KEGG   ORTHOLOGY: K00719
Entry
K00719                      KO                                     
Symbol
B3GALNT1, B3GALT3
Name
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]
Pathway
map00601  Glycosphingolipid biosynthesis - lacto and neolacto series
map00603  Glycosphingolipid biosynthesis - globo and isoglobo series
map01100  Metabolic pathways
Module
M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer
Reaction
R05962  
R11321  
R11378  
R11379  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.79  globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase
     K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  GLOB blood group
   K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Glycosyltransferase reactions [br08203.html]
 N-Acetylgalactosaminyltransferase reactions
  K00719
Other DBs
GO: 0047273
CAZy: GT31
Genes
HSA: 8706(B3GALNT1)
PTR: 460824(B3GALNT1)
PPS: 103783664(B3GALNT1)
GGO: 101128316(B3GALNT1)
PON: 100174453(B3GALNT1)
PPYG: 129033748(B3GALNT1)
NLE: 100582204(B3GALNT1)
HMH: 116481195(B3GALNT1)
SSYN: 134732944(B3GALNT1)
MCC: 703939(B3GALNT1)
MCF: 102122721(B3GALNT1)
MTHB: 126948315
MNI: 105488519(B3GALNT1)
CSAB: 103241387(B3GALNT1)
CATY: 105571923(B3GALNT1)
PANU: 101014119(B3GALNT1)
TGE: 112619482(B3GALNT1)
MLEU: 105530136(B3GALNT1)
RRO: 104665025(B3GALNT1)
RBB: 108513415(B3GALNT1)
TFN: 117079007(B3GALNT1)
PTEH: 111550131(B3GALNT1)
CANG: 105523987(B3GALNT1)
CJC: 100412790(B3GALNT1)
SBQ: 104650882(B3GALNT1)
CIMI: 108310326(B3GALNT1)
ANAN: 105713613(B3GALNT1)
CSYR: 103270002(B3GALNT1)
MMUR: 105865205 105881201(B3GALNT1)
LCAT: 123630229(B3GALNT1)
PCOQ: 105815284(B3GALNT1) 105815298
OGA: 100948114(B3GALNT1)
MMU: 26879(B3galnt1)
MCAL: 110291625(B3galnt1)
MPAH: 110320437(B3galnt1)
RNO: 310508(B3galnt1)
MCOC: 116092991(B3galnt1)
ANU: 117707692(B3galnt1)
ASYL: 127683266(B3galnt1)
MUN: 110555067(B3galnt1)
CGE: 100756438(B3galnt1)
MAUA: 101842661(B3galnt1)
PROB: 127232681(B3galnt1)
PLEU: 114691707(B3galnt1)
MORG: 121452942(B3galnt1)
MFOT: 126504866
AAMP: 119826479(B3galnt1)
NGI: 103738016(B3galnt1)
HGL: 101706281(B3galnt1)
CPOC: 100729840(B3galnt1)
CCAN: 109687568(B3galnt1)
DORD: 105985632(B3galnt1)
DSP: 122107279(B3galnt1)
DMER: 138827334(B3galnt1)
PLOP: 125352009(B3galnt1)
NCAR: 124993439
MMMA: 107151148(B3galnt1)
ITI: 101970786(B3galnt1)
OCU: 100352272
OPI: 101535578(B3GALNT1)
TUP: 102470507(B3GALNT1)
GVR: 103608030(B3GALNT1)
CFA: 100683634(B3GALNT1)
CLUD: 112645890(B3GALNT1)
VVP: 112933319(B3GALNT1)
VLG: 121477463(B3GALNT1)
NPO: 129498624(B3GALNT1)
AML: 100472542(B3GALNT1)
UMR: 103677240(B3GALNT1)
UAH: 113254148(B3GALNT1)
UAR: 123801336(B3GALNT1)
ELK: 111149669
LLV: 125099839
MPUF: 101670826(B3GALNT1)
MNP: 132012076(B3GALNT1)
MLK: 131824912(B3GALNT1)
NVS: 122908661(B3GALNT1)
ORO: 101362550(B3GALNT1)
EJU: 114209060(B3GALNT1)
ZCA: 113918056(B3GALNT1)
MLX: 118005935(B3GALNT1)
