KEGG ORTHOLOGY: K04724

ORTHOLOGY: K04724

Entry

K04724                      KO

Symbol

CFLAR, FLIP

Name

CASP8 and FADD-like apoptosis regulator

Pathway

map04064

NF-kappa B signaling pathway

map04140

Autophagy - animal

map04210

Apoptosis

map04217

Necroptosis

map04668

TNF signaling pathway

map05142

Chagas disease

map05160

Hepatitis C

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   04668 TNF signaling pathway
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
  09143 Cell growth and death
   04210 Apoptosis
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
   04217 Necroptosis
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C14: caspase family
   K04724  CFLAR, FLIP; CASP8 and FADD-like apoptosis regulator

Genes

HSA:	8837(CFLAR)

PTR:	459872(CFLAR)

PPS:	100972044(CFLAR)

PON:	100172025(CFLAR)

PPYG:

129031081(CFLAR)

NLE:	100589650(CFLAR)

HMH:	116810462(CFLAR)

SSYN:

129488260(CFLAR)

MCC:	574234(CFLAR)

MCF:	101867183(CFLAR)

MTHB:

126932113

MNI:	105468108(CFLAR)

CSAB:

103217632(CFLAR)

CATY:

105580032(CFLAR)

PANU:

101006231(CFLAR)

MLEU:

105535425(CFLAR)

RRO:	104671861(CFLAR)

RBB:	108532119(CFLAR)

TFN:	117095224(CFLAR)

PTEH:

111547069(CFLAR)

CANG:

105517472(CFLAR)

CJC:	100393782(CFLAR)

SBQ:	101028366(CFLAR)

CIMI:

108315748(CFLAR)

ANAN:

105712839(CFLAR)

CSYR:

103273363(CFLAR)

MMUR:

105856964(CFLAR)

LCAT:

123643897(CFLAR)

PCOQ:

105819401(CFLAR)

OGA:	100966424(CFLAR)

MMU:	12633(Cflar)

MCAL:

110293482(Cflar)

MPAH:

110321922(Cflar)

RNO:	117279(Cflar)

MCOC:

116088466(Cflar)

ANU:	117705809(Cflar)

MUN:	110557663(Cflar)

CGE:	100757136(Cflar)

MAUA:

101825734(Cflar)

PROB:

127226336(Cflar)

PLEU:

114704457(Cflar)

MORG:

121444859 121458930

MFOT:

126511840

AAMP:

119803853(Cflar)

NGI:	103738673(Cflar)

HGL:	101713835(Cflar)

CPOC:

100717997(Cflar)

CCAN:

109688488(Cflar)

DORD:

105982383(Cflar)

DSP:	122096420(Cflar)

PLOP:

125350402(Cflar)

NCAR:

124979040

MMMA:

107138602(Cflar)

OCU:

100346964

OPI:	101521112(CFLAR)

TUP:	102494501(CFLAR)

GVR:	103608942(CFLAR)

CFA:	488471(CFLAR)

CLUD:

112656294(CFLAR)

VVP:	112922876(CFLAR)

VLG:	121480765(CFLAR)

NPO:	129522736(CFLAR)

AML:	100474872(CFLAR)

UAH:	113250596(CFLAR)

UAR:	123798196(CFLAR)

ELK:

111141134

LLV:

125095000

MPUF:

101675551(CFLAR)

MNP:	132013447(CFLAR)

MLK:	131827577(CFLAR)

NVS:	122902187(CFLAR)

ORO:	101366831(CFLAR)

EJU:	114223358(CFLAR)

ZCA:	113920559(CFLAR)

MLX:	118012153(CFLAR)

NSU:	110592404(CFLAR)

LWW:	102745394(CFLAR)

FCA:	100142680(CFLAR)

PYU:	121030906(CFLAR)

PCOO:

112867877(CFLAR)

PBG:	122481639(CFLAR)

PVIV:

125172181(CFLAR)

LRUF:

124514773

PTG:	102963219(CFLAR)

PPAD:

109260755(CFLAR)

AJU:

106987988

HHV:	120220695(CFLAR)

BTA:	497199(CFLAR)

BOM:	102283650(CFLAR)

BIU:	109569493(CFLAR)

BBUB:

102412372(CFLAR)

BBIS:

105003652(CFLAR)

CHX:	100860786(CFLAR)

OAS:	101106914(CFLAR)

BTAX:

128066790(CFLAR)

ODA:	120854626(CFLAR)

CCAD:

122426204(CFLAR)

MBEZ:

129537598(CFLAR)

SSC:	414381(CFLAR)

CFR:	102508474(CFLAR)

CBAI:

105082302(CFLAR)

CDK:	105099179(CFLAR)

VPC:	102541623(CFLAR)

BACU:

103002342(CFLAR)

BMUS:

118897928(CFLAR)

LVE:	103076340(CFLAR)

OOR:	101282267(CFLAR)

DLE:	111171724(CFLAR)

PCAD:

102981647(CFLAR)

PSIU:

116756986(CFLAR)

NASI:

112407870(CFLAR)

