KEGG   ORTHOLOGY: K04533
Entry
K04533                      KO                                     

Name
HD
Definition
huntingtin
Pathway
ko05016  Huntington disease
Disease
H00059  Huntington disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04533  HD; huntingtin
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K04533  HD; huntingtin
   04131 Membrane trafficking
    K04533  HD; huntingtin
   03029 Mitochondrial biogenesis
    K04533  HD; huntingtin
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     K04533  HD; huntingtin
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K04533  HD; huntingtin
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K04533  HD; huntingtin
Genes
HSA: 3064(HTT)
PTR: 461084(HTT)
PPS: 100978882(HTT)
GGO: 101125657(HTT)
PON: 100442500(HTT)
NLE: 100595586(HTT)
MCC: 700306(HTT)
MCF: 102128821(HTT)
CSAB: 103246449(HTT)
RRO: 104678957(HTT)
RBB: 108522748(HTT)
CJC: 100403524(HTT)
SBQ: 101027463(HTT)
MMU: 15194(Htt)
MCAL: 110295148(Htt)
MPAH: 110330941(Htt)
RNO: 29424(Htt)
MUN: 110552401(Htt)
CGE: 100764729(Htt)
NGI: 103741151(Htt)
HGL: 101697599(Htt)
CCAN: 109687432(Htt)
OCU: 100351801(HTT)
TUP: 102496123(HTT)
CFA: 479074(HTT)
VVP: 112922672(HTT)
AML: 100466808(HTT)
UMR: 103677033(HTT)
UAH: 113245750(HTT)
ORO: 101375437(HTT)
ELK: 111149245
FCA: 101086476(HTT)
PTG: 102961886(HTT)
PPAD: 109269744(HTT)
AJU: 106978831(HTT)
BTA: 615059(HTT)
BOM: 102283586(HTT)
BIU: 109560744(HTT)
BBUB: 102416640(HTT)
CHX: 102183227(HTT)
OAS: 100216476(HTT)
SSC: 397014(HTT)
CFR: 102521890(HTT)
CDK: 105103925(HTT)
BACU: 103013686(HTT)
LVE: 103073863(HTT)
OOR: 101289696(HTT)
DLE: 111164902(HTT)
PCAD: 102987968(HTT)
ECB: 100053721(HTT)
EPZ: 103558676(HTT)
EAI: 106842003
MYB: 102250928(HTT)
MYD: 102768616(HTT)
MNA: 107524070(HTT)
HAI: 109390906(HTT)
DRO: 112316670(HTT)
PALE: 102896722(HTT)
RAY: 107517979(HTT)
MJV: 108395692
LAV: 100670335(HTT)
TMU: 101360779
MDO: 100015315(HTT)
SHR: 100930812(HTT)
PCW: 110212213(HTT)
OAA: 103169301(HTT)
GGA: 422878(HTT)
MGP: 100540532
CJO: 107313923(HTT)
NMEL: 110397762(HTT)
APLA: 101789649(HTT)
ACYG: 106034665(HTT)
TGU: 100219938(HTT)
LSR: 110481892(HTT)
SCAN: 103823923(HTT)
GFR: 102039142(HTT)
FAB: 101807378(HTT)
PHI: 102109876(HTT)
PMAJ: 107202828(HTT)
CCAE: 111928237(HTT)
CCW: 104690918(HTT)
ETL: 114061216(HTT)
FPG: 101912601(HTT)
FCH: 102053260(HTT)
CLV: 102097560(HTT)
EGZ: 104130204(HTT)
NNI: 104018056(HTT)
ACUN: 113479031(HTT)
PADL: 103920991(HTT)
AAM: 106498723(HTT)
ASN: 102381087(HTT)
AMJ: 102572238(HTT)
PSS: 102450502(HTT)
CMY: 102938975(HTT)
CPIC: 101939389(HTT)
ACS: 100565638(htt)
