KEGG ORTHOLOGY: K05742

ORTHOLOGY: K05742

Entry

K05742                      KO

Symbol

SLC9A1, NHE1

Name

solute carrier family 9 (sodium/hydrogen exchanger), member 1

Pathway

map04024

cAMP signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04371

Apelin signaling pathway

map04810

Regulation of actin cytoskeleton

map04919

Thyroid hormone signaling pathway

map04970

Salivary secretion

map04971

Gastric acid secretion

map04972

Pancreatic secretion

map04976

Bile secretion

map05205

Proteoglycans in cancer

Disease

H01891

Autosomal recessive spinocerebellar ataxias

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
   04024 cAMP signaling pathway
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
   04261 Adrenergic signaling in cardiomyocytes
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
  09154 Digestive system
   04970 Salivary secretion
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
   04971 Gastric acid secretion
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
   04972 Pancreatic secretion
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
   04976 Bile secretion
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC9: Na+/H+ exchanger
   K05742  SLC9A1, NHE1; solute carrier family 9 (sodium/hydrogen exchanger), member 1

Other DBs

GO:

0015385

TC:	2.A.36.1.1 2.A.36.1.4

Genes

HSA:	6548(SLC9A1)

PTR:	456669(SLC9A1)

PPS:	100995124(SLC9A1)

GGO:	101134383(SLC9A1)

PON:	100450045(SLC9A1)

PPYG:

129026890(SLC9A1)

NLE:	100581293(SLC9A1)

HMH:	116813140(SLC9A1)

SSYN:

129471865(SLC9A1)

MCC:	720079(SLC9A1)

MCF:	101865259(SLC9A1)

MTHB:

126957182

MNI:	105494527(SLC9A1)

CSAB:

103225299(SLC9A1)

CATY:

105594911(SLC9A1)

PANU:

101025420(SLC9A1)

TGE:	112635877(SLC9A1)

MLEU:

105540915(SLC9A1)

RRO:	104675732(SLC9A1)

RBB:	108518204(SLC9A1)

TFN:	117093042(SLC9A1)

PTEH:

111547635(SLC9A1)

CANG:

105521356(SLC9A1)

CJC:	100388466(SLC9A1)

SBQ:	101042099(SLC9A1)

CIMI:

108308813(SLC9A1)

ANAN:

105708557(SLC9A1)

CSYR:

103262706(SLC9A1)

MMUR:

105863538(SLC9A1)

LCAT:

123634341(SLC9A1)

PCOQ:

105811736(SLC9A1)

OGA:	100948977(SLC9A1)

MMU:	20544(Slc9a1)

MCAL:

110292287(Slc9a1)

MPAH:

110322856(Slc9a1)

RNO:	24782(Slc9a1)

MCOC:

116096786(Slc9a1)

ANU:	117708502(Slc9a1)

MUN:	110552459(Slc9a1)

CGE:	100689320(Slc9a1)

MAUA:

101829817(Slc9a1)

PROB:

127225488(Slc9a1)

PLEU:

114705938(Slc9a1)

MORG:

121448105(Slc9a1)

MFOT:

126506383

AAMP:

119817666(Slc9a1)

NGI:	103737082(Slc9a1)

HGL:	101724784(Slc9a1)

CPOC:

100712925(Slc9a1)

CCAN:

109698756(Slc9a1)

DORD:

105999990(Slc9a1)

DSP:	122115294(Slc9a1)

PLOP:

125354778(Slc9a1)

NCAR:

124990681

MMMA:

107142074(Slc9a1)

OCU:	100009586(SLC9A1)

OPI:	101536442(SLC9A1)

TUP:	102501147(SLC9A1)

GVR:	103601876(SLC9A1)

CFA:	478171(SLC9A1)

CLUD:

112660000(SLC9A1)

VVP:	112931659(SLC9A1)

VLG:	121497607(SLC9A1)

NPO:	129513730(SLC9A1)

AML:	100478707(SLC9A1)

UMR:	103666507(SLC9A1)

UAH:	113268442(SLC9A1)

UAR:	123782222(SLC9A1)

