KEGG ORTHOLOGY: K04501

ORTHOLOGY: K04501

Entry

K04501                      KO

Symbol

SMAD4

Name

mothers against decapentaplegic homolog 4

Pathway

map04068

FoxO signaling pathway

map04081

Hormone signaling

map04110

Cell cycle

map04310

Wnt signaling pathway

map04350

TGF-beta signaling pathway

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04520

Adherens junction

map04550

Signaling pathways regulating pluripotency of stem cells

map04659

Th17 cell differentiation

map04933

AGE-RAGE signaling pathway in diabetic complications

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05220

Chronic myeloid leukemia

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Disease

H00019

Pancreatic cancer

H00020

Colorectal cancer

H00533

Hereditary hemorrhagic telangiectasia

H01023

Juvenile polyposis syndrome

H02102

Myhre syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04371 Apelin signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K04501  SMAD4; mothers against decapentaplegic homolog 4
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04501  SMAD4; mothers against decapentaplegic homolog 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05225 Hepatocellular carcinoma
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05226 Gastric cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04501  SMAD4; mothers against decapentaplegic homolog 4

Other DBs

GO:

0070412

Genes

HSA:	4089(SMAD4)

PTR:	468537(SMAD4)

PPS:	100991127(SMAD4)

GGO:	101153595(SMAD4)

PON:	100439171(SMAD4)

PPYG:

129018723(SMAD4)

NLE:	100599586(SMAD4)

HMH:	116468535(SMAD4)

SSYN:

129493119(SMAD4)

MCC:	701803(SMAD4)

MCF:	102142438(SMAD4)

MTHB:

126941313

MNI:	105489417(SMAD4)

CSAB:

103222414(SMAD4)

CATY:

105592487(SMAD4)

PANU:

101019266(SMAD4)

TGE:	112611379(SMAD4)

MLEU:

105531177(SMAD4)

RRO:	104672916(SMAD4)

RBB:	108533135(SMAD4)

TFN:	117063892(SMAD4)

PTEH:

111539654(SMAD4)

CANG:

105502346(SMAD4)

CJC:	100409302(SMAD4)

SBQ:	101032066(SMAD4)

CIMI:

108305081(SMAD4)

ANAN:

105725296(SMAD4)

CSYR:

103257913(SMAD4)

MMUR:

105874233(SMAD4)

LCAT:

123621953(SMAD4)

PCOQ:

105816381(SMAD4)

OGA:	100955502(SMAD4)

MMU:	17128(Smad4)

MCAL:

110284933(Smad4)

MPAH:

110333204(Smad4)

RNO:	50554(Smad4)

MCOC:

116087335(Smad4)

ANU:	117719590(Smad4)

ASYL:

127698144(Smad4)

MUN:	110550715(Smad4)

CGE:	100770737(Smad4)

MAUA:

101843946(Smad4)

PROB:

127234354(Smad4)

PLEU:

114690183(Smad4)

MORG:

121438756(Smad4)

MFOT:

126507371

AAMP:

119814141(Smad4)

NGI:	103726635(Smad4)

HGL:	101703764(Smad4)

CPOC:

100717853(Smad4)

CCAN:

109687032(Smad4)

DORD:

105987581(Smad4)

DSP:	122104309(Smad4)

DMER:

138831988(Smad4)

PLOP:

125364252(Smad4)

NCAR:

124965442

MMMA:

107139501(Smad4)

ITI:	101962278(Smad4)

OCU:

100342294

OPI:	101525575(SMAD4)

TUP:	102494008(SMAD4)

GVR:	103600109(SMAD4)

CFA:	476196(SMAD4)

CLUD:

112644105(SMAD4)

VVP:	112919269(SMAD4)

VLG:	121482063(SMAD4)

NPO:	129495555 129514601

AML:	100465063(SMAD4)

UMR:	103664305(SMAD4)

UAH:	113253422(SMAD4)

UAR:	123787394(SMAD4)

ELK:

111142438

LLV:

125082527

MPUF:

101675099(SMAD4)

MNP:	132023630(SMAD4)

MLK:	131810886(SMAD4)

NVS:	122902875(SMAD4)

ORO:	101374152(SMAD4)

EJU:	114204951(SMAD4)

