KEGG   ORTHOLOGY: K00559
Entry
K00559                      KO                                     
Symbol
SMT1, ERG6
Name
sterol 24-C-methyltransferase [EC:2.1.1.41]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Reaction
R04427  S-adenosyl-L-methionine:zymosterol C-methyltransferase
R07481  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K00559  SMT1, ERG6; sterol 24-C-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.41  sterol 24-C-methyltransferase
     K00559  SMT1, ERG6; sterol 24-C-methyltransferase
Other DBs
COG: COG0500
GO: 0003838
Genes
NAI: NECAME_03546
BMY: BM_BM4647(Bma-strm-1)
AQU: 100639491
ATH: AT5G13710(SMT1)
ALY: 9307650
CRB: 17882375
CSAT: 104705624 104735382 104769590
EUS: EUTSA_v10014014mg
BRP: 103850891 103856028
BNA: 106371823 106431054 106440921
BOE: 106322658 106329263
RSZ: 108839810 108844631
THJ: 104809850 104819084 104819086 104819087
CPAP: 110809321
CIT: 102628258
CIC: CICLE_v10031748mg
PVY: 116132255 116132258
MINC: 123197557 123214703 123216668 123216669 123216670
TCC: 18598956 18614599 18614600
GRA: 105790583
GHI: 107915814 107950679
GAB: 108470188
HSYR: 120129642 120136785 120165276 120188812
DZI: 111305861 111313689
EGR: 104454605 104454641 104454642 104455966
RARG: 115753046 115753057
GMX: 100796978 100817534 100818061 548073
GSJ: 114372208 114378245 114379538 114386323
PVU: 137834769 137836171 137836176
VRA: 106760797
VAR: 108332339
VUN: 114165537
VUM: 124835473
CCAJ: 109799147 109806010
APRC: 113854972 113865316
MTR: 11415411
TPRA: 123913735
CAM: 101497864
PSAT: 127085609
VVO: 131636217 131662694
LJA: 130747906 130748158
ADU: 107471578 107479358
AIP: 107622756 107630475
AHF: 112716746 112738324 112783834 112790500
LANG: 109333713 109346157
PCIN: 129296047 129315800
QSA: O6P43_006507 O6P43_029576
FVE: 101293342
AANS: 126801448
RCN: 112181939
PPER: 18785581
PMUM: 103330640
PAVI: 110765835
PDUL: 117619806
MDM: 103418631 103438422
MSYL: 126613669 126628384
PCOX: 137735012 137748123
ZJU: 107425735
MNT: 112091791 21388176
CSAV: 115709304
CSV: 101217151 101217389
CMO: 103500325 103500326
BHJ: 120089794 120091030
MCHA: 111020326 111020366
CMAX: 111481504 111481505 111493094
CMOS: 111441927 111442447 111452027
CPEP: 111787513 111789805 111789806
RCU: 8259297 8286298
MEAN: 126661270
JCU: 105628730
HBR: 110634256 110659984
MESC: 110618568 110620358 110623913
POP: 18095100 18106161 7467341
PEU: 105117376 105126337 105131854 105141731
PALZ: 118027720 118047027 118051651
PNZ: 133677017 133680239 133689251
JRE: 108987693 108988702 109019397
CILL: 122292529 122292668 122293402
CAVE: 132167241 132173586
AGLU: 133879284 133880094 133880295 133880389 133882289
QSU: 112025906 112027940
QLO: 115953357 115967771 115986962
TWL: 120011980 120014669
VVI: 100252116 100263590
VRI: 117919779 117928779 117928780
SLY: 101252433 101256047
SPEN: 107008176 107032350
SOT: 102581721 102589132
SSTN: 125853521 125866069
SDUL: 129886986
CANN: 107839483 107845155
LBB: 132607399 132644773
NTA: 107772103 107806298 107813194 107813488 107821929 107825894
NSY: 104213731 104221372 104248706
NTO: 104104807 104117345 104120777
NAU: 109216067 109225324 109237978
INI: 109156026 109156027
ITR: 115995625 115997067
SIND: 105169293
OEU: 111410481 111410482
EGT: 105969542
SSPL: 121759270 121791175 121805340 121809614
SMIL: 131022313
SHIS: 125194076 125217903
APAN: 127246285
HPUM: 140881013
PHUA: 140957598 140973511
PEBU: 140809540
HAN: 110888576 110918161 110921577
ECAD: 122595873
LSV: 111900335 111912645 111912658
CCAV: 112522572
DCR: 108196395 108226507
