KEGG ORTHOLOGY: K04556

ORTHOLOGY: K04556

Entry

K04556                      KO

Symbol

PARK2

Name

parkin [EC:2.3.2.31]

Pathway

map04120

Ubiquitin mediated proteolysis

map04137

Mitophagy - animal

map04141

Protein processing in endoplasmic reticulum

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00027

Ovarian cancer

H00057

Parkinson disease

H01600

Parkinsonian syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04556  PARK2; parkin
   04120 Ubiquitin mediated proteolysis
    K04556  PARK2; parkin
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04556  PARK2; parkin
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04556  PARK2; parkin
   05014 Amyotrophic lateral sclerosis
    K04556  PARK2; parkin
   05022 Pathways of neurodegeneration - multiple diseases
    K04556  PARK2; parkin
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04556  PARK2; parkin
   04121 Ubiquitin system
    K04556  PARK2; parkin
   03029 Mitochondrial biogenesis
    K04556  PARK2; parkin
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K04556  PARK2; parkin
Membrane trafficking [BR:ko04131]
Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K04556  PARK2; parkin
  Aggrephagy
   Other aggrephagy associated proteins
    K04556  PARK2; parkin
  Xenophagy
   Other xenophagy associated proteins
    K04556  PARK2; parkin
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K04556  PARK2; parkin
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K04556  PARK2; parkin

Genes

HSA:	5071(PRKN)

PTR:	741350(PRKN)

PPS:	100978701(PRKN)

GGO:	101154322(PRKN)

PON:	100172433(PRKN)

PPYG:

129037998(PRKN)

NLE:	100589757(PRKN)

HMH:	116473652(PRKN)

SSYN:

129476259(PRKN) 134736323

MCC:	710899(PRKN)

MCF:	102134446(PRKN)

MTHB:

126953705

MNI:	105487519(PRKN)

CSAB:

103240862(PARK2)

CATY:

105594235(PARK2)

PANU:

101013061(PRKN)

TGE:	112623531(PRKN)

MLEU:

105553540(PARK2)

RRO:	104669996(PRKN)

RBB:	108527984(PARK2)

TFN:	117096908(PRKN)

PTEH:

111550282(PRKN)

CANG:

105506721(PARK2)

CJC:	100390242(PRKN)

SBQ:	101029277(PARK2)

CIMI:

108310303(PRKN)

ANAN:

105717673(PRKN)

LCAT:

123633441(PRKN)

PCOQ:

105812371(PARK2)

OGA:	100965001(PRKN)

MMU:	50873(Prkn)

MCAL:

110312630(Prkn)

MPAH:

110338080(Prkn)

RNO:	56816(Prkn)

MCOC:

116076805(Prkn)

ANU:	117700262(Prkn)

MUN:	110554861(Prkn)

CGE:	100764359(Prkn)

MAUA:

101825108(Prkn)

PROB:

127237704(Prkn)

PLEU:

114691391(Prkn)

MORG:

121466547(Prkn)

MFOT:

126497719

AAMP:

119820894(Prkn)

NGI:	103729225 103737054(Park2)

HGL:	101700770(Park2)

CPOC:

100724550(Prkn)

CCAN:

109688031

DORD:

105991798(Park2)

DSP:	122116126(Prkn)

PLOP:

125357474(Prkn)

NCAR:

124987958

MMMA:

107153167(Prkn)

OCU:	100358886(PRKN)

OPI:	101518416(PRKN)

TUP:	102469732(PARK2)

CFA:	612316(PRKN)

CLUD:

112644403(PRKN)

VVP:	112932949(PRKN)

VLG:	121485024(PRKN)

NPO:	129501049(PRKN)

AML:	100465415(PRKN)

UMR:	103660821(PRKN)

UAH:	113259330(PRKN)

UAR:	123797535(PRKN)

ELK:

111158711

LLV:

125102349

MPUF:

101689578(PARK2)

MNP:	132018447(PRKN)

MLK:	131833389(PRKN)

NVS:	122902732(PRKN)

ORO:	101385500(PARK2)