ZCA:	113912422(SMAD4)

MLX:	118004627(SMAD4)

NSU:	110577109(SMAD4)

LWW:	102738394(SMAD4)

FCA:	101093650(SMAD4)

PYU:	121032920(SMAD4)

PCOO:

112868129(SMAD4)

PBG:	122470775(SMAD4)

PVIV:

125148629(SMAD4)

LRUF:

124516988

LGF:	123587753(SMAD4)

AJU:

106974966

PTG:	102961093(SMAD4)

PPAD:

109275709(SMAD4)

PUC:

125914595

PLEZ:

122204203(SMAD4)

HHV:	120229684(SMAD4)

BTA:	540248(SMAD4)

BOM:	102265995(SMAD4)

BIU:	109577834(SMAD4)

BBUB:

102390834(SMAD4)

BBIS:

104995794(SMAD4)

CHX:	100861019(SMAD4)

OAS:	443171(SMAD4)

BTAX:

128067298(SMAD4)

CSUM:

138097418(SMAD4)

ODA:	120880976(SMAD4)

CCAD:

122425381(SMAD4)

MREE:

136166473(SMAD4)

OVR:	110122209(SMAD4)

MBEZ:

129549854(SMAD4)

SSC:	397142(SMAD4)

CFR:	102507868(SMAD4)

CBAI:

105073943(SMAD4)

CDK:	105103392(SMAD4)

VPC:	102532183(SMAD4)

BACU:

103014916(SMAD4)

BMUS:

118906696(SMAD4)

LVE:	103084261(SMAD4)

OOR:	101285250(SMAD4)

LALB:

132504550(SMAD4)

GMF:	115859257(SMAD4)

DDP:	132436288(SMAD4)

DLE:	111180252(SMAD4)

PCAD:

102986517(SMAD4)

PSIU:

116764896(SMAD4)

PPHC:

136132427(SMAD4)

NASI:

112407459(SMAD4)

ECB:	100033846(SMAD4)

EPZ:	103558026(SMAD4)

EAI:	106834799(SMAD4)

MYB:	102259994(SMAD4)

MYD:	102752949(SMAD4)

MMYO:

118662909(SMAD4)

MLF:	102419263(SMAD4)

MDT:	132240023(SMAD4)

MYUM:

139014213(SMAD4)

PKL:	118707871(SMAD4)

EFUS:

103292171(SMAD4)

MNA:	107546640(SMAD4)

DRO:	112322994(SMAD4)

SHON:

118978766(SMAD4)

AJM:	119063626(SMAD4)

PDIC:

114506309(SMAD4)

PHAS:

123825966(SMAD4)

MMF:	118618177(SMAD4)

PPAM:

129078725(SMAD4)

HAI:	109373579(SMAD4)

RFQ:	117011826(SMAD4)

PALE:

102886521(SMAD4)

PGIG:

120585140(SMAD4)

PVP:	105292297(SMAD4)

RAY:	107512852(SMAD4)

MJV:	108394195(SMAD4)

TOD:	119243034(SMAD4)

SARA:

101552483(SMAD4)

SFUM:

130045257(SMAD4)

SETR:

126020077(SMAD4)

LAV:	100659509(SMAD4)

TMU:

101358763

ETF:	101648760(SMAD4)

DNM:	101427870(SMAD4)

MDO:	100010143(SMAD4)

GAS:	123237642(SMAD4) 123253784 123254358

SHR:	100923569(SMAD4)

AFZ:

127543493

PCW:	110198138(SMAD4)

TVP:	118831683 118853504(SMAD4)

PBRV:

138173929(SMAD4)

MLAO:

141501388(SMAD4)

OAA:	100077136(SMAD4)

TACU:

119925571(SMAD4)

GGA:	107055136(SMAD4)

CJO:	107306999(SMAD4) 107324374

TPAI:

128074252 128090580

LMUT:

125685915 125686513(SMAD4)

NMEL:

110387828 110391990

APLA:

101805274(SMAD4) 119713770

ACYG:

106037328(SMAD4) 125180227

CATA:

118254640(SMAD4) 118258600

AFUL:

116499524 116500438(SMAD4)

TGU:	115498449 116806878(SMAD4)

LSR:	110476847 110484326

SCAN:

103824828(SMAD4)

PMOA:

120501908 120513683(SMAD4)

OTC:	121335661 121343094(SMAD4)

PRUF:

121353526 121357722(SMAD4) 121361270

ATRC:

139585109 139589417(SMAD4) 139598969

GFR:	102041942 102043998(SMAD4)

PHI:	102111851 102113882(SMAD4)

PMAJ:

107198457(SMAD4) 107214624

CCW:	104686787(SMAD4)

CBRC:

103615654(SMAD4) 103619457

ACOE:

138098577 138102865 138103786(SMAD4)

ETL:	114068328 114072528 114073282

ZLE:	135457610 135460647 135460649(SMAD4)

ACHL:

103809398

SVG:	106865058(SMAD4)

MMEA:

130586878

HRT:	120764293 120764918(SMAD4)

SATI:

136373349(SMAD4)

CCIC:

134055316 134056882(SMAD4)

FPG:	101918184(SMAD4) 101924446

FCH:	102048236 102057734(SMAD4)

CCRI:

104162095(SMAD4)

NNT:	104407820(SMAD4)

SHAB:

115602493 115619208 115619810(SMAD4)

ACUN:

113490495(SMAD4)

TALA:

104366947(SMAD4) 116960559

ACHC:

115336664(SMAD4) 115345300

HALD:

104321621(SMAD4)

HLE:	104830562 104841392(SMAD4)

AGEN:

126035602 126041371

HHAR:

128136504(SMAD4) 128145962

GCL:

127027857

CSTI:

104563810(SMAD4)

LDI:	104346660(SMAD4)

MNB:	103771905(SMAD4)

DPUB:

104301016 104308024

PPUS:

135192620 135192885 135193250(SMAD4)

AVIT:

104274580(SMAD4)

BRHI:

104488808(SMAD4)

EGZ:	104134164(SMAD4)

NNI:	104010840(SMAD4) 104018277(SNAPIN)

PCRI:

104032665(SMAD4)

PCAO:

104040541(SMAD4)

PADL:

103916117(SMAD4)

AFOR:

103894433(SMAD4)

FGA:	104080776(SMAD4)

GSTE:

104261406(SMAD4)

CBOY:

140644102 140650446(SMAD4)

CLV:	102095020(SMAD4)

CNIC:

136000186 136001645(SMAD4)

PGUU:

104468430(SMAD4)

PLET:

104618928(SMAD4)

EHS:	104506900 104514591(SMAD4)

CMAC:

104487705(SMAD4)

CUCA:

104061405(SMAD4) 128850261

TEO:	104381283(SMAD4)

BREG:

104634282(SMAD4)

OHA:	104335570(SMAD4)

ACAR:

104517461(SMAD4)

CPEA:

104398386(SMAD4)

CVF:	104285280(SMAD4)

RTD:	128901164 128901941 128902351

CRID:

134508873(SMAD4) 134525821

AAM:	106494875(SMAD4)

AROW:

112973246 112978608(SMAD4)

NPD:	112947233(SMAD4)

TGT:	104565903 104575613(SMAD4)

DNE:	112994456(SMAD4)

SCAM:

104138484(SMAD4)

ASN:	102373921 102375399(SMAD4)

AMJ:	102572775 102576984(SMAD4)

GGN:	109301075(SMAD4)

PSS:	102451711(SMAD4)

CMY:	102945563(SMAD4) 114021305

CCAY:

125625862 125636758(SMAD4)

DCC:	119847714 119855666(SMAD4)

CPIC:

101944321 101946126(SMAD4)

TST:	117878789(SMAD4)

CABI:

116823287(SMAD4) 116832740

MRV:	120390408 120407854(SMAD4)

ACS:	100552093(smad4)

ASAO:

132766876(SMAD4)

PVT:	110088492 110088634(SMAD4)

SUND:

121921188(SMAD4)

PBI:	103061201(SMAD4)

PMUR:

107284129(SMAD4)

CTIG:

120296769(SMAD4)

TSR:	106556453(SMAD4)

PGUT:

117654711(SMAD4)

PCAE:

139313358(SMAD4)

APRI:

131192098(SMAD4)

PTEX:

113445700(SMAD4)

NSS:	113411346(SMAD4)