CSIN: 114279643 114312087 114318153
RVL: 131326980 131327876 131334351 131334352 131334353
AEW: 130756790 130780608 130782335
DLT: 127802732
BVG: 104907757
SOE: 110778345
CQI: 110702765 110705694
ATRI: 130804259
MOF: 131165006
NNU: 104597375
MING: 122071445 122071905 122091901
TSS: 122642777 122642790 122642791
PSOM: 113313126 113322869 113354420
OSA: 4342690(Smt1-1) 9269350
DOSA: Os03g0807600 Os07g0206700
OBR: 102713236
OGL: 127755018 127766216 127779788
BDI: 100826864 100834229
ATS: 109734415 109756778
TDC: 119291992 119304087
TAES: 123093722 123105904 543246
TUA: 125529735
LPER: 127292258 127323344
LRD: 124674874 124674972 124697778 124697779
SBI: 8057107 8064726 8078421 8081208
ZMA: 100282501 100286381 541682
MFLO: 136486773 136513377 136517854 136535197 136545482 136549562 136549565
SITA: 101753762 101756008 101780888
SVS: 117834191 117845345 117866533
PVIR: 120639714 120644214 120644215 120644245 120645629 120649372 120659670 120665784
PHAI: 112872433 112877095 112883041
PAUA: 133890967 133893375 133913599 133913600
TANG: 140758856 140763023 140763582
PDA: 103696988 103696989 103697536 103717656 103717657 113461272 120104527
EGU: 105035517 105046511 105055167
MUS: 103979889 103980161 103993068 135609970
ZOF: 122020552 122020864 122024007 122024078 122024744 122051188 122055892
DCT: 110109799 110110369 110116065
PEQ: 110018546 110018549
AOF: 109833715
MSIN: 131221626 131222583
ACAK: 137945411 137949864
NCOL: 116249160
ATR: 18428920 18428921 18428922
CJF: 131046850 131046869
SMO: SELMODRAFT_449609(SMT1-2) SELMODRAFT_449613(SMT1-1)
PPP: 112291818
MNG: MNEG_11110
OLU: OSTLU_30710
OTA: OT_ostta03g03830
BPG: Bathy09g04120
MIS: MICPUN_93596(SMT1)
MPP: MICPUCDRAFT_50903
CME: CYME_CMP275C
GSL: Gasu_26310 Gasu_60150
SCE: YML008C(ERG6)
SEUB: DI49_4081
SPAO: SPAR_M01190
AGO: AGOS_ADR196W
ERC: Ecym_4063
KLA: KLLA0_A01738g
KMX: KLMA_30671(ERG6)
LTH: KLTH0G03806g
VPO: Kpol_1004p23
ZRO: ZYRO0D12606g
CGR: 2888522(ERG6)
NCS: NCAS_0H02570(NCAS0H02570)
NDI: NDAI_0C01050(NDAI0C01050)
TPF: TPHA_0D02350(TPHA0D02350)
TBL: TBLA_0D01630(TBLA0D01630)
TGB: HG536_0A05480
TDL: TDEL_0A03930(TDEL0A03930)
KAF: KAFR_0C05410(KAFR0C05410)
KNG: KNAG_0B03670(KNAG0B03670)
ZMK: HG535_0D04960
SLUD: SCDLUD_003309
DHA: DEHA2D17622g
PIC: PICST_80971
PGU: PGUG_00661
SPAA: SPAPADRAFT_62031
LEL: PVL30_003580(ERG6)
LBG: 92208639(LODBEIA_P34430)
CAL: CAALFM_C302150CA(ERG6)
CTP: CTRG_02396
COT: CORT_0C04430
CDU: CD36_82130(ERG6)
CTEN: 18247249(ERG6)
CLU: CLUG_02673
CLUS: A9F13_07g01804
CAUR: CJI96_0004127
ASAU: 88174163(PUMCH_003099)
PPA: PAS_chr3_0371
PKZ: C5L36_0E02630
BNN: FOA43_002150(ERG6)
BBRX: BRETT_003844(ERG6)
OPA: HPODL_01877
YLI: 2908368(YALI2_F00173g)
SLB: AWJ20_2170(ERG6)
NCR: NCU02502 NCU03006(erg-4)
NTE: NEUTE1DRAFT150553(NEUTE1DRAFT_150553) NEUTE1DRAFT73978(NEUTE1DRAFT_73978)
SMP: 10808713(SMAC4_05969) 10810018(SMAC4_01214)
PAN: PODANSg3800 PODANSg4053 PODANSg4704
PBEL: QC761_115810(ERG6_1) QC761_124410(ERG6_2)
PPSD: QC762_115810(ERG6_1) QC762_124410(ERG6_2)
PPSP: QC763_115810(ERG6_1) QC763_124410(ERG6_2)
PPSA: QC764_115810(ERG6_1) QC764_124410(ERG6_2)
TTT: THITE_68084
MTM: MYCTH_110670 MYCTH_42269
CTHR: CTHT_0006340
RTHE: 98123353(VTJ83DRAFT_2439) 98124731(VTJ83DRAFT_3682)
MGR: MGG_04346 MGG_10568 MGG_10860
PPEI: PpBr36_03960 PpBr36_10036
PGRI: PgNI_03580 PgNI_09085 PgNI_11040
TMN: UCRPA7_4321 UCRPA7_5376 UCRPA7_8731
SSCK: SPSK_06325 SPSK_06557 SPSK_06653
FGR: FGSG_02783 FGSG_05740
FPU: FPSE_05610 FPSE_08317
FPOA: FPOAC1_005133(ERG6_1) FPOAC1_008700(ERG4)
FVN: FVRRES_05661 FVRRES_09296
FVR: FVEG_05904 FVEG_13091