NSU: 110591647(B3GALNT1)
LWW: 102743098(B3GALNT1)
FCA: 101092536(B3GALNT1)
PYU: 121033933(B3GALNT1)
PCOO: 112849744(B3GALNT1)
PBG: 122491774(B3GALNT1)
PVIV: 125174722(B3GALNT1)
LRUF: 124525900
LGF: 123611301(B3GALNT1)
AJU: 106969458
PTG: 102967614(B3GALNT1)
PPAD: 109262073(B3GALNT1)
PUC: 125921190
PLEZ: 122229618(B3GALNT1)
HHV: 120238283(B3GALNT1)
BTA: 767844(B3GALNT1)
BOM: 102268013(B3GALNT1)
BIU: 109558643(B3GALNT1)
BBUB: 102399951(B3GALNT1)
BBIS: 104988491(B3GALNT1)
CHX: 102172392(B3GALNT1)
OAS: 101104544(B3GALNT1)
BTAX: 128047004(B3GALNT1)
CSUM: 138086982(B3GALNT1)
ODA: 120868988(B3GALNT1)
CCAD: 122444977(B3GALNT1)
MREE: 136173160(B3GALNT1)
OVR: 110141755(B3GALNT1) 139033679
MBEZ: 129545867(B3GALNT1)
SSC: 397634(B3GALNT1)
CFR: 102520987(B3GALNT1)
CBAI: 105066656(B3GALNT1)
CDK: 105085986(B3GALNT1)
VPC: 102528588(B3GALNT1)
BACU: 103007706(B3GALNT1)
BMUS: 118894474(B3GALNT1)
LVE: 103081769(B3GALNT1) 103082553
OOR: 101281290(B3GALNT1)
LALB: 132520977(B3GALNT1)
GMF: 115846444(B3GALNT1)
DDP: 132413402 132424956(B3GALNT1)
DLE: 111174411(B3GALNT1) 111185630 111185631
PCAD: 102984339 102987471(B3GALNT1)
PSIU: 116753608(B3GALNT1)
PPHC: 136122438(B3GALNT1)
NASI: 112412096(B3GALNT1)
ECB: 100062101(B3GALNT1)
EPZ: 103556050(B3GALNT1)
EAI: 106841036(B3GALNT1)
MYB: 102245995(B3GALNT1)
MYD: 102751273(B3GALNT1)
MMYO: 118676619(B3GALNT1)
MLF: 102437524 102439809(B3GALNT1)
MDT: 132230073(B3GALNT1)
MYUM: 138994240 139004133(B3GALNT1)
PKL: 118722297(B3GALNT1)
EFUS: 103286698(B3GALNT1)
MNA: 107539305(B3GALNT1)
DRO: 112307143(B3GALNT1)
SHON: 118987441(B3GALNT1)
AJM: 119046051(B3GALNT1)
PDIC: 114491031(B3GALNT1)
PHAS: 123827240(B3GALNT1)
MMF: 118617221(B3GALNT1) 118636326
PPAM: 129075988(B3GALNT1)
HAI: 109373391(B3GALNT1)
RFQ: 117031627(B3GALNT1)
PALE: 102885235(B3GALNT1)
PGIG: 120598486(B3GALNT1)
PVP: 105305269(B3GALNT1)
RAY: 107513039(B3GALNT1)
MJV: 108396279(B3GALNT1)
TOD: 119257657(B3GALNT1)
SARA: 101549871(B3GALNT1)
SFUM: 130030544(B3GALNT1)
SETR: 126012166(B3GALNT1)
LAV: 100672964(B3GALNT1)
TMU: 101351705
ETF: 101642922(B3GALNT1)
DNM: 101433163(B3GALNT1)
MDO: 100015392(B3GALNT1)
GAS: 123240276(B3GALNT1)
SHR: 100914641(B3GALNT1)
AFZ: 127552841
PCW: 110210070(B3GALNT1)
TVP: 118847706(B3GALNT1)
PBRV: 138157744(B3GALNT1)
OAA: 100077633(B3GALNT1)
TACU: 119926691(B3GALNT1)
GGA: 425011(B3GALNT1)
PCOC: 116235495(B3GALNT1)
MGP: 100542332(B3GALNT1)
CJO: 107318361(B3GALNT1)
TPAI: 128082487(B3GALNT1)
LMUT: 125697817(B3GALNT1)
NMEL: 110397553(B3GALNT1)
APLA: 106019552(B3GALNT1)
ACYG: 106043526(B3GALNT1)
CATA: 118253127(B3GALNT1)
AFUL: 116492328(B3GALNT1)
TGU: 100228838(B3GALNT1)
LSR: 110476616(B3GALNT1)
SCAN: 103815586(B3GALNT1)
PMOA: 120504195(B3GALNT1)
OTC: 121336527(B3GALNT1)
PRUF: 121353689(B3GALNT1)
ATRC: 139595148(B3GALNT1)
GFR: 102040599(B3GALNT1)
FAB: 101809193(B3GALNT1)
OMA: 130256667(B3GALNT1)
PHI: 102106993(B3GALNT1)
