KEGG   ORTHOLOGY: K01068
Entry
K01068                      KO                                     
Symbol
ACOT1_2_4
Name
acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
Pathway
map00062  Fatty acid elongation
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04913  Ovarian steroidogenesis
Reaction
R01274  palmitoyl-CoA hydrolase
R08174  stearoyl-CoA hydrolase
R08175  icosanoyl-CoA hydrolase
R08176  oleoyl-CoA hydrolase
R08177  linoleoyl-CoA hydrolase
R08178  
R08179  (5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA hydrolase
R08180  
R08181  
R08182  
R08183  
R09450  long-chain fatty-acyl-CoA hydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
   01040 Biosynthesis of unsaturated fatty acids
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K01068  ACOT1_2_4; acyl-coenzyme A thioesterase 1/2/4
Other DBs
COG: COG1946
GO: 0016290
Genes
HSA: 10965(ACOT2) 122970(ACOT4) 641371(ACOT1)
PTR: 453017(ACOT2) 453018(ACOT4)
PPS: 100971608(ACOT2) 100973111(ACOT4)
GGO: 101139031(ACOT2) 101139653(ACOT4)
PON: 100442699 100443692(ACOT4) 100444412(ACOT2)
NLE: 100591629 100600674 100601709(ACOT4)
HMH: 116484626 116484653 116484793(ACOT4)
MCC: 697011(ACOT2) 697131(ACOT4)
MCF: 101925489(ACOT2) 102144834(ACOT4)
MTHB: 126959533 126959538
MNI: 105494284
CSAB: 103229305(ACOT4) 103229306
PANU: 101003993 101004347(ACOT4)
MLEU: 105541855(ACOT4) 105541879(ACOT2) 105541881
RRO: 104662094 104677548(ACOT2) 104677549(ACOT4)
PTEH: 111520549 111520556(ACOT4)
CANG: 105517184(ACOT2) 105517185(ACOT4)
CJC: 100404918(ACOT4)
SBQ: 101029645(ACOT4)
CSYR: 103273240
MMU: 171210(Acot2) 171281(Acot3) 171282(Acot4) 217698(Acot5) 26897(Acot1)
RNO: 192272(Acot2) 314304(Acot3) 503049(Acot5) 50559(Acot1) 681337(Acot4)
HGL: 101722826
TUP: 102487858 102502559(ACOT4) 102502991(ACOT2)
GVR: 103599833(ACOT4) 103599897
CFA: 490770 490771(ACOT4)
CLUD: 112657831 112657832(ACOT4)
VVP: 112927252(ACOT4)
VLG: 121493578
NPO: 129496023 129496025(ACOT4)
ELK: 111140503
ORO: 101365289 101378920(ACOT4)
EJU: 114199379 114207764(ACOT4)
NSU: 110571431(ACOT4) 110580062
LWW: 102736135(ACOT4) 102740458
PUC: 125917563
BTA: 511033(ACOT2) 511431(ACOT4) 512541 785383
CFR: 102507701 116664344(ACOT4)
CBAI: 105075438 105075447(ACOT4)
CDK: 105086124 105086252(ACOT4)
VPC: 102545132
BACU: 102997243(ACOT4) 103004901(ACOT2)
LVE: 103071761(ACOT4) 103072862(ACOT2) 103079978
OOR: 101276207 101276466(ACOT4)
DLE: 111176277 111176280(ACOT4)
PCAD: 102980644(ACOT4) 102981477
PSIU: 116749076(ACOT4) 116749791
EPZ: 103543883(ACOT4) 103545366
MYB: 102254770 102258610(ACOT1) 102258906(ACOT4)
MYD: 102759368(ACOT2) 102759648(ACOT4)
MMYO: 118657803 118657821(ACOT4)
MLF: 102440418 102441032(ACOT4)
EFUS: 103283892 129147054(ACOT4)
HAI: 109381542 109381571(ACOT4)
DRO: 112311477
SHON: 118976680
AJM: 119035528(ACOT4)
RFQ: 117022754 117022756(ACOT4)
PGIG: 120619479(ACOT4)
PVP: 105299271
MJV: 108397199(ACOT4)
SARA: 101546815
LAV: 100670605 100670886(ACOT4)
DNM: 101439958 101440394(ACOT4)
MDO: 100024487(ACOT2)
SHR: 100913369
PCW: 110208487
GGA: 423222(ACOT1L) 423247(ACOT2L) 428872(ACOT4)
CCAE: 111930084
AVIT: 104275260
AMJ: 102560956 102561188(ACOT1)