FOX: FOXG_08765 FOXG_15629
NHE: NECHADRAFT_101488 NECHADRAFT_33136 NECHADRAFT_59530
FFC: NCS54_00221300 NCS54_00445000
FKR: NCS57_00216400 NCS57_00451800
FMU: J7337_004853(ERG6_2) J7337_008919(ERG6_3)
TRE: TRIREDRAFT_121166 TRIREDRAFT_56236
TRR: M419DRAFT_108988 M419DRAFT_72858
TATV: 25776029(TrAtP1_002228) 25785708(TrAtP1_007734)
TASP: 36608857(ERG6_3) 36615740(ERG6_1)
MAW: 19252549(ERG6_1)
MAJ: MAA_02798 MAA_10087
MBRN: 26241702(erg6_0) 26243633(erg6_1)
PCHM: VFPPC_07182 VFPPC_10999
CMT: CCM_04684 CCM_08656
AMUS: LMH87_001661 LMH87_006959 LMH87_009165
PLJ: 28892488(PLICBS_006480) 28893235(PLICBS_006719)
PTKZ: JDV02_008053(ERG6_1) JDV02_009647(ERG6_2)
VAL: VDBG_01914 VDBG_08910
VDA: VDAG_01643 VDAG_06572
CFJ: CFIO01_00904 CFIO01_00910 CFIO01_12167
CLUP: CLUP02_08421 CLUP02_11674 CLUP02_11681
CHIG: CH63R_07675 CH63R_11163 CH63R_11195
CDET: 87944887(CDEST_08384) 87945928(CDEST_09425) 87945956(CDEST_09453)
SAPO: SAPIO_CDS4855 SAPIO_CDS6557
ELA: UCREL1_1004 UCREL1_1267 UCREL1_1354
PFY: PFICI_00782 PFICI_01643 PFICI_06847 PFICI_10966
SSL: SS1G_03467 SS1G_03686
BFU: BCIN_04g01200 BCIN_08g01540
MBE: MBM_02476 MBM_07594
PSCO: LY89DRAFT_628125 LY89DRAFT_684462 LY89DRAFT_725473 LY89DRAFT_789176
GLZ: GLAREA_04347 GLAREA_05164
ANI: ANIA_01614 ANIA_07146
AFM: AFUA_4G03630 AFUA_4G09190
ACT: ACLA_048560 ACLA_054780
NFI: NFIA_029790 NFIA_106980
AOR: AO090011000289 AO090012000932 AO090023000624
ANG: An04g04210 An14g01590 An16g00300
AFV: AFLA_002655 AFLA_006968 AFLA_007687
ALUC: AKAW2_40856S(ERG6) AKAW2_51426S
ACHE: ACHE_40345A ACHE_60580A(ERG6)
APUU: APUU_21581S APUU_22198S(ERG6_1) APUU_80754S(ERG6_2)
PCS: N7525_001128 N7525_007611
PDP: PDIP_13570 PDIP_13580 PDIP_57520 PDIP_76970
POU: POX_g09270
TMF: EYB26_009195
TRG: TRUGW13939_07336
CIM: CIMG_06139 CIMG_08444 CIMG_09630
CPW: 9695881(ERG6_1)
URE: UREG_02519 UREG_04245
ABE: ARB_05210 ARB_05997
TVE: TRV_02353 TRV_06345
PBL: PAAG_01575
PBN: PADG_00204
AJE: HCAG_07564
BGH: BDBG_08700
PNO: SNOG_08443
PTE: PTT_11273
PTRR: 6346862(PtrM4_146510)
BZE: COCCADRAFT_22623
BSC: COCSADRAFT_39890
BOR: COCMIDRAFT_90360
AALT: CC77DRAFT_1024280 CC77DRAFT_984927
ADAC: 96080506(ACET3X_000184) 96083565(ACET3X_003243)
ARAB: EKO05_0005085
ZTR: MYCGRDRAFT_33363 MYCGRDRAFT_70113(ERG6) MYCGRDRAFT_70899 MYCGRDRAFT_98820
PFJ: MYCFIDRAFT_33221 MYCFIDRAFT_64115 MYCFIDRAFT_84237
FFU: CLAFUR5_00943 CLAFUR5_09835
CBET: CB0940_01475 CB0940_06157
BCOM: BAUCODRAFT_129875 BAUCODRAFT_37733 BAUCODRAFT_61348
NPA: UCRNP2_1782 UCRNP2_3336
TML: GSTUM_00004489001
SPO: 2539602(erg6)
SOM: SOMG_01545(erg6)
CNE: CNB03100
CNB: CNBB2600
CNG: CNAG_03819
CGI: CGB_A3260C
CDEU: CNBG_1537
CDEC: 89988844(IAS62_002070)
CTEG: 91988225(I308_101367)
CBAS: 91981406(I312_101358)
CDEP: 91086185(L203_101973)
KMG: 30164895(I203_108188)
KNE: 92177636(IAR55_000376)
KDJ: 28967422(I303_103707)
KBI: 30212796(I302_105110)
KPIN: 30169961(I206_103404)
KSH: 87956240(IL334_004109)
KER: 91107076(V865_008275)
TMS: TREMEDRAFT_44172
TASA: A1Q1_06727
CCAC: CcaHIS019_0705320(ERG6)
PPL: POSPLDRAFT_89636
TVS: TRAVEDRAFT_74073
DSQ: DICSQDRAFT_141756
PCO: PHACADRAFT_252042
SHS: STEHIDRAFT_119615
HIR: HETIRDRAFT_388200
PSQ: PUNSTDRAFT_126433
ADL: AURDEDRAFT_110716 AURDEDRAFT_121438 AURDEDRAFT_139717
FME: FOMMEDRAFT_23815
GTR: GLOTRDRAFT_122852
RSX: RhiXN_00557 RhiXN_05850
LBC: LACBIDRAFT_184995(erg6)
CCI: CC1G_05622 CC1G_06149 CC1G_07728
ABP: AGABI1DRAFT115299(AGABI1DRAFT_115299)
ABV: AGABI2DRAFT194260(AGABI2DRAFT_194260)
PCUB: JR316_0008774
MRR: Moror_12565
MORE: E1B28_012717