PMAJ: 107208685(B3GALNT1)
CCAE: 111933293(B3GALNT1)
CCW: 104688069(B3GALNT1)
CBRC: 103615715(B3GALNT1)
ACOE: 138114460(B3GALNT1)
ETL: 114062933(B3GALNT1)
ACHL: 103805940(B3GALNT1)
SVG: 106858074(B3GALNT1)
MMEA: 130586147(B3GALNT1)
HRT: 120757091(B3GALNT1)
SATI: 136365330(B3GALNT1)
CCIC: 134047867(B3GALNT1)
FPG: 101912356(B3GALNT1)
FCH: 102056837(B3GALNT1)
CCRI: 104160078(B3GALNT1)
NNT: 104403793(B3GALNT1)
SHAB: 115611651(B3GALNT1)
TALA: 104363308(B3GALNT1)
ACHC: 115347025(B3GALNT1)
HALD: 104314644(B3GALNT1)
HLE: 104842551(B3GALNT1)
AGEN: 126039173
HHAR: 128148751(B3GALNT1)
GCL: 127020102
CSTI: 104560631(B3GALNT1)
LDI: 104353329(B3GALNT1)
MNB: 103779678(B3GALNT1)
DPUB: 104301660(B3GALNT1)
PPUS: 135180492(B3GALNT1)
AVIT: 104270872(B3GALNT1)
BRHI: 104495474(B3GALNT1)
EGZ: 104122266(B3GALNT1)
NNI: 104011569(B3GALNT1)
PCRI: 104028548(B3GALNT1)
PCAO: 104047083(B3GALNT1)
PADL: 103925238(B3GALNT1)
AFOR: 103898640(B3GALNT1)
FGA: 104080350(B3GALNT1)
GSTE: 104253870(B3GALNT1)
CBOY: 140654794(B3GALNT1)
CLV: 102087526(B3GALNT1)
CNIC: 135991569(B3GALNT1)
MUI: 104539654(B3GALNT1)
PGUU: 104463437(B3GALNT1)
PLET: 104627882(B3GALNT1)
CMAC: 104475757(B3GALNT1)
TEO: 104372231(B3GALNT1)
BREG: 104642724(B3GALNT1)
OHA: 104334441(B3GALNT1)
ACAR: 104523712(B3GALNT1)
CPEA: 104387033(B3GALNT1)
CVF: 104285904(B3GALNT1)
RTD: 128910764(B3GALNT1)
CRID: 134517664(B3GALNT1)
AAM: 106495105(B3GALNT1)
AROW: 112961979(B3GALNT1)
NPD: 112952483(B3GALNT1)
TGT: 104565268(B3GALNT1)
DNE: 112986451(B3GALNT1)
SCAM: 104140021(B3GALNT1)
ASN: 102381398(B3GALNT1)
AMJ: 102574149(B3GALNT1)
CPOO: 109310352(B3GALNT1)
GGN: 109287747(B3GALNT1)
PSS: 102454980(B3GALNT1)
CMY: 102942089(B3GALNT1)
CCAY: 125643154(B3GALNT1)
DCC: 119860888(B3GALNT1)
CPIC: 101934527(B3GALNT1)
TST: 117882635(B3GALNT1)
CABI: 116823590(B3GALNT1)
MRV: 120372022(B3GALNT1)
ACS: 100564179(b3galnt1)
ASAO: 132770546(B3GALNT1)
PVT: 110078057(B3GALNT1)
SUND: 121927083(B3GALNT1)
VKO: 123025660(B3GALNT1)
PMUA: 114597936(B3GALNT1)
PRAF: 128414722(B3GALNT1)
ZVI: 118093800(B3GALNT1)
HCG: 128349449(B3GALNT1)
GJA: 107107027(B3GALNT1)
STOW: 125437503(B3GALNT1)
EMC: 129332501(B3GALNT1)
PWL: 138265485 138266582
MUO: 115478714(B3GALNT1)
GSH: 117366587 117366589 117367012
LOC: 102690089(b3galnt1)
PSPA: 121322566 121323543 121326691
ARUT: 117416799 117423202
LCM: 102358886 102363803
LERI: 129703687
HAKA: 140725487
SPU: 115927124 765098
SKO: 102800712 102807352
PFLL: 139121610 139135274
HRF: 124150667
HRJ: 124259260 124269462 124290859
HASI: 137273565
CRG: 105335519
CANU: 128166403
CVN: 111119565
OED: 125646280 125655608 125671243
MYI: 110441288 110452220 110453853 110460297 110463413
PMAX: 117335478 117337035
LJP: 135477646
LAK: 112042554
 » show all
Reference
PMID:10993897
  Authors
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K
  Title
Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.
