KEGG   ORTHOLOGY: K00719
Entry
K00719                      KO                                     

Name
B3GALNT1, B3GALT3
Definition
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]
Pathway
ko00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ko01100  Metabolic pathways
Module
M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.79  globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase
     K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  GLOB blood group
   K00719  B3GALNT1, B3GALT3; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Other DBs
RN: R05962 R11321 R11378 R11379
GO: 0047273
CAZy: GT31
Genes
HSA: 8706(B3GALNT1)
PTR: 460824(B3GALNT1)
PPS: 103783664(B3GALNT1)
GGO: 101128316(B3GALNT1)
PON: 100174453(B3GALNT1)
NLE: 100582204(B3GALNT1)
MCC: 703939(B3GALNT1)
MCF: 102122721(B3GALNT1)
CSAB: 103241387(B3GALNT1)
RRO: 104665025(B3GALNT1)
RBB: 108513415(B3GALNT1)
CJC: 100412790(B3GALNT1)
SBQ: 104650882(B3GALNT1)
MMU: 26879(B3galnt1)
MCAL: 110291625(B3galnt1)
MPAH: 110320437(B3galnt1)
RNO: 310508(B3galnt1)
MUN: 110555067(B3galnt1)
CGE: 100756438(B3galnt1)
NGI: 103738016(B3galnt1)
HGL: 101706281(B3galnt1)
CCAN: 109687568(B3galnt1)
OCU: 100352272(B3GALNT1)
TUP: 102470507(B3GALNT1)
CFA: 100683634(B3GALNT1)
VVP: 112933319(B3GALNT1)
AML: 100472542(B3GALNT1)
UMR: 103677240(B3GALNT1)
UAH: 113254148(B3GALNT1)
ORO: 101362550(B3GALNT1)
ELK: 111149669
FCA: 101092536(B3GALNT1)
PTG: 102967614(B3GALNT1)
PPAD: 109262073(B3GALNT1)
AJU: 106969458(B3GALNT1)
BTA: 767844(B3GALNT1)
BOM: 102268013(B3GALNT1)
BIU: 109558643(B3GALNT1)
BBUB: 102399951(B3GALNT1)
CHX: 102172392(B3GALNT1)
OAS: 101104544(B3GALNT1)
SSC: 397634(B3GALNT1)
CFR: 102520987(B3GALNT1)
CDK: 105085986(B3GALNT1)
BACU: 103007706(B3GALNT1)
LVE: 103081769(B3GALNT1) 103082553
OOR: 101281290(B3GALNT1) 101288742
DLE: 111174411(B3GALNT1) 111185630 111185631
PCAD: 102984339 102987471(B3GALNT1)
ECB: 100062101(B3GALNT1)
EPZ: 103556050(B3GALNT1)
EAI: 106841036(B3GALNT1)
MYB: 102245995(B3GALNT1)
MYD: 102751273(B3GALNT1)
MNA: 107539305(B3GALNT1)
HAI: 109373391(B3GALNT1)
DRO: 112307143(B3GALNT1)
PALE: 102885235(B3GALNT1)
RAY: 107513039(B3GALNT1)
MJV: 108396279(B3GALNT1)
LAV: 100672964(B3GALNT1)
TMU: 101351705
MDO: 100015392(B3GALNT1)
SHR: 100914641(B3GALNT1)
PCW: 110210070(B3GALNT1)
OAA: 100077633(B3GALNT1)
GGA: 425011(B3GALNT1)
MGP: 100542332(B3GALNT1)
CJO: 107318361(B3GALNT1)
NMEL: 110397553(B3GALNT1)
APLA: 106019552(B3GALNT1)
ACYG: 106043526(B3GALNT1)
TGU: 100228838(B3GALNT1)
LSR: 110476616(B3GALNT1)
SCAN: 103815586(B3GALNT1)
GFR: 102040599(B3GALNT1)
FAB: 101809193(B3GALNT1)
PHI: 102106993(B3GALNT1)
PMAJ: 107208685(B3GALNT1)
CCAE: 111933293(B3GALNT1)
CCW: 104688069(B3GALNT1)
ETL: 114062933(B3GALNT1)
FPG: 101912356(B3GALNT1)
FCH: 102056837(B3GALNT1)
CLV: 102087526(B3GALNT1)
EGZ: 104122266(B3GALNT1)
NNI: 104011569(B3GALNT1)
PADL: 103925238(B3GALNT1)
AAM: 106495105(B3GALNT1)
ASN: 102381398(B3GALNT1)
AMJ: 102574149(B3GALNT1)
PSS: 102454980(B3GALNT1)
CMY: 102942089(B3GALNT1)
CPIC: 101934527(B3GALNT1)
ACS: 100564179(b3galnt1)
PVT: 110078057(B3GALNT1)
PMUA: 114597936(B3GALNT1)
GJA: 107107027(B3GALNT1)
LCM: 102358886 102363803
SPU: 115927124 765098
SKO: 102800712 102807352
CSOL: 105363716
NVL: 108559940
DPTE: 113791389
CRG: 105344116
MYI: 110441288 110452220 110453853 110460297 110463413
LAK: 112042554
NVE: 5521041
AMIL: 114961936 114962069
SPIS: 111343749
DGT: 114517053
YLI: YALI0F31097g
 » show all
Reference
  Authors
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K
  Title
Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.
  Journal
J Biol Chem 275:40498-503 (2000)
DOI:10.1074/jbc.M006902200
  Sequence
[hsa:8706]