SCM: SCHCO_02052297(SCHCODRAFT_02052297) SCHCO_02512248(SCHCODRAFT_02512248) SCHCO_02601905(SCHCODRAFT_02601905) SCHCO_02627257(SCHCODRAFT_02627257) SCHCO_02680330(SCHCODRAFT_02680330) SCHCO_02751485(SCHCODRAFT_02751485)
CPUT: CONPUDRAFT_138796
SLA: SERLADRAFT_457598
WSE: WALSEDRAFT_15798
WIC: J056_002357
UMA: UMAG_03182
PFP: PFL1_05601
SGRA: EX895_005848
MGL: MGL_2877
MRT: MRET_3473
MSYM: MSY001_0359
PGR: PGTG_02203 PGTG_17346
PTRC: PtA15_2A427 PtA15_2A801 PtA15_2A804
PSTR: Pst134EA_005187 Pst134EA_005301
MLR: MELLADRAFT_41694 MELLADRAFT_73949
RIE: OCT59_023027 OCT59_026390
MBR: MONBRDRAFT_33702
DDI: DDB_G0288907(smt1)
DPP: DICPUDRAFT_92595
DFA: DFA_09943(smt1)
ACAN: ACA1_193300 ACA1_237870
PTI: PHATRDRAFT_10824
TPS: THAPSDRAFT_32029 THAPSDRAFT_36203(SMT1)
AAF: AURANDRAFT_21939 AURANDRAFT_52760 AURANDRAFT_59110
SPAR: SPRG_05001
TBR: Tb10.6k15.3820
TBG: TbgDal_X8450
TCR: 504191.10 505683.10 510185.10
LMA: LMJF_36_2380 LMJF_36_2390(LmSMT)
LIF: LINJ_36_2510 LINJ_36_2520
LDO: LDBPK_362510 LDBPK_362520
LMI: LMXM_36_2380 LMXM_36_2390
LMAT: 92510414(LSCM1_00250) 92510415(LSCM1_00251)
LBZ: LBRM_35_2600
LPAN: LPMP_352450(LMSMT)
LOI: 92356276(LSCM4_00253) 92356277(LSCM4_00254)
LEIS: 94175909(GH5_00259) 94175910(GH5_00260)
LENR: 94167552(CUR178_00251)
LEIN: 94184027(JIQ42_00256) 94184028(JIQ42_00257)
PHET: 94286365(JKF63_00236)
NGR: NAEGRDRAFT_81379 NAEGRDRAFT_83028
EHX: EMIHUDRAFT_432780
GTT: GUITHDRAFT_63072
TMC: LMI_2904
SUS: Acid_3267
AEV: EI546_13790
SRK: FGW37_00260
NDK: I601_4050(rebM_4)
AEB: C6I20_03155
FRI: FraEuI1c_2154
ABAI: IMCC26256_112265
 » show all
Reference
PMID:18563465
  Authors
Jayasimha P, Nes WD
  Title
Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site.
  Journal
Lipids 43:681-93 (2008)
DOI:10.1007/s11745-008-3198-x
  Sequence
[sce:YML008C]
Reference
PMID:20946868
  Authors
Ganapathy K, Kanagasabai R, Nguyen TT, Nes WD
  Title
Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans.
  Journal
Arch Biochem Biophys 505:194-201 (2011)
DOI:10.1016/j.abb.2010.10.008
  Sequence
[cal:CAALFM_C302150CA]
Reference
PMID:10852933
  Authors
Diener AC, Li H, Zhou W, Whoriskey WJ, Nes WD, Fink GR
  Title
Sterol methyltransferase 1 controls the level of cholesterol in plants.
  Journal
Plant Cell 12:853-70 (2000)
DOI:10.1105/tpc.12.6.853
  Sequence
[ath:AT5G13710]

  All links  
Ontology (2)   
   GO (1)   
   COG (1)   
Gene (7246)   
   MGENES (615)   
   RefGene (6619)   
   OC (12)   
All databases (7248)   

Download RDF
KEGG   ENZYME: 2.1.1.41
Entry
EC 2.1.1.41                 Enzyme                                 
Name
sterol 24-C-methyltransferase;
Delta24-methyltransferase;
Delta24-sterol methyltransferase;
zymosterol-24-methyltransferase;
S-adenosyl-4-methionine:sterol Delta24-methyltransferase;
SMT1;
24-sterol C-methyltransferase;
S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase;
phytosterol methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol [RN:R04427]
Reaction(KEGG)
R04427;
(other) R07481
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5alpha-cholesta-8,24-dien-3beta-ol [CPD:C05437]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
24-methylene-5alpha-cholest-8-en-3beta-ol [CPD:C04525]
Comment
Requires glutathione. Acts on a range of sterols with a 24(25)-double bond in the sidechain. While zymosterol is the preferred substrate it also acts on desmosterol, 5alpha-cholesta-7,24-dien-3beta-ol, 5alpha-cholesta-5,7,24-trien-3beta-ol, 4alpha-methylzymosterol and others. S-Adenosyl-L-methionine attacks the Si-face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond.