EJU:	114209290(PRKN)

ZCA:	113927504(PRKN)

MLX:	118001822 118001946

NSU:	110583162(PRKN)

FCA:	101098228(PRKN)

PYU:	121013069(PRKN)

PCOO:

112862211(PRKN)

PBG:	122490161(PRKN)

PVIV:

125166201(PRKN)

LRUF:

124528391

PTG:	102964689(PARK2)

PPAD:

109245483(PARK2)

PUC:

125938088

AJU:	106985022(PRKN)

BTA:	530858(PRKN)

BOM:	102270304 102284805

BIU:	109564101(PARK2)

BBUB:

102406619(PRKN)

BBIS:

104986252(PARK2)

CHX:	102172812(PARK2)

OAS:	101113503(PRKN)

BTAX:

128053056(PRKN)

ODA:	120862828(PRKN)

CCAD:

122434169(PRKN)

MBEZ:

129561338(PRKN)

SSC:	733673(PRKN)

CFR:	102508809(PRKN)

CBAI:

105077461

CDK:	105086287(PRKN)

VPC:	102541584(PRKN)

BACU:

103006032(PARK2)

BMUS:

118904941(PRKN)

LVE:	103072488(PARK2)

DLE:	111168498(AGPAT4)

PCAD:

102982022(PRKN)

PSIU:

116763621(PRKN)

NASI:

112401646(PRKN)

ECB:	100057832(PRKN)

EAI:	106842050(PRKN)

MYB:	102255484(PARK2)

MYD:	102757960(PARK2)

MMYO:

118660195(PRKN)

MLF:	102439703(PRKN)

MDT:	132236719(PRKN)

PKL:	118708853(PRKN)

EFUS:

103299829(PRKN)

MNA:	107535732(PARK2)

DRO:

112297296

SHON:

118996188(PRKN)

AJM:	119034893(PRKN)

PDIC:

114490084(PRKN)

PHAS:

123822135(PRKN)

MMF:	118621965(PRKN)

PPAM:

129088228(PRKN)

HAI:

109394305

RFQ:	117020770(PRKN)

PALE:

102888747(PRKN)

PGIG:

120617538(PRKN)

PVP:	105301214(PRKN)

RAY:	107501685(PARK2)

SARA:

101557307(PARK2)

SETR:

125996569(PRKN)

LAV:	100665442(PRKN)

TMU:

101340669

ETF:	101639304(PRKN)

DNM:	101440790(PRKN)

MDO:	100032502(PARK2)

GAS:	123246664(PRKN)

SHR:	100928463(PRKN)

AFZ:

127562395

PCW:	110208624(PRKN)

TVP:	118855905(PRKN)

OAA:	114809162(PRKN)

GGA:	421577(PARK2)

PCOC:

116243219(PRKN)

CJO:	107311526(PRKN)

TPAI:

128080954(PRKN)

LMUT:

125690073(PRKN)

NMEL:

110395954(PRKN)

APLA:

101796091(PRKN)

ACYG:

106039539(PRKN)

CATA:

118244030(PRKN)

AFUL:

116487205(PRKN)

TGU:	100221229(PRKN)

LSR:	110477920(PRKN)

SCAN:

103821619(PRKN)

PMOA:

120506840(PRKN)

OTC:	121335883(PRKN)

PRUF:

121358731(PRKN)

GFR:	102043879(PARK2)

FAB:	101810988(PARK2)

OMA:	130251513(PRKN)

PHI:	102105199(PARK2)

PMAJ:

107202287(PRKN)

CCAE:

111926948(PRKN)

CCW:	104684351(PRKN)

CBRC:

103624193(PARK2)

ETL:	114055652(PRKN)

ZAB:	102067017(PRKN)

ZLE:	135445726(PRKN)

SVG:	106852963(PARK2)

MMEA:

130576043(PRKN)

HRT:	120751006(PRKN)

SATI:

136359323(PRKN)

FPG:	101918371(PARK2)

FCH:	102048210(PRKN)

SHAB:

115613649(PRKN)

ACUN:

113477882(PRKN)

TALA:

116965931(PRKN)

ACHC:

115344548(PRKN)

HLE:	104842281(PARK2)

AGEN:

126039051

GCL:

127014119

DPUB:

104307712(PARK2)

AVIT:

104277174(PARK2)

EGZ:	104131677 104132542

NNI:	104018425(PARK2)

PCAO:

104045783(PARK2)

PADL:

103914151(PARK2)

AFOR:

103907876(PARK2)

CLV:	102084040(PRKN)

CUCA:

104056488(PRKN)

OHA:	104331772(PARK2)

ACAR:

104521538

CPEA:

104390821(PARK2)

CVF:	104287023(PARK2)

RTD:	128907633(PRKN)

AAM:	106486766(PARK2)

AROW:

112972874(PRKN)

NPD:	112951949(PRKN)

DNE:	112988992(PRKN)

SCAM:

104152834(PARK2)

ASN:	102381887(PRKN)

AMJ:	102573688(PARK2)

CPOO:

109320057(PARK2)

GGN:	109304408(PARK2)

PSS:	102451562(PRKN)

CMY:	102935998(PRKN)

CCAY:

125633981(PRKN)

DCC:	119852618(PRKN)

CPIC:

101941171(PRKN)

TST:	117874779(PRKN)

CABI:

116832464(PRKN)

MRV:	120400709(PRKN)

ACS:	100559435(park2)

ASAO:

132761113(PRKN)

PVT:	110087285(PRKN)

SUND:

121936318(PRKN)

PBI:

103051791

PMUR:

107295102(PRKN)

CTIG:

120312740

TSR:	106550720(PARK2)

PGUT:

117672071(PRKN)

APRI:

131190781(PRKN)

PTEX:

113439291(PRKN)

NSS:	113417048(PRKN)

VKO:	123019079(PRKN)

PMUA:

114594313(PRKN)

PRAF:

128410723(PRKN)

ZVI:	118081953(PRKN)

HCG:	128344625(PRKN)

GJA:	107113335(PARK2) 107118842

STOW:

125428076(PRKN)

EMC:	129324792(PRKN)

DRE:	550328(prkn)

SRX:

107739476

SANH:

107669573 107696378

SGH:	107586494(park2)

CCAR:

109081461(park2)

CAUA:

113057245(prkn)

CGIB:

127969883

PTET:

122356881(prkn)

LROH:

127175445(prkn)

OMC:	131551991(prkn)

PPRM:

120492274(prkn)

RKG:	130084763(prkn)

MAMB:

125277476(prkn)

CIDE:

127525038

CERY:

137020782(prkn)

MASI:

127412044 127413705

TROS:

130559188(prkn)

TDW:	130431135(prkn)

MANU:

129416543(prkn)

IPU:	108263700(prkn)

IFU:	128605392(prkn)

PHYP:

113545038(prkn)

SMEO:

124402771(prkn)

TFD:	113644945(prkn)

TVC:	132847114(prkn)

TRN:	134314416(prkn)

AMEX:

103027813(prkn)

CMAO:

118810201(prkn)

EEE:	113572720(prkn)

CHAR:

105912317(prkn)

TRU:	101073892(prkn)

TFS:	130533547(prkn)

TNG:	GSTEN00025039G001

LCO:	104934697(prkn)

TBEN:

117486002(prkn)

CGOB:

115005371 115005373

GACU:

117533533(prkn)

ELY:	117247857(prkn)

EFO:	125903238(prkn)

SLUC:

116034168(prkn)

ECRA:

117940542(prkn)

PFLV:

114572102(prkn)

GAT:	120820523 120820571(prkn)

PPUG:

119214569(prkn)

AFB:	129092676(prkn) 129116199 129116200

CLUM:

117743657 117744402

MSAM:

119911359(prkn)

SCHU:

122884124(prkn)

CUD:	121511048(prkn)

ALAT:

119033279(prkn)

MZE:	101482320(prkn)

ONL:	100708029(prkn)

OAU:	116317395(prkn)