ELK:	111140152 111140243

LLV:

125098221

MPUF:

101671364(SLC9A1)

MNP:	132001864(SLC9A1)

MLK:	131809234(SLC9A1)

NVS:	122899627(SLC9A1)

ORO:	101369980(SLC9A1)

EJU:	114216990(SLC9A1)

ZCA:	113936540(SLC9A1)

MLX:	118019822(SLC9A1)

NSU:	110575192(SLC9A1)

LWW:	102739307(SLC9A1)

FCA:	101088766(SLC9A1)

PYU:	121023973(SLC9A1)

PCOO:

112871858(SLC9A1)

PBG:	122480146(SLC9A1)

PVIV:

125173276(SLC9A1)

LRUF:

124514790

PTG:	102956531(SLC9A1)

PPAD:

109256776(SLC9A1)

PUC:

125912887

AJU:

106977548

HHV:	120231816(SLC9A1)

BTA:	317654(SLC9A1)

BOM:	102275424(SLC9A1)

BIU:	109573208(SLC9A1)

BBUB:

102403111(SLC9A1)

BBIS:

104981253(SLC9A1)

CHX:	102179249(SLC9A1)

OAS:	494435(SLC9A1)

BTAX:

128063641(SLC9A1)

ODA:	120855120(SLC9A1)

CCAD:

122426216(SLC9A1)

MBEZ:

129537871(SLC9A1)

SSC:	397458(SLC9A1)

CFR:	102517893(SLC9A1)

CBAI:

105063448(SLC9A1)

CDK:	105100703(SLC9A1)

VPC:	102531731(SLC9A1)

BACU:

103013771(SLC9A1)

BMUS:

118884016(SLC9A1)

LVE:	103083053(SLC9A1)

OOR:	101272326(SLC9A1)

DLE:	111163304(SLC9A1)

PCAD:

102979091(SLC9A1)

PSIU:

116761037(SLC9A1)

NASI:

112414346(SLC9A1)

ECB:	100070959(SLC9A1)

EPZ:	103550531(SLC9A1)

EAI:	106839089(SLC9A1)

MYB:	102260344(SLC9A1)

MYD:	102754223(SLC9A1)

MMYO:

118675346(SLC9A1)

MLF:	102436075(SLC9A1)

PKL:	118724295(SLC9A1)

EFUS:

103291901(SLC9A1)

MNA:	107540015(SLC9A1)

DRO:	112299258(SLC9A1)

SHON:

118977748(SLC9A1)

AJM:	119052315(SLC9A1)

PDIC:

114496434(SLC9A1)

PHAS:

123831818(SLC9A1)

MMF:	118626285(SLC9A1)

PPAM:

129069216(SLC9A1)

HAI:	109386737(SLC9A1)

RFQ:	117026708(SLC9A1)

PALE:

102888463(SLC9A1)

PGIG:

120595972(SLC9A1)

PVP:	105290506(SLC9A1)

RAY:	107503560(SLC9A1)

MJV:	108383513(SLC9A1)

TOD:	119235177(SLC9A1)

SARA:

101537005(SLC9A1)

SETR:

126011038(SLC9A1)

LAV:	104846349(SLC9A1)

TMU:

101342248

ETF:	101656593(SLC9A1)

DNM:	101430812(SLC9A1)

MDO:	100017140(SLC9A1)

GAS:	123240388(SLC9A1)

SHR:	100927417(SLC9A1)

AFZ:

127555631

PCW:	110206146(SLC9A1)

TVP:	118839303(SLC9A1)

OAA:	100088668(SLC9A1)

GGA:	419580(SLC9A1)

PCOC:

116230104(SLC9A1)

MGP:	100008573(SLC9A1)

CJO:	107323990(SLC9A1)

TPAI:

128088524(SLC9A1)

LMUT:

125703891(SLC9A1)

NMEL:

110387336(SLC9A1)

APLA:

101803574(SLC9A1)

ACYG:

106047889(SLC9A1)

CATA:

118255811(SLC9A1)

AFUL:

116498117(SLC9A1)

TGU:	100229450(SLC9A1)

