C00037]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
sarcosine [CPD:C00213]
Comment
This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.
History
EC 2.1.1.20 created 1972, modified 2005
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K00552  glycine N-methyltransferase
Genes
HSA: 27232(GNMT)
PTR: 462703(GNMT)
PPS: 100993237(GNMT)
GGO: 101143848(GNMT)
PON: 100432507(GNMT)
NLE: 100603199(GNMT)
MCC: 697722(GNMT)
MCF: 102133929(GNMT)
CSAB: 103221484(GNMT)
RRO: 104667328(GNMT)
RBB: 108533480(GNMT)
CJC: 100413047(GNMT)
SBQ: 101053276(GNMT)
MMU: 14711(Gnmt)
MCAL: 110284012(Gnmt)
MPAH: 110335591
RNO: 100911564 25134(Gnmt)
MUN: 110550343(Gnmt)
CGE: 100769585
NGI: 103730804(Gnmt)
HGL: 101697457(Gnmt)
CCAN: 109682081(Gnmt)
OCU: 100009512(GNMT)
TUP: 102501380(GNMT)
CFA: 474905(GNMT)
VVP: 112913997(GNMT)
AML: 100477196(GNMT)
UMR: 103664079(GNMT)
UAH: 113261284(GNMT)
ORO: 101377523(GNMT)
FCA: 101083006(GNMT)
PTG: 102965502(GNMT)
PPAD: 109271639(GNMT)
AJU: 106973967(GNMT)
BTA: 112443696 538212(GNMT)
BOM: 102287446(GNMT)
BIU: 109577223(GNMT)
BBUB: 102395585(GNMT)
CHX: 102170645(GNMT)
OAS: 101111134(GNMT)
SSC: 397444(GNMT)
CFR: 102506340(GNMT)
CDK: 105088648(GNMT)
BACU: 103001201(GNMT)
LVE: 103077097(GNMT)
OOR: 101270773(GNMT)
DLE: 111178834(GNMT)
PCAD: 102994709(GNMT)
ECB: 100067145(GNMT)
EPZ: 103548169(GNMT)
EAI: 106828715(GNMT)
MYB: 102250180(GNMT)
MYD: 102760706(GNMT)
MNA: 107536922(GNMT)
HAI: 109382878
DRO: 112302127(GNMT)
PALE: 102898977(GNMT)
RAY: 107501992(GNMT)
MJV: 108395057(GNMT)
LAV: 100660725(GNMT)
TMU: 101355018
MDO: 100010632(GNMT)
SHR: 100925098
PCW: 110201291(GNMT)
OAA: 100092827(GNMT)
GGA: 769542(GNMT)
MGP: 100540940(GNMT)
CJO: 107310908(GNMT)
NMEL: 110395296(GNMT)
APLA: 113842961
TGU: 100231507(GNMT)
LSR: 110472810(GNMT)
SCAN: 103821310
FAB: 101818171(GNMT)
PHI: 102109993(GNMT)
PMAJ: 107202337(GNMT)
CCAE: 111922583
ETL: 114066770(GNMT)
FCH: 102046712
CLV: 102096572
EGZ: 104128772(GNMT)
NNI: 104015806(GNMT)
AAM: 106494152(GNMT)
ASN: 102386281
AMJ: 102566047(GNMT)
PSS: 102460961
CMY: 102938095(GNMT)
CPIC: 101948133(GNMT)
ACS: 100552842(gnmt)
PVT: 110087012(GNMT)
PBI: 103067312(GNMT)
PMUR: 107297201(GNMT)
TSR: 106538009(GNMT)
PMUA: 114594784(GNMT)
GJA: 107123075(GNMT)
XTR: 116410885(gnmt)
NPR: 108803755
DRE: 403338(gnmt)
SANH: 107697528(gnmt) 107703804
CCAR: 109106978
IPU: 108270118(gnmt)
PHYP: 113545046(gnmt)
AMEX: 103028138
EEE: 113572147(gnmt)
LCO: 104932648(gnmt)
NCC: 104954782(gnmt)
MZE: 101484870(gnmt)
ONL: 100706279(gnmt)
OLA: 101154832(gnmt)
XMA: 102219353(gnmt)
XCO: 114134382(gnmt)
CVG: 107084845(gnmt)
NFU: 107389170 107392578(gnmt)
KMR: 108246999(gnmt)
ALIM: 106521247(gnmt)
AOCE: 111562587(gnmt)
CSEM: 103380842(gnmt)
POV: 109628164(gnmt)
LCF: 108898000(gnmt)
SDU: 111226206(gnmt)
SLAL: 111668120(gnmt)
HCQ: 109530231(gnmt)
BPEC: 110155508(gnmt)
MALB: 109973687(gnmt)
SASA: 106561891(gnmt)
OTW: 112263437(gnmt)
SALP: 111969168(gnmt)
ELS: 105006939(gnmt)
SFM: 108923148(gnmt)
PKI: 111834432(gnmt)
LCM: 102360222(GNMT)
CMK: 103187634(gnmt)
RTP: 109919411
SKO: 100378448
DME: Dmel_CG6188(Gnmt)