TSR: 106541789
XLA: 108699174 108699179(acot2.L) 414573(acot2.S)
XTR: 100144968(acot2) 100498625
DRE: 492778(acot19) 553440(acot20) 562047(acot21)
SGH: 107595264
PTET: 122324598(acot20) 122330984(acot19)
LROH: 127157115(acot19) 127183339(acot20)
OMC: 131527457(acot20) 131533937(acot19)
PPRM: 120459102(acot19) 120493728(acot20) 120493729
RKG: 130075494(acot20) 130099281(acot19)
TROS: 130565597(acot20)
TDW: 130414688(acot19) 130434762(acot20)
IPU: 108257587(acot20) 108275292(acot19) 108279984
IFU: 128600928(acot20) 128618552(acot19)
SMEO: 124377008(acot20) 124391878(acot19) 124392265
TFD: 113658040(acot20)
APLC: 110978425
CLON: 129617032
PMOO: 119592226
EAF: 111697602
TCF: 131887779
BGT: 106080254
CANU: 128175586
OED: 125652745
NVE: 5506196
ATEN: 116306587
PDAM: 113665009
SPIS: 111329196
DGT: 114517224
THJ: 104814102
CPAP: 110819430
PVY: 116142639
TCC: 18614145
GRA: 105802688
GHI: 107923939
GAB: 108474131
LJA: Lj0g3v0161459.1(Lj0g3v0161459.1) Lj1g3v2658230.1(Lj1g3v2658230.1) Lj1g3v2658230.2(Lj1g3v2658230.2) Lj1g3v2658230.3(Lj1g3v2658230.3) Lj1g3v2658230.4(Lj1g3v2658230.4) Lj1g3v2658230.5(Lj1g3v2658230.5) Lj1g3v2658230.6(Lj1g3v2658230.6)
PCIN: 129291271
FVE: 101302104
RCN: 112182258
PPER: 18784798
PMUM: 103331993
PAVI: 110744916
PDUL: 117619726
ZJU: 107404880
MNT: 21400292
CSAV: 115706516
CSV: 101222848
CMO: 103483275
BHJ: 120092474
MCHA: 111016341
RCU: 8261870
JCU: 105642991
POP: 7464929
PEU: 105133760
PALZ: 118041654
CAVE: 132186252
QSU: 112035681
VVI: 100256759
VRI: 117932638
CANN: 107839179
LBB: 132645586
NSY: 104243361
NTO: 104100056
NAU: 109207941
INI: 109184689
ITR: 116014946
SIND: 105173170
EGT: 105960549
SMIL: 131020677
APAN: 127252528
CSIN: 114294903
RVL: 131315109
SOE: 110789465
ATRI: 130811305
MOF: 131166183
NNU: 104586388
MING: 122086263
TSS: 122666177
OSA: 4336637
DOSA: Os04t0558400-01(Os04g0558400)
OBR: 102718259
OGL: 127771214
BDI: 100842302
ATS: 109761356
TUA: 125539372
LPER: 127335979
ZMA: 100273486
SITA: 101781418
SVS: 117863992
PHAI: 112899284
PDA: 103722362
EGU: 105034433
DCT: 110094120
PEQ: 110032560
NCOL: 116252603
ATR: 18423021
SCE: YJR019C(TES1)
SEUB: DI49_3034
ERC: Ecym_7379
KMX: KLMA_60086(TES1)
NCS: NCAS_0D01710(NCAS0D01710)
NDI: NDAI_0C02900(NDAI0C02900)
TPF: TPHA_0A04850(TPHA0A04850)
TBL: TBLA_0H02360(TBLA0H02360)
TDL: TDEL_0E04960(TDEL0E04960)
KAF: KAFR_0E01960(KAFR0E01960)
KNG: KNAG_0M01300(KNAG0M01300)
 » show all
Reference
  Authors
Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE
  Title
Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
  Journal
FASEB J 20:1855-64 (2006)
DOI:10.1096/fj.06-6042com
  Sequence

KEGG   ORTHOLOGY: K00659
Entry
K00659                      KO                                     
Symbol
BAAT
Name
bile acid-CoA:amino acid N-acyltransferase [EC:2.3.1.65 3.1.2.2]
Pathway
map00120  Primary bile acid biosynthesis
map00430  Taurine and hypotaurine metabolism
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map04146  Peroxisome
map04976  Bile secretion
Module
M00106  Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate
Reaction
R03718  choloyl-CoA:glycine N-choloyltransferase