  Journal
J Biol Chem 275:40498-503 (2000)
DOI:10.1074/jbc.M006902200
  Sequence
[hsa:8706]

  All links  
Ontology (2)   
   GO (1)   
   CAZY (1)   
Gene (254)   
   MGENES (158)   
   RefGene (93)   
   OC (3)   
All databases (256)   

Download RDF
KEGG   ENZYME: 2.4.1.79
Entry
EC 2.4.1.79                 Enzyme                                 
Name
globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase;
globoside synthetase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase;
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase;
globoside synthase;
gUDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase;
beta3GalNAc-T1;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05631 R05962]
Reaction(KEGG)
R05631 R05962(G);
(other) R11321(G) R11378(G) R11379(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.
History
EC 2.4.1.79 created 1976, modified 2006
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00719  galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Genes
HSA: 8706(B3GALNT1)
PTR: 460824(B3GALNT1)
PPS: 103783664(B3GALNT1)
GGO: 101128316(B3GALNT1)
PON: 100174453(B3GALNT1)
PPYG: 129033748(B3GALNT1)
NLE: 100582204(B3GALNT1)
HMH: 116481195(B3GALNT1)
SSYN: 134732944(B3GALNT1)
MCC: 703939(B3GALNT1)
MCF: 102122721(B3GALNT1)
MTHB: 126948315
MNI: 105488519(B3GALNT1)
CSAB: 103241387(B3GALNT1)
CATY: 105571923(B3GALNT1)
PANU: 101014119(B3GALNT1)
TGE: 112619482(B3GALNT1)
MLEU: 105530136(B3GALNT1)
RRO: 104665025(B3GALNT1)
RBB: 108513415(B3GALNT1)
TFN: 117079007(B3GALNT1)
PTEH: 111550131(B3GALNT1)
CANG: 105523987(B3GALNT1)
CJC: 100412790(B3GALNT1)
SBQ: 104650882(B3GALNT1)
CIMI: 108310326(B3GALNT1)
ANAN: 105713613(B3GALNT1)
CSYR: 103270002(B3GALNT1)
MMUR: 105865205 105881201(B3GALNT1)
LCAT: 123630229(B3GALNT1)
PCOQ: 105815284(B3GALNT1) 105815298
OGA: 100948114(B3GALNT1)
MMU: 26879(B3galnt1)
MCAL: 110291625(B3galnt1)
MPAH: 110320437(B3galnt1)
RNO: 310508(B3galnt1)
MCOC: 116092991(B3galnt1)
ANU: 117707692(B3galnt1)
ASYL: 127683266(B3galnt1)
MUN: 110555067(B3galnt1)
CGE: 100756438(B3galnt1)
MAUA: 101842661(B3galnt1)
PROB: 127232681(B3galnt1)
PLEU: 114691707(B3galnt1)
MORG: 121452942(B3galnt1)
MFOT: 126504866
AAMP: 119826479(B3galnt1)
NGI: 103738016(B3galnt1)
HGL: 101706281(B3galnt1)
CPOC: 100729840(B3galnt1)
CCAN: 109687568(B3galnt1)
DORD: 105985632(B3galnt1)
DSP: 122107279(B3galnt1)
DMER: 138827334(B3galnt1)
PLOP: 125352009(B3galnt1)
NCAR: 124993439
MMMA: 107151148(B3galnt1)
ITI: 101970786(B3galnt1)
OCU: 100352272
OPI: 101535578(B3GALNT1)
TUP: 102470507(B3GALNT1)
GVR: 103608030(B3GALNT1)
CFA: 100683634(B3GALNT1)
CLUD: 112645890(B3GALNT1)
VVP: 112933319(B3GALNT1)
VLG: 121477463(B3GALNT1)
NPO: 129498624(B3GALNT1)
