KEGG ORTHOLOGY: K04501

ORTHOLOGY: K04501

Entry

K04501                      KO

Symbol

SMAD4

Name

mothers against decapentaplegic homolog 4

Pathway

map04068

FoxO signaling pathway

map04110

Cell cycle

map04310

Wnt signaling pathway

map04350

TGF-beta signaling pathway

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04520

Adherens junction

map04550

Signaling pathways regulating pluripotency of stem cells

map04659

Th17 cell differentiation

map04933

AGE-RAGE signaling pathway in diabetic complications

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05220

Chronic myeloid leukemia

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Disease

H00019

Pancreatic cancer

H00020

Colorectal cancer

H00533

Hereditary hemorrhagic telangiectasia

H01023

Juvenile polyposis syndrome

H02102

Myhre syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04371 Apelin signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04501  SMAD4; mothers against decapentaplegic homolog 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05225 Hepatocellular carcinoma
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05226 Gastric cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04501  SMAD4; mothers against decapentaplegic homolog 4

Other DBs

GO:

0070412

Genes

HSA:	4089(SMAD4)

PTR:	468537(SMAD4)

PPS:	100991127(SMAD4)

GGO:	101153595(SMAD4)

PON:	100439171(SMAD4)

NLE:	100599586(SMAD4)

HMH:	116468535(SMAD4)

MCC:	701803(SMAD4)

MCF:	102142438(SMAD4)

MTHB:

126941313

MNI:	105489417(SMAD4)

CSAB:

103222414(SMAD4)

CATY:

105592487(SMAD4)

PANU:

101019266(SMAD4)

TGE:	112611379(SMAD4)

MLEU:

105531177(SMAD4)

RRO:	104672916(SMAD4)

RBB:	108533135(SMAD4)

TFN:	117063892(SMAD4)

PTEH:

111539654(SMAD4)

CANG:

105502346(SMAD4)

CJC:	100409302(SMAD4)

SBQ:	101032066(SMAD4)

CIMI:

108305081(SMAD4)

CSYR:

103257913(SMAD4)

MMUR:

105874233(SMAD4)

LCAT:

123621953(SMAD4)

PCOQ:

105816381(SMAD4)

OGA:	100955502(SMAD4)

MMU:	17128(Smad4)

MCAL:

110284933(Smad4)

MPAH:

110333204(Smad4)

RNO:	50554(Smad4)

MCOC:

116087335(Smad4)

ANU:	117719590(Smad4)

MUN:	110550715(Smad4)

CGE:	100770737(Smad4)

MAUA:

101843946(Smad4)

PROB:

127234354(Smad4)

PLEU:

114690183(Smad4)

MORG:

121438756(Smad4)

MFOT:

126507371

AAMP:

119814141(Smad4)

NGI:	103726635(Smad4)

HGL:	101703764(Smad4)

CPOC:

100717853(Smad4)

CCAN:

109687032(Smad4)

DORD:

105987581(Smad4)

DSP:	122104309(Smad4)

NCAR:

124965442

OCU:

100342294

OPI:	101525575(SMAD4)

TUP:	102494008(SMAD4)

GVR:	103600109(SMAD4)

CFA:	476196(SMAD4)

CLUD:

112644105(SMAD4)

VVP:	112919269(SMAD4)

VLG:	121482063(SMAD4)

AML:	100465063(SMAD4)

UMR:	103664305(SMAD4)

UAH:	113253422(SMAD4)

UAR:	123787394(SMAD4)

ELK:

111142438

LLV:

125082527

MPUF:

101675099(SMAD4)

NVS:	122902875(SMAD4)

ORO:	101374152(SMAD4)

EJU:	114204951(SMAD4)

ZCA:	113912422(SMAD4)

MLX:	118004627(SMAD4)

NSU:	110577109(SMAD4)

LWW:	102738394(SMAD4)

FCA:	101093650(SMAD4)

PYU:	121032920(SMAD4)

PBG:	122470775(SMAD4)

LRUF:

124516988

PTG:	102961093(SMAD4)

PPAD:

109275709(SMAD4)

PUC:

125914595

AJU:	106974966(SMAD4)

HHV:	120229684(SMAD4)

BTA:	540248(SMAD4)

BOM:	102265995(SMAD4)

BIU:	109577834(SMAD4)

BBUB:

102390834(SMAD4)

BBIS:

104995794(SMAD4)

CHX:	100861019(SMAD4)

OAS:	443171(SMAD4)

ODA:	120880976(SMAD4)

CCAD:

122425381(SMAD4)

SSC:	397142(SMAD4)

CFR:	102507868(SMAD4)

CBAI:

105073943(SMAD4)

CDK:	105103392(SMAD4)

VPC:	102532183(SMAD4)

BACU:

103014916(SMAD4)

LVE:	103084261(SMAD4)

OOR:	101285250(SMAD4)

DLE:	111180252(SMAD4)

PCAD:

102986517(SMAD4)

PSIU:

116764896(SMAD4)

NASI:

112407459(SMAD4)

ECB:	100033846(SMAD4)

EPZ:	103558026(SMAD4)

EAI:	106834799(SMAD4)

MYB:	102259994(SMAD4)

MYD:	102752949(SMAD4)

MMYO:

118662909(SMAD4)

MLF:	102419263(SMAD4)

MNA:	107546640(SMAD4)

PKL:	118707871(SMAD4)

HAI:	109373579(SMAD4)

DRO:	112322994(SMAD4)

SHON:

118978766(SMAD4)

AJM:	119063626(SMAD4)

PDIC:

114506309(SMAD4)

PHAS:

123825966(SMAD4)

MMF:	118618177(SMAD4)

RFQ:	117011826(SMAD4)

PALE:

102886521(SMAD4)

PGIG:

120585140(SMAD4)

PVP:	105292297(SMAD4)

RAY:	107512852(SMAD4)

MJV:	108394195(SMAD4)

TOD:	119243034(SMAD4)

SARA:

101552483(SMAD4)

LAV:	100659509(SMAD4)

TMU:

101358763

ETF:	101648760(SMAD4)

DNM:	101427870(SMAD4)

MDO:	100010143(SMAD4)

GAS:	123237642(SMAD4) 123253784 123254358

SHR:	100923569(SMAD4)

AFZ:

127543493

PCW:	110198138(SMAD4)

OAA:	100077136(SMAD4)

GGA:	107055136(SMAD4)

CJO:	107306999(SMAD4) 107324374

NMEL:

110387828 110391990

APLA:

101805274(SMAD4)

ACYG:

106037328(SMAD4) 125180227

AFUL:

116499524 116500438(SMAD4)

TGU:	115498449 116806878(SMAD4)

LSR:	110476847 110484326

SCAN:

103824828(SMAD4)

PMOA:

120501908 120513683(SMAD4)

OTC:	121335661 121343094(SMAD4)

PRUF:

121353526 121357722(SMAD4) 121361270

GFR:	102041942 102043998(SMAD4)

PHI:	102111851 102113882(SMAD4)

PMAJ:

107198457(SMAD4) 107214624

CCW:	104686787(SMAD4)

CBRC:

103615654(SMAD4) 103619457

ETL:	114068328 114072528 114073282

ACHL:

103809398

SVG:	106865058(SMAD4)

FPG:	101918184(SMAD4) 101924446

FCH:	102048236 102057734(SMAD4)

CLV:	102095020(SMAD4)

EGZ:	104134164(SMAD4)

NNI:	104010840(SMAD4) 104018277(SNAPIN)

PLET:

104618928(SMAD4)

PCRI:

104032665(SMAD4)

PCAO:

104040541(SMAD4)

ACUN:

113490495(SMAD4)

TALA:

104366947(SMAD4) 116960559

PADL:

103916117(SMAD4)

AFOR:

103894433(SMAD4)

ACHC:

115336664(SMAD4) 115345300

HALD:

104321621(SMAD4)

HLE:	104830562 104841392(SMAD4)

AGEN:

126035602 126041371

GCL:

127027857

CCRI:

104162095(SMAD4)

CSTI:

104563810(SMAD4)

EHS:	104506900 104514591(SMAD4)

CMAC:

104487705(SMAD4)

FGA:	104080776(SMAD4)

GSTE:

104261406(SMAD4)

LDI:	104346660(SMAD4)

MNB:	103771905(SMAD4)

OHA:	104335570(SMAD4)

NNT:	104407820(SMAD4)

SHAB:

115602493 115619208 115619810(SMAD4)

DPUB:

104301016 104308024

PGUU:

104468430(SMAD4)

ACAR:

104517461(SMAD4)

CPEA:

104398386(SMAD4)

AVIT:

104274580(SMAD4)

CVF:	104285280(SMAD4)

CUCA:

104061405(SMAD4)

TEO:	104381283(SMAD4)

BRHI:

104488808(SMAD4)

AAM:	106494875(SMAD4)

AROW:

112973246 112978608(SMAD4)

NPD:	112947233(SMAD4)

TGT:	104565903 104575613(SMAD4)

DNE:	112994456(SMAD4)

SCAM:

104138484(SMAD4)

ASN:	102373921 102375399(SMAD4)

AMJ:	102572775 102576984(SMAD4)

GGN:	109301075(SMAD4)

PSS:	102451711(SMAD4)

CMY:	102945563(SMAD4) 114021305

CPIC:

101944321 101946126(SMAD4)

TST:	117878789(SMAD4)

CABI:

116823287(SMAD4) 116832740

MRV:	120390408 120407854(SMAD4)

ACS:	100552093(smad4)

PVT:	110088492 110088634(SMAD4)

SUND:

121921188(SMAD4)

PBI:	103061201(SMAD4)

PMUR:

107284129(SMAD4)

CTIG:

120296769(SMAD4)

TSR:	106556453(SMAD4)

PGUT:

117654711(SMAD4)

VKO:	123019736 123024015(SMAD4) 123032680

PMUA:

114586471 114606190(SMAD4)

ZVI:	118076190 118077059(SMAD4)

GJA:	107110886 107122009(SMAD4)

STOW:

125436389(SMAD4) 125440182

XLA:	108700426(smad4.2.S) 108707339(smad4.S) 403356(smad4.2.L) 780764(smad4.L)

XTR:	100038088(smad4.1) 100188925(smad4.2)

NPR:	108790704(SMAD4) 108803114 108803625

RTEM:

120920394 120926812(SMAD4)

BBUF:

120981775 120992204(SMAD4)

BGAR:

122921809 122924875(SMAD4)

DRE:	100151181(si:dkey-239n17.4) 559111(smad4a) 560317(smad10a) 794669(gb:cr929477)

SRX:	107710400 107717798 107725139 107741365 107741768 107745035 107748055 107748351

SANH:

107659302 107665456 107668639 107672874 107681580 107689912 107698642 107704085

SGH:	107549232 107550085 107557579 107559658 107563920 107570722 107594567 107597968

CCAR:

109053851 109066417 109088112 109090805 109095423 109109954

CAUA:

113054765 113059136 113068262 113073748 113097398 113110084 113110142 113116616 113119205

CGIB:

127935660 127966326 127975090 127979320 128014843 128020899 128029996

PPRM:

120478430(smad4a) 120484418(smad10b) 120485002(smad10a) 120489318(smad4)

MAMB:

125243586(smad10b) 125262552(smad4a) 125266930(smad4) 125275164(smad10a)

CIDE:

127496713 127500561 127512124 127513285 127520369

MASI:

127420708 127424840 127428145 127433081 127433821 127440027 127452762 127454639

IPU:	108255640(smad4) 108267606(smad10b) 108273360(smad10a) 108277009(smad4a)

PHYP:

113542418 113543707 113544828(smad4)

SMEO:

124380660(smad4) 124382125(smad10a) 124384364(smad10b) 124393756(smad4a)

TFD:	113637368(smad4) 113638482(smad4a) 113644556(smad10b) 113662831(smad10a)

AMEX:

103022359 103029394 103033551 103033599(smad4)

EEE:	113567946 113571196 113573295(smad4) 113590440

TRU:	101068039 101068466 101072080

TNG:	GSTEN00004746G001 GSTEN00008799G001 GSTEN00017220G001

LCO:	104924734 104933066 104933118

NCC:	104941765 104949724(smad4) 104954188 104959345

CGOB:

115013358(smad4) 115015442 115017230

ELY:	117252732 117263121(si:dkey-222b8.1) 117270121(smad4a)

EFO:	125889774 125904836(smad10a) 125905617(smad4a)

PLEP:

121939292 121944631 121957650(smad10a) 121959609(smad4a)

SLUC:

116034988(smad4a) 116035687(si:dkey-222b8.1) 116056835

ECRA:

117944210 117956380(si:dkey-222b8.1) 117959041(smad4a)

ESP:	116688903(smad4) 116702155 116704114

PFLV:

114555571 114568081 114570708

GAT:	120810129 120826726(smad10a) 120831378 120831605(smad4a)

PPUG:

119198112 119218763(si:dkey-222b8.1) 119224476 119226199(smad4a)

MSAM:

119887885 119891427 119898232 119907298(smad10a) 119914352(smad4a)

CUD:	121509744 121513584(smad10b) 121523734(smad10a) 121524992(smad4a)

ALAT:

119006144 119017208(si:dkey-222b8.1) 119019615 119029646(smad4a)

MZE:	101467180 101481185 101485383 101485614

ONL:	100693833 100700558 100705094 100708381

OAU:	116322108(smad10a) 116322541(smad4a) 116327276 116336414

OLA:	101163504 101168872 101173916

OML:	112136177(smad4a) 112136593 112148176

XMA:	102225323 102228719 102232588

XCO:	114141666 114149415 114154836

XHE:	116717102 116724106 116729985

PRET:

103470200 103473773 103477474

PFOR:

103131176 103135398 103149412

PLAI:

106937460 106939239 106944326

PMEI:

106909302 106923107 106923514

GAF:	122819501(smad4a) 122828777 122830878

CVG:	107084459 107088450 107095262

CTUL:

119779423(smad4a) 119780946 119796787

GMU:	124865538 124872337(smad4a) 124878113

NFU:	107373891 107379013 107394046

KMR:	108228999 108234628 108247541(smad4a)

ALIM:

106511631 106513759 106514439 106535874

NWH:	119409772 119413929 119424621(smad4a)

AOCE:

111567984 111577007 111580941 111587893

MCEP:

124996415(smad4a) 125012591 125015992

CSEM:

103390155 103394304 103397887

POV:	109626289 109641002 109642417 109643214

SSEN:

122769811 122786380(smad10a) 122787103(smad4a)

HHIP:

117767308 117771112(si:dkey-222b8.1) 117771484(smad4a) 117776628

HSP:	118114354 118115002 118124522(smad10a) 118125601(smad4a)

LCF:	108878621 108884647 108888967(smad4a) 108896340(smad10a)

SDU:	111230597 111230797 111234093 111237770

SLAL:

111644705 111645724 111664827 111669183

XGL:	120783821 120786932(smad10a) 120805209 120806078(smad4a)

HCQ:	109514211 109514703 109515154

SSCV:

125979642 125987164 125994639

BPEC:

110156379 110157900 110160469

MALB:

109961575 109970820 109970860 109974571

BSPL:

114842818 114862819 114865467(smad10a) 114866478(smad4a)

SASA:

100195274(smad4) 106563948 106568180 106569881 106580167 106585826(smad4) 106588319 106605446(SMAD4)

STRU:

115149222 115159360 115164984(smad4) 115173628 115175837 115176558 115180008 115199711

OTW:	112219493(smad4a) 112222845 112228561 112229740 112248311 112257537 112263427 112264720

OMY:	101268920 101268921 110488280 110496821 110503878 110523770 110525240(smad4) 110537152

OGO:	123997833 123999105 124005023 124013125 124034657(smad4) 124035966 124043467 124048761(smad4a)