History
EC 2.1.1.41 created 1972, modified 2001
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00559  sterol 24-C-methyltransferase
Genes
NAI: NECAME_03546
BMY: BM_BM4647(Bma-strm-1)
AQU: 100639491
ATH: AT5G13710(SMT1)
ALY: 9307650
CRB: 17882375
CSAT: 104705624 104735382 104769590
EUS: EUTSA_v10014014mg
BRP: 103850891 103856028
BNA: 106371823 106431054 106440921
BOE: 106322658 106329263
RSZ: 108839810 108844631
THJ: 104809850 104819084 104819086 104819087
CPAP: 110809321
CIT: 102628258
CIC: CICLE_v10031748mg
PVY: 116132255 116132258
MINC: 123197557 123214703 123216668 123216669 123216670
TCC: 18598956 18614599 18614600
GRA: 105790583
GHI: 107915814 107950679
GAB: 108470188
HSYR: 120129642 120136785 120165276 120188812
DZI: 111305861 111313689
EGR: 104454605 104454641 104454642 104455966
RARG: 115753046 115753057
GMX: 100796978 100817534 100818061 548073
GSJ: 114372208 114378245 114379538 114386323
PVU: 137834769 137836171 137836176
VRA: 106760797
VAR: 108332339
VUN: 114165537
VUM: 124835473
CCAJ: 109799147 109806010
APRC: 113854972 113865316
MTR: 11415411
TPRA: 123913735
CAM: 101497864
PSAT: 127085609
VVO: 131636217 131662694
LJA: 130747906 130748158
ADU: 107471578 107479358
AIP: 107622756 107630475
AHF: 112716746 112738324 112783834 112790500
LANG: 109333713 109346157
PCIN: 129296047 129315800
QSA: O6P43_006507 O6P43_029576
FVE: 101293342
AANS: 126801448
RCN: 112181939
PPER: 18785581
PMUM: 103330640
PAVI: 110765835
PDUL: 117619806
MDM: 103418631 103438422
MSYL: 126613669 126628384
PCOX: 137735012 137748123
ZJU: 107425735
MNT: 112091791 21388176
CSAV: 115709304
CSV: 101217151 101217389
CMO: 103500325 103500326
BHJ: 120089794 120091030
MCHA: 111020326 111020366
CMAX: 111481504 111481505 111493094
CMOS: 111441927 111442447 111452027
CPEP: 111787513 111789805 111789806
RCU: 8259297 8286298
MEAN: 126661270
JCU: 105628730
HBR: 110634256 110659984
MESC: 110618568 110620358 110623913
POP: 18095100 18106161 7467341
PEU: 105117376 105126337 105131854 105141731
PALZ: 118027720 118047027 118051651
PNZ: 133677017 133680239 133689251
JRE: 108987693 108988702 109019397
CILL: 122292529 122292668 122293402
CAVE: 132167241 132173586
AGLU: 133879284 133880094 133880295 133880389 133882289
QSU: 112025906 112027940
QLO: 115953357 115967771 115986962
TWL: 120011980 120014669
VVI: 100252116 100263590
VRI: 117919779 117928779 117928780
SLY: 101252433 101256047
SPEN: 107008176 107032350
SOT: 102581721 102589132
SSTN: 125853521 125866069
SDUL: 129886986
CANN: 107839483 107845155
LBB: 132607399 132644773
NTA: 107772103 107806298 107813194 107813488 107821929 107825894
NSY: 104213731 104221372 104248706
NTO: 104104807 104117345 104120777
NAU: 109216067 109225324 109237978
INI: 109156026 109156027
ITR: 115995625 115997067
SIND: 105169293
OEU: 111410481 111410482
EGT: 105969542
SSPL: 121759270 121791175 121805340 121809614
SMIL: 131022313
SHIS: 125194076 125217903
APAN: 127246285
HPUM: 140881013
PHUA: 140957598 140973511
PEBU: 140809540
HAN: 110888576 110918161 110921577
ECAD: 122595873
LSV: 111900335 111912645 111912658
CCAV: 112522572
DCR: 108196395 108226507
CSIN: 114279643 114312087 114318153
RVL: 131326980 131327876 131334351 131334352 131334353
AEW: 130756790 130780608 130782335
DLT: 127802732
BVG: 104907757
SOE: 110778345
CQI: 110702765 110705694
ATRI: 130804259
MOF: 131165006
NNU: 104597375
MING: 122071445 122071905 122091901
TSS: 122642777 122642790 122642791
PSOM: 113313126 113322869 113354420
OSA: 4342690(Smt1-1) 9269350
DOSA: Os03g0807600 Os07g0206700
OBR: 102713236
OGL: 127755018 127766216 127779788
BDI: 100826864 100834229