AML: 100472542(B3GALNT1)
UMR: 103677240(B3GALNT1)
UAH: 113254148(B3GALNT1)
UAR: 123801336(B3GALNT1)
ELK: 111149669
LLV: 125099839
MPUF: 101670826(B3GALNT1)
MNP: 132012076(B3GALNT1)
MLK: 131824912(B3GALNT1)
NVS: 122908661(B3GALNT1)
ORO: 101362550(B3GALNT1)
EJU: 114209060(B3GALNT1)
ZCA: 113918056(B3GALNT1)
MLX: 118005935(B3GALNT1)
NSU: 110591647(B3GALNT1)
LWW: 102743098(B3GALNT1)
FCA: 101092536(B3GALNT1)
PYU: 121033933(B3GALNT1)
PCOO: 112849744(B3GALNT1)
PBG: 122491774(B3GALNT1)
PVIV: 125174722(B3GALNT1)
LRUF: 124525900
LGF: 123611301(B3GALNT1)
AJU: 106969458
PTG: 102967614(B3GALNT1)
PPAD: 109262073(B3GALNT1)
PUC: 125921190
PLEZ: 122229618(B3GALNT1)
HHV: 120238283(B3GALNT1)
BTA: 767844(B3GALNT1)
BOM: 102268013(B3GALNT1)
BIU: 109558643(B3GALNT1)
BBUB: 102399951(B3GALNT1)
BBIS: 104988491(B3GALNT1)
CHX: 102172392(B3GALNT1)
OAS: 101104544(B3GALNT1)
BTAX: 128047004(B3GALNT1)
CSUM: 138086982(B3GALNT1)
ODA: 120868988(B3GALNT1)
CCAD: 122444977(B3GALNT1)
MREE: 136173160(B3GALNT1)
OVR: 110141755(B3GALNT1) 139033679
MBEZ: 129545867(B3GALNT1)
SSC: 397634(B3GALNT1)
CFR: 102520987(B3GALNT1)
CBAI: 105066656(B3GALNT1)
CDK: 105085986(B3GALNT1)
VPC: 102528588(B3GALNT1)
BACU: 103007706(B3GALNT1)
BMUS: 118894474(B3GALNT1)
LVE: 103081769(B3GALNT1) 103082553
OOR: 101281290(B3GALNT1)
LALB: 132520977(B3GALNT1)
GMF: 115846444(B3GALNT1)
DDP: 132413402 132424956(B3GALNT1)
DLE: 111174411(B3GALNT1) 111185630 111185631
PCAD: 102984339 102987471(B3GALNT1)
PSIU: 116753608(B3GALNT1)
PPHC: 136122438(B3GALNT1)
NASI: 112412096(B3GALNT1)
ECB: 100062101(B3GALNT1)
EPZ: 103556050(B3GALNT1)
EAI: 106841036(B3GALNT1)
MYB: 102245995(B3GALNT1)
MYD: 102751273(B3GALNT1)
MMYO: 118676619(B3GALNT1)
MLF: 102437524 102439809(B3GALNT1)
MDT: 132230073(B3GALNT1)
MYUM: 138994240 139004133(B3GALNT1)
PKL: 118722297(B3GALNT1)
EFUS: 103286698(B3GALNT1)
MNA: 107539305(B3GALNT1)
DRO: 112307143(B3GALNT1)
SHON: 118987441(B3GALNT1)
AJM: 119046051(B3GALNT1)
PDIC: 114491031(B3GALNT1)
PHAS: 123827240(B3GALNT1)
MMF: 118617221(B3GALNT1) 118636326
PPAM: 129075988(B3GALNT1)
HAI: 109373391(B3GALNT1)
RFQ: 117031627(B3GALNT1)
PALE: 102885235(B3GALNT1)
PGIG: 120598486(B3GALNT1)
PVP: 105305269(B3GALNT1)
RAY: 107513039(B3GALNT1)
MJV: 108396279(B3GALNT1)
TOD: 119257657(B3GALNT1)
SARA: 101549871(B3GALNT1)
SFUM: 130030544(B3GALNT1)
SETR: 126012166(B3GALNT1)
LAV: 100672964(B3GALNT1)
TMU: 101351705
ETF: 101642922(B3GALNT1)
DNM: 101433163(B3GALNT1)
MDO: 100015392(B3GALNT1)
GAS: 123240276(B3GALNT1)
SHR: 100914641(B3GALNT1)
AFZ: 127552841
PCW: 110210070(B3GALNT1)
TVP: 118847706(B3GALNT1)
PBRV: 138157744(B3GALNT1)
OAA: 100077633(B3GALNT1)
TACU: 119926691(B3GALNT1)
GGA: 425011(B3GALNT1)
PCOC: 116235495(B3GALNT1)