OLA:	101170614(prkn)

OML:	112162103(prkn)

CSAI:

133463368(prkn)

XMA:	102219281(prkn)

XCO:	114137605 114137879

XHE:	116712912(prkn)

PFOR:

103130874(park2)

PLAI:

106936929(park2)

PMEI:

106909354(park2)

GAF:	122842768(prkn)

PPRL:

129356086

CVG:	107101386(park2)

CTUL:

119791950(prkn)

GMU:	124859578(prkn)

NFU:	107396230(park2)

ALIM:

106531494(park2)

NWH:	119419881(prkn)

MCEP:

125018888(prkN)

CSEM:

103387132(park2)

POV:	109644595(park2)

SSEN:

122781835(prkn)

HHIP:

117775686(prkn)

HSP:	118119285(prkn)

PPLT:

128453111(prkn)

LCF:	108874357(prkn) 108891574

SDU:	111223871(prkn)

SLAL:

111656069(prkn)

XGL:	120796450(prkn)

BPEC:

110168027(prkn)

MALB:

109973015(prkn)

BSPL:

114841811(prkn)

SJO:	128373185(prkn)

SASA:

106576740(park2)

STRU:

115193909(prkn)

OTW:	112252884(prkn)

OMY:	110527247(prkn)

OGO:	124041364(prkn)

ONE:	115135230(prkn)

OKI:	109889838(prkn)

OKE:	118369586(prkn)

SALP:

111951983(prkn)

SNH:	120017907(prkn)

CCLU:

121553251(prkn)

ELS:	105025493(prkn)

SFM:	108942718(prkn)

PKI:	111848830(prkn)

AANG:

118218150(prkn)

LOC:	102693248(park2)

PSPA:

121316301(prkn)

ARUT:

117403298(prkn)

PSEX:

120516635(prkn)

CMK:	103176050(prkn)

CPLA:

122552975(prkn)

HOC:	132819480(prkn)

LERI:

129699537(prkn)

BFO:	118421822 118422731

BBEL:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG10523(park)

DER:

6546488

DSE:

6616405

DSI:	Dsimw501_GD12138(Dsim_GD12138)

DYA:	Dyak_GE22356 Dyak_GE28149

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12208

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ014867

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105667495(park)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106680820(park)

NLU:

111056715

HVI:	124358001 124370560

MQU:	128985404 128986976

PHU:	Phum_PHUM233570

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_221739

DMK:

116921750

DPZ:

124337026

PVM:	113806358 113825825

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

CVS:	136968623(park)

PTEP:

107455549

ABRU:

129976418

UDV:	129227433 129227651

SDM:

118182692

LPOL:

106467635

PMEO:

129587444

CEL:	CELE_K08E3.7(pdr-1)

CBR:	CBG_18262(Cbr-pdr-1)

CRQ:	GCK72_010359

NAI:	NECAME_11618

LOA:	LOAG_05984

LGI:	LOTGIDRAFT_107352

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111104077 111104494

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

MAEA:

OSN:	115230822 118767830

LJP:

LAK:

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114541205 114541208 114541209

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_26044

AQU:	100634532 109582858

» show all

Reference

PMID:12150907

Authors

Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R

Title

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

Journal

Mol Cell 10:55-67 (2002)
DOI:10.1016/S1097-2765(02)00583-X

Sequence

[hsa:5071]

Reference

PMID:15105460

Authors

Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM

Title

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

Journal

Science 304:1328-31 (2004)
DOI:10.1126/science.1093891

Sequence

[hsa:5071] [mmu:50873]

Reference

PMID:9560156

Authors

Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N

Title

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.

Journal

Nature 392:605-8 (1998)
DOI:10.1038/33416

Sequence

[hsa:5071]

All links

Ontology (5)   
   KEGG BRITE (5)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (3)   
   KEGG DISEASE (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1738)   
   KEGG GENES (599)   
   KEGG MGENES (210)   
   RefGene (926)   
   OC (3)   
Literature (3)   
   PubMed (3)   
All databases (1762)   

Download RDF

DBGET integrated database retrieval system