ATS: 109734415 109756778
TDC: 119291992 119304087
TAES: 123093722 123105904 543246
TUA: 125529735
LPER: 127292258 127323344
LRD: 124674874 124674972 124697778 124697779
SBI: 8057107 8064726 8078421 8081208
ZMA: 100282501 100286381 541682
MFLO: 136486773 136513377 136517854 136535197 136545482 136549562 136549565
SITA: 101753762 101756008 101780888
SVS: 117834191 117845345 117866533
PVIR: 120639714 120644214 120644215 120644245 120645629 120649372 120659670 120665784
PHAI: 112872433 112877095 112883041
PAUA: 133890967 133893375 133913599 133913600
TANG: 140758856 140763023 140763582
PDA: 103696988 103696989 103697536 103717656 103717657 113461272 120104527
EGU: 105035517 105046511 105055167
MUS: 103979889 103980161 103993068 135609970
ZOF: 122020552 122020864 122024007 122024078 122024744 122051188 122055892
DCT: 110109799 110110369 110116065
PEQ: 110018546 110018549
AOF: 109833715
MSIN: 131221626 131222583
ACAK: 137945411 137949864
NCOL: 116249160
ATR: 18428920 18428921 18428922
CJF: 131046850 131046869
SMO: SELMODRAFT_449609(SMT1-2) SELMODRAFT_449613(SMT1-1)
PPP: 112291818
MNG: MNEG_11110
OLU: OSTLU_30710
OTA: OT_ostta03g03830
BPG: Bathy09g04120
MIS: MICPUN_93596(SMT1)
MPP: MICPUCDRAFT_50903
CME: CYME_CMP275C
GSL: Gasu_26310 Gasu_60150
SCE: YML008C(ERG6)
SEUB: DI49_4081
SPAO: SPAR_M01190
AGO: AGOS_ADR196W
ERC: Ecym_4063
KLA: KLLA0_A01738g
KMX: KLMA_30671(ERG6)
LTH: KLTH0G03806g
VPO: Kpol_1004p23
ZRO: ZYRO0D12606g
CGR: 2888522(ERG6)
NCS: NCAS_0H02570(NCAS0H02570)
NDI: NDAI_0C01050(NDAI0C01050)
TPF: TPHA_0D02350(TPHA0D02350)
TBL: TBLA_0D01630(TBLA0D01630)
TGB: HG536_0A05480
TDL: TDEL_0A03930(TDEL0A03930)
KAF: KAFR_0C05410(KAFR0C05410)
KNG: KNAG_0B03670(KNAG0B03670)
ZMK: HG535_0D04960
SLUD: SCDLUD_003309
DHA: DEHA2D17622g
PIC: PICST_80971
PGU: PGUG_00661
SPAA: SPAPADRAFT_62031
LEL: PVL30_003580(ERG6)
LBG: 92208639(LODBEIA_P34430)
CAL: CAALFM_C302150CA(ERG6)
CTP: CTRG_02396
COT: CORT_0C04430
CDU: CD36_82130(ERG6)
CTEN: 18247249(ERG6)
CLU: CLUG_02673
CLUS: A9F13_07g01804
CAUR: CJI96_0004127
ASAU: 88174163(PUMCH_003099)
PPA: PAS_chr3_0371
PKZ: C5L36_0E02630
BNN: FOA43_002150(ERG6)
BBRX: BRETT_003844(ERG6)
OPA: HPODL_01877
YLI: 2908368(YALI2_F00173g)
SLB: AWJ20_2170(ERG6)
NCR: NCU02502 NCU03006(erg-4)
NTE: NEUTE1DRAFT150553(NEUTE1DRAFT_150553) NEUTE1DRAFT73978(NEUTE1DRAFT_73978)
SMP: 10808713(SMAC4_05969) 10810018(SMAC4_01214)
PAN: PODANSg3800 PODANSg4053 PODANSg4704
PBEL: QC761_115810(ERG6_1) QC761_124410(ERG6_2)
PPSD: QC762_115810(ERG6_1) QC762_124410(ERG6_2)
PPSP: QC763_115810(ERG6_1) QC763_124410(ERG6_2)
PPSA: QC764_115810(ERG6_1) QC764_124410(ERG6_2)
TTT: THITE_68084
MTM: MYCTH_110670 MYCTH_42269
CTHR: CTHT_0006340
RTHE: 98123353(VTJ83DRAFT_2439) 98124731(VTJ83DRAFT_3682)
MGR: MGG_04346 MGG_10568 MGG_10860
PPEI: PpBr36_03960 PpBr36_10036
PGRI: PgNI_03580 PgNI_09085 PgNI_11040
TMN: UCRPA7_4321 UCRPA7_5376 UCRPA7_8731
SSCK: SPSK_06325 SPSK_06557 SPSK_06653
FGR: FGSG_02783 FGSG_05740
FPU: FPSE_05610 FPSE_08317
FPOA: FPOAC1_005133(ERG6_1) FPOAC1_008700(ERG4)
FVN: FVRRES_05661 FVRRES_09296
FVR: FVEG_05904 FVEG_13091
FOX: FOXG_08765 FOXG_15629
NHE: NECHADRAFT_101488 NECHADRAFT_33136 NECHADRAFT_59530
FFC: NCS54_00221300 NCS54_00445000
FKR: NCS57_00216400 NCS57_00451800
FMU: J7337_004853(ERG6_2) J7337_008919(ERG6_3)
TRE: TRIREDRAFT_121166 TRIREDRAFT_56236
TRR: M419DRAFT_108988 M419DRAFT_72858
TATV: 25776029(TrAtP1_002228) 25785708(TrAtP1_007734)
TASP: 36608857(ERG6_3) 36615740(ERG6_1)
MAW: 19252549(ERG6_1)
MAJ: MAA_02798 MAA_10087
MBRN: 26241702(erg6_0) 26243633(erg6_1)
PCHM: VFPPC_07182 VFPPC_10999
CMT: CCM_04684 CCM_08656