MGP: 100542332(B3GALNT1)
CJO: 107318361(B3GALNT1)
TPAI: 128082487(B3GALNT1)
LMUT: 125697817(B3GALNT1)
NMEL: 110397553(B3GALNT1)
APLA: 106019552(B3GALNT1)
ACYG: 106043526(B3GALNT1)
CATA: 118253127(B3GALNT1)
AFUL: 116492328(B3GALNT1)
TGU: 100228838(B3GALNT1)
LSR: 110476616(B3GALNT1)
SCAN: 103815586(B3GALNT1)
PMOA: 120504195(B3GALNT1)
OTC: 121336527(B3GALNT1)
PRUF: 121353689(B3GALNT1)
ATRC: 139595148(B3GALNT1)
GFR: 102040599(B3GALNT1)
FAB: 101809193(B3GALNT1)
OMA: 130256667(B3GALNT1)
PHI: 102106993(B3GALNT1)
PMAJ: 107208685(B3GALNT1)
CCAE: 111933293(B3GALNT1)
CCW: 104688069(B3GALNT1)
CBRC: 103615715(B3GALNT1)
ACOE: 138114460(B3GALNT1)
ETL: 114062933(B3GALNT1)
ACHL: 103805940(B3GALNT1)
SVG: 106858074(B3GALNT1)
MMEA: 130586147(B3GALNT1)
HRT: 120757091(B3GALNT1)
SATI: 136365330(B3GALNT1)
CCIC: 134047867(B3GALNT1)
FPG: 101912356(B3GALNT1)
FCH: 102056837(B3GALNT1)
CCRI: 104160078(B3GALNT1)
NNT: 104403793(B3GALNT1)
SHAB: 115611651(B3GALNT1)
TALA: 104363308(B3GALNT1)
ACHC: 115347025(B3GALNT1)
HALD: 104314644(B3GALNT1)
HLE: 104842551(B3GALNT1)
AGEN: 126039173
HHAR: 128148751(B3GALNT1)
GCL: 127020102
CSTI: 104560631(B3GALNT1)
LDI: 104353329(B3GALNT1)
MNB: 103779678(B3GALNT1)
DPUB: 104301660(B3GALNT1)
PPUS: 135180492(B3GALNT1)
AVIT: 104270872(B3GALNT1)
BRHI: 104495474(B3GALNT1)
EGZ: 104122266(B3GALNT1)
NNI: 104011569(B3GALNT1)
PCRI: 104028548(B3GALNT1)
PCAO: 104047083(B3GALNT1)
PADL: 103925238(B3GALNT1)
AFOR: 103898640(B3GALNT1)
FGA: 104080350(B3GALNT1)
GSTE: 104253870(B3GALNT1)
CBOY: 140654794(B3GALNT1)
CLV: 102087526(B3GALNT1)
CNIC: 135991569(B3GALNT1)
MUI: 104539654(B3GALNT1)
PGUU: 104463437(B3GALNT1)
PLET: 104627882(B3GALNT1)
CMAC: 104475757(B3GALNT1)
TEO: 104372231(B3GALNT1)
BREG: 104642724(B3GALNT1)
OHA: 104334441(B3GALNT1)
ACAR: 104523712(B3GALNT1)
CPEA: 104387033(B3GALNT1)
CVF: 104285904(B3GALNT1)
RTD: 128910764(B3GALNT1)
CRID: 134517664(B3GALNT1)
AAM: 106495105(B3GALNT1)
AROW: 112961979(B3GALNT1)
NPD: 112952483(B3GALNT1)
TGT: 104565268(B3GALNT1)
DNE: 112986451(B3GALNT1)
SCAM: 104140021(B3GALNT1)
ASN: 102381398(B3GALNT1)
AMJ: 102574149(B3GALNT1)
CPOO: 109310352(B3GALNT1)
GGN: 109287747(B3GALNT1)
PSS: 102454980(B3GALNT1)
CMY: 102942089(B3GALNT1)
CCAY: 125643154(B3GALNT1)
DCC: 119860888(B3GALNT1)
CPIC: 101934527(B3GALNT1)
TST: 117882635(B3GALNT1)
CABI: 116823590(B3GALNT1)
MRV: 120372022(B3GALNT1)
ACS: 100564179(b3galnt1)
ASAO: 132770546(B3GALNT1)
PVT: 110078057(B3GALNT1)
SUND: 121927083(B3GALNT1)
VKO: 123025660(B3GALNT1)
PMUA: 114597936(B3GALNT1)
PRAF: 128414722(B3GALNT1)
ZVI: 118093800(B3GALNT1)
HCG: 128349449(B3GALNT1)
GJA: 107107027(B3GALNT1)
STOW: 125437503(B3GALNT1)
EMC: 129332501(B3GALNT1)
PWL: 138265485 138266582