ECB:	100068181(CFLAR)

EPZ:	103565999(CFLAR)

EAI:	106823485(CFLAR)

MYB:	102244844(CFLAR)

MYD:	102763362(CFLAR)

MMYO:

118661639(CFLAR)

MLF:	102438769(CFLAR)

MDT:	132238116(CFLAR)

PKL:	118708993(CFLAR)

EFUS:

103290542

MNA:	107533941(CFLAR)

DRO:	112307654(CFLAR)

SHON:

118985241(CFLAR)

AJM:	119047616 119065514(CFLAR)

PDIC:

114494605(CFLAR)

PHAS:

123824432(CFLAR)

MMF:	118625230(CFLAR)

PPAM:

129080428(CFLAR)

HAI:	109379239(CFLAR)

RFQ:	117025759(CFLAR)

PALE:

102898217(CFLAR)

PGIG:

120587523(CFLAR)

PVP:	105298129(CFLAR)

RAY:	107503157(CFLAR)

MJV:	108395422(CFLAR)

TOD:	119256096 119256098

SARA:

101541834(CFLAR)

SETR:

126009011(CFLAR)

LAV:	100660836(CFLAR)

TMU:

101343780

ETF:	101664220(CFLAR)

DNM:	101434584(CFLAR)

MDO:	100617513(CFLAR)

GAS:	123242696(CFLAR)

SHR:	100927927(CFLAR)

AFZ:

127553230

PCW:	110197210(CFLAR)

TVP:	118846540(CFLAR)

OAA:	100076553(CFLAR)

GGA:	424080(CFLAR)

PCOC:

116233977(CFLAR)

MGP:	100549881(CFLAR)

CJO:	107316522(CFLAR)

TPAI:

128077302(CFLAR)

LMUT:

125696902(CFLAR)

NMEL:

110400219(CFLAR)

APLA:

101799915(CFLAR)

ACYG:

106040001(CFLAR)

CATA:

118243189(CFLAR)

AFUL:

116490546(CFLAR)

TGU:	100230013(CFLAR)

LSR:	110484600(CFLAR)

SCAN:

103814508(CFLAR)

PMOA:

120497040(CFLAR)

OTC:	121335316(CFLAR)

PRUF:

121356472(CFLAR)

GFR:	102045043(CFLAR)

FAB:	101816960(CFLAR)

OMA:	130255260(CFLAR)

PHI:	102104024(CFLAR)

PMAJ:

107207333(CFLAR)

CCAE:

111931986(CFLAR)

CCW:	104693776(CFLAR)

CBRC:

103612155(CFLAR)

ETL:	114055712(CFLAR)

ZAB:	102073635(CFLAR)

ZLE:	135450167(CFLAR)

ACHL:

103803667(CFLAR)

SVG:	106855084(CFLAR)

MMEA:

130579139(CFLAR)

HRT:	120754972(CFLAR)

SATI:

136363400(CFLAR)

FPG:	101916800(CFLAR)

FCH:	102056426(CFLAR)

CCRI:

104168862(CFLAR)

NNT:	104402968(CFLAR)

SHAB:

115607875(CFLAR)

ACUN:

113482557(CFLAR)

TALA:

104369202(CFLAR)

ACHC:

115343325(CFLAR)

HALD:

104312458(CFLAR)

HLE:	104830073(CFLAR)

AGEN:

126047948

GCL:

127018712

CSTI:

104554618(CFLAR)

LDI:	104346832(CFLAR)

DPUB:

104296654(CFLAR)

AVIT:

104269999(CFLAR)

BRHI:

104488191(CFLAR)

EGZ:	104130513(CFLAR)

NNI:	104010193(CFLAR)

PCRI:

104029419(CFLAR)

PCAO:

104047508(CFLAR)

PADL:

103923407(CFLAR)

AFOR:

103903458(CFLAR)

FGA:	104075096(CFLAR)

GSTE:

104255016(CFLAR)

CLV:	102084239(CFLAR)

MUI:	104545012(CFLAR)

PGUU:

104458088(CFLAR)

PLET:

104620851(CFLAR)

EHS:	104504027(CFLAR)

CMAC:

104483191(CFLAR)

CUCA:

104058295(CFLAR)

TEO:	104372721(CFLAR)

BREG:

104634077(CFLAR)

OHA:	104334212(CFLAR)

ACAR:

104525637(CFLAR)

CPEA:

104397388(CFLAR)

CVF:	104290989(CFLAR)

RTD:	128912445(CFLAR)

AAM:	106492411(CFLAR)

AROW:

112976386(CFLAR)

NPD:	112956349(CFLAR)

TGT:	104577124(CFLAR)

DNE:	112987969(CFLAR)

SCAM:

104150171(CFLAR)

ASN:	102381131(CFLAR)

AMJ:	102574231(CFLAR)

CPOO:

109322725(CFLAR)

GGN:	109301901(CFLAR)

PSS:	102455949(CFLAR)

CMY:	102931806(CFLAR)

CCAY:

125644796(CFLAR)

DCC:	119863331(CFLAR)