AMUS: LMH87_001661 LMH87_006959 LMH87_009165
PLJ: 28892488(PLICBS_006480) 28893235(PLICBS_006719)
PTKZ: JDV02_008053(ERG6_1) JDV02_009647(ERG6_2)
VAL: VDBG_01914 VDBG_08910
VDA: VDAG_01643 VDAG_06572
CFJ: CFIO01_00904 CFIO01_00910 CFIO01_12167
CLUP: CLUP02_08421 CLUP02_11674 CLUP02_11681
CHIG: CH63R_07675 CH63R_11163 CH63R_11195
CDET: 87944887(CDEST_08384) 87945928(CDEST_09425) 87945956(CDEST_09453)
SAPO: SAPIO_CDS4855 SAPIO_CDS6557
ELA: UCREL1_1004 UCREL1_1267 UCREL1_1354
PFY: PFICI_00782 PFICI_01643 PFICI_06847 PFICI_10966
SSL: SS1G_03467 SS1G_03686
BFU: BCIN_04g01200 BCIN_08g01540
MBE: MBM_02476 MBM_07594
PSCO: LY89DRAFT_628125 LY89DRAFT_684462 LY89DRAFT_725473 LY89DRAFT_789176
GLZ: GLAREA_04347 GLAREA_05164
ANI: ANIA_01614 ANIA_07146
AFM: AFUA_4G03630 AFUA_4G09190
ACT: ACLA_048560 ACLA_054780
NFI: NFIA_029790 NFIA_106980
AOR: AO090011000289 AO090012000932 AO090023000624
ANG: An04g04210 An14g01590 An16g00300
AFV: AFLA_002655 AFLA_006968 AFLA_007687
ALUC: AKAW2_40856S(ERG6) AKAW2_51426S
ACHE: ACHE_40345A ACHE_60580A(ERG6)
APUU: APUU_21581S APUU_22198S(ERG6_1) APUU_80754S(ERG6_2)
PCS: N7525_001128 N7525_007611
PDP: PDIP_13570 PDIP_13580 PDIP_57520 PDIP_76970
POU: POX_g09270
TMF: EYB26_009195
TRG: TRUGW13939_07336
CIM: CIMG_06139 CIMG_08444 CIMG_09630
CPW: 9695881(ERG6_1)
URE: UREG_02519 UREG_04245
ABE: ARB_05210 ARB_05997
TVE: TRV_02353 TRV_06345
PBL: PAAG_01575
PBN: PADG_00204
AJE: HCAG_07564
BGH: BDBG_08700
PNO: SNOG_08443
PTE: PTT_11273
PTRR: 6346862(PtrM4_146510)
BZE: COCCADRAFT_22623
BSC: COCSADRAFT_39890
BOR: COCMIDRAFT_90360
AALT: CC77DRAFT_1024280 CC77DRAFT_984927
ADAC: 96080506(ACET3X_000184) 96083565(ACET3X_003243)
ARAB: EKO05_0005085
ZTR: MYCGRDRAFT_33363 MYCGRDRAFT_70113(ERG6) MYCGRDRAFT_70899 MYCGRDRAFT_98820
PFJ: MYCFIDRAFT_33221 MYCFIDRAFT_64115 MYCFIDRAFT_84237
FFU: CLAFUR5_00943 CLAFUR5_09835
CBET: CB0940_01475 CB0940_06157
BCOM: BAUCODRAFT_129875 BAUCODRAFT_37733 BAUCODRAFT_61348
NPA: UCRNP2_1782 UCRNP2_3336
TML: GSTUM_00004489001
SPO: 2539602(erg6)
SOM: SOMG_01545(erg6)
CNE: CNB03100
CNB: CNBB2600
CNG: CNAG_03819
CGI: CGB_A3260C
CDEU: CNBG_1537
CDEC: 89988844(IAS62_002070)
CTEG: 91988225(I308_101367)
CBAS: 91981406(I312_101358)
CDEP: 91086185(L203_101973)
KMG: 30164895(I203_108188)
KNE: 92177636(IAR55_000376)
KDJ: 28967422(I303_103707)
KBI: 30212796(I302_105110)
KPIN: 30169961(I206_103404)
KSH: 87956240(IL334_004109)
KER: 91107076(V865_008275)
TMS: TREMEDRAFT_44172
TASA: A1Q1_06727
CCAC: CcaHIS019_0705320(ERG6)
PPL: POSPLDRAFT_89636
TVS: TRAVEDRAFT_74073
DSQ: DICSQDRAFT_141756
PCO: PHACADRAFT_252042
SHS: STEHIDRAFT_119615
HIR: HETIRDRAFT_388200
PSQ: PUNSTDRAFT_126433
ADL: AURDEDRAFT_110716 AURDEDRAFT_121438 AURDEDRAFT_139717
FME: FOMMEDRAFT_23815
GTR: GLOTRDRAFT_122852
RSX: RhiXN_00557 RhiXN_05850
LBC: LACBIDRAFT_184995(erg6)
CCI: CC1G_05622 CC1G_06149 CC1G_07728
ABP: AGABI1DRAFT115299(AGABI1DRAFT_115299)
ABV: AGABI2DRAFT194260(AGABI2DRAFT_194260)
PCUB: JR316_0008774
MRR: Moror_12565
MORE: E1B28_012717
SCM: SCHCO_02052297(SCHCODRAFT_02052297) SCHCO_02512248(SCHCODRAFT_02512248) SCHCO_02601905(SCHCODRAFT_02601905) SCHCO_02627257(SCHCODRAFT_02627257) SCHCO_02680330(SCHCODRAFT_02680330) SCHCO_02751485(SCHCODRAFT_02751485)
CPUT: CONPUDRAFT_138796
SLA: SERLADRAFT_457598
WSE: WALSEDRAFT_15798
WIC: J056_002357
UMA: UMAG_03182
PFP: PFL1_05601
SGRA: EX895_005848
MGL: MGL_2877
MRT: MRET_3473
MSYM: MSY001_0359
PGR: PGTG_02203 PGTG_17346
PTRC: PtA15_2A427 PtA15_2A801 PtA15_2A804
PSTR: Pst134EA_005187 Pst134EA_005301
MLR: MELLADRAFT_41694 MELLADRAFT_73949
RIE: OCT59_023027 OCT59_026390