MUO: 115478714(B3GALNT1)
GSH: 117366587 117366589 117367012
LOC: 102690089(b3galnt1)
PSPA: 121322566 121323543 121326691
ARUT: 117416799 117423202
LCM: 102358886 102363803
LERI: 129703687
HAKA: 140725487
SPU: 115927124 765098
SKO: 102800712 102807352
PFLL: 139121610 139135274
HRF: 124150667
HRJ: 124259260 124269462 124290859
HASI: 137273565
CRG: 105335519
CANU: 128166403
CVN: 111119565
OED: 125646280 125655608 125671243
MYI: 110441288 110452220 110453853 110460297 110463413
PMAX: 117335478 117337035
LJP: 135477646
LAK: 112042554
 » show all
Reference
1  [PMID:4632917]
  Authors
Chien JL, Williams T, Basu S.
  Title
Biosynthesis of a globoside-type glycosphingolipid by a  -N-acetylgalactosaminyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 248:1778-85 (1973)
Reference
2  [PMID:4433547]
  Authors
Ishibashi T, Kijimoto S, Makita A.
  Title
Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney.
  Journal
Biochim Biophys Acta 337:92-106 (1974)
DOI:10.1016/0005-2760(74)90043-5
Reference
3  [PMID:6425294]
  Authors
Taniguchi N, Makita A.
  Title
Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.
  Journal
J Biol Chem 259:5637-42 (1984)
Reference
4  [PMID:10993897]
  Authors
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K
  Title
Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.
  Journal
J Biol Chem 275:40498-503 (2000)
DOI:10.1074/jbc.M006902200
  Sequence
[hsa:8706]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.79
IUBMB Enzyme Nomenclature: 2.4.1.79
ExPASy - ENZYME nomenclature database: 2.4.1.79
BRENDA, the Enzyme Database: 2.4.1.79
CAS: 62213-46-1

  All links  
Gene (251)   
   MGENES (158)   
   RefGene (93)   
Protein sequence (66)   
   UniProt (10)   
   SWISS-PROT (6)   
   RefSeq(pep) (49)   
   PMD (1)   
DNA sequence (61)   
   RefSeq(nuc) (52)   
   GenBank (5)   
   EMBL (4)   
Protein domain (1)   
   InterPro (1)   
All databases (379)   

Download RDF
KEGG   REACTION: R05962
Entry
R05962                      Reaction                               
Definition
UDP-N-acetyl-D-galactosamine + Globotriaosylceramide <=> UDP + Globoside
Equation
G10611 + G00093 <=> G10619 + G00094
Remark
Same as: R05631
Enzyme
2.4.1.79
Pathway
rn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rn01100  Metabolic pathways
Module
M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.79
     R05962  UDP-N-acetyl-D-galactosamine + Globotriaosylceramide <=> UDP + Globoside
Glycosyltransferase reactions [br08203.html]
 N-Acetylgalactosaminyltransferase reactions
  R05962
Orthology
K00719  galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]

  All links  
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