KEGG   ORTHOLOGY: K05604
Entry
K05604                      KO                                     

Name
CNDP1
Definition
beta-Ala-His dipeptidase [EC:3.4.13.20]
Pathway
ko00330  Arginine and proline metabolism
ko00340  Histidine metabolism
ko00410  beta-Alanine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K05604  CNDP1; beta-Ala-His dipeptidase
   00340 Histidine metabolism
    K05604  CNDP1; beta-Ala-His dipeptidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K05604  CNDP1; beta-Ala-His dipeptidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K05604  CNDP1; beta-Ala-His dipeptidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.13  Dipeptidases
    3.4.13.20  beta-Ala-His dipeptidase
     K05604  CNDP1; beta-Ala-His dipeptidase
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M20
   K05604  CNDP1; beta-Ala-His dipeptidase
Other DBs
RN: R01166 R01992 R03288
Genes
HSA: 84735(CNDP1)
PTR: 455474(CNDP1)
GGO: 101127378(CNDP1)
PON: 100172721(CNDP1)
NLE: 100583488(CNDP1)
MCC: 114675569 695195(CNDP1)
MCF: 102131452(CNDP1)
CSAB: 103244082(CNDP1)
RRO: 104656992(CNDP1)
RBB: 108525057(CNDP1)
CJC: 100395623(CNDP1)
SBQ: 101048509(CNDP1)
MMU: 338403(Cndp1)
MCAL: 110284617(Cndp1)
MPAH: 110333472(Cndp1)
RNO: 307212(Cndp1)
MUN: 110555520(Cndp1)
CGE: 100761203(Cndp1)
NGI: 103748140(Cndp1)
HGL: 101707301(Cndp1)
CCAN: 109681064(Cndp1)
OCU: 100345937(CNDP1)
TUP: 102489508(CNDP1)
CFA: 476165(CNDP1)
VVP: 112919334(CNDP1)
AML: 100467604(CNDP1)
UMR: 103658416(CNDP1)
UAH: 113253529(CNDP1)
ORO: 101378722(CNDP1)
ELK: 111154244
FCA: 101099503(CNDP1)
PTG: 102964440(CNDP1)
PPAD: 109251775(CNDP1)
AJU: 106982253(CNDP1)
BTA: 614200(CNDP1)
BOM: 102267168(CNDP1)
BIU: 109578014(CNDP1)
BBUB: 102402300(CNDP1)
CHX: 102180002(CNDP1)
OAS: 101110987(CNDP1)
SSC: 100516053(CNDP1)
CFR: 102512299(CNDP1)
CDK: 105105074(CNDP1)
BACU: 103016948(CNDP1)
LVE: 103084929(CNDP1)
OOR: 101281356(CNDP1)
DLE: 111167305(CNDP1)
PCAD: 102991690(CNDP1)
ECB: 100061728(CNDP1)
EPZ: 103544994 103561746
EAI: 106832860
MYB: 102242328(CNDP1)
MYD: 102767022(CNDP1)
MNA: 107537575(CNDP1)
HAI: 109383171(CNDP1)
DRO: 112322841(CNDP1)
PALE: 102890418(CNDP1)
RAY: 107512645(CNDP1)
MJV: 108409039(CNDP1)
LAV: 100657615(CNDP1)
TMU: 101356417
MDO: 100619431(CNDP1)
SHR: 100922964(CNDP1)
PCW: 110215824(CNDP1)
OAA: 100076860(CNDP1)
GGA: 421012(CNDP1)
MGP: 100541194(CNDP1)
CJO: 107309982(CNDP1)
NMEL: 110394441(CNDP1)
APLA: 101791863(CNDP1)
ACYG: 106035949(CNDP1)
TGU: 100232073
LSR: 110470903(CNDP1)
SCAN: 103815755(CNDP1)
GFR: 102040432(CNDP1)
FAB: 101819344(CNDP1)
PHI: 102111429(CNDP1)
PMAJ: 107200306(CNDP1)
CCAE: 111925250(CNDP1)
CCW: 104685799(CNDP1)
ETL: 114057532(CNDP1)
FPG: 101915873(CNDP1)
FCH: 102045939(CNDP1)
CLV: 102095516
EGZ: 104128655(CNDP1)
NNI: 104018184(CNDP1)
ACUN: 113476758(CNDP1)
PADL: 103924881(CNDP1)
AAM: 106482719(CNDP1)
ASN: 102367881(CNDP1)
AMJ: 106737110(CNDP1)
PSS: 102445657
CMY: 102938002
CPIC: 101937111(CNDP1)
ACS: 100554161(cndp1)
PVT: 110083379(CNDP1)
PMUR: 107291693(CNDP1)
TSR: 106550218
PMUA: 114600793 114600796
GJA: 107115115(CNDP1)
XLA: 398917(cndp1.L)
XTR: 100135225(cndp1)
NPR: 108799252
IPU: 108261199(Cndp1)
AMEX: 103026681
EEE: 113574437
SASA: 100196692(cndp1)
OTW: 112247755
SALP: 111964936 112068906
ELS: 105019194
SFM: 108940582
PKI: 111844178 111844287
LCM: 102355447
 » show all
Reference
PMID:7116644
  Authors
Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS
  Title
Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.
  Journal
Clin Chim Acta 123:221-31 (1982)
DOI:10.1016/0009-8981(82)90166-8
  Sequence
[hsa:84735]
Reference
  Authors
Ahluwalia TS, Lindholm E, Groop LC
  Title
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
  Journal
Diabetologia 54:2295-302 (2011)
DOI:10.1007/s00125-011-2178-5

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (165)   
   KEGG GENES (118)   
   KEGG MGENES (19)   
   RefGene (24)   
   OC (4)   
Literature (2)   
   PubMed (2)   
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KEGG   ENZYME: 3.4.13.20
Entry
EC 3.4.13.20                Enzyme                                 

Name
beta-Ala-His dipeptidase;
serum carnosinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
Reaction(IUBMB)
Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine [RN:R01166 R03288]
Reaction(KEGG)
R01166 R03288 > R01992
Comment
Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.
History
EC 3.4.13.20 created 1992
Pathway
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K05604  beta-Ala-His dipeptidase
Genes
HSA: 84735(CNDP1)
PTR: 455474(CNDP1)
GGO: 101127378(CNDP1)
PON: 100172721(CNDP1)
NLE: 100583488(CNDP1)
MCC: 114675569 695195(CNDP1)
MCF: 102131452(CNDP1)
CSAB: 103244082(CNDP1)
RRO: 104656992(CNDP1)
RBB: 108525057(CNDP1)
CJC: 100395623(CNDP1)
SBQ: 101048509(CNDP1)
MMU: 338403(Cndp1)
MCAL: 110284617(Cndp1)
MPAH: 110333472(Cndp1)
RNO: 307212(Cndp1)
MUN: 110555520(Cndp1)
CGE: 100761203(Cndp1)
NGI: 103748140(Cndp1)
HGL: 101707301(Cndp1)
CCAN: 109681064(Cndp1)
OCU: 100345937(CNDP1)
TUP: 102489508(CNDP1)
CFA: 476165(CNDP1)
VVP: 112919334(CNDP1)
AML: 100467604(CNDP1)
UMR: 103658416(CNDP1)
UAH: 113253529(CNDP1)
ORO: 101378722(CNDP1)
ELK: 111154244
FCA: 101099503(CNDP1)
PTG: 102964440(CNDP1)
PPAD: 109251775(CNDP1)
AJU: 106982253(CNDP1)
BTA: 614200(CNDP1)
BOM: 102267168(CNDP1)
BIU: 109578014(CNDP1)
BBUB: 102402300(CNDP1)
CHX: 102180002(CNDP1)
OAS: 101110987(CNDP1)
SSC: 100516053(CNDP1)
CFR: 102512299(CNDP1)
CDK: 105105074(CNDP1)
BACU: 103016948(CNDP1)
LVE: 103084929(CNDP1)
OOR: 101281356(CNDP1)
DLE: 111167305(CNDP1)
PCAD: 102991690(CNDP1)
ECB: 100061728(CNDP1)
EPZ: 103544994 103561746
EAI: 106832860
MYB: 102242328(CNDP1)
MYD: 102767022(CNDP1)
MNA: 107537575(CNDP1)
HAI: 109383171(CNDP1)
DRO: 112322841(CNDP1)
PALE: 102890418(CNDP1)
RAY: 107512645(CNDP1)
MJV: 108409039(CNDP1)
LAV: 100657615(CNDP1)
TMU: 101356417
MDO: 100619431(CNDP1)
SHR: 100922964(CNDP1)
PCW: 110215824(CNDP1)
OAA: 100076860(CNDP1)
GGA: 421012(CNDP1)
MGP: 100541194(CNDP1)
CJO: 107309982(CNDP1)
NMEL: 110394441(CNDP1)
APLA: 101791863(CNDP1)
ACYG: 106035949(CNDP1)
TGU: 100232073
LSR: 110470903(CNDP1)
SCAN: 103815755(CNDP1)
GFR: 102040432(CNDP1)
FAB: 101819344(CNDP1)
PHI: 102111429(CNDP1)
PMAJ: 107200306(CNDP1)
CCAE: 111925250(CNDP1)
CCW: 104685799(CNDP1)
ETL: 114057532(CNDP1)
FPG: 101915873(CNDP1)
FCH: 102045939(CNDP1)
CLV: 102095516
EGZ: 104128655(CNDP1)
NNI: 104018184(CNDP1)
ACUN: 113476758(CNDP1)
PADL: 103924881(CNDP1)
AAM: 106482719(CNDP1)
ASN: 102367881(CNDP1)
AMJ: 106737110(CNDP1)
PSS: 102445657
CMY: 102938002
CPIC: 101937111(CNDP1)
ACS: 100554161(cndp1)
PVT: 110083379(CNDP1)
PMUR: 107291693(CNDP1)
TSR: 106550218
PMUA: 114600793 114600796
GJA: 107115115(CNDP1)
XLA: 398917(cndp1.L)
XTR: 100135225(cndp1)
NPR: 108799252
IPU: 108261199(Cndp1)
AMEX: 103026681
EEE: 113574437
SASA: 100196692(cndp1)
OTW: 112247755
SALP: 111964936 112068906
ELS: 105019194
SFM: 108940582
PKI: 111844178 111844287
LCM: 102355447
 » show all
Reference
1  [PMID:7116644]
  Authors
Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS
  Title
Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.
  Journal
Clin Chim Acta 123:221-31 (1982)
DOI:10.1016/0009-8981(82)90166-8
  Sequence
[hsa:84735]
Reference
2  [PMID:1903095]
  Authors
Jackson MC, Kucera CM, Lenney JF.
  Title
Purification and properties of human serum carnosinase.
  Journal
Clin Chim Acta 196:193-205 (1991)
DOI:10.1016/0009-8981(91)90073-L
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.20
IUBMB Enzyme Nomenclature: 3.4.13.20
ExPASy - ENZYME nomenclature database: 3.4.13.20
BRENDA, the Enzyme Database: 3.4.13.20
CAS: 525589-43-9

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Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Gene (162)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (118)   
   KEGG MGENES (19)   
   RefGene (24)   
Protein sequence (4621)   
   UniProt (742)   
   SWISS-PROT (3)   
   RefSeq(pep) (3872)   
   PDBSTR (4)   
DNA sequence (8233)   
   RefSeq(nuc) (7353)   
   GenBank (496)   
   EMBL (384)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   InterPro (4)   
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KEGG   REACTION: R01992
Entry
R01992                      Reaction                               

Name
alpha-Aminobutyryl histidine hydrolase
Definition
Homocarnosine + H2O <=> 4-Aminobutanoate + L-Histidine
Equation
Reaction class
RC00064  C00135_C00884
RC00090  C00334_C00884
Enzyme
3.4.13.18       3.4.13.20
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K05604  beta-Ala-His dipeptidase [EC:3.4.13.20]
K08660  cytosolic nonspecific dipeptidase [EC:3.4.13.18]
Other DBs
RHEA: 59575

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (446)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (444)   
All databases (461)   

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