KEGG ORTHOLOGY: K05871

ORTHOLOGY: K05871

Entry

K05871                      KO

Symbol

PTK2B, FAK2

Name

focal adhesion kinase 2 [EC:2.7.10.2]

Pathway

map04020

Calcium signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04670

Leukocyte transendothelial migration

map04912

GnRH signaling pathway

map05135

Yersinia infection

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05170

Human immunodeficiency virus 1 infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   04072 Phospholipase D signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   04670 Leukocyte transendothelial migration
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   04062 Chemokine signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
  09152 Endocrine system
   04912 GnRH signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   05161 Hepatitis B
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   05163 Human cytomegalovirus infection
    K05871  PTK2B, FAK2; focal adhesion kinase 2
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05871  PTK2B, FAK2; focal adhesion kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05871  PTK2B, FAK2; focal adhesion kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05871  PTK2B, FAK2; focal adhesion kinase 2
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  FAK family
   K05871  PTK2B, FAK2; focal adhesion kinase 2

Other DBs

GO:

0004715

Genes

HSA:	2185(PTK2B)

PTR:	464073(PTK2B)

PPS:	100991936(PTK2B)

GGO:	101135800(PTK2B)

PON:	100174613(PTK2B)

PPYG:

129043148(PTK2B)

NLE:	100599503(PTK2B)

HMH:	116461989(PTK2B)

SSYN:

129491434(PTK2B)

MCC:	712787(PTK2B)

MCF:	102130539(PTK2B)

MTHB:

126961760

MNI:	105482017(PTK2B)

CSAB:

103215524(PTK2B)

CATY:

105579176(PTK2B)

PANU:

101023887(PTK2B)

TGE:	112630290(PTK2B)

MLEU:

105542344(PTK2B)

RRO:	104673947(PTK2B)

RBB:	108537591(PTK2B)

TFN:	117093809(PTK2B)

PTEH:

111545732(PTK2B)

CANG:

105513663(PTK2B)

CJC:	100404210(PTK2B)

SBQ:	101032561(PTK2B)

CIMI:

108312440(PTK2B)

ANAN:

105705327(PTK2B)

CSYR:

103251411(PTK2B)

MMUR:

105877126(PTK2B)

LCAT:

123626648(PTK2B)

PCOQ:

105825274(PTK2B)

OGA:	100959766(PTK2B)

MMU:	19229(Ptk2b)

MCAL:

110308944(Ptk2b)

MPAH:

110325924(Ptk2b)

RNO:	50646(Ptk2b)

MCOC:

116085323(Ptk2b)

ANU:	117705222(Ptk2b)

MUN:	110559230(Ptk2b)

CGE:	100758086(Ptk2b)

MAUA:

101835508(Ptk2b)

PROB:

127230243(Ptk2b)

PLEU:

114707316(Ptk2b)

MORG:

121455807(Ptk2b)

MFOT:

126507587

AAMP:

119799720(Ptk2b)

NGI:	103730003(Ptk2b)

HGL:	101714384(Ptk2b)

CPOC:

100734027(Ptk2b)

CCAN:

109698054(Ptk2b)

DORD:

105991587(Ptk2b)

DSP:	122123482(Ptk2b)

PLOP:

125339296(Ptk2b)

NCAR:

124982353

MMMA:

107153900(Ptk2b)

OCU:

100342358

OPI:	101526211(PTK2B)

TUP:	102481841(PTK2B)

GVR:	103595200(PTK2B)

CFA:	486102(PTK2B)

CLUD:

112669698(PTK2B)

VVP:	112926788(PTK2B)

VLG:	121497328(PTK2B)

NPO:	129523357(PTK2B)

AML:	100478801(PTK2B)

UMR:	103675966(PTK2B)

UAH:	113269957(PTK2B)

UAR:	123777394(PTK2B)

ELK:

111153692

LLV:

125092973

MPUF:

101688546(PTK2B)

MNP:	131999727(PTK2B)

MLK:	131833269(PTK2B)

NVS:	122889648(PTK2B)

ORO:	101373391(PTK2B)

EJU:	114217420(PTK2B)

ZCA:	113924963(PTK2B)

MLX:	118022110(PTK2B)

NSU:	110588553(PTK2B)

LWW:

102736119

FCA:	101091691(PTK2B)

PYU:	121022204(PTK2B)

PCOO:

112858915(PTK2B)

PBG:	122473846(PTK2B)

PVIV:

125163560(PTK2B)