DER: 6553637
DSE: 6606629
DSI: Dsimw501_GD18854(Dsim_GD18854)
DAN: 6499903
DSR: 110186710
DPE: 113566232
DMN: 108156785
DWI: 6651484
DAZ: 108608851
DNV: 115561966
DHE: 111598317
DVI: 6630429
MDE: 101892983
LCQ: 111682604
AAG: 5576784
AME: 552832
BIM: 100742588
BTER: 100647936
CCAL: 108624035
OBB: 114880987
SOC: 105193482
MPHA: 105837902
AEC: 105154304
ACEP: 105618894
PBAR: 105430839
VEM: 105561988
HST: 105191076
DQU: 106745158
CFO: 105256576
LHU: 105675201
PGC: 109860071
OBO: 105277551
PCF: 106788778
CSOL: 105367921
DPA: 109541622
ATD: 109598594
NVL: 108569224
PMAC: 106708644
PRAP: 110995024
HAW: 110374194
PXY: 105387574
ZNE: 110837685
FCD: 110843745
PVM: 113822744
CSCU: 111617666
PTEP: 107452716
LAK: 106167602
NVE: 5504443
EPA: 110240485
AMIL: 114967239
PDAM: 113684111
SPIS: 111338256
DGT: 114520307
HMG: 100206590
 » show all
Reference
1  [PMID:13971907]
  Authors
BLUMENSTEIN J, WILLIAMS GR.
  Title
Glycine methyltransferase.
  Journal
Can J Biochem Physiol 41:201-10 (1963)
Reference
2  [PMID:9597750]
  Authors
Ogawa H, Gomi T, Takusagawa F, Fujioka M.
  Title
Structure, function and physiological role of glycine N-methyltransferase.
  Journal
Int J Biochem Cell Biol 30:13-26 (1998)
DOI:10.1016/S1357-2725(97)00105-2
Reference
3  [PMID:10608809]
  Authors
Yeo EJ, Briggs WT, Wagner C.
  Title
Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate.
  Journal
J Biol Chem 274:37559-64 (1999)
DOI:10.1074/jbc.274.53.37559
Reference
4  [PMID:10833353]
  Authors
Martinov MV, Vitvitsky VM, Mosharov EV, Banerjee R, Ataullakhanov FI.
  Title
A substrate switch: a new mode of regulation in the methionine metabolic pathway.
  Journal
J Theor Biol 204:521-32 (2000)
DOI:10.1006/jtbi.2000.2035
Reference
5  [PMID:12859184]
  Authors
Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F.
  Title
Catalytic mechanism of glycine N-methyltransferase.
  Journal
Biochemistry 42:8394-402 (2003)
DOI:10.1021/bi034245a
  Sequence
[rno:25134]
Reference
6  [PMID:15340920]
  Authors
Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME.
  Title
Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.
  Journal
Proteins 57:331-7 (2004)
DOI:10.1002/prot.20209
  Sequence
[hsa:27232] [mmu:14711]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.20
IUBMB Enzyme Nomenclature: 2.1.1.20
ExPASy - ENZYME nomenclature database: 2.1.1.20
BRENDA, the Enzyme Database: 2.1.1.20
CAS: 37228-72-1

KEGG   REACTION: R00367
Entry
R00367                      Reaction                               

Name
S-Adenosyl-L-methionine:glycine N-methyltransferase
Definition
S-Adenosyl-L-methionine + Glycine <=> S-Adenosyl-L-homocysteine + Sarcosine
Equation
Comment
further methylation of sarcosine to N,N-dimethylglycine (ec 2.1.1.156, see R07243)
Reaction class
RC00003  C00019_C00021
RC00060  C00037_C00213
Enzyme
2.1.1.20        2.1.1.156       2.1.1.162
Pathway
rn00260  Glycine, serine and threonine metabolism
rn01100  Metabolic pathways
Orthology
K00552  glycine N-methyltransferase [EC:2.1.1.20]
Other DBs
RHEA: 19940

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