PVT: 110091151(HTT) 110091731
PBI: 103059334(HTT)
PMUR: 107298580(HTT)
PMUA: 114604110(HTT)
GJA: 107118340(HTT)
XLA: 108697843
XTR: 493287(htt)
NPR: 108785827(HTT)
DRE: 30214(htt)
SRX: 107714228 107749891(htt)
IPU: 108263566(htt)
PHYP: 113538549(htt)
AMEX: 103040957(htt)
EEE: 113571465(htt)
TRU: 101065600(htt)
LCO: 104921948(htt)
NCC: 104946108
MZE: 101475773(htt)
ONL: 100703195(htt)
OLA: 101174004(htt)
XMA: 102230889(htt)
XCO: 114144472(htt)
PRET: 103464399(htt)
CVG: 107093761(htt)
NFU: 107393230(htt)
KMR: 108236369(htt)
ALIM: 106524348(htt)
AOCE: 111567212(htt)
CSEM: 103384197(htt)
POV: 109627550(htt)
LCF: 108875667(htt)
SDU: 111217939(htt)
SLAL: 111664606(htt)
HCQ: 109527350(htt)
BPEC: 110175726(htt)
MALB: 109957861(htt)
ELS: 105020824(htt)
SFM: 108925735(htt)
PKI: 111853089(htt)
LCM: 102363933(HTT)
CMK: 103186321(htt)
RTP: 109933868(htt)
CIN: 100145818(htt)
APLC: 110973838
SKO: 100329031(Htt)
DME: Dmel_CG9995(htt)
DER: 6555425
DSE: 6612602
DSI: Dsimw501_GD21379(Dsim_GD21379)
DSR: 110186345
DPE: 6594769
DMN: 108155943
DWI: 6647961
DAZ: 108615381
DNV: 108653479
DHE: 111596156
DVI: 6629686
MDE: 101892436
LCQ: 111675673
AAG: 5566195
AME: 726358
BIM: 100740343
BTER: 100644330
CCAL: 108632282
OBB: 114875319
SOC: 105203053
MPHA: 105836611
AEC: 105154744
ACEP: 105626824
PBAR: 105430054
VEM: 105560419
HST: 105190061
DQU: 106751914
CFO: 105253979
LHU: 105673384
PGC: 109857652
OBO: 105281049
PCF: 106784709
NVI: 100120106
CSOL: 105364173
MDL: 103570186
TCA: 656784
DPA: 109545059
ATD: 109597202
NVL: 108566239
BMOR: 101746788
BMAN: 114248681
PMAC: 106713898
PRAP: 110998919
HAW: 110380834
TNL: 113494697
API: 100169022
DNX: 107173018
AGS: 114128248
RMD: 113549500
BTAB: 109039108
CLEC: 106662467
ZNE: 110832891
FCD: 110858221
PVM: 113820996
TUT: 107364915
DPTE: 113794963
CSCU: 111632204
PTEP: 107443709
BMY: Bm1_40225
TSP: Tsp_02358
PCAN: 112565189
CRG: 105336135
MYI: 110457176
OBI: 106883334
LAK: 106165242
SHX: MS3_06168
EGL: EGR_09022
NVE: 5521364
EPA: 110236979
ADF: 107333034
AMIL: 114955748
PDAM: 113680248
SPIS: 111322762
DGT: 114516287
HMG: 101237115
AQU: 105312249
DDI: DDB_G0272344(hd)
DFA: DFA_08956(hd)
 » show all
Reference
PMID:8458085
  Title
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
  Journal
Cell 72:971-83 (1993)
DOI:10.1016/0092-8674(93)90585-e
  Sequence
[hsa:3064]
Reference
  Authors
Tourette C, Li B, Bell R, O'Hare S, Kaltenbach LS, Mooney SD, Hughes RE
  Title
A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.
  Journal
J Biol Chem 289:6709-26 (2014)
DOI:10.1074/jbc.M113.523696
  Sequence
[hsa:3064]

DBGET integrated database retrieval system