LRUF:

124520193

PTG:	102955963(PTK2B)

PPAD:

109262338(PTK2B)

PUC:

125923801

AJU:

106973108

HHV:	120220289(PTK2B)

BTA:	541008(PTK2B)

BOM:	102266592(PTK2B)

BIU:	109563157(PTK2B)

BBUB:

102411722(PTK2B)

BBIS:

104988719(PTK2B)

CHX:	102184810(PTK2B)

OAS:	101106906(PTK2B)

BTAX:

128052409(PTK2B)

ODA:	120860357 120866066

CCAD:

122431820(PTK2B)

MBEZ:

129556920(PTK2B)

SSC:	100157507(PTK2B)

CFR:	102520664(PTK2B)

CBAI:

105063850(PTK2B)

CDK:	105102240(PTK2B)

VPC:	102535738(PTK2B)

BACU:

103016023(PTK2B)

BMUS:

118896881(PTK2B)

LVE:	103083166(PTK2B)

OOR:	101281402(PTK2B)

DLE:	111185408(PTK2B)

PCAD:

102995810(PTK2B)

PSIU:

116755418(PTK2B)

NASI:

112414976(PTK2B)

ECB:	100054547(PTK2B)

EPZ:	103550428(PTK2B)

EAI:	106832511(PTK2B)

MYB:	102256791(PTK2B)

MYD:	102756394(PTK2B)

MMYO:

118659060(PTK2B)

MLF:	102442091(PTK2B)

MDT:	132235324(PTK2B)

PKL:	118710950(PTK2B)

EFUS:

103294332(PTK2B)

MNA:	107538557(PTK2B)

DRO:	112312413(PTK2B)

SHON:

118984359(PTK2B)

AJM:	119044625(PTK2B)

PDIC:

114502461(PTK2B)

PHAS:

123814030(PTK2B)

MMF:	118615360(PTK2B)

PPAM:

129072531(PTK2B)

HAI:	109379535(PTK2B)

RFQ:	117037602(PTK2B)

PALE:

102886432(PTK2B)

PGIG:

120613198(PTK2B)

PVP:	105292221(PTK2B)

RAY:	107515459(PTK2B)

MJV:	108394326(PTK2B)

TOD:	119258011(PTK2B)

SARA:

101544808(PTK2B)

SETR:

126006104(PTK2B)

LAV:	100667505(PTK2B)

TMU:

101354947

ETF:	101661831(PTK2B)

DNM:	101440141(PTK2B)

MDO:	100025175(PTK2B)

GAS:	123237099(PTK2B)

SHR:	100923387(PTK2B)

AFZ:

127548792

PCW:	110206529(PTK2B)

TVP:	118843207(PTK2B)

OAA:	100085161(PTK2B)

GGA:	421998(PTK2B)

PCOC:

116235641(PTK2B)

MGP:	100549921(PTK2B)

CJO:	107312386(PTK2B)

TPAI:

128084692(PTK2B)

LMUT:

125689756(PTK2B)

NMEL:

110395785(PTK2B)

ACYG:

106049520(PTK2B)

CATA:

118259056(PTK2B)

AFUL:

116487529(PTK2B)

LSR:	110477410(PTK2B)

PMOA:

120503435(PTK2B)

OTC:

121341216

FAB:	101806020(PTK2B)

PHI:	102099730(PTK2B)

PMAJ:

107199198

CCAE:

111927477(PTK2B)

CBRC:

103611216(PTK2B)

ZLE:	135446305(PTK2B)

ACHL:

103812159(PTK2B)

SVG:	106860376(PTK2B)

FPG:	101919541(PTK2B)

FCH:	102058792(PTK2B)

CCRI:

104164311(PTK2B)

NNT:	104407198(PTK2B)

SHAB:

115609824(PTK2B)

ACUN:

113478314(PTK2B)

TALA:

116959317(PTK2B)

ACHC:

115351243(PTK2B)

HLE:	104841481(PTK2B)

AGEN:

126046526

GCL:

127015229

CSTI:

104555780(PTK2B)

DPUB:

104306721(PTK2B)

AVIT:

104281029(PTK2B)

BRHI:

104500477(PTK2B)

EGZ:	104132028(PTK2B)

NNI:	104014715(PTK2B)

PCRI:

104027161(PTK2B)

AFOR:

103895523(PTK2B)

CLV:	102085172(PTK2B)

MUI:	104541088(PTK2B)

PGUU:

104462502(PTK2B)