  All links  
Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   CAZY (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Gene (260)   
   KEGG GENES (125)   
   KEGG MGENES (39)   
   RefGene (93)   
   OC (3)   
Protein sequence (46)   
   UniProt (41)   
   SWISS-PROT (5)   
Literature (1)   
   PubMed (1)   
All databases (324)   

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KEGG   ENZYME: 2.4.1.79
Entry
EC 2.4.1.79                 Enzyme                                 

Name
globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase;
globoside synthetase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase;
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase;
globoside synthase;
gUDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase;
beta3GalNAc-T1;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05631 R05962]
Reaction(KEGG)
R05631 R05962(G);
(other) R11321(G) R11378(G) R11379(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.
History
EC 2.4.1.79 created 1976, modified 2006
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00719  galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase
Genes
HSA: 8706(B3GALNT1)
PTR: 460824(B3GALNT1)
PPS: 103783664(B3GALNT1)
GGO: 101128316(B3GALNT1)
PON: 100174453(B3GALNT1)
NLE: 100582204(B3GALNT1)
MCC: 703939(B3GALNT1)
MCF: 102122721(B3GALNT1)
CSAB: 103241387(B3GALNT1)
RRO: 104665025(B3GALNT1)
RBB: 108513415(B3GALNT1)
CJC: 100412790(B3GALNT1)
SBQ: 104650882(B3GALNT1)
MMU: 26879(B3galnt1)
MCAL: 110291625(B3galnt1)
MPAH: 110320437(B3galnt1)
RNO: 310508(B3galnt1)
MUN: 110555067(B3galnt1)
CGE: 100756438(B3galnt1)
NGI: 103738016(B3galnt1)
HGL: 101706281(B3galnt1)
CCAN: 109687568(B3galnt1)
OCU: 100352272(B3GALNT1)
TUP: 102470507(B3GALNT1)
CFA: 100683634(B3GALNT1)
VVP: 112933319(B3GALNT1)
AML: 100472542(B3GALNT1)
UMR: 103677240(B3GALNT1)
UAH: 113254148(B3GALNT1)
ORO: 101362550(B3GALNT1)
ELK: 111149669
FCA: 101092536(B3GALNT1)
PTG: 102967614(B3GALNT1)
PPAD: 109262073(B3GALNT1)
AJU: 106969458(B3GALNT1)
BTA: 767844(B3GALNT1)
BOM: 102268013(B3GALNT1)
BIU: 109558643(B3GALNT1)
BBUB: 102399951(B3GALNT1)
CHX: 102172392(B3GALNT1)
OAS: 101104544(B3GALNT1)
SSC: 397634(B3GALNT1)
CFR: 102520987(B3GALNT1)
CDK: 105085986(B3GALNT1)
BACU: 103007706(B3GALNT1)
LVE: 103081769(B3GALNT1) 103082553
OOR: 101281290(B3GALNT1) 101288742
DLE: 111174411(B3GALNT1) 111185630 111185631
PCAD: 102984339 102987471(B3GALNT1)
ECB: 100062101(B3GALNT1)
EPZ: 103556050(B3GALNT1)
EAI: 106841036(B3GALNT1)
MYB: 102245995(B3GALNT1)
MYD: 102751273(B3GALNT1)
MNA: 107539305(B3GALNT1)
HAI: 109373391(B3GALNT1)
DRO: 112307143(B3GALNT1)
PALE: 102885235(B3GALNT1)
RAY: 107513039(B3GALNT1)
MJV: 108396279(B3GALNT1)
LAV: 100672964(B3GALNT1)
TMU: 101351705
MDO: 100015392(B3GALNT1)
SHR: 100914641(B3GALNT1)
PCW: 110210070(B3GALNT1)
OAA: 100077633(B3GALNT1)
GGA: 425011(B3GALNT1)
MGP: 100542332(B3GALNT1)
CJO: 107318361(B3GALNT1)
NMEL: 110397553(B3GALNT1)
APLA: 106019552(B3GALNT1)
ACYG: 106043526(B3GALNT1)
TGU: 100228838(B3GALNT1)
LSR: 110476616(B3GALNT1)
SCAN: 103815586(B3GALNT1)
GFR: 102040599(B3GALNT1)
FAB: 101809193(B3GALNT1)
PHI: 102106993(B3GALNT1)