VKO:	123019736 123024015(SMAD4) 123032680

PMUA:

114586471 114606190(SMAD4)

PRAF:

128403693 128423578(SMAD4)

ZVI:	118076190 118077059(SMAD4)

HCG:	128337022 128343525(SMAD4)

GJA:	107110886 107122009(SMAD4)

STOW:

125436389(SMAD4) 125440182

EMC:	129334460(SMAD4) 129341987

XLA:	108700426(smad4.2.S) 108707339(smad4.S) 403356(smad4.2.L) 780764(smad4.L)

XTR:	100038088(smad4.1) 100188925(smad4.2)

NPR:	108790704(SMAD4) 108803114 108803625

RTEM:

120920394 120926812(SMAD4)

ACAT:

141116745 141131947(SMAD4)

BBUF:

120981775 120992204(SMAD4)

BGAR:

122921809 122924875(SMAD4)

DTC:	141048370(SMAD4) 141075881

PWL:	138268449 138279131(SMAD4)

MUO:	115462885 115462887(SMAD4)

GSH:	117355577 117355604

DRE:	100151181(smad10b) 559111(smad4a) 560317(smad10a) 794669(smad4b)

SRX:	107710400 107717798 107725139 107741365 107741768 107745035 107748055 107748351

SANH:

107659302 107665456 107668639 107672874 107681580 107689912 107698642 107704085

SGH:	107549232 107550085 107557579 107559658 107563920 107570722 107594567 107597968

CCAR:

109053851 109066417 109072940 109088112 109090805 109104067 109109954 109109961(smad4a)

CAUA:

113054765 113059136 113068262 113073748 113097398 113110084 113110142 113116616 113119205

CGIB:

127935660 127966326 127975090 127979320 128014843 128020899 128029996

PTET:

122333889(smad4a) 122345375(smad4) 122360660(smad10b)

LROH:

127165029(smad4b) 127171745(smad4a) 127178786(smad10b) 127181773(smad10a)

GRF:	141289289(smad10a) 141298848(smad4a) 141342351(smad10b)

OMC:	131521709(smad10b) 131525891(smad10a) 131540754(smad4b) 131547803(smad4a)

PPRM:

120478430(smad4a) 120484418(smad10b) 120485002(smad10a) 120489318(smad4)

RKG:	130069280(smad10b) 130075920(smad4a) 130087989(smad10a) 130088190(smad4b)

MAMB:

125243586(smad10b) 125262552(smad4a) 125266930(smad4) 125275164(smad10a)

CIDE:

127496713 127500561 127512124 127513285 127520369

CERY:

137028476(smad4a) 137033938(smad4b) 137034677(smad10b) 137037247(smad10a)

MASI:

127420708 127424840 127428145 127433081 127433821 127440027 127452762 127454639

TROS:

130546225(smad4a) 130557737(smad10b) 130565773(smad4b) 130567525(smad10a)

TDW:	130411666(smad4a) 130419746(smad4b) 130432596(smad10b)

MANU:

129439594(smad4b) 129446398(smad4a) 129448103(smad10b) 129454416(smad10a)

PDAB:

135727579(smad10b) 135732748(smad4b) 135745865(smad4a) 135782958(smad10a)

IPU:	108255640(smad4) 108267606(smad10b) 108273360(smad10a) 108277009(smad4a)

IFU:	128609803(smad10b) 128615975(smad10a) 128619991(smad4a) 128625675(smad4b)

PHYP:

113542418 113543707 113544828(smad4)

SMEO:

124380660(smad4) 124382125(smad10a) 124384364(smad10b) 124393756(smad4a)

TFD:	113637368(smad4) 113638482(smad4a) 113644556(smad10b) 113662831(smad10a)

TVC:	132842697(smad10a) 132845948(smad10b) 132854569(smad4b) 132863382(smad4a)

CGAR:

128509621(smad4b) 128515778(smad10a) 128520361(smad10b) 128545393(smad4a)

NGRA:

132870745(smad10a) 132872672(smad4b) 132873405(smad4a) 132886793(smad10b)

TRN:	134310771(smad10b) 134328405(smad10a) 134332094(smad4a)

AMEX:

103022359(smad10b) 103029394(smad4a) 103033551(smad10a) 103033599(smad4)

