KEGG   ORTHOLOGY: K04432
Entry
K04432                      KO                                     
Symbol
MAP2K3, MKK3
Name
mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Pathway
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04015  Rap1 signaling pathway
map04218  Cellular senescence
map04620  Toll-like receptor signaling pathway
map04624  Toll and Imd signaling pathway
map04664  Fc epsilon RI signaling pathway
map04668  TNF signaling pathway
map04714  Thermogenesis
map04750  Inflammatory mediator regulation of TRP channels
map04912  GnRH signaling pathway
map04935  Growth hormone synthesis, secretion and action
map04936  Alcoholic liver disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05132  Salmonella infection
map05135  Yersinia infection
map05145  Toxoplasmosis
map05161  Hepatitis B
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04013 MAPK signaling pathway - fly
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04015 Rap1 signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04668 TNF signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04624 Toll and Imd signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04664 Fc epsilon RI signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04935 Growth hormone synthesis, secretion and action
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05161 Hepatitis B
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05169 Epstein-Barr virus infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05135 Yersinia infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Other DBs
GO: 0004708
Genes
HSA: 5606(MAP2K3)
PTR: 107972404 112206088
PPS: 100975020 117978302
GGO: 101145420(MAP2K3)
PON: 100457536(MAP2K3)
NLE: 100588703(MAP2K3)
MCC: 705195(MAP2K3)
MCF: 102116823(MAP2K3)
CSAB: 103242535(MAP2K3)
CATY: 105593750(MAP2K3)
PANU: 101012583(MAP2K3)
TGE: 112608997(MAP2K3)
RRO: 104678467(MAP2K3)
RBB: 108521513(MAP2K3)
TFN: 117089741(MAP2K3)
PTEH: 111528301(MAP2K3)
CJC: 100398593(MAP2K3)
SBQ: 101034633(MAP2K3)
CSYR: 103264569(MAP2K3)
MMUR: 105856318(MAP2K3)
OGA: 100955929(MAP2K3)
MMU: 26397(Map2k3)
MCAL: 110304977(Map2k3)
MPAH: 110331197(Map2k3)
RNO: 303200(Map2k3)
MCOC: 116077938(Map2k3)
MUN: 110561677(Map2k3)
CGE: 100756793(Map2k3)
PLEU: 114683276(Map2k3)
NGI: 103724822(Map2k3)
HGL: 101718318(Map2k3)
CPOC: 100726100(Map2k3)
CCAN: 109692052(Map2k3)
DORD: 105985703(Map2k3)
DSP: 122103259(Map2k3)
NCAR: 124980599
OCU: 100339953(MAP2K3)
OPI: 101517788(MAP2K3)
TUP: 102499419(MAP2K3)
CFA: 489547(MAP2K3)
VVP: 112924977(MAP2K3)
VLG: 121499935(MAP2K3)
AML: 100476678(MAP2K3)
UMR: 103658475(MAP2K3)
UAH: 113271318(MAP2K3)
UAR: 123779716(MAP2K3)
ELK: 111139240
LLV: 125087473
MPUF: 101679855(MAP2K3)
ORO: 101378651(MAP2K3)
EJU: 114198178(MAP2K3)
ZCA: 113939775(MAP2K3)
MLX: 118000167(MAP2K3)
FCA: 101082274(MAP2K3)
PYU: 121015779(MAP2K3)
PBG: 122485071(MAP2K3)
PTG: 102949954(MAP2K3)
PPAD: 109245742(MAP2K3)
AJU: 106981449(MAP2K3)
HHV: 120228759(MAP2K3)
BTA: 516039(MAP2K3)
BOM: 102267773(MAP2K3)
BIU: 109574182(MAP2K3)
BBUB: 102391709(MAP2K3)
CHX: 102173967(MAP2K3)
OAS: 101122959(MAP2K3)
ODA: 120867361(MAP2K3)
CCAD: 122443696(MAP2K3)
SSC: 110256149(MAP2K3)
CFR: 102523780(MAP2K3)
CBAI: 105084150(MAP2K3)
CDK: 105100607(MAP2K3)
VPC: 102530139(MAP2K3)
BACU: 103019100(MAP2K3)
LVE: 103091611(MAP2K3)
OOR: 101275666(MAP2K3)
DLE: 111167700(MAP2K3)
PCAD: 102978047(MAP2K3)
PSIU: 116745655(MAP2K3)
ECB: 100053481(MAP2K3)
EPZ: 103563092(MAP2K3)
EAI: 106825518(MAP2K3)
MYB: 102259712(MAP2K3)
MYD: 102765923(MAP2K3)
MMYO: 118662418
MNA: 107542219(MAP2K3)
PKL: 118721075(MAP2K3)
HAI: 109390353(MAP2K3)
DRO: 112308621(MAP2K3)
SHON: 119002731(MAP2K3)
AJM: 119062274(MAP2K3)
PDIC: 114515272(MAP2K3)
PHAS: 123809430(MAP2K3)
MMF: 118641294(MAP2K3)
RFQ: 117013305(MAP2K3) 117018399
PALE: 102886389(MAP2K3)
PGIG: 120589895(MAP2K3)
PVP: 105304165(MAP2K3)
RAY: 107506757(MAP2K3)