PMAJ: 107208685(B3GALNT1)
CCAE: 111933293(B3GALNT1)
CCW: 104688069(B3GALNT1)
ETL: 114062933(B3GALNT1)
FPG: 101912356(B3GALNT1)
FCH: 102056837(B3GALNT1)
CLV: 102087526(B3GALNT1)
EGZ: 104122266(B3GALNT1)
NNI: 104011569(B3GALNT1)
PADL: 103925238(B3GALNT1)
AAM: 106495105(B3GALNT1)
ASN: 102381398(B3GALNT1)
AMJ: 102574149(B3GALNT1)
PSS: 102454980(B3GALNT1)
CMY: 102942089(B3GALNT1)
CPIC: 101934527(B3GALNT1)
ACS: 100564179(b3galnt1)
PVT: 110078057(B3GALNT1)
PMUA: 114597936(B3GALNT1)
GJA: 107107027(B3GALNT1)
LCM: 102358886 102363803
SPU: 115927124 765098
SKO: 102800712 102807352
CSOL: 105363716
NVL: 108559940
DPTE: 113791389
CRG: 105344116
MYI: 110441288 110452220 110453853 110460297 110463413
LAK: 112042554
NVE: 5521041
AMIL: 114961936 114962069
SPIS: 111343749
DGT: 114517053
YLI: YALI0F31097g
 » show all
Reference
1  [PMID:4632917]
  Authors
Chien JL, Williams T, Basu S.
  Title
Biosynthesis of a globoside-type glycosphingolipid by a  -N-acetylgalactosaminyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 248:1778-85 (1973)
Reference
2  [PMID:4433547]
  Authors
Ishibashi T, Kijimoto S, Makita A.
  Title
Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney.
  Journal
Biochim Biophys Acta 337:92-106 (1974)
DOI:10.1016/0005-2760(74)90043-5
Reference
3  [PMID:6425294]
  Authors
Taniguchi N, Makita A.
  Title
Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.
  Journal
J Biol Chem 259:5637-42 (1984)
Reference
4  [PMID:10993897]
  Authors
Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K.
  Title
Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.
  Journal
J Biol Chem 275:40498-503 (2000)
DOI:10.1074/jbc.M006902200
  Sequence
[hsa:8706]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.79
IUBMB Enzyme Nomenclature: 2.4.1.79
ExPASy - ENZYME nomenclature database: 2.4.1.79
BRENDA, the Enzyme Database: 2.4.1.79
CAS: 62213-46-1

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (14)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (10)   
Chemical reaction (7)   
   KEGG REACTION (5)   
   KEGG RCLASS (2)   
Gene (258)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (125)   
   KEGG MGENES (39)   
   RefGene (93)   
Protein sequence (60)   
   UniProt (6)   
   SWISS-PROT (6)   
   RefSeq(pep) (47)   
   PMD (1)   
DNA sequence (61)   
   RefSeq(nuc) (50)   
   GenBank (6)   
   EMBL (5)   
Protein domain (1)   
   InterPro (1)   
All databases (408)   

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KEGG   REACTION: R05962
Entry
R05962                      Reaction                               

Definition
UDP-N-acetyl-D-galactosamine + Globotriaosylceramide <=> UDP + Globoside
Equation
Remark
Same as: R05631
Enzyme
Pathway
rn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rn01100  Metabolic pathways
Module
M00068  Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer
Orthology
K00719  galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG GLYCAN (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (126)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (125)   
All databases (138)   

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