KEGG ORTHOLOGY: K02729

ORTHOLOGY: K02729

Entry

K02729 KO

Name

PSMA5

Definition

20S proteasome subunit alpha 5 [EC:3.4.25.1]

Pathway

ko03050

Proteasome

ko05010

Alzheimer disease

ko05012

Parkinson disease

ko05016

Huntington disease

ko05017

Spinocerebellar ataxia

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    K02729  PSMA5; 20S proteasome subunit alpha 5
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02729  PSMA5; 20S proteasome subunit alpha 5
   05012 Parkinson disease
    K02729  PSMA5; 20S proteasome subunit alpha 5
   05016 Huntington disease
    K02729  PSMA5; 20S proteasome subunit alpha 5
   05017 Spinocerebellar ataxia
    K02729  PSMA5; 20S proteasome subunit alpha 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K02729  PSMA5; 20S proteasome subunit alpha 5
  09182 Protein families: genetic information processing
   03051 Proteasome
    K02729  PSMA5; 20S proteasome subunit alpha 5
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     K02729  PSMA5; 20S proteasome subunit alpha 5
Peptidases and inhibitors [BR:ko01002]
Threonine peptidases
  Family T1: proteasome family
   K02729  PSMA5; 20S proteasome subunit alpha 5
Proteasome [BR:ko03051]
Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    K02729  PSMA5; 20S proteasome subunit alpha 5

Other DBs

COG:

COG0638

Genes

HSA:	5686(PSMA5)

PTR:	112204966 112207728 469795(PSMA5)

PPS:	100972383(PSMA5)

GGO:	101151849(PSMA5) 109028113

PON:	100458349(PSMA5)

NLE:	100580173(PSMA5)

MCC:	698435(PSMA5)

MCF:	101925588(PSMA5)

CSAB:

103224293(PSMA5)

RRO:	104655901(PSMA5)

RBB:	108519637(PSMA5)

CJC:	100403566(PSMA5)

SBQ:	101029804(PSMA5)

MMU:	26442(Psma5)

MCAL:

110290942(Psma5)

MPAH:

110320113(Psma5)

RNO:	29672(Psma5)

MUN:	110545536(Psma5)

CGE:	100774039(Psma5)

NGI:	103747840(Psma5)

HGL:	101699124(Psma5)

CCAN:

109685939(Psma5)

OCU:	100338247(PSMA5)

TUP:	102473391(PSMA5) 102480926

CFA:	100856348(PSMA5)

VVP:	112918261(PSMA5)

AML:	100481497(PSMA5)

UMR:	103674995(PSMA5)

UAH:	113244929(PSMA5)

ORO:	101369446(PSMA5)

ELK:

111143461

FCA:	101098808(PSMA5)

PTG:	102953650(PSMA5)

PPAD:

109271991(PSMA5)

AJU:	106977738(PSMA5)

BTA:	510155(PSMA5)

BOM:	102286734(PSMA5)

BIU:	109555980(PSMA5)

BBUB:

102404589(PSMA5)

CHX:	102186449(PSMA5)

OAS:	101104946(PSMA5)

SSC:	497063(PSMA5)

CFR:	102523817(PSMA5)

CDK:	105085640(PSMA5)

BACU:

103011116(PSMA5)

LVE:	103082551(PSMA5)

OOR:	101275300(PSMA5)

DLE:	111180078(PSMA5)

PCAD:

102994783(PSMA5)

ECB:	100061457(PSMA5)

EPZ:	103553059(PSMA5)

EAI:	106827395(PSMA5)

MYB:	102246596(PSMA5)

MYD:	102764728(PSMA5)

MNA:	107545343(PSMA5)

HAI:	109375304(PSMA5)

DRO:	112314015(PSMA5)

PALE:

102891315(PSMA5)

RAY:	107516149(PSMA5)

MJV:	108400475(PSMA5)

LAV:	100667388(PSMA5)

TMU:

101347799

MDO:	100030041(PSMA5)

SHR:	100921704(PSMA5)

PCW:	110218156(PSMA5)

OAA:	100086434(PSMA5)

GGA:	426937(PSMA5)

MGP:	100545664(PSMA5)

