Entry |
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Name |
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
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Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
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Sysname |
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase
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Reaction(IUBMB) |
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein [RN: R05911]
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Reaction(KEGG) |
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Substrate |
CMP-N-acetylneuraminate [CPD: C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
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Product |
CMP [CPD: C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
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Comment |
alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.
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History |
EC 2.4.99.3 created 1984, modified 1986
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Pathway |
ec00512 | Mucin type O-glycan biosynthesis |
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Orthology |
K03479 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) |
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Genes |
» show all
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Reference |
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Authors |
Sadler JE, Rearick JI, Hill RL. |
Title |
Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands. |
Journal |
J Biol Chem 254:5934-41 (1979) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.4.99.3 |
ExPASy - ENZYME nomenclature database: | 2.4.99.3 |
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