R03720  choloyl-CoA:glycine N-choloyltransferase
R08744  3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:glycine N-choloyltransferase
R08745  3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase
Disease
H01935  Familial hypercholanemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
   01040 Biosynthesis of unsaturated fatty acids
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.65  bile acid-CoA:amino acid N-acyltransferase
     K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.2  palmitoyl-CoA hydrolase
     K00659  BAAT; bile acid-CoA:amino acid N-acyltransferase
Other DBs
GO: 0047963 0016290
Genes
HSA: 570(BAAT)
PTR: 472997
PPS: 100992429(BAAT)
GGO: 101140183(BAAT)
PON: 100431907(BAAT) 100461881
NLE: 100598200(BAAT)
HMH: 116475340(BAAT)
MCC: 100429419(BAAT)
MCF: 102132073(BAAT)
MTHB: 126937773
MNI: 105480981(BAAT)
CSAB: 103219118(BAAT)
CATY: 105593023(BAAT)
PANU: 101007875(BAAT)
TGE: 112608227(BAAT)
MLEU: 105546769(BAAT) 105546778
RRO: 104670797(BAAT)
RBB: 108537176(BAAT)
TFN: 117098906(BAAT)
PTEH: 111536312(BAAT)
CANG: 105518150(BAAT)
CJC: 100394190 100396712(BAAT)
SBQ: 101036806
CIMI: 108303855(BAAT)
MMUR: 105873759(BAAT) 105873760
LCAT: 123645821(BAAT)
PCOQ: 105805378(BAAT) 105805407
MMU: 12012(Baat) 209186(Acnat2) 230161(Acnat1)
MPAH: 110323775(Baat) 110323900
RNO: 29725(Baat) 313220(Acnat2) 681043(Acnat1)
MCOC: 116095310(Baat) 116096003
CGE: 100756252(Baat) 100756541
PLEU: 114702315(Baat) 114702326
HGL: 101716142(Baat) 101717293
CPOC: 100719696(Baat) 100719973
CCAN: 109696243(Baat)
DORD: 105990724
DSP: 122122419(Baat) 122123761
MMMA: 107147751(Baat) 107147755
OPI: 101519913(BAAT)
TUP: 102472797 102473647(BAAT)
GVR: 103607004
CFA: 481634 481635(BAAT)
CLUD: 112649971(BAAT) 112649972
VVP: 112930766(BAAT) 112930863
UMR: 103678524 103678630(BAAT)
UAH: 113260385 113260386(BAAT)
MPUF: 101671389 101671902(BAAT)
ZCA: 113934001
MLX: 118018214(BAAT) 118018215
NSU: 110581717(BAAT) 110581808
FCA: 101095691(BAAT) 101096116
PYU: 121034756(BAAT) 121034758
PCOO: 112850975 112860692(BAAT)
PBG: 122474312 122474485(BAAT)
PTG: 102969591(BAAT) 102969870
HHV: 120224623(BAAT) 120224624
BOM: 102268462
BIU: 109563300(BAAT)
BBIS: 104992074
CHX: 102174570(BAAT)
OAS: 101106149 101106409(BAAT)
BTAX: 128052871
ODA: 120863959
CCAD: 122431993
CFR: 102523415(BAAT)
CBAI: 105067405(BAAT)
CDK: 105086911(BAAT)
VPC: 102529299(BAAT)
BACU: 103006095 103017253(BAAT)
LVE: 103081315 103082496(BAAT)
DLE: 111188015(BAAT)
PCAD: 102984994(BAAT)
NASI: 112392644(BAAT) 112392655
ECB: 100054567 100063137(BAAT)
EPZ: 103552469(BAAT) 103568036
MLF: 102433860 102434162(BAAT)
MNA: 107546604(BAAT)
EFUS: 103286385(BAAT)
HAI: 109395040(BAAT)
DRO: 112304453(BAAT)
SHON: 118979701(BAAT)
AJM: 119045945(BAAT)
PDIC: 114503289(BAAT)
PHAS: 123819950(BAAT)
MMF: 118629687(BAAT)
RFQ: 117032410(BAAT)
PPAM: 129079385(BAAT)
PALE: 102892341(BAAT) 102897591
PGIG: 120597018
PVP: 105296259(BAAT) 105296291
MJV: 108397381(BAAT)
TOD: 119232402(BAAT)
SARA: 101540428(BAAT)
TMU: 101357199
MDO: 100017693 100023136(BAAT)
AFZ: 127554786
PCW: 110219134(BAAT)
OAA: 100084056(BAAT)
GGA: 769879(BAAT)
PCOC: 116242919