ONE:	115102988 115111251(smad4) 115125499 115128452 115131545 115139688

SALP:

111954979 111957685 111961433 111980997

SNH:	120022602 120025700 120027415 120031528 120043826(smad4) 120045007 120048474

CCLU:

121570091 121571774 121572434 121573846 121582175 121584382(smad4)

ELS:	105012677 105014576(smad4) 105025164 105031060

SFM:	108938097(smad4) 108941913 108942527

PKI:	111838434 111856532(smad4)

AANG:

118206576(smad4) 118212702 118233022(si:dkey-222b8.1) 118236698(si:dkey-239n17.4)

LOC:	102684763 102696431(smad4)

PSPA:

121304289 121317857

ARUT:

117395592 117409333 117421209 117962470 117968709

PSEX:

120527232(smad4) 120538179(smad10a)

LCM:	102353847(SMAD4) 102358988

CMK:

103187334

RTP:	109911226(smad4) 109922540 109928938

CPLA:

122544738(smad10a) 122564931(smad4)

BFO:

118412430

BBEL:

109468770

CIN:	778905(smad4)

SCLV:

120347761

SPU:	115918267 575230

APLC:

110974480

AJC:

117110721

SKO:

100369846

DME:	Dmel_CG1775(Med)

DER:

6554734

DSE:

6619505

DSI:	Dsimw501_GD21590(Dsim_GD21590)

DYA:	Dyak_GE10952

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23400

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:	108364279 108369592

MDE:

SCAC:

LCQ:

LSQ:

HIS:	119656494 119656495

AGA:	AgaP_AGAP002902

ACOZ:

AARA:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ002562 CpipJ_CPIJ002563

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:	106746140 106750394

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:	100677849 103315855

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

LHT:

CCIN:

TCA:	660074(Med)

DPA:	109537984 109540540

SOY:	115875015 115885332

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207335

BANY:

NIQ:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

API:	100158948 100162614 100164543 100167677

DNX:

107162437

AGS:

114127172

RMD:	113551348 113554935

BTAB:

109035933 109036001 109041855

DCI:

103509341

CLEC:

106661881

HHAL:

106677672 106677843 106677844

NLU:

111051884

PHU:	Phum_PHUM002670

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

FCD:

DPX:	DAPPUDRAFT_304115

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

EAF:	111707971 111710317

LSM:

121121479

PPOI:

119089845 119089846 119111147

ISC:	IscW_ISCW018468

DSV:

119455703

RSAN:

119393690

RMP:

119172204

VDE:	111243399 111247107

VJA:	111267180 111269026

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_F25E2.5(daf-3) CELE_R12B2.1(sma-4)

CBR:	CBG_08108(Cbr-daf-3) CBG_09090(Cbr-sma-4)

BMY:	BM_BM3575(Bma-daf-3) BM_BM5359(Bma-sma-4)

LOA:	LOAG_05337 LOAG_08923

NAI:	NECAME_01081 NECAME_09559

TSP:

Tsp_07524

HRO:	HELRODRAFT_76435 HELRODRAFT_88197

LGI:	LOTGIDRAFT_131078

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OBI:

OSN:

LAK:	106169999 106170001

SMM:	Smp_033950.1

OVI:	T265_11013

EGL:

NVE:

EPA:

ATEN:

ADF:	107335512 107357814(AdiSmad4)

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124439902 124450740

HMG:	100198878 100199160

TAD:	TRIADDRAFT_30731

AQU:	100637596 100640097

» show all

Reference

PMID:8553070

Authors

Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE

Title

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.

Journal

Science 271:350-3 (1996)
DOI:10.1126/science.271.5247.350

Sequence

[hsa:4089]

All links

Ontology (2)   
   KEGG BRITE (1)   
   GO (1)   
Pathway (36)   
   KEGG PATHWAY (36)   
Disease (5)   
   KEGG DISEASE (5)   
Gene (4310)   
   KEGG GENES (882)   
   KEGG MGENES (1333)   
   RefGene (2091)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (4354)   

Download RDF

DBGET integrated database retrieval system