LSR:	110472858(SLC9A1)

SCAN:

103823594(SLC9A1)

PMOA:

120513847(SLC9A1)

OTC:	121342704(SLC9A1)

PRUF:

121351223(SLC9A1)

GFR:	102032850(SLC9A1)

FAB:	101817623(SLC9A1)

OMA:	130262223(SLC9A1)

PHI:	102103995(SLC9A1)

PMAJ:

107214153(SLC9A1)

CCAE:

111938953(SLC9A1)

CBRC:

103616890(SLC9A1)

ETL:	114068051(SLC9A1)

ZAB:	102070269(SLC9A1)

ZLE:	135457183(SLC9A1)

ACHL:

103810670(SLC9A1)

SVG:	106861895(SLC9A1)

MMEA:

130586961(SLC9A1) 130587038

HRT:	120763167(SLC9A1)

FPG:	101911642(SLC9A1)

FCH:	102059778(SLC9A1)

CLV:	102086647(SLC9A1)

EGZ:	104134879(SLC9A1)

NNI:	104017832(SLC9A1)

PCRI:

104038030(SLC9A1)

PLET:

104624089(SLC9A1)

EHS:	104513598(SLC9A1)

PCAO:

104049927(SLC9A1)

ACUN:

113488369(SLC9A1)

TALA:

104360066(SLC9A1)

PADL:

103925878(SLC9A1)

AFOR:

103896410(SLC9A1)

ACHC:

115352135(SLC9A1)

HALD:

104313135(SLC9A1)

HLE:	104837199(SLC9A1)

AGEN:

126047210

GCL:

127025080

CCRI:

104160981(SLC9A1)

CSTI:

104552837(SLC9A1)

CMAC:

104478206(SLC9A1)

MUI:	104541202(SLC9A1)

BREG:

104637383(SLC9A1)

FGA:	104080805(SLC9A1)

GSTE:

104261938(SLC9A1)

LDI:	104353085(SLC9A1)

MNB:	103781391(SLC9A1)

OHA:	104337067(SLC9A1)

NNT:	104411303(SLC9A1)

SHAB:

115615511(SLC9A1)

DPUB:

104307516(SLC9A1)

PGUU:

104472298(SLC9A1)

ACAR:

104522817(SLC9A1)

CPEA:

104394130(SLC9A1)

AVIT:

104281496(SLC9A1)

CVF:	104283960(SLC9A1)

RTD:	128918828(SLC9A1)

CUCA:

104056314(SLC9A1)

TEO:	104376294(SLC9A1)

BRHI:

104501950(SLC9A1)

AROW:

112964377(SLC9A1)

NPD:	112950848(SLC9A1)

TGT:	104564467(SLC9A1)

DNE:	112982025(SLC9A1)

SCAM:

104149003(SLC9A1)

ASN:	102370779(SLC9A1)

AMJ:	102575554(SLC9A1)

CPOO:

109318619(SLC9A1)

GGN:	109294195(SLC9A1)

PSS:	102447706(SLC9A1)

CMY:	102944004(SLC9A1)

CCAY:

125624820(SLC9A1)

DCC:	119845526(SLC9A1)

CPIC:

101944127(SLC9A1)

TST:	117868272(SLC9A1)

CABI:

116837951(SLC9A1)

MRV:	120389145(SLC9A1)

ACS:	100555032(slc9a1)

ASAO:

132780763(SLC9A1)

PVT:	110090947(SLC9A1)

SUND:

121915811(SLC9A1)

PBI:	103064198(SLC9A1)

PMUR:

107294309(SLC9A1)

CTIG:

120304097(SLC9A1)

TSR:	106544692(SLC9A1)

PGUT:

117663527(SLC9A1)

APRI:

131204529(SLC9A1)

PTEX:

113437502(SLC9A1)

NSS:	113417644(SLC9A1)

VKO:	123025894(SLC9A1)

PMUA:

114601510(SLC9A1)

PRAF:

128418685(SLC9A1)

ZVI:	118086339(SLC9A1)

HCG:	128333030(SLC9A1)