CMAO:

118805292(si:dkey-222b8.1) 118816927(si:dkey-239n17.4) 118825297(smad4a) 118827315(smad4)

EEE:	113567946 113571196 113573295(smad4) 113590440

CHAR:

105896117(smad10b) 105901183(smad4) 105906332(smad10a) 105911919(smad4a)

SPIL:

134071132(smad4a) 134073216(smad10a) 134082608(smad10b) 134088817(smad4b)

TRU:	101068039 101068466 101072080

TFS:	130517159(smad4a) 130518262(smad10a) 130525278

TNG:	GSTEN00004746G001 GSTEN00008799G001 GSTEN00017220G001

LCO:	104924734 104933066 104933118

NCC:	104941765 104949724(smad4) 104954188 104959345

TBEN:

117470654 117472912 117476375(smad4a) 117479211(si:dkey-222b8.1)

CGOB:

115013358(smad4) 115015442 115017230

PGEO:

117452470 117455129(smad10a) 117456314(smad4a)

GACU:

117534919 117538269(smad4a) 117540958(si:dkey-222b8.1) 117558648

EMAC:

134862737 134868858(smad4a) 134873487 134874679(smad10a)

ELY:	117252732 117263121(si:dkey-222b8.1) 117270121(smad4a)

EFO:	125889774 125904836(smad10a) 125905617(smad4a)

PLEP:

121939292 121944631 121957650(smad10a) 121959609(smad4a)

SLUC:

116034988(smad4a) 116035687(si:dkey-222b8.1) 116056835

ECRA:

117944210 117956380(si:dkey-222b8.1) 117959041(smad4a)

ESP:	116688903(smad4) 116702155 116704114

PFLV:

114555571 114568081 114570708

GAT:	120810129 120826726(smad10a) 120831378 120831605(smad4a)

PPUG:

119198112(smad10b) 119218763(smad10a) 119224476 119226199(smad4a)

AFB:	129097247(smad10a) 129101770 129101981(smad4a) 129110054

CLUM:

117736424 117738600(si:dkey-222b8.1) 117740108(smad4a)

PSWI:

130196919 130204974(smad4a) 130209106(smad10a)

CANA:

137780908 137784142(smad4a) 137784452(smad10a) 137805112

CVE:	137866882 137869074(smad4a) 137872524(smad10a)

MSAM:

119887885 119891427 119898232 119907298(smad10a) 119914352(smad4a)

SCHU:

122863799 122865489(smad4a) 122876696

CUD:	121509744 121513584(smad10b) 121523734(smad10a) 121523809 121524992(smad4a)

SPUL:

138602353(smad4a) 138606702 138606735 138608980(smad10a) 138609883

LMIX:

132974645 132983203 132991625(smad10a) 132992687(smad4a)

ALAT:

119006144 119017208(si:dkey-222b8.1) 119019615 119029646(smad4a)

ASTR:

137592687 137601204 137607416(smad10a) 137608084(smad4a)

MZE:	101467180 101481185 101485383 101485614

ONL:	100693833 100700558 100705094 100708381

OAU:	116322108(smad10a) 116322541(smad4a) 116327276 116336414

OLA:	101163504 101168872 101173916

OML:	112136177(smad4a) 112136593 112148176

CSAI:

133440520 133450568 133455223(smad4a)

XMA:	102225323 102228719 102232588

XCO:	114141666 114149415 114154836

XHE:	116717102 116724106 116729985

PRET:

103470200 103473773 103477474

PFOR:

103131176 103135398 103149412

PLAI:

106937460 106939239 106944326

PMEI:

106909302 106923107 106923514

GAF:	122819501(smad4a) 122828777 122830878

PPRL:

129351021 129366108 129366354(smad4a)

CVG:	107084459 107088450 107095262

CTUL:

119779423(smad4a) 119780946 119796787

GMU:	124865538 124872337(smad4a) 124878113

NFU:	107373891 107379013 107394046

KMR:	108228999 108234628 108247541(smad4a)

ALIM:

106511631 106513759 106514439 106535874

NWH:	119409772 119413929 119424621(smad4a)

AOCE:

111567984(smad4a) 111577007 111580941(smad10a) 111587893(smad10b)