CPIC:

101941100

TST:	117884731(CFLAR)

CABI:

116836066(CFLAR)

MRV:	120374824(CFLAR)

ACS:	100564476(cflar)

ASAO:

132779618(CFLAR)

PVT:	110089016(CFLAR)

SUND:

121934733(CFLAR)

PBI:	103051805(CFLAR)

PMUR:

107291756

CTIG:

120312824(CFLAR)

TSR:	106541631(CFLAR)

PTEX:

113433952(CFLAR)

NSS:	113412358(CFLAR)

VKO:	123024248(CFLAR)

PRAF:

128399479(CFLAR)

ZVI:

118095856

HCG:	128337905(CFLAR)

GJA:

107122428

STOW:

125426206(CFLAR)

EMC:

129324791

XLA:	108701437(cflar.L) 780745(cflar.S)

XTR:	779578(cflar)

NPR:	108798399(CFLAR)

RTEM:

120943728(CFLAR)

BBUF:

121008981(CFLAR)

BGAR:

122944654(CFLAR)

MUO:	115473678(CFLAR)

GSH:	117361461(CFLAR)

DRE:	373114(cflara)

SRX:	107720945 107737222 107751127 107752585

SANH:

107670324 107689499 107691294 107695070

SGH:	107549893 107555958 107570294 107577992

CCAR:

109054329 109107075 109109203

CAUA:

113053425 113055299 113109066 113111065

CGIB:

127964796 127968376 128019545 128022218

PTET:

122351829 122354579(cflara)

LROH:

127171351 127173252(cflara)

OMC:	131546495 131548925(cflara)

PPRM:

120480386(cflara) 120492696

RKG:	130083602(cflara)

MAMB:

125257039(cflara) 125269848

CIDE:

127519170 127522206

CERY:

137021486(cflara) 137036317

MASI:

127426205 127427757

TROS:

130555694 130571113(cflara)

TDW:	130410019(cflara) 130427509

MANU:

129427726(cflara) 129452286

IPU:	108259510(cflara) 108266354

IFU:

128609165

PHYP:

113525356 113547094(cflar)

SMEO:

TFD:

TVC:

TRN:

AMEX:

103037295(cflara) 103047016

CMAO:

118803815(cflara) 118812213

EEE:	113577703 113584644(cflar)

CHAR:

105896625(cflara) 105908702

TRU:	101063858(cflar)

TFS:

130522887

TNG:	GSTEN00030511G001

LCO:	104928804(cflar)

NCC:	104963314(cflar)

TBEN:

117485923

CGOB:

115025951(cflar)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116697690(cflar)

PFLV:

114564036(cflar)

GAT:	100653428(cflar)

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101464799(cflar)

ONL:	100712109 100712377

OAU:

116335368

OLA:	100529185(cflar)

OML:

112154781

CSAI:

133446473

XMA:	102228359(cflar)

XCO:	114147948(cflar)

XHE:	116722787(cflar)

PRET:

103461648(cflar)

PFOR:

103155490(cflar)

PLAI:

106948030(cflar)

PMEI:

106922760(cflar)

GAF:

122839942

PPRL:

129361527

CVG:	107091904(cflar)

CTUL:

119788729

GMU:

124870920

NFU:	107390131(cflar)

KMR:

108240700

ALIM:

106523341(cflar)

NWH:

119419088

AOCE:

111562391(cflar)

MCEP:

125017234

CSEM:

103392053(cflar)

POV:	109631097(cflar)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111218114(cflar)

SLAL:

111671504(cflar)

XGL:

120801162

HCQ:	109523284(cflar)

SSCV:

125973293

SBIA:

133493374 133493499 133493507 133493976 133493996 133493997 133497168 133497181 133497184 133497223 133512016

PEE:

133410391

PTAO:

133486459

BPEC:

110168798

MALB:

109957132(cflar)

BSPL:

114847049

SJO:

128367554

SASA:

106582588 106596153

STRU:

115180808(cflar)

OTW:

112224883

OMY:

110501891

ONE:

115128090

OKI:	109882130(cflar)

OKE:

118380379

SALP:

112075049(cflar)

SNH:

120036443

CCLU:

121554872

ELS:	105007210(cflar)

SFM:	108942112(cflar)

PKI:	111858290(cflar)

AANG:

118213703 118222872

LOC:	102682725(cflar)

PSPA:

121322098 121323671

ARUT:

117413297

LCM:	102359774(CFLAR)

RTP:

HOC:

LERI:

PMRN:

LRJ:

Reference

PMID:9326610

Authors

Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L

Title

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.

Journal

Proc Natl Acad Sci U S A 94:11333-8 (1997)
DOI:10.1073/pnas.94.21.11333

Sequence

[hsa:8837]

Reference

PMID:10894163

Authors

Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW

Title

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

Journal

Immunity 12:633-42 (2000)
DOI:10.1016/S1074-7613(00)80214-9

Sequence

[mmu:12633]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Gene (514)   
   KEGG GENES (440)   
   KEGG MGENES (61)   
   RefGene (11)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (532)   

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