GJA:	107110810(SLC9A1)

STOW:

125434756(SLC9A1)

EMC:	129343116(SLC9A1)

XLA:	108708100(slc9a1.L) 397917(slc9a1.S)

XTR:	100496739(slc9a1)

NPR:	108790812(SLC9A1)

RTEM:

120927367(SLC9A1)

BBUF:

120995213(SLC9A1)

BGAR:

122933199(SLC9A1)

MUO:	115479434(SLC9A1)

GSH:	117364880(SLC9A1)

DRE:	101885761(slc9a1a) 795135(slc9a1b)

SRX:	107713848(slc9a1) 107737341

SANH:

107671463 107688187 107700340

SGH:	107552533 107564092 107574818

CCAR:

109083024 109090531 109090532

CAUA:

113059462 113062461 113115650

CGIB:

127935208 127974998 128030322

PTET:

122335292(slc9a1b) 122360351(slc9a1a)

LROH:

127178372(slc9a1a) 127182141(slc9a1b)

OMC:	131521599(slc9a1a) 131525995(slc9a1b)

PPRM:

120474025(slc9a1b) 120491187(slc9a1a)

RKG:	130069821(slc9a1a) 130076378(slc9a1b)

MAMB:

125242798(slc9a1a) 125276063(slc9a1b)

CIDE:

127497134 127500864

MASI:

127425030 127453102 127454291

TROS:

130557634(slc9a1a) 130567485(slc9a1b)

TDW:	130415434(slc9a1b) 130432707(slc9a1a)

MANU:

129448862(slc9a1a) 129455984(slc9a1b)

IPU:	108256597(slc9a1a) 108274795(slc9a1b)

IFU:	128599586(slc9a1a) 128618310(slc9a1b)

PHYP:

113525374 113532843(slc9a1)

SMEO:

124375330(slc9a1a) 124392164(slc9a1b)

TFD:	113647201(slc9a1a) 113647390

TVC:	132840402(slc9a1a) 132857095(slc9a1b)

TRN:	134300833(slc9a1a) 134317033(slc9a1b)

AMEX:

103040045(slc9a1a) 103046642(slc9a1b)

CMAO:

118798731(slc9a1a) 118812754

EEE:	113583546(slc9a1) 113590159

CHAR:

105897780(slc9a1a) 105905315

TRU:	101067841 101068533

TFS:	130517808 130532884(slc9a1a)

TNG:	GSTEN00010467G001 GSTEN00022739G001

LCO:	104924410 104924712

NCC:	104952406 104953974(slc9a1)

TBEN:

117478181 117500559(slc9a1a)

CGOB:

115015521 115020992(slc9a1)

PGEO:

117455003 117460528(slc9a1a)

GACU:

117536657 117562102(slc9a1a)

EMAC:

134861599(slc9a1a) 134874653

ELY:	117263830 117265759(slc9a1a)

EFO:	125892531(slc9a1a) 125905108

PLEP:

121945900(slc9a1a) 121957776

SLUC:

116047130 116060760(slc9a1a)

ECRA:

117946136(slc9a1a) 117956214

ESP:	116690450 116701869

PFLV:

114556830 114568021

GAT:	120810001(slc9a1a) 120826957

PPUG:

119197771(slc9a1a) 119219404

AFB:	129096760 129109049(slc9a1a)

CLUM:

117738663 117745112(slc9a1a)

PSWI:

130196188 130212556(slc9a1a)

MSAM:

119897251(slc9a1a) 119907251

SCHU:

122864973 122881789(slc9a1a)

CUD:	121513220(slc9a1a) 121523741

ALAT:

119005653(slc9a1a) 119016505

MZE:	101464569 101464596(slc9a1)

ONL:	100693255 100705611 109196493

OAU:	116315166 116320903(slc9a1a)

OLA:	101159279 101169232

OML:	112137653 112143495(slc9a1a)

CSAI:

133437368(slc9a1a) 133460619

XMA:	102218019 102232120(slc9a1)

XCO:	114141527 114155455

XHE:	116716910 116730769

PRET:

103473001 103477776

PFOR:

103139290 103143467

PLAI:

106944619(slc9a1) 106951939

PMEI:

106916615(slc9a1) 106923528

GAF:	122830810(slc9a1a) 122843173

PPRL:

129370908(slc9a1a) 129375767

CVG:	107081039 107082978

CTUL:

119777459(slc9a1a) 119790508

GMU:	124865536(slc9a1a) 124879676

NFU:	107379331 107394941

KMR:	108240374(slc9a1a) 108247901

ALIM:

106523060 106530115

NWH:	119409909(slc9a1a) 119425950

AOCE:

111564499 111578585

MCEP:

125016172(slc9a1a) 125019487

CSEM:

103388013 103393918

POV:	109633492 109642949

SSEN:

122774397(slc9a1a) 122786706

HHIP:

117770924 117777405(slc9a1a)

HSP:	118113353(slc9a1a) 118124588

PPLT:

128450131(slc9a1a) 128461354

SMAU:

118291840 118299746(slc9a1a)

LCF:	108898979 108899520(slc9a1a)

SDU:	111230510 111235712

SLAL:

111649465 111651770(slc9a1)

XGL:	120784304(slc9a1a) 120786347

HCQ:	109515389(slc9a1) 109516318

SSCV:

125975259 125986527

SBIA:

133501272(slc9a1a) 133502493(slc9a1b)

PEE:	133395510(slc9a1b) 133401523(slc9a1a)

PTAO:

133470783(slc9a1b) 133479370(slc9a1a)

BPEC:

110168855 110174232

MALB:

109954622 109958593

BSPL:

114843111(slc9a1a) 114865369

SJO:	128367026(slc9a1a) 128373718

SASA:

106570377 106582892 106605147

STRU:

115175592 115177066 115177122

OTW:	112223053 112229545(slc9a1b) 112246138

OMY:	100136740(slc9a1b) 110488849 110517020(slc9a1a)

OGO:	124004698(slc9a1a) 124017667 124043294(slc9a1b)

ONE:	115105336 115131357 115141201

OKI:	109877270 109903432 109909783

OKE:	118364304 118367366 118371968(slc9a1b)

SALP:

111955156 111959135 111959156

SNH:	120027422 120031147 120047130(slc9a1a)

CCLU:

121571853 123487330

ELS:	105012566 105028363

SFM:

108919129

PKI:	111843924 111844542

AANG:

118230682(slc9a1a) 118233475

LOC:	102687426(slc9a1)

PSPA:

121308281

ARUT:

117413273 117964095

PSEX:

120517185(slc9a1a)

LCM:	102351735(SLC9A1)

CMK:

103179577

RTP:	109914572(slc9a1a)

CPLA:

122563565(slc9a1a)

HOC:	132830143(slc9a1a)

LERI:

129709792(slc9a1a)

ARUN:

CSEC:

HAME:

HAZT:

LSM:	121115671 121117321 121119439 121123039 121126158 121130828

TCF:	131884380 131887879

PPOI:

DFR:

ABRU:

UDV:

LPOL:

NAI:	NECAME_01970

PVUL:

126827725

PCAN:

112555699

GAE:	121370086 121370124 121371817

HRF:

124130842

HRJ:

124253204

CRG:	105322233 105349034

CANU:

128179764 128180381

CVN:	111135252 111135925

OED:	125658049 130050191

PMAX:

MMER:

RPHI:

MAEA:

OBI:

OSN:	115222036 115222200 115222298

LJP:

135479455

EGL:	EGR_05159 EGR_08904

LLON:

ADF:

HSY:

RES:

AQU:

MBR:	MONBRDRAFT_29272

» show all

Reference

PMID:2536298

Authors

Sardet C, Franchi A, Pouyssegur J

Title

Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

Journal

Cell 56:271-80 (1989)
DOI:10.1016/0092-8674(89)90901-X

Sequence

[hsa:6548]

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Pathway (22)   
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Drug (2)   
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Gene (1320)   
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   KEGG MGENES (264)   
   RefGene (473)   
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Literature (1)   
   PubMed (1)   
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