EHS:	104508908(PTK2B)

CUCA:

104061781(PTK2B)

TEO:	104376880(PTK2B)

OHA:	104329906(PTK2B)

ACAR:

104518097(PTK2B)

CPEA:

104392787(PTK2B)

CVF:	104295692(PTK2B)

RTD:	128907579(PTK2B)

AAM:	106486362(PTK2B)

AROW:

112966660(PTK2B)

NPD:	112948924(PTK2B)

TGT:	104578163(PTK2B)

DNE:	112993186(PTK2B)

SCAM:

104154089(PTK2B)

ASN:	102383255(PTK2B)

AMJ:	102569140(PTK2B)

CPOO:

109311565(PTK2B)

PSS:	102461932(PTK2B)

CMY:	102944545(PTK2B)

CCAY:

125634745(PTK2B)

DCC:	119852626(PTK2B)

CPIC:

101946809(PTK2B)

TST:	117875441(PTK2B)

CABI:

116830885(PTK2B)

MRV:	120400397(PTK2B)

ACS:	100563957(ptk2b)

ASAO:

132761642(PTK2B)

PVT:	110089495(PTK2B)

SUND:

121921082(PTK2B)

PBI:	103053129(PTK2B)

PMUR:

107293495(PTK2B)

CTIG:

120309118(PTK2B)

TSR:

106543337

PGUT:

117667683(PTK2B)

APRI:

131189001(PTK2B)

PTEX:

113446316(PTK2B)

NSS:	113414579(PTK2B)

VKO:	123033644(PTK2B)

PMUA:

114594952(PTK2B)

PRAF:

128411461(PTK2B)

ZVI:	118082945(PTK2B)

HCG:	128324699(PTK2B)

GJA:	107111937(PTK2B)

STOW:

125444273(PTK2B)

EMC:	129335860(PTK2B)

XLA:	108717254(ptk2b.L) 108718305(ptk2b.S)

XTR:	496459(ptk2b)

NPR:

108801309

RTEM:

120936042(PTK2B)

BBUF:

120997154(PTK2B)

BGAR:

122936340(PTK2B)

MUO:	115467030(PTK2B)

GSH:	117357009(PTK2B)

DRE:	245950(ptk2bb) 557258(ptk2ba)

SRX:	107707077 107733482(ptk2b)

SANH:

107653750 107692419 107697310 107701495

SGH:	107552084(ptk2b) 107563684 107589060 107594075

CCAR:

109103027 109106793(ptk2b) 109113399

CAUA:

113060836 113091776 113097198 113117730 113121041 113121042

CGIB:

127938895 127976309 127983888 128031808

PTET:

122343211 122362180(ptk2ba)

LROH:

127179473(ptk2ba) 127183199(ptk2bb)

OMC:	131522807(ptk2ba) 131526926(ptk2bb)

PPRM:

120470523(ptk2bb) 120480831(ptk2ba)

RKG:	130088952(ptk2ba) 130097563(ptk2bb)

MAMB:

125268325(ptk2ba) 125277755(ptk2bb)

CIDE:

127499105 127502502

CERY:

137006698(ptk2ba) 137018848(ptk2bb)

MASI:

127409784 127411419 127455323

TROS:

130560132(ptk2ba) 130565649(ptk2bb)

TDW:	130434320(ptk2bb) 130436856(ptk2ba)

MANU:

129417672(ptk2ba) 129429005(ptk2bb)

IPU:	108258133(ptk2bb) 108270138(ptk2ba)

IFU:	128601246(ptk2bb) 128612220(ptk2ba)

PHYP:

113538681(ptk2b) 113545212

SMEO:

124376976(ptk2bb) 124389721(ptk2ba)

TFD:	113644777(ptk2bb) 113659549(ptk2ba)

TVC:	132843328(ptk2bb) 132852357(ptk2ba)

TRN:	134320875(ptk2bb) 134325823(ptk2ba)

AMEX:

103031863(ptk2bb) 103036889(ptk2ba)

CMAO:

118815521(ptk2bb) 118823514(ptk2ba)

EEE:	113572664(ptk2b) 113573003

CHAR:

105895697(ptk2ba) 105897727(ptk2bb)

TRU:	101066596(ptk2b) 101067972

TFS:	130515673(ptk2bb) 130523181

TNG:	GSTEN00027121G001 GSTEN00030312G001

LCO:	104922431(ptk2b) 104929121

NCC:	104964448(ptk2b)

TBEN:

117492574(ptk2bb) 117499048

CGOB:

115003734(ptk2b) 115017135

PGEO:

117439984(ptk2bb) 117460188

GACU:

117533772(ptk2bb) 117546892

EMAC:

134860757 134876646(ptk2bb)

ELY:	117255568 117270872(ptk2bb)

EFO:	125884879 125896531(ptk2bb)

PLEP:

121955332 121962660

SLUC:

116044716 116066076(ptk2bb)

ECRA:

117939207 117961384(ptk2bb)

ESP:	116673744 116706211(ptk2b)

PFLV:

114550829 114572960(ptk2b)

GAT:	120808070(ptk2bb) 120824977

PPUG:

119194952(ptk2bb) 119221937

AFB:	129107377(ptk2bb) 129111585

CLUM:

117727328(ptk2bb) 117743579

PSWI:

130202125(ptk2bb) 130204622

MSAM:

119887582 119902997 119908914(ptk2bb)

SCHU:

122863255(ptk2bb) 122871805

CUD:	121506250 121521567(ptk2bb)

ALAT:

119012956(ptk2bb) 119015368

MZE:	101466145 101469888(ptk2b)

ONL:	100691138(ptk2b) 100702843

OAU:	116314090(ptk2bb) 116327901

OLA:	101166779 101168007(ptk2b)

OML:	112138372 112157942(ptk2bb)

CSAI:

133418528(ptk2bb) 133425339

XMA:	102220254(ptk2b) 102237728

XCO:	114137677 114158618(ptk2b)

XHE:	116715778 116734185

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122825179(ptk2bb) 122826862

PPRL:

129351157(ptk2bb) 129355414

CVG:	107083800(ptk2b) 107092212

CTUL:

119785101(ptk2bb) 119793630

GMU:	124861361 124881821(ptk2bb)

NFU:	107380902 107397038(ptk2b)

KMR:	108242464(ptk2bb) 108244129

ALIM:

106525285(ptk2b) 106529652

NWH:	119418531(ptk2bb) 119428711

AOCE:

111585687 111587153(ptk2b)

MCEP:

124998729(ptk2bb) 125000744

CSEM:

103389360 103398680

POV:	109636011 109640090

SSEN:

122784027(ptk2bb)

HHIP:

117758326(ptk2bb) 117772460

HSP:	118099834(ptk2bb) 118103620

PPLT:

128430878 128460416(ptk2bb)

SMAU:

118289928(ptk2bb) 118301915

LCF:	108892923 108895601(ptk2bb)

SDU:	111237992 111239921

SLAL:

111652662 111665302

XGL:	120788723(ptk2bb) 120798377

HCQ:	109520887 109524920(ptk2b)

SSCV:

125988876 125990611

SBIA:

133492446 133496510(ptk2bb)

PEE:	133411001 133417259(ptk2bb)

PTAO:

133467880(ptk2bb) 133490120

BPEC:

110166006 110175523(ptk2b)

MALB:

109960575 109970009

BSPL:

114849564(ptk2bb) 114851144

SJO:	128354547(ptk2ba)

SASA:

106571025(ptk2b) 106603693 106608317

STRU:

115147339 115172956 115175167

OTW:	112235635 112236672 112262237

OMY:	110498235(ptk2ba) 110522644 110529162

OGO:	123990476 124001761(ptk2ba) 124019145

ONE:	115110872 115120329 115123001(ptk2b)

OKI:	109879499 109883186 109887799

OKE:	118377175 118377755

SNH:	120019200 120024469 120060127

CCLU:

121539063(ptk2ba) 121552414 121556174(ptk2bb)

ELS:	105007684 105028736

SFM:	108924101 108934847

PKI:	111841315 111857950

AANG:

118229639(ptk2bb)

LOC:	102695443(ptk2b)

PSPA:

121316233 121317355(ptk2ba)

ARUT:

117402900 117411343

PSEX:

120526386(ptk2ba)

LCM:	102364762(PTK2B)

RTP:	109915589(ptk2ba)

HOC:	132819612(ptk2ba)

LERI:

129699358(ptk2ba)

OVI:	T265_13813

EPA:

110254117

» show all

Reference

PMID:7544443

Authors

Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J

Title

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.

Journal

Nature 376:737-45 (1995)
DOI:10.1038/376737a0

Sequence

[hsa:2185]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (20)   
   KEGG PATHWAY (20)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1131)   
   KEGG GENES (510)   
   KEGG MGENES (368)   
   RefGene (247)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (1159)   

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