EJA:	138191784 138212194(smad4a) 138214408(smad10a) 138214877

BFRE:

138621420 138629861(smad4a) 138630643(smad10a) 138633809

MCEP:

124996415(smad4a) 125012591 125015992

CSEM:

103390155 103394304 103397887

POV:	109626289 109641002 109642417 109643214

SSEN:

122769811 122786380(smad10a) 122787103(smad4a)

SSOE:

131445868(smad4a) 131447144(smad10a) 131463908

HHIP:

117767308 117771112(si:dkey-222b8.1) 117771484(smad4a) 117776628

HSP:	118114354 118115002 118124522(smad10a) 118125601(smad4a)

PPLT:

128424863(smad4a) 128438775(smad4b) 128448869 128461480(smad10a)

SMAU:

118284760(smad4a) 118285476 118310429(smad10a) 118314169

LCF:	108878621 108884647 108888967(smad4a) 108896340(smad10a)

SDU:	111230597 111230797 111234093 111237770

SLAL:

111644705 111645724 111664827 111669183

XGL:	120783821 120786932(smad10a) 120805209 120806078(smad4a)

HCQ:	109514211 109514703 109515154

SSCV:

125979642(smad4a) 125987164(smad10a) 125994639

SBIA:

133490404(smad4a) 133500011 133506176(smad10a)

PEE:	133395526(smad10a) 133399878 133414233(smad4a)

PTAO:

133471023(smad10a) 133475289 133489798(smad4a)

BPEC:

110156379 110157900 110160469

ENY:	140346913 140366872(smad4a) 140374136

MALB:

109961575 109970820 109970860 109974571

BSPL:

114842818 114862819 114865467(smad10a) 114866478(smad4a)

SJO:	128364810 128367045 128373630(smad10a) 128379807(smad4a)

SSCO:

133979013 133983091 133994885(smad4a) 133996998(smad10a)

GMH:	115545114 115545596(smad4)

SASA:

100195274(smad4) 106563948 106568180 106569881 106580167 106585826(smad4) 106588319 106605446(SMAD4)

STRU:

115149222 115159360 115164984(smad4) 115173628 115175837 115176558 115180008 115199711

OTW:	112219493(smad4a) 112222845 112228561 112229740 112248311 112257537 112263427 112264720

OMY:	101268920 101268921 110488280 110496821 110503878 110523770 110525240(smad4) 110537152

OGO:	123997833 123999105 124005023 124013125 124034657(smad4) 124035966 124043467 124048761(smad4a)

ONE:	115102988 115111251(smad4) 115125499 115128452 115131545 115139688

OKI:	109867936 109875136(smad4) 109875810 109892493 109895591 109901938 109907933 109908449

OKE:	118367687 118387716(smad4a) 118391427 118392860(smad4b) 118398110 118399390(smad10a)

OMM:	135514430(smad4b) 135517796(smad4a) 135520330 135522164 135548307 135549898 135552147(smad10a)

OCLA:

139373517 139391756 139392296 139408781 139410605 139422869 139424632

SALP:

111954979 111957685 111961433 111980997

SNH:	120022602 120025700 120027415 120031528 120043826(smad4) 120045007 120048474

CCLU:

121570091 121571774 121572434 121573846 121582175 121584382(smad4)

ELS:	105012677 105014576(smad4) 105025164 105031060

OEP:	134015432(smad4b) 134023136 134033514(smad4a) 134040774

SFM:	108938097(smad4) 108941913 108942527

PKI:	111838434 111856532(smad4)

AANG:

118206576(smad4) 118212702 118233022(si:dkey-222b8.1) 118236698(si:dkey-239n17.4)

AROT:

135233589(smad4b) 135239586 135260402(smad10a) 135264315(smad10b)

CCOG:

133123022(smad10b) 133136876(smad10a) 133140146 133141884

LOC:	102684763 102696431(smad4)

PSPA:

121304289 121317857

ARUT:

117395592 117409333 117421209 117962470 117968709

PSEX:

120527232(smad4) 120538179(smad10a)

LCM:	102353847(SMAD4) 102358988

CMK:

103187334

RTP:	109911226 109928938

CPLA:

122544738(smad10a) 122564931(smad4)