MBR: MONBRDRAFT_33702
DDI: DDB_G0288907(smt1)
DPP: DICPUDRAFT_92595
DFA: DFA_09943(smt1)
ACAN: ACA1_193300 ACA1_237870
PTI: PHATRDRAFT_10824
TPS: THAPSDRAFT_32029 THAPSDRAFT_36203(SMT1)
AAF: AURANDRAFT_21939 AURANDRAFT_52760 AURANDRAFT_59110
SPAR: SPRG_05001
TBR: Tb10.6k15.3820
TBG: TbgDal_X8450
TCR: 504191.10 505683.10 510185.10
LMA: LMJF_36_2380 LMJF_36_2390(LmSMT)
LIF: LINJ_36_2510 LINJ_36_2520
LDO: LDBPK_362510 LDBPK_362520
LMI: LMXM_36_2380 LMXM_36_2390
LMAT: 92510414(LSCM1_00250) 92510415(LSCM1_00251)
LBZ: LBRM_35_2600
LPAN: LPMP_352450(LMSMT)
LOI: 92356276(LSCM4_00253) 92356277(LSCM4_00254)
LEIS: 94175909(GH5_00259) 94175910(GH5_00260)
LENR: 94167552(CUR178_00251)
LEIN: 94184027(JIQ42_00256) 94184028(JIQ42_00257)
PHET: 94286365(JKF63_00236)
NGR: NAEGRDRAFT_81379 NAEGRDRAFT_83028
EHX: EMIHUDRAFT_432780
GTT: GUITHDRAFT_63072
TMC: LMI_2904
SUS: Acid_3267
AEV: EI546_13790
SRK: FGW37_00260
NDK: I601_4050(rebM_4)
AEB: C6I20_03155
FRI: FraEuI1c_2154
ABAI: IMCC26256_112265
 » show all
Reference
1  [PMID:5354959]
  Authors
Moore JT, Gaylor JL.
  Title
Isolation and purification of an S-adenosylmethionine: delta 24-sterol methyltransferase from yeast.
  Journal
J Biol Chem 244:6334-40 (1969)
Reference
2  [PMID:8597586]
  Authors
Venkatramesh M, Guo DA, Jia Z, Nes WD.
  Title
Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1299:313-24 (1996)
DOI:10.1016/0005-2760(95)00218-9
Reference
3
  Authors
Tong Y, McCourt BS, Guo D, Mangla AT, Zhou WX, Jenkins MD, Zhou W, Lopez M, Nes WD.
  Title
, Stereochemical features of C-methylation on the path to Delta24(28)-methylene and Delta24(28)-ethylidene sterols: studies on the recombinant phytosterol methyl transferase from Arabidopsis thaliana.
  Journal
Tetrahedron Lett 38:6115-6118 (1997)
Reference
4  [PMID:9746350]
  Authors
Bouvier-Nave P, Husselstein T, Benveniste P
  Title
Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis.
  Journal
Eur J Biochem 256:88-96 (1998)
DOI:10.1046/j.1432-1327.1998.2560088.x
  Sequence
[osa:4342690]
Reference
5  [PMID:9606964]
  Authors
Nes WD, McCourt BS, Zhou WX, Ma J, Marshall JA, Peek LA, Brennan M.
  Title
Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae.
  Journal
Arch Biochem Biophys 353:297-311 (1998)
DOI:10.1006/abbi.1998.0665
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.41
IUBMB Enzyme Nomenclature: 2.1.1.41
ExPASy - ENZYME nomenclature database: 2.1.1.41
BRENDA, the Enzyme Database: 2.1.1.41
CAS: 37257-07-1

  All links  
Gene (7234)   
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Protein sequence (333)   
   UniProt (248)   
   SWISS-PROT (14)   
   RefSeq(pep) (69)   
   PMD (2)   
DNA sequence (295)   
   RefSeq(nuc) (126)   
   GenBank (94)   
   EMBL (75)   
Protein domain (5)   
   InterPro (5)   
All databases (7867)   

Download RDF
KEGG   REACTION: R04427
Entry
R04427                      Reaction                               
Name
S-adenosyl-L-methionine:zymosterol C-methyltransferase
Definition
S-Adenosyl-L-methionine + Zymosterol <=> S-Adenosyl-L-homocysteine + Fecosterol
Equation
C00019 + C05437 <=> C00021 + C04525
Reaction class
RC00003  C00019_C00021
RC01154  C04525_C05437
Enzyme
2.1.1.41
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.41
     R04427  S-Adenosyl-L-methionine + Zymosterol <=> S-Adenosyl-L-homocysteine + Fecosterol
Orthology
K00559  sterol 24-C-methyltransferase [EC:2.1.1.41]
Other DBs
RHEA: 21131

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Chemical reaction (1)   
   SABIO-RK (1)   
All databases (1)   

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