CJO:	107324750(PSMA5)

NMEL:

110388085(PSMA5)

APLA:

101790383(PSMA5)

ACYG:

106049767(PSMA5)

TGU:	100225030(PSMA5)

LSR:	110469151(PSMA5)

SCAN:

103822431(PSMA5)

GFR:	102038127(PSMA5)

FAB:	101806011(PSMA5)

PHI:	102100501(PSMA5)

PMAJ:

107215033(PSMA5)

CCAE:

111939729(PSMA5)

CCW:	104692442(PSMA5)

ETL:	114072388(PSMA5)

FPG:	101917822(PSMA5)

FCH:	102055803(PSMA5)

CLV:	102095590(PSMA5)

EGZ:	104123420(PSMA5)

NNI:	104011581(PSMA5)

ACUN:

113490432(PSMA5)

PADL:

103925457(PSMA5)

AAM:	106493516 106495455(PSMA5)

ASN:	102380685(PSMA5)

AMJ:	102576354(PSMA5)

PSS:	102452932(PSMA5)

CMY:	102932011(PSMA5)

CPIC:

101938969(PSMA5)

ACS:	100562151(psma5)

PVT:	110085288(PSMA5)

PBI:	103049339(PSMA5)

PMUR:

107302538(PSMA5)

TSR:	106554283(PSMA5)

PMUA:

114599180(PSMA5)

GJA:	107111180(PSMA5)

XLA:	108704550(psma5.L) 444215(psma5.S)

XTR:	100124849(psma5)

NPR:	108795708(PSMA5)

DRE:	403011(psma5)

SRX:	107715776(psma5) 107736674

SANH:

107659547 107685984

SGH:	107577240(psma5) 107582453

CCAR:

109097290(psma5)

IPU:	100528640(psma5)

PHYP:

113539566(psma5)

AMEX:

103028903(psma5)

EEE:	113578921(psma5)

TRU:	101073541(psma5)

TNG:	GSTEN00013981G001

LCO:	109137920(psma5)

NCC:	104942998(psma5)

MZE:	101478925(psma5) 112434037

ONL:	100690533(psma5)

OLA:	101160065(psma5)

XMA:	102221481(psma5)

XCO:	114136225(psma5)

PRET:

103464891(psma5)

CVG:	107083305(psma5)

NFU:	107385581(psma5)

KMR:	108246854(psma5)

ALIM:

106513322(psma5)

AOCE:

111587435(psma5)

CSEM:

103386092(psma5)

POV:	109629022(psma5)

LCF:	108889403(psma5)

SDU:	111221537(psma5)

SLAL:

111645770 111667661(psma5) 111672663

HCQ:	109522358(psma5)

BPEC:

110168438(psma5)

MALB:

109956099(psma5)

SASA:

100195931(psma5)

OTW:	112254516(psma5)

SALP:

111970016(psma5)

ELS:	105025120(psma5)

SFM:	108933634(psma5)

PKI:	111858931(psma5)

LCM:	102360890(PSMA5)

CMK:	103182489(psma5)

RTP:	109926782(psma5)

BFO:	BRAFLDRAFT_280892

CIN:

100176195

SPU:	115919498 576984

APLC:

110982065

SKO:

100370586

DME:	Dmel_CG10938(Prosalpha5)

DER:

6548137

DSE:

6609586

DSI:	Dsimw501_GD11263(Dsim_GD11263)

DYA:	Dyak_GE11658(Dyak_ProsMA5)

DAN:

6495960

DSR:	110181832 110189441

DPO:	Dpse_GA10654

DPE:

6590866

DMN:	108159718 117185739

DWI:

6640334

DGR:	Dgri_GH21393

DMO:	Dmoj_GI18573

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP008816

AAG:

5564545

AALB:

109427525

CQU:	CpipJ_CPIJ010114 CpipJ_CPIJ018162

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_202375

PMAC:

106711002

PRAP:

110995133

HAW:

110383197

PXY:	105384825 105388544 105389216

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM116710

ZNE:

110840796

FCD:

110845725

DPX:	DAPPUDRAFT_231717

PVM:

113811304

TUT:	107367423 107370521

DPTE:

113788849

CSCU:

111617998 111618014

PTEP:

107456614

CEL:	CELE_F25H2.9(pas-5)

CBR:	CBG02261(Cbr-pas-5)

BMY:

Bm1_37390

LOA:	LOAG_01073

NAI:	NECAME_09520

TSP:

Tsp_05973

HRO:	HELRODRAFT_185707

LGI:	LOTGIDRAFT_232029

PCAN:

CRG:

MYI:

OBI:

LAK:

SMM:	Smp_032580.1

SHX:

MS3_04526

OVI:	T265_15436

EGL:

EGR_03486

NVE:

5511121

EPA:

110243013

ADF:	107330309 107340108

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_19919

AQU:

100638511

ATH:	AT1G53850(PAE1) AT3G14290(PAE2)

ALY:	9321097 9327838

CRB:	17887936 17893813 17898476

CSAT:

104742907 104745703 104758736 104765243 104766680 104778322 104779139

EUS:	EUTSA_v10011748mg

BRP:	103832649 103848506 103871106

BNA:	106345808 106360398 106360399 106367110 106367639 106377315 106416418

BOE:	106300243 106300475 106331422

RSZ:	108819367 108840600 108862699

THJ:	104810393 104815597

CPAP:

110814571 110818478

CIT:

102620751

CIC:	CICLE_v10009299mg CICLE_v10026377mg

TCC:

18596311

GRA:	105772695 105777887 105798999

GHI:	107889031 107891756 107897462 107897671 107898177 107913836 107940582 107960746

GAB:	108454581 108465774 108470833 108487269

DZI:	111274748 111279037 111281373

EGR:

104422894

GMX:	100499756 100796147 100799919 547598(PAE1)

GSJ:	114369230 114372685 114378541 114401447

PVU:	PHAVU_007G021000g PHAVU_007G215500g

VRA:	106770758 106770775

VAR:	108324017 108326643

VUN:	114191599 114192629

CCAJ:

109797429

MTR:	MTR_1g112250 MTR_6g013300

CAM:

101493198

LJA:	Lj5g3v2240990.1(Lj5g3v2240990.1) Lj5g3v2240990.2(Lj5g3v2240990.2)

ADU:

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:	103435285 114827728

PXB:

103945159

ZJU:	107412893 107412898

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110634615 110634642

MESC:

110613507 110626443

POP:	18094673 7470748

PEU:	105118834 105134012 105142610

JRE:	109003580 109006458 109020971

QSU:	112018897 112023186 112023815

VVI:

100263432

SLY:	101247093 101266742

SPEN:

107008899 107026691

SOT:	102583874 102599627

CANN:

107859091 107879020

NTA:	107783032 107785901 107799456 107805624 107805979(a5) 107806762 107814220 107817032

NSY:	104212832 104236604 104246563

NTO:	104095025 104107275 104109129

NAU:	109212215 109233237 109242009

INI:	109187499 109192428

SIND:

105157881 105162872

OEU:	111403447 111405080

HAN:	110880306 110913075

LSV:	111906891 111921871

CCAV:

112509638

DCR:	108193013 108220210

BVG:	104905638 104906614

SOE:

110782366

CQI:	110685501 110689359 110717734 110719803

NNU:	104600453 104609256

PSOM:

113308749 113323678 113326542 113339885

OSA:

4350922

DOSA:

Os11t0615700-01(Os11g0615700)

OBR:

102701489

BDI:	100825853 100836191

ATS:	109741020(LOC109741020) 109747979(LOC109747979)

SBI:	8068293 8080549

ZMA:	100282220 100283546

SITA:

101764288

PDA:	103702605 103712585 103714831

EGU:	105041995 105056664 105058583

MUS:	103968604 103970768

DCT:	110101825 110103556

PEQ:	110021857 110026015

AOF:	109833659 109848629

ATR:

18423967

SMO:	SELMODRAFT_181529 SELMODRAFT_267349

PPP:	112291088 112291196 112294358

CRE:	CHLREDRAFT_184847(POA5)

VCN:	VOLCADRAFT_102676(poa5)

MNG:

MNEG_4028

CSL:	COCSUDRAFT_32542

CVR:	CHLNCDRAFT_26444

APRO:

F751_6012

OLU:	OSTLU_38146

OTA:	OT_ostta10g01180

BPG:	Bathy11g01100

MIS:	MICPUN_107684

MPP:	MICPUCDRAFT_49545

CME:	CYME_CMQ225C

GSL:	Gasu_15880

CCP:	CHC_T00009346001

SCE:	YGR253C(PUP2)

AGO:	AGOS_AER296W

ERC:

Ecym_5100

KLA:	KLLA0_A05093g

KMX:	KLMA_40435(PUP2)

LTH:	KLTH0H00528g

VPO:	Kpol_1062p2

ZRO:	ZYRO0C11770g

CGR:	CAGL0I02442g

NCS:	NCAS_0D01340(NCAS0D01340)

NDI:	NDAI_0C03400(NDAI0C03400)

TPF:	TPHA_0H01190(TPHA0H01190)

TBL:	TBLA_0C06620(TBLA0C06620)

TDL:	TDEL_0G00880(TDEL0G00880)

KAF:	KAFR_0B04440(KAFR0B04440)

PPA:	PAS_chr3_1129

DHA:	DEHA2G23562g

PIC:	PICST_87371

PGU:	PGUG_04079

SPAA:

SPAPADRAFT_59544

LEL:	LELG_03226

CAL:	CAALFM_CR06750CA(PUP2)

CTP:	CTRG_00670

COT:	CORT_0D04860

CDU:	CD36_32290

CTEN:

CANTEDRAFT_115821

YLI:	YALI0E02794g

CLU:	CLUG_02475

CLUS:

A9F13_28g00275

CAUR:

CJI97_005213

PKZ:	C5L36_0A11220

NCR:	NCU05295(pca-5)

NTE:	NEUTE1DRAFT121593(NEUTE1DRAFT_121593)

SMP:	SMAC_01694

PAN:	PODANSg6254

TTT:	THITE_2150567

MTM:	MYCTH_2299195

CTHR:

CTHT_0029600

MGR:

MGG_07130

TMN:	UCRPA7_7958

SSCK:

SPSK_07727

FGR:	FGSG_06159

FPU:	FPSE_02511

FVR:	FVEG_06117

FOX:	FOXG_08551

NHE:	NECHADRAFT_58084

TRE:	TRIREDRAFT_55644(psa5)

TRR:	M419DRAFT_26658

MAW:

MAC_00725

MAJ:

MAA_06522

CMT:

CCM_04342

PLJ:	VFPFJ_00950

VAL:	VDBG_04387

CFJ:	CFIO01_12267

SAPO:

SAPIO_CDS7128

ELA:	UCREL1_3325

PFY:	PFICI_05183

SSL:	SS1G_09762

BFU:	BCIN_07g06340(Bcpup2)

MBE:

MBM_01677

PSCO:

LY89DRAFT_633210

GLZ:	GLAREA_12616

ANI:

AN5872.2

AFM:	AFUA_2G11440

ACT:	ACLA_070390

NFI:	NFIA_086680

AOR:	AO090026000504

ANG:	ANI_1_466024(An02g03400)

AFV:	AFLA_134290

PCS:	Pc15g00320

PDP:	PDIP_10930

TMF:	PMAA_048730

CIM:	CIMG_08182

CPW:	CPC735_022020

PBL:	PAAG_03687

PBN:	PADG_03192

URE:	UREG_02436

ABE:

ARB_01311

TVE:

TRV_00017

AJE:	HCAG_07121

BGH:	BDBG_00624

PNO:	SNOG_01567

PTE:

PTT_11507

BZE:	COCCADRAFT_2600

BSC:	COCSADRAFT_40361

BOR:	COCMIDRAFT_6494

AALT:

CC77DRAFT_1001936

ZTR:	MYCGRDRAFT_76460

PFJ:	MYCFIDRAFT_65271

BCOM:

BAUCODRAFT_70766

NPA:	UCRNP2_10345

TML:	GSTUM_00000405001

SPO:	SPAC323.02c(pup2)

CNE:

CNH01360

CNB:

CNBL1310

CGI:	CGB_L1410W

TMS:	TREMEDRAFT_62955

TASA:

A1Q1_08146

TVS:	TRAVEDRAFT_111373

DSQ:	DICSQDRAFT_131813

PCO:	PHACADRAFT_248487

SHS:	STEHIDRAFT_63480

HIR:	HETIRDRAFT_58514

PSQ:	PUNSTDRAFT_123874

ADL:	AURDEDRAFT_132883

FME:	FOMMEDRAFT_18901

GTR:	GLOTRDRAFT_51851

LBC:	LACBIDRAFT_291793

MRR:	Moror_1703

CCI:	CC1G_00621

SCM:	SCHCODRAFT_49745

ABP:	AGABI1DRAFT110820(AGABI1DRAFT_110820)

ABV:	AGABI2DRAFT189272(AGABI2DRAFT_189272)

CPUT:

CONPUDRAFT_96588

WSE:	WALSEDRAFT_59392

WIC:	J056_002785

UMA:	UMAG_05986

PFP:	PFL1_06255

MGL:

MGL_1134

MRT:

MRET_3019

MSYM:

MSY001_0739

PGR:	PGTG_13400

MLR:	MELLADRAFT_73374

ECU:	ECU05_1400

EIN:	Eint_051460

EHE:	EHEL_051530

ERO:	EROM_051470

NCE:	NCER_100782

MBR:	MONBRDRAFT_35217

SRE:	PTSG_05590

DDI:	DDB_G0268538(psmA5)

DPP:	DICPUDRAFT_49129 DICPUDRAFT_74767

DFA:	DFA_05184(psmA5)

EHI:	EHI_004760(81.t00025) EHI_023020(203.t00020)

EDI:	EDI_022270 EDI_235000

EIV:	EIN_177760

ACAN:

ACA1_389440

PFA:	PF3D7_0727400

PFD:	PFDG_00127

PFH:	PFHG_02179

PYO:	PY17X_0212900

PCB:	PCHAS_020990(PC000270.04.0)

PBE:	PBANKA_0211500

PKN:	PKH_021180

PVX:	PVX_081675

PCY:	PCYB_022230

TAN:

TA20200

TPV:

TP01_1231

TOT:	TOT_010001272

BEQ:	BEWA_001500

BBO:	BBOV_I001480(19.m02285)

BMIC:

BmR1_04g04985

CPV:

cgd5_1820

CHO:	Chro.50200

TGO:	TGME49_249590

TET:	TTHERM_00043880

PTM:	GSPATT00023801001 GSPATT00033581001 GSPATT00035566001

PTI:	PHATR_28202

FCY:	FRACYDRAFT_275128

TPS:	THAPSDRAFT_30075(PSA5)

AAF:	AURANDRAFT_60080

PIF:	PITG_12122

PSOJ:

PHYSODRAFT_354158

SPAR:

SPRG_09441 SPRG_18485

GTT:	GUITHDRAFT_155595

TBR:	Tb10.100.0120

TBG:	TbgDal_X140

TCR:	504069.53 511145.43

LMA:	LMJF_21_1830

LIF:	LINJ_21_2200

LDO:	LDBPK_212200

LMI:	LMXM_21_1830

LBZ:	LBRM_33_0890

LPAN:

LPMP_212140

NGR:	NAEGRDRAFT_55551

TVA:	TVAG_293540

GLA:	GL50803_2980

» show all

Reference

PMID:16338359

Authors

Hirano Y, Murata S, Tanaka K

Title

Large- and small-scale purification of mammalian 26S proteasomes.

Journal

Methods Enzymol 399:227-40 (2005)
DOI:10.1016/S0076-6879(05)99015-0

Reference

PMID:22341445

Authors

Huber EM, Basler M, Schwab R, Heinemeyer W, Kirk CJ, Groettrup M, Groll M

Title

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

Journal

Cell 148:727-38 (2012)
DOI:10.1016/j.cell.2011.12.030

Sequence

[mmu:26442]

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Ontology (5)   
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Pathway (10)   
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Chemical reaction (1)   
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Gene (7741)   
   KEGG GENES (670)   
   KEGG MGENES (263)   
   RefGene (6795)   
   OC (13)   
Protein sequence (398)   
   UniProt (385)   
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