HOC:	132805608(smad10a) 132832430(smad4b)

LERI:

129712660(smad4b)

HAKA:

140735720(smad10a) 140737615(smad4b)

PMRN:

116942223 116950786

LRJ:	133343877 133354255

BFO:

118412430

BBEL:

109468770

CIN:	778905(smad4)

SCLV:

120347761

SPU:	115918267 575230

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG1775(Med)

DER:

6554734

DSE:

6619505

DSI:	Dsimw501_GD21590(Dsim_GD21590)

DYA:	Dyak_GE10952

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23400

DAZ:

108610346

DNV:

108654126

DHE:

111594485

DVI:	6629746(Med)

CCAT:

101448903

BOD:

106617405

BDR:

105231514

RZE:	108364279 108369592

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135961386(Med)

GFS:

119639409

ECOE:

129939569

CLON:

129616134

HIS:	119656494 119656495

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002562 CpipJ_CPIJ002563

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108722565(Med)

CCOA:

108782811

PBAR:

105424697

VEM:

105568407

COBS:

139108575(Med)

TLN:	139809708(Med)

HST:

105185083

DQU:	106746140 106750394

CFO:

105249584

FEX:

115234205

PMEC:

138937595(Med)

LHU:	105675683(Med)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100677849 103315855

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141525275(Med)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124221563(Med)

NFB:

NLO:

NVG:

AROA:

TCA:	660074(Med)

TMOL:

138140342(Med)

DPA:	109537984 109540540

ESIM:

136409676 136413804

EFOR:

136339809 136347081

SOY:	115875015 115885332

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:	114336235 126878423

NVL:

DCOR:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207335

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137920158(Med)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110383006(med)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141438922(Med)

CFEL:

113384506 113387054

CCRN:

123302614

API:	100158948 100162614 100164543 100167677

DNX:

107162437

AGS:

114127172

RMD:	113551348 113554935

DVT:

126906999

BTAB:

109035933 109036001 109041855

DCI:

103509341

CLEC:

106661881

HHAL:

106677672 106677843 106677844

NLU:

111051884

HVI:

124353192

MQU:

128982570

PHU:	Phum_PHUM002670

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138697607(Med)

SGRE:

126268083

BROR:

134535773

IEL:

124163378

HAMR:

139696573 139696576(Med)

FCD:

110848123

DPX:	DAPPUDRAFT_304115

DMK:

116922575

DPZ:

124340948

AFRA:

136040849

PVM:	113805492(Med)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123758267(Med)

CQD:	128687072(Med)

PTRU:

123501138

ESN:

126986385

MNZ:

135217868

MRJ:	136836916(Med)

PORN:

139751839(Med)

HAZT:

108677922

EAF:	111707971 111710317

LSM:	121121479(Med)

TCF:	131878123 131881380

PPOI:

119089845 119089846 119111147

ISC:

DSV:

RSAN:

RMP:

VDE:	111243399 111247107

VJA:	111267180 111269026

GOE:	100898583 100903134

TUT:

DPTE:

DFR:

CSCU:

CVS:	136978721(Med)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

129590039 129598555 129598829

CEL:	CELE_F25E2.5(daf-3) CELE_R12B2.1(sma-4)

CBR:	CBG_08108(Cbr-daf-3) CBG_09090(Cbr-sma-4)

CRQ:	GCK72_010632

NAI:	NECAME_01081 NECAME_09559

BMY:	BM_BM3575(Bma-daf-3) BM_BM5359(Bma-sma-4)

LOA:	LOAG_05337 LOAG_08923

TSP:

Tsp_07524

HRO:	HELRODRAFT_76435 HELRODRAFT_88197

LGI:	LOTGIDRAFT_131078

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106169999 106170001

SMM:	Smp_033950.1

OVI:	T265_11013

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:	107357814(AdiSmad4)

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_30731

AQU:	100637596 100640097

» show all

Reference

PMID:8553070

Authors

Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE

Title

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.

Journal

Science 271:350-3 (1996)
DOI:10.1126/science.271.5247.350

Sequence

[hsa:4089]

All links

Ontology (1)   
   GO (1)   
Gene (3160)   
   MGENES (1065)   
   RefGene (2091)   
   OC (4)   
All databases (3161)   

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