MGP: 100539658
CJO: 107314177
TPAI: 128085669
LMUT: 125694885(BAAT)
NMEL: 110400838
APLA: 101797844
ACYG: 106048282
CATA: 118244478
AFUL: 116490259
TGU: 115495423
LSR: 110485078
SCAN: 103822142
PMOA: 120499625
OTC: 121339708
PRUF: 121355202
GFR: 102037789
FAB: 101815920
OMA: 130254435
PHI: 102101793
PMAJ: 107206148
CCAE: 111930612
CCW: 120410054
CBRC: 103611827
ETL: 114063343
ZAB: 102062391
ACHL: 103805502(BAAT)
SVG: 106854675
MMEA: 130580050
HRT: 120753731
FPG: 101924136
FCH: 102059453
CLV: 102094683
EGZ: 104134405(BAAT)
NNI: 104008979(BAAT)
PCRI: 104030139
ACUN: 113481099
TALA: 116961616
AFOR: 103895438
ACHC: 115352108
HLE: 104829793(BAAT)
AGEN: 126046987
GCL: 127017185
MNB: 103778534(BAAT)
OHA: 104328517
NNT: 104406607
SHAB: 115606966
DPUB: 104296264(BAAT)
ACAR: 104522067
CPEA: 104393367
CVF: 104283272(BAAT)
RTD: 128908803
CUCA: 104063337(BAAT)
TEO: 104377729
AAM: 106494986
AROW: 112960829(BAAT)
NPD: 112952722
TGT: 104578818
DNE: 112988642
SCAM: 104151146(BAAT)
CMY: 102939533(BAAT) 102947935
CCAY: 125636624(BAAT) 125638328
DCC: 119856403(BAAT) 119857880
CPIC: 101932563 101938826(BAAT)
TST: 117876003 117879669(BAAT)
CABI: 116825950(BAAT)
ACS: 100566890(baat)
ASAO: 132772260(BAAT)
PVT: 110078385(BAAT)
SUND: 121930998
PBI: 103065567(BAAT)
TSR: 106538123(BAAT)
PGUT: 117667061(BAAT)
APRI: 131184117(BAAT)
PTEX: 113449132(BAAT)
NSS: 113421915(BAAT)
PMUA: 114600844(BAAT)
PRAF: 128418018(BAAT)
ZVI: 118089420(BAAT)
HCG: 128341173 128341626(BAAT)
GJA: 107106123 107106126(BAAT)
STOW: 125427301 125436721(BAAT)
EMC: 129324679 129334736(BAAT)
XLA: 100137716(XB5872576.L) 108707337(baat.S)
BBUF: 120992241(BAAT) 121008572
MUO: 115482004(BAAT)
SRX: 107726829
CCAR: 109068937
IPU: 108280978
IFU: 128625280
PHYP: 113532413
TFD: 113656460
TVC: 132838449
CMAO: 118799894
EEE: 113584003
CHAR: 105912192
TFS: 130523915
TBEN: 117489722
CGOB: 115008157
PGEO: 117447318
GACU: 117534190
SLUC: 116066678
ECRA: 117944007
ESP: 116688512
PFLV: 114553794
GAT: 120835251
PPUG: 119193948
AFB: 129105536
CLUM: 117730964
SCHU: 122867513
CUD: 121506802
ALAT: 119021228
ONL: 109198392
OAU: 116329896
OLA: 101166298
OML: 112145720
XMA: 102226402
XCO: 114135870
XHE: 116711136
PRET: 103465285
PFOR: 103144302
PLAI: 106934498
PMEI: 106906822
GAF: 122834742
PPRL: 129353154
CVG: 107083302
CTUL: 119791826
GMU: 124856113
NFU: 107385610
KMR: 108235667
NWH: 119411976
MCEP: 125006140
HHIP: 117761208
HSP: 118105133
SDU: 111221490
SLAL: 111667779
HCQ: 109522368
SSCV: 125976910
PEE: 133409198
PTAO: 133483319
MALB: 109956248
BSPL: 114856054
SJO: 128356051
STRU: 115208005
OGO: 124003938
ONE: 115143032
OKI: 109894173
OKE: 118388720
CCLU: 121577792
ELS: 105010081
SFM: 108933858
AANG: 118211819
HAME: 121871783
PCLA: 123754342
PTRU: 123506716
HAZT: 108682704
PVUL: 126821684
CRG: 105328098
MYI: 110465077
OBI: 106881808
LAK: 106169569
NVE: 5519541
ADF: 107346883
AMIL: 114966874
 » show all
Reference
PMID:8034703
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J Biol Chem 269:19375-9 (1994)
  Sequence
[hsa:570]
Reference
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712

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