MJV: 108392844(MAP2K3)
TOD: 119230399(MAP2K3)
SARA: 101555912(MAP2K3)
LAV: 100675607(MAP2K3)
TMU: 101355711
MDO: 100016872(MAP2K3)
GAS: 123233796(MAP2K3)
SHR: 100925586(MAP2K3)
PCW: 110223168(MAP2K3)
OAA: 100080734(MAP2K3)
GGA: 416496(MAP2K3)
PCOC: 116237354(MAP2K3)
MGP: 100542290(MAP2K3)
CJO: 107320760(MAP2K3)
NMEL: 110405901(MAP2K3)
APLA: 101803371(MAP2K3)
ACYG: 106032094(MAP2K3)
AFUL: 116495505(MAP2K3)
TGU: 100229860(MAP2K3)
LSR: 110481212(MAP2K3)
SCAN: 103817610(MAP2K3)
PMOA: 120513145(MAP2K3)
OTC: 121334535(MAP2K3)
PRUF: 121350851(MAP2K3)
GFR: 102039295(MAP2K3)
FAB: 101809415(MAP2K3)
PHI: 102109535(MAP2K3)
PMAJ: 107211348(MAP2K3)
CCAE: 111936127(MAP2K3)
CCW: 104684789(MAP2K3)
ETL: 114060189(MAP2K3)
ZAB: 102069824(MAP2K3)
FPG: 101919170(MAP2K3)
FCH: 102052703(MAP2K3)
CLV: 102085143(MAP2K3)
EGZ: 104132608(MAP2K3)
NNI: 104015109(MAP2K3)
ACUN: 113485588(MAP2K3)
TALA: 104357596(MAP2K3)
PADL: 103918788(MAP2K3)
ACHC: 115335899(MAP2K3)
AAM: 106486833
AROW: 112974370
NPD: 112960040(MAP2K3)
DNE: 112980388(MAP2K3)
ASN: 102383945(MAP2K3)
AMJ: 102566638(MAP2K3)
CPOO: 109314684(MAP2K3)
GGN: 109294332(MAP2K3)
PSS: 102454019(MAP2K3)
CMY: 102939584(MAP2K3)
CPIC: 101936976(MAP2K3)
TST: 117883675(MAP2K3)
CABI: 116826312(MAP2K3)
MRV: 120373319(MAP2K3)
ACS: 100561588(map2k3)
PVT: 110087206(MAP2K3)
SUND: 121914162(MAP2K3)
PBI: 103065723(MAP2K3)
PGUT: 117676778(MAP2K3)
VKO: 123024965(MAP2K3)
PMUA: 114584096(MAP2K3)
ZVI: 118092693(MAP2K3)
GJA: 107120519
SFM: 108923933(map2k3) 108941534
PKI: 111836901 111847733(map2k3)
LOC: 102691753(map2k3)
LCM: 102351267(MAP2K3)
CMK: 103185143(map2k6)
RTP: 109922694
DME: Dmel_CG12244(lic)
DER: 6551001
DSE: 6618621
DSI: Dsimw501_GD24803(Dsim_lic)
DAN: 6504087
DSR: 110183512
DPE: 6597693
DMN: 108165042
DWI: 6648558
DGR: 6566302
DAZ: 108619408
DNV: 108656880
DHE: 111593410
DVI: 6633830
CCAT: 101462574
BOD: 106620421
MDE: 101897152
SCAC: 106087371
LCQ: 111681275
ACOZ: 120961524
AARA: 120906533
AAG: 5571505
AALB: 109431380
CNS: 116343518
AME: 725374
ACER: 108003391
ALAB: 122712477
BIM: 100750211
BBIF: 117205690
BVK: 117233150
BVAN: 117155197
BTER: 100650253
BPYO: 122574870
CCAL: 108632919
OBB: 114874246
MGEN: 117222679
NMEA: 116428080
CGIG: 122402162
SOC: 105196733
MPHA: 105840352
AEC: 105144410
ACEP: 105622342
PBAR: 105431216
VEM: 105560671
HST: 105192423
DQU: 106743296
CFO: 105257778
FEX: 115235985
LHU: 105669425
PGC: 109853168
OBO: 105276227
PCF: 106788422
PFUC: 122522474
VPS: 122634690
NVI: 100120952
CSOL: 105361381
TPRE: 106648396
MDL: 103568921
CGLO: 123258765
FAS: 105271274
DAM: 107037658
AGIF: 122852974
CCIN: 107267810
TCA: 661608
DPA: 109536941
SOY: 115884252
ATD: 109608832
CSET: 123317408
AGB: 108911256
LDC: 111506752
NVL: 108559292
APLN: 108742532
PPYR: 116178175
OTU: 111426404
BMAN: 114253196
MSEX: 115446465
BANY: 112049528
PMAC: 106718087
PPOT: 106107197
PXU: 106118805
PRAP: 110992502
ZCE: 119832133
HAW: 110377974
TNL: 113492124
OFU: 114360674
PXY: 105380228
API: 100164531
DNX: 107163491
AGS: 114129813
RMD: 113559162
BTAB: 109034669
DCI: 113466461
CLEC: 106666144
HHAL: 106688597
NLU: 111053498
FOC: 113205327
ZNE: 110837639
CSEC: 111871191
FCD: 110850082
DMK: 116927380
PVM: 113806070
PJA: 122250833
PCHN: 125047045
HAME: 121873203
PCLA: 123756868
PTRU: 123507755
HAZT: 108681958
EAF: 111714880
VDE: 111252897
DPTE: 113798303
DFR: 124490611
CSCU: 111635533
PTEP: 107448971
SDM: 118197392
TSP: Tsp_02206
PCAN: 112565230
BGT: 106069640
HRF: 124144569
HRJ: 124282127
OSN: 115214176
EGL: EGR_04099
 » show all
Reference
PMID:8900184
  Authors
Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K, Nishida E
  Title
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.
  Journal
J Biol Chem 271:26981-8 (1996)
DOI:10.1074/jbc.271.43.26981
  Sequence
[hsa:5606] [mmu:26397]
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5606]

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