KEGG ORTHOLOGY: K05659

ORTHOLOGY: K05659

Entry

K05659                      KO

Symbol

ABCB4

Name

ATP-binding cassette, subfamily B (MDR/TAP), member 4 [EC:7.6.2.2]

Pathway

map02010

ABC transporters

map04976

Bile secretion

Disease

H00624

Progressive familial intrahepatic cholestasis

H01213

Gallbladder disease

H02193

Intrahepatic cholestasis of pregnancy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
Enzymes [BR:ko01000]
7. Translocases
  7.6  Catalysing the translocation of other compounds
   7.6.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.6.2.2  ABC-type xenobiotic transporter
     K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4
Transporters [BR:ko02000]
ABC transporters, eukaryotic type
  ABCB (MDR/TAP) subfamily
   ABCB1, 4, 5 subgroups
    K05659  ABCB4; ATP-binding cassette, subfamily B (MDR/TAP), member 4

Other DBs

GO:

0008559

TC:

3.A.1.201

Genes

HSA:	5244(ABCB4)

PTR:	748364(ABCB4)

PPS:	100976274(ABCB4)

GGO:	101141298(ABCB4)

PON:	100455534(ABCB4)

PPYG:

129041428(ABCB4)

NLE:	100602308(ABCB4)

HMH:	116810860(ABCB4)

SSYN:

129479537(ABCB4)

MCC:	706683(ABCB4)

MCF:	102115339(ABCB4)

MTHB:

126951269

MNI:	105475442(ABCB4)

CSAB:

103226609(ABCB4)

CATY:

105595522(ABCB4)

PANU:

101006038(ABCB4)

TGE:	112620647(ABCB4)

MLEU:

105550951(ABCB4)

RRO:	104668032(ABCB4)

RBB:

108515081

TFN:	117072398(ABCB4)

PTEH:

111552468(ABCB4)

CANG:

105525959(ABCB4)

CJC:	100398854(ABCB4)

SBQ:	101051647(ABCB4)

CIMI:

108309913(ABCB4)

ANAN:

105716248(ABCB4)

CSYR:

103263646(ABCB4)

MMUR:

105879325(ABCB4)

LCAT:

123647731(ABCB4)

PCOQ:

105809669(ABCB4)

OGA:	100941619(ABCB4)

MMU:	18670(Abcb4)

MCAL:

110294486(Abcb4)

MPAH:

110316212

RNO:	24891(Abcb4)

MCOC:

116097475(Abcb4)

ANU:	117720593(Abcb4)

MUN:

110555239

CGE:	100682535(Abcb4)

MAUA:

101827092

PROB:

127214161(Abcb4)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103725175(Abcb4)

HGL:	101717251(Abcb4)

CCAN:

109689161

DORD:

105992956(Abcb4)

DSP:

122111906

PLOP:

125346969(Abcb4)

NCAR:

124991744

MMMA:

107156325(Abcb4)

OCU:

100354947

OPI:	101536241(ABCB4)

TUP:	102478068(ABCB4)

GVR:	103604812(ABCB4)

CFA:	482284(ABCB4)

CLUD:

112674995(ABCB4)

VVP:	112935084(ABCB4)

VLG:	121474668(ABCB4)

NPO:	129498288(ABCB4)

AML:	100475375(ABCB4)

UAH:	113259445(ABCB4)

UAR:	123789332(ABCB4)

ELK:

111155264

LLV:

125080472

MPUF:

101686685(ABCB4)

MNP:

132015976

MLK:	131829329(ABCB4)

NVS:	122904776(ABCB4)

ORO:	101368373(ABCB4)

EJU:	114220419(ABCB4)

ZCA:	113911239(ABCB4)

MLX:	118020707(ABCB4)

NSU:	110580161(ABCB4)

LWW:

102741359

FCA:	109497287(ABCB4)

PYU:	121028770(ABCB4)

PCOO:

112866669(ABCB4)

PBG:	122487837(ABCB4)

PVIV:

125155311(ABCB4)

LRUF:

124524791

PTG:	102972907(ABCB4)

PPAD:

109263643(ABCB4)

PUC:

125929866

AJU:

106987580

HHV:	120222235(ABCB4)

BTA:	100336913(ABCB4)

BOM:	102280988(ABCB4)

BIU:

109557315

BBUB:

102391160

CHX:	102171298(ABCB4)

OAS:

101122517

BTAX:

128046261(ABCB4)

ODA:

120878091

CCAD:

122438231

MBEZ:

129552321(ABCB4)

SSC:	100144586(ABCB4)

CFR:

102513941

CBAI:

105062361

CDK:	105087357(ABCB4)

VPC:	102537160(ABCB4)

BACU:

103002339(ABCB4)

BMUS:

118900924(ABCB4)

LVE:	103088229(ABCB4)

OOR:	101279182(ABCB4)

DLE:	111182170(ABCB4)

PCAD:

102983763(ABCB4)

PSIU:

116759679(ABCB4)

NASI:

112395342(ABCB4)

ECB:	100147513(ABCB4)

MYB:	102246156(ABCB4)

MYD:	102755637(ABCB4)

MMYO:

118666261(ABCB4)

MLF:	102429434(ABCB4)

MDT:	132242902(ABCB4)

PKL:	118714338(ABCB4)

EFUS:

129147028(ABCB4)

MNA:	107541721(ABCB4)

DRO:	112302075(ABCB4)

SHON:

119000975(ABCB4)

AJM:	119037193(ABCB4)

PDIC:

114507870(ABCB4)

PHAS:

123811391(ABCB4)

PPAM:

129063075(ABCB4)

HAI:	109371296(ABCB4)

RFQ:	117012091(ABCB4)

PALE:

102880063

PGIG:

120615075(ABCB4)

PVP:

105294804

RAY:	107512456(ABCB4)

MJV:

108409276

TOD:	119244682(ABCB4)

SARA:

101550735(ABCB4)

SETR:

126005159(ABCB4)

LAV:	100662269(ABCB4)

TMU:

101349036

ETF:	101638263(ABCB4)

DNM:	101424470(ABCB4)

MDO:	100462975(ABCB4)

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:	100077786(ABCB4)

GGA:	420534(ABCB1LA)

PCOC:

116243230

MGP:	100548646(ABCB1)

CJO:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TALA:

GCL:

LDI:

MNB:

DPUB:

AVIT:

BRHI:

CLV:

OHA:

AAM:

AROW:

NPD:

TGT:	104577100(ABCB4)

DNE:

112982321

SCAM:

104144102

ASN:

102387370

AMJ:	102558575(ABCB4)

CPOO:

109308449 109308457

GGN:	109291375 109291376(ABCB1)

CCAY:

125631396(ABCB1)

DCC:

119851057

TST:	117872178(ABCB1)

CABI:

116839971

MRV:	120399500(ABCB1)

ASAO:

132778877(ABCB1)

SUND:

121934120(ABCB1)

CTIG:

120302655

PGUT:

117655157(ABCB1)

APRI:

131197660(ABCB1)

PTEX:

113446443(ABCB1)

NSS:	113421121(ABCB1)

VKO:	123020652(ABCB1)

PRAF:

128423915(ABCB1)

HCG:	128330717(ABCB1)

STOW:

125440773(ABCB1)

EMC:

CCIN:

PPOT:

ACOO:

DVT:

HHAL:

106680715 106684013 106684014 106688466

HVI:

MQU:

FOC:

TPAL:

BROR:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

ABRU:

129960075 129965747 129965748

SDM:

GAE:

OED:

LJP:

LLON:

ATEN:

XEN:

TAD:	TRIADDRAFT_54424

» show all

Reference

PMID:20103563

Authors

Klaassen CD, Aleksunes LM

Title

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Journal

Pharmacol Rev 62:1-96 (2010)
DOI:10.1124/pr.109.002014

Reference

PMID:3405218

Authors

Gros P, Raymond M, Bell J, Housman D

Title

Cloning and characterization of a second member of the mouse mdr gene family.

Journal

Mol Cell Biol 8:2770-8 (1988)
DOI:10.1128/mcb.8.7.2770

Sequence

[mmu:18670]

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (1)   
   TC (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (420)   
   KEGG GENES (226)   
   KEGG MGENES (85)   
   RefGene (100)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (435)   

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