KEGG   ORTHOLOGY: K04501
Entry
K04501                      KO                                     

Name
SMAD4
Definition
mothers against decapentaplegic homolog 4
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04310  Wnt signaling pathway
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00533  Hereditary hemorrhagic telangiectasia
H01023  Juvenile polyposis syndrome
H02102  Myhre syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04371 Apelin signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05225 Hepatocellular carcinoma
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05226 Gastric cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04501  SMAD4; mothers against decapentaplegic homolog 4
Other DBs
GO: 0070412
Genes
HSA: 4089(SMAD4)
PTR: 468537(SMAD4)
PPS: 100991127(SMAD4)
GGO: 101153595(SMAD4)
PON: 100439171(SMAD4)
NLE: 100599586(SMAD4)
MCC: 701803(SMAD4)
MCF: 102142438(SMAD4)
CSAB: 103222414(SMAD4)
RRO: 104672916(SMAD4)
RBB: 108533135(SMAD4)
CJC: 100409302(SMAD4)
SBQ: 101032066(SMAD4)
MMU: 17128(Smad4)
MCAL: 110284933(Smad4)
MPAH: 110333204(Smad4)
RNO: 50554(Smad4)
MUN: 110550715(Smad4)
CGE: 100770737(Smad4)
NGI: 103726635(Smad4)
HGL: 101703764(Smad4)
CCAN: 109687032(Smad4)
OCU: 100342294(SMAD4)
TUP: 102494008(SMAD4)
CFA: 476196(SMAD4)
VVP: 112919269(SMAD4)
AML: 100465063(SMAD4)
UMR: 103664305(SMAD4)
UAH: 113253422(SMAD4)
ORO: 101374152(SMAD4)
ELK: 111142438
FCA: 101093650(SMAD4)
PTG: 102961093(SMAD4)
PPAD: 109275709(SMAD4)
AJU: 106974966(SMAD4)
BTA: 540248(SMAD4)
BOM: 102265995(SMAD4)
BIU: 109577834(SMAD4)
BBUB: 102390834(SMAD4)
CHX: 100861019(SMAD4)
OAS: 443171(SMAD4)
SSC: 397142(SMAD4)
CFR: 102507868(SMAD4)
CDK: 105103392(SMAD4)
BACU: 103014916(SMAD4)
LVE: 103084261(SMAD4)
OOR: 101285250(SMAD4)
DLE: 111180252(SMAD4)
PCAD: 102986517(SMAD4)
ECB: 100033846(SMAD4)
EPZ: 103558026(SMAD4)
EAI: 106834799(SMAD4)
MYB: 102259994(SMAD4)
MYD: 102752949(SMAD4)
MNA: 107546640(SMAD4)
HAI: 109373579(SMAD4)
DRO: 112322994(SMAD4)
PALE: 102886521(SMAD4)
RAY: 107512852(SMAD4)
MJV: 108394195(SMAD4)
LAV: 100659509(SMAD4)
TMU: 101358763
MDO: 100010143(SMAD4)
SHR: 100923569(SMAD4)
PCW: 110198138(SMAD4)
OAA: 100077136(SMAD4)
GGA: 107055136(SMAD4)
CJO: 107306999(SMAD4) 107324374
NMEL: 110387828 110391990
APLA: 101805274(SMAD4)
ACYG: 106037328(SMAD4)
TGU: 115498449 116806878(SMAD4)
LSR: 110476847 110484326
SCAN: 103824828(SMAD4)
GFR: 102041942 102043998(SMAD4)
PHI: 102111851 102113882(SMAD4)
PMAJ: 107198457(SMAD4) 107214624
CCW: 104686787(SMAD4)
ETL: 114068328 114072528 114073282
FPG: 101918184(SMAD4) 101924446
FCH: 102048236 102057734(SMAD4)
CLV: 102095020(SMAD4)
EGZ: 104134164(SMAD4)
NNI: 104010840(SMAD4) 104018277(SNAPIN)
ACUN: 113490495(SMAD4)
PADL: 103916117(SMAD4)
AAM: 106494875(SMAD4)
ASN: 102373921 102375399(SMAD4)
AMJ: 102572775 102576984(SMAD4)
PSS: 102451711(SMAD4)
CMY: 102945563(SMAD4) 114021305
CPIC: 101944321 101946126(SMAD4)
ACS: 100552093(smad4)
PVT: 110088492 110088634(SMAD4)
PBI: 103061201(SMAD4)
PMUR: 107284129(SMAD4)
TSR: 106556453(SMAD4)
PMUA: 114586471 114606190(SMAD4)
GJA: 107110886 107122009(SMAD4)
XLA: 108700426 108707339 403356(smad4.2.L) 403398(smad4.2.S) 779167 780764(smad4.1.L)
XTR: 100038088(smad4.1) 100188925(smad4.2)
NPR: 108790704(SMAD4) 108803114 108803625
DRE: 100151181(si:dkey-239n17.4) 559111(smad4a) 560317(smad10a) 794669(gb:cr929477)
SRX: 107710400 107717798 107725139 107741365 107741768 107745035 107748055 107748351
SANH: 107659302 107665456 107668639 107672874 107681580 107689912 107698642 107704085
SGH: 107549232 107550085 107557579 107559658 107563920 107570722 107594567 107597968
CCAR: 109053851 109066417 109088112 109090805 109095423 109109954
IPU: 108255640 108267606 108273360 108277009(smad4)
PHYP: 113542418 113543707 113544828(smad4)
AMEX: 103022359 103029394 103033551 103033599(smad4)
EEE: 113567946 113571196 113573295(smad4) 113590440
TRU: 101068039 101068466 101072080
TNG: GSTEN00004746G001 GSTEN00008799G001 GSTEN00017220G001
LCO: 104924734 104933066 104933118
NCC: 104941765 104949724(smad4) 104954188 104959345
MZE: 101467180 101481185 101485383 101485614
ONL: 100693833 100700558 100705094 100708381
OLA: 101163504 101168872 101173916
XMA: 102225323 102228719 102232588
XCO: 114141666 114149415 114154836
PRET: 103470200 103473773 103477474
CVG: 107084459 107088450 107095262
NFU: 107373891 107379013 107394046
KMR: 108228999 108234628 108247541(smad4a)
ALIM: 106511631 106513759 106514439 106535874
AOCE: 111567984 111577007 111580941 111587893
CSEM: 103390155 103394304 103397887
POV: 109626289 109641002 109642417 109643214
LCF: 108878621 108884647 108888967 108896340
SDU: 111230597 111230797 111234093 111237770
SLAL: 111644705 111645724 111664827 111669183
HCQ: 109514211 109514703 109515154
BPEC: 110156379 110157900 110160469
MALB: 109961575 109970820 109970860 109974571
SASA: 100195274(smad4) 106563948 106568180 106569881 106580167 106585826(smad4) 106588319 106605446(SMAD4)
OTW: 112219493 112222845 112228561 112229740 112232409 112248311(smad4) 112257537 112263427 112264720
SALP: 111954979 111957685 111961433 111980997
ELS: 105012677 105014576(smad4) 105025164 105031060
SFM: 108938097(smad4) 108941913 108942527
PKI: 111838434 111856532(smad4)
LCM: 102353847(SMAD4) 102358988
CMK: 103187334(smad4)
RTP: 109911226(smad4) 109922540 109928938
BFO: 118412430
CIN: 778905(smad4)
SPU: 115918267 575230
APLC: 110974480
SKO: 100369846
DME: Dmel_CG1775(Med)
DER: 6554734
DSE: 6619505
DSI: Dsimw501_GD21590(Dsim_GD21590)
DYA: Dyak_GE10952
DAN: 6505622
DSR: 110186250
DPO: Dpse_GA14643
DPE: 6588525
DMN: 108156482
DWI: 6647945
DGR: Dgri_GH18642
DMO: Dmoj_GI23400
DAZ: 108610346
DNV: 108654126
DHE: 111594485
DVI: 6629746
MDE: 101896100
LCQ: 111682411
AGA: AgaP_AGAP002902
AAG: 5578896
AALB: 109414141 109417340
CQU: CpipJ_CPIJ002562 CpipJ_CPIJ002563
AME: 409321
BIM: 100745462
BTER: 100644192
CCAL: 108630884
OBB: 114875096
SOC: 105196014
MPHA: 105831004
AEC: 105151202
ACEP: 105625203
PBAR: 105424697
VEM: 105568407
HST: 105185083
DQU: 106746140 106750394
CFO: 105249584
LHU: 105675683
PGC: 109853770
OBO: 105276105
PCF: 106784432
NVI: 100677849 103315855
CSOL: 105362107
MDL: 103571057
TCA: 660074(Med)
DPA: 109537984 109540540
ATD: 109598093
NVL: 108564214
BMOR: 101745398
BMAN: 114239402
DPL: KGM_207335
PMAC: 106721123
PRAP: 110994482
HAW: 110383006
TNL: 113499255
PXY: 105390488
API: 100158948 100162614 100164543 100167677
DNX: 107162437
AGS: 114127172
RMD: 113551348 113554935
BTAB: 109035933 109036001 109041855
CLEC: 106661881
PHU: Phum_PHUM002670
ZNE: 110836883
FCD: 110848123
DPX: DAPPUDRAFT_304115
PVM: 113805492
ISC: IscW_ISCW018468
TUT: 107363666
DPTE: 113789239
CSCU: 111630983
PTEP: 107442576
CEL: CELE_F25E2.5(daf-3) CELE_R12B2.1(sma-4)
CBR: CBG08108(Cbr-daf-3) CBG09090(Cbr-sma-4)
BMY: Bm1_00340 Bm1_17920 Bm1_38760
LOA: LOAG_05337 LOAG_08923
NAI: NECAME_01081 NECAME_09559
TSP: Tsp_07524
HRO: HELRODRAFT_76435 HELRODRAFT_88197
LGI: LOTGIDRAFT_131078
PCAN: 112556742
CRG: 105331371
MYI: 110466964
OBI: 106876392
LAK: 106169999 106170001
SMM: Smp_033950.1
SHX: MS3_10165
OVI: T265_11013
EGL: EGR_08649
NVE: 5502276
EPA: 110239172
ADF: 107335512 107357814(AdiSmad4)
AMIL: 114958820
PDAM: 113670804
SPIS: 111341478
DGT: 114525393
HMG: 100198878 100199160
TAD: TRIADDRAFT_30731
AQU: 100637596 100640097
 » show all
Reference
PMID:8553070
  Authors
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE
  Title
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
  Journal
Science 271:350-3 (1996)
DOI:10.1126/science.271.5247.350
  Sequence
[hsa:4089]

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Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (36)   
   KEGG PATHWAY (36)   
Disease (5)   
   KEGG DISEASE (5)   
Gene (3848)   
   KEGG GENES (420)   
   KEGG MGENES (1333)   
   RefGene